The kidney speaks: Interpreting urinary sodium and osmolality

Archives of Disease in Childhood: Education and Practice Edition

Volumn 96, Issue 6, 2011, Pages 223-227

  Bockenhauer, Detlef ^a   Aitkenhead, H ^b  

^a Great Ormond Street Hospital for Children NHS Trust ^*  (United Kingdom)

^b GREAT ORMOND STREET HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CREATININE; SODIUM; VASOPRESSIN;

CREATININE URINE LEVEL; DIURESIS; HUMAN; HYPERNATREMIA; KIDNEY; NEPHROTIC SYNDROME; PRIORITY JOURNAL; REVIEW; SODIUM EXCRETION; SODIUM URINE LEVEL; URINALYSIS; URINE; URINE OSMOLALITY; URINE VOLUME; WATER RETENTION;

ACID-BASE EQUILIBRIUM; CHEMISTRY, CLINICAL; HUMANS; KIDNEY; KIDNEY DISEASES; OSMOLAR CONCENTRATION; PEDIATRICS; SODIUM; WATER-ELECTROLYTE BALANCE;

EID: 81155139619     PISSN: 17430585     EISSN: 17430593     Source Type: Journal    
DOI: 10.1136/archdischild-2011-300115     Document Type: Review

References (45)

1. Smith HW. From Fish to Philosopher: The Story of our Internal Environment. Summit, NJ: CIBA Pharmaceutical Products Inc 1959.
2. Moritz ML, Ayus JC. Preventing neurological complications from dysnatremias in children. Pediatr Nephrol 2005;20:1687-700. (Pubitemid 41722951)
3. Cansick J, Rees L, Koffman G, et al. A fatal case of cerebral oedema with hyponatraemia and massive polyuria after renal transplantation. Pediatr Nephrol 2009;24:1231-4.
4. Hoorn EJ, Halperin ML, Zietse R. Diagnostic approach to a patient with hyponatraemia: traditional versus physiology-based options. QJM 2005;98:529-40. (Pubitemid 41418674)
5. Abele JE. The physical background to freezing point osmometry and its medical-biological applications. Am J Med Electron 1963;2:32-41.
6. Kamel KS, Ethier JH, Richardson RM, et al. Urine electrolytes and osmolality: when and how to use them. Am J Nephrol 1990;10:89-102.
7. Rose BD. Meaning and application of urine chemistries. In: Rose BD, ed. Clinical Physiology of Acid-base and Elecrolyte Disorders. New York, NY: McGraw-Hill 2001:405-14.
8. Handa SP, Morrin PA. Diagnostic indices in acute renal failure. Can Med Assoc J 1967;96:78-82.
9. Espinel CH. The FENa test. Use in the differential diagnosis of acute renal failure. JAMA 1976;236:579-81.
10. Miller TR, Anderson RJ, Linas SL, et al. Urinary diagnostic indices in acute renal failure: a prospective study. Ann Intern Med 1978;89:47-50. (Pubitemid 8390144)
11. Mathew OP, Jones AS, James E, et al. Neonatal renal failure: usefulness of diagnostic indices. Pediatrics 1980;65:57-60. (Pubitemid 10068621)
12. Ellis EN, Arnold WC. Use of urinary indexes in renal failure in the newborn. Am J Dis Child 1982;136:615-17. (Pubitemid 12075629)
13. Airede A, Bello M, Weerasinghe HD. Acute renal failure in the newborn: incidence and outcome. J Paediatr Child Health 1997;33:246-9. (Pubitemid 27295021)
14. Pru C, Kjellstrand CM. The FENa test is of no prognostic value in acute renal failure. Nephron 1984;36:20-3. (Pubitemid 14211338)
15. Durakovic Z, Durakovic A, Durakovic S. The lack of clinical value of laboratory parameters in predicting outcome in acute renal failure. Ren Fail 1989;11:213-19. (Pubitemid 20270798)
16. Fahimi D, Mohajeri S, Hajizadeh N, et al. Comparison between fractional excretions of urea and sodium in children with acute kidney injury. Pediatr Nephrol 2009;24:2409-12.
17. Brosius FC, Lau K. Low fractional excretion of sodium in acute renal failure: role of timing of the test and ischemia. Am J Nephrol 1986;6:450-7. (Pubitemid 17014767)
18. Rees L, Webb NJ, Brogan PA. Paediatric Nephrology. First edition. Oxford: Oxford University Press 2007.
19. Van de Walle JG, Donckerwolcke RA, Greidanus TB, et al. Renal sodium handling in children with nephrotic relapse: relation to hypovolaemic symptoms. Nephrol Dial Transplant 1996;11:2202-8. (Pubitemid 26385915)
20. Kapur G, Valentini RP, Imam AA, et al. Treatment of severe edema in children with nephrotic syndrome with diuretics alone-a prospective study. Clin J Am Soc Nephrol 2009;4:907-13.
21. Camici M. Molecular pathogenetic mechanisms of nephrotic edema: progress in understanding. Biomed Pharmacother 2005;59:215-23. (Pubitemid 40799173)
22. Svenningsen P, Bistrup C, Friis UG, et al. Plasmin in nephrotic urine activates the epithelial sodium channel. J Am Soc Nephrol 2009;20:299-310.
23. Polzin D, Kaminski HJ, Kastner C, et al. Decreased renal corin expression contributes to sodium retention in proteinuric kidney diseases. Kidney Int 2010;78:650-9.
24. Ganong CA, Kappy MS. Cerebral salt wasting in children. The need for recognition and treatment. Am J Dis Child 1993;147:167-9. (Pubitemid 23057399)
25. Jiménez R, Casado-Flores J, Nieto M, et al. Cerebral salt wasting syndrome in children with acute central nervous system injury. Pediatr Neurol 2006;35:261-3. (Pubitemid 44397433)
26. Bitew S, Imbriano L, Miyawaki N, et al. More on renal salt wasting without cerebral disease: response to saline infusion. Clin J Am Soc Nephrol 2009;4:309-15.
27. Rivkees SA. Differentiating appropriate antidiuretic hormone secretion, inappropriate antidiuretic hormone secretion and cerebral salt wasting: the common, uncommon, and misnamed. Curr Opin Pediatr 2008;20:448-52.
28. Leblanc PE, Cheisson G, Geeraerts T, et al. [Does cerebral salt wasting syndrome exist?]. Ann Fr Anesth Reanim 2007;26:948-53.
29. Yee AH, Burns JD, Wijdicks EF. Cerebral salt wasting: pathophysiology, diagnosis, and treatment. Neurosurg Clin N Am 2010;21:339-52.
30. Coulthard MG, Haycock GB. Distinguishing between salt poisoning and hypernatraemic dehydration in children. BMJ 2003;326:157-60. (Pubitemid 36135576)
31. Bockenhauer D. Diabetes insipidus. In: Geary DF, Schaefer F, eds. Comprehensive Pediatric Nephrology. Philadelphia, PA: Mosby Elsevier 2008:489-98.
32. Bennett M, Dent CL, Ma Q, et al. Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study. Clin J Am Soc Nephrol 2008;3:665-73.
33. Nguyen MT, Devarajan P. Biomarkers for the early detection of acute kidney injury. Pediatr Nephrol 2008;23:2151-7.
34. Mishra J, Dent C, Tarabishi R, et al. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet 2005;365:1231-8. (Pubitemid 40469655)
35. Machnik A, Neuhofer W, Jantsch J, et al. Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism. Nat Med 2009;15:545-52.
36. Titze J, Maillet A, Lang R, et al. Long-term sodium balance in humans in a terrestrial space station simulation study. Am J Kidney Dis 2002;40:508-16. (Pubitemid 34971279)
37. Sørensen JB, Andersen MK, Hansen HH. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in malignant disease. J Intern Med 1995;238:97-110.
38. Bichet DG, Razi M, Lonergan M, et al. Hemodynamic and coagulation responses to 1-desamino[8-D-arginine] vasopressin in patients with congenital nephrogenic diabetes insipidus. N Engl J Med 1988;318:881-7. (Pubitemid 18090272)
39. Winberg J. Determination of renal concentration capacity in infants and children without renal disease. Acta Paediatrica 1958;48:318-28.
40. Bockenhauer D, Carpentier E, Rochdi D, et al. Vasopressin Type 2 Receptor V88M Mutation: Molecular Basis of Partial and Complete Nephrogenic Diabetes Insipidus. Nephron Physiol 2009;114:p1-p10.
41. Sadeghi H, Robertson GL, Bichet DG, et al. Biochemical basis of partial nephrogenic diabetes insipidus phenotypes. Mol Endocrinol 1997;11:1806-13. (Pubitemid 27467759)
42. Ala Y, Morin D, Mouillac B, et al. Functional studies of twelve mutant V2 vasopressin receptors related to nephrogenic diabetes insipidus: molecular basis of a mild clinical phenotype. J Am Soc Nephrol 1998;9:1861-72.
43. Laredo S, Yuen K, Sonnenberg B, et al. Coexistence of central diabetes insipidus and salt wasting: the diffi culties in diagnosis, changes in natremia, and treatment. J Am Soc Nephrol 1996;7:2527-32. (Pubitemid 27469558)
44. Bockenhauer D, Cruwys M, Kleta R, et al. Antenatal Bartter's syndrome: why is this not a lethal condition? QJM 2008;101:927-42.
45. Bockenhauer D, van't Hoff W, Dattani M, et al. Secondary nephrogenic diabetes insipidus as a complication of inherited renal diseases. Nephron Physiol 2010;116:23-9.