Red blood cell-coupled tissue plasminogen activator prevents impairment of cerebral vasodilatory responses through inhibition of c-Jun-N-terminal kinase and potentiation of p38 mitogen-activated protein kinase after cerebral photothrombosis in the newborn pig

Pediatric Critical Care Medicine

Volumn 12, Issue 6, 2011, Pages

  Armstead, William M ^a,b   Ganguly, Kumkum ^f   Riley, John ^a   Kiessling, Willis J ^a   Cines, Douglas B ^c   Higazi, Abd A R ^c,g   Zaitsev, Sergei ^b,d   Muzykantov, Vladimir R ^b,d,e  

^a Biomedical Informatics and Entrepreneurial Sciences   (United States)

^b Departments of Molecular Pharmacology   (United States)

^c Pathology and Laboratory Medicine   (United States)

^d Institute for Translational Medicine and Therapeutics   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f LOS ALAMOS NATIONAL LABORATORY   (United States)

^g HEBREW UNIVERSITY   (Israel)

Author keywords

cerebral hemodynamics; pediatric; plasminogen activators; signal transduction; stroke

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; DJNKI 1; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; STRESS ACTIVATED PROTEIN KINASE; TISSUE PLASMINOGEN ACTIVATOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; BLOOD CHEMISTRY; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; CEREBRAL PHOTOTHROMBOSIS; CEREBROSPINAL FLUID; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; ERYTHROCYTE; FEMALE; HYPERCAPNIA; HYPOTENSION; MALE; NEWBORN; NONHUMAN; OCCLUSIVE CEREBROVASCULAR DISEASE; PIA ARTERY; PRIORITY JOURNAL; REVIEW; TREATMENT RESPONSE; UPREGULATION; VASODILATATION;

ANIMALS; ANIMALS, NEWBORN; BRAIN; ERYTHROCYTES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROSPECTIVE STUDIES; RANDOM ALLOCATION; TISSUE PLASMINOGEN ACTIVATOR; TOXOPLASMOSIS, CEREBRAL; VASODILATION;

EID: 81155138207     PISSN: 15297535     EISSN: 19473893     Source Type: Journal    
DOI: 10.1097/PCC.0b013e3181fe40a7     Document Type: Article

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