667C > T and 1298A > C polymorphisms of MTHFR do not predict response to methotrexate in patients with gestational trophoblastic neoplasia

Gynecologic Oncology

Volumn 123, Issue 3, 2011, Pages 605-609

  Lasecka, Lidia ^a   Dixon, Peter H ^a   Molokhia, Mariam ^b   Sharma, Nima ^a   Schleh, Annabel ^a   Wang, Chiuhui Mary ^a   Steel, Jennifer H ^a   Seckl, Michael J ^c   Savage, Philip M ^c   Fisher, Rosemary A ^a,c  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

1298A > C; 677C > T; Gestational trophoblastic neoplasia; Hydatidiform mole; Methotrexate; MTHFR polymorphisms

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); CHORIONIC GONADOTROPIN; DNA; FOLINIC ACID; METHOTREXATE;

ALLELE; ARTICLE; DRUG EFFICACY; FEMALE; GENETIC ASSOCIATION; GENOTYPE; GESTATIONAL AGE; HUMAN; HUMAN TISSUE; HYDATIDIFORM MOLE; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; PREGNANCY OUTCOME; PREGNANT WOMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; TROPHOBLASTIC TUMOR;

ADULT; ANTIMETABOLITES, ANTINEOPLASTIC; DNA, NEOPLASM; FEMALE; GESTATIONAL TROPHOBLASTIC DISEASE; HUMANS; METHOTREXATE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; YOUNG ADULT;

EID: 81155152250     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2011.08.012     Document Type: Article

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