Methylmercury and selenium speciation in different tissues of beluga whales (Delphinapterus leucas) from the western Canadian Arctic

Environmental Toxicology and Chemistry

Volumn 30, Issue 12, 2011, Pages 2732-2738

  Lemes, Marcos ^a   Wang, Feiyue ^a   Stern, Gary A ^a,b   Ostertag, Sonja K ^c   Chan, Hing Man ^c  

^a UNIVERSITY OF MANITOBA   (Canada)

^b FISHERIES AND OCEANS CANADA   (Canada)

^c UNIVERSITY OF NORTHERN BRITISH COLUMBIA   (Canada)

Author keywords

Analytical toxicology; Marine mammals; Mercury; Selenium; Speciation

Indexed keywords

ANALYTICAL TOXICOLOGY; ARCTIC MARINE; BELUGA WHALES; BLOOD-BRAIN BARRIER; BRAIN TISSUE; CANADIAN ARCTIC; DELPHINAPTERUS LEUCAS; GLUTATHIONES; HG COMPLEXES; HIGH CONCENTRATION; MARINE MAMMALS; METHYL MERCURY; MONOMETHYLMERCURY; RETENTION TIME; SELENIUM SPECIATION; SELENOAMINO ACIDS; SPECIATION; TOXIC EFFECT;

BRAIN; MAMMALS; MERCURY (METAL); MERCURY COMPOUNDS; MUSCLE; SELENIUM; TOXICITY;

HISTOLOGY;

CYSTEINE ETHYL ESTER; GLUTATHIONE DERIVATIVE; METHYLMERCURY DERIVATIVE; SELENIUM; SELENOAMINO ACID; THIOL DERIVATIVE;

CONCENTRATION (COMPOSITION); DATA SET; ENVIRONMENTAL MONITORING; FUNCTIONAL MORPHOLOGY; ION; MARINE ENVIRONMENT; METABOLISM; METHYLMERCURY; MOLECULAR ANALYSIS; POLLUTION EFFECT; SELENIUM; TOXICITY; TOXICOLOGY; WHALE;

ANIMAL TISSUE; ARCTIC; ARTICLE; BELUGA WHALE; BLOOD BRAIN BARRIER; CANADA; NONHUMAN; PRIORITY JOURNAL; SPECIES DIFFERENTIATION;

ANIMALS; ARCTIC REGIONS; BELUGA WHALE; BLOOD-BRAIN BARRIER; CANADA; ENVIRONMENTAL MONITORING; KIDNEY; LIVER; METHYLMERCURY COMPOUNDS; MUSCLES; SELENIUM; TISSUE DISTRIBUTION; WATER POLLUTANTS, CHEMICAL;

CANADA; CANADIAN ARCTIC;

DELPHINAPTERUS LEUCAS; MAMMALIA;

EID: 81155137908     PISSN: 07307268     EISSN: 15528618     Source Type: Journal    
DOI: 10.1002/etc.684     Document Type: Article

References (36)

1. Gaden A, Ferguson SH, Harwood L, Melling H, Stern GA. 2009. Mercury trends in ringed seals (Phoca hispida) from the western Canadian Arctic since 1973: Associations with length of ice-free season. Environ Sci Technol 43: 3646-3651.
2. Lockhart WL, Stern GA, Wagemann R, Hunt RV, Metner DA, DeLaronde J, Dunn B, Stewart REA, Hyatt CK, Harwood L, Mount K. 2005. Concentrations of mercury in tissues of beluga whales (Delphinapterus leucas) from several communities in the Canadian Arctic from 1981 to 2002. Sci Total Environ 351/352: 391-412.
3. Arctic Monitoring and Assessment Program. 2011. AMAP Assessment 2011: Mercury in the Arctic. Oslo, Norway.
4. Wagemann R, Trebacz E, Boila G, Lockhart WL. 1998. Methylmercury and total mercury in tissues of arctic marine mammals. Sci Total Environ 218: 19-31.
5. Aschner M, Aschner JL. 1990. Mercury neurotoxicity: Mechanisms of blood-brain barrier transport. Neurosci Biobehav Rev 14: 169-176.
6. Korbas M, O'Donoghue JL, Watson GE, Pickering IJ, Singh SP, Myers GJ, Clarkson TW, George GN. 2010. The chemical nature of mercury in human brain following poisoning or environmental exposure. ACS Chem Neurosci 1: 810-818.
7. Mergler D, Anderson HA, Chan LHM, Mahaffey KR, Murray M, Sakamoto M, Stern AH. 2007. Methylmercury exposure and health effects in humans: A worldwide concern. Ambio 36: 3-11.
8. Loseto LL, Stern GA, Ferguson SH. 2008. Size and biomagnification: How habitat selection explains beluga mercury levels. Environ Sci Technol 42: 3982-3988.
9. Canadian Food Inspection Agency. 2001. Canadian Guidelines for Chemical Contaminants and Toxins in Fish and Fish Products. Ottawa, ON, Canada.
10. Arctic Monitoring and Assessment Program. 2009. AMAP Assessment 2009: Human Health in the Arctic. Oslo, Norway.
11. Van Oostdam J, Donaldson SG, Feeley M, Arnold D, Ayotte P, Bondy G, Chan L, Dewaily E, Furgal CM, Kuhnlein H, Loring E, Muckle G, Myles H, Receveur O, Tracy B, Gill U, Kalhok S. 2005. Human health implications of environmental contaminants in Arctic Canada: A review. Sci Total Environ 351-352: 165-246.
12. Dietz R, Riget F, Born EW. 2000. An assessment of selenium to mercury in Greenland marine animals. Sci Total Environ 245: 15-24.
13. Wang F, Lemes M, Khan MA. 2011. Metallomics of mercury: Role of thiol- and selenol-containing biomolecules. In Liu G, Cai Y, O'Driscoll N, eds, Environmental Chemistry and Toxicology of Mercury. Wiley-Blackwell, New York, NY, in press.
14. Lemes M, Wang F. 2009. Methylmercury speciation in fish muscle by HPLC-ICP-MS following enzymatic hydrolysis. J Anal At Spectrom 24: 663-668.
15. Clarkson TW. 1993. Molecular and ionic mimicry of toxic metals. Annu Rev Pharmacol Toxicol 33: 545-571.
16. Simmons-Willis TA, Koh AS, Clarkson TW, Ballatori N. 2002. Transport of a neurotoxicant by molecular mimicry: The methylmercury-L-cysteine complex is a substrate for human L-type large neutral amino acid transporter (LAT) 1 and LAT2. Biochem J 367: 239-246.
17. Khan MAK, Wang F. 2010. Chemical demethylation of methylmercury by selenoamino acids. Chem Res Toxicol 23: 1202-1206.
18. Belzile N, Chen Y-W, Yang D-Y, Truong H-Y, Zhao Q-X. 2009. Selenium bioaccumulation in freshwater organisms and antagonistic effect against mercury assimilation. Environ Bioind 4: 203-221.
19. Ralston NVC, Raymond LJ. 2010. Dietary selenium's protective effects against methylmercury toxicity. Toxicology 278: 112-123.
20. Khan MAK, Wang F. 2009. Mercury-selenium compounds and their toxicological significance: toward a molecular understanding of the mercury-selenium antagonism. Environ Toxicol Chem 28: 1567-1577.
21. Stewart REA, Campana SE, Jones CM, Stewart BE. 2006. Bomb radiocarbon dating calibrates beluga (Delphinapterus leucas) age estimates. Can J Zool 84: 1840-1852.
22. Loseto LL, Stern GA, Deibel D, Connelly TL, Prokopowicz A, Lean DRS, Fortier L, Ferguson SH. 2008. Linking mercury exposure to habitat and feeding behaviour in Beaufort Sea beluga whales. J Mar Systems 74: 1012-1024.
23. U.S. Environmental Protection Agency. 2002. Mercury in water by oxidation, purge and trap, and cold vapor atomic fluorescence spectrometry. Method 1631, Revision E. Washington, DC.
24. Uthe JF, Solomon J, Grift B. 1972. Rapid semimicro method for the determination of methyl mercury in fish tissue. J AOAC Intern 55: 583-589.
25. Wagemann RF, Trebacz E, Hunt R, Boila G. 1997. Percent methylmercury and organic mercury in tissues of marine mammals and fish using different experimental and calculation methods. Environ Toxicol Chem 16: 1859-1866.
26. Li L, Wang F, Meng B, Lemes M, Feng XB, Jiang GB. 2010. Speciation of methylmercury in rice grown from a mercury mining area. Environ Pollut 158: 3103-3107.
27. Hu X, Wang F, Hanson M. 2009. Selenium concentration, speciation and behavior in surface waters of the Canadian prairies. Sci Total Environ 407: 5869-5876.
28. 1-x nanoparticles and possible significance in Hg-Se antagonism. Chem Res Toxicol 22: 1827-1832.
29. Wagemann R, Kozlowska H. 2005. Mercury distribution in the skin of beluga (Delphinapterus leucas) and narwhal (Monodon monoceros) from the Canadian Arctic and mercury burdens and excretion by moulting. Sci Total Environ 351-352: 333-343.
30. Meador JP, Varanasi U, Robisch PA, Chan S-L. 1993. Toxic metals in pilot whales (Globicephaki meaelaena) from strandings in 1986 and 1990 on Cape Cod, Massachusetts. Can J Fish Aquat Sci 50: 2698-2706.
31. Basu N, Scheuhammer AM, Sonne C, Letcher RJ, Born EW, Dietz R. 2009. Is dietary mercury of neurotoxicological concern to wild polar bears (Ursus maritimus)? Environ Toxicol Chem 28: 133-140.
32. Suzuki KT, Sasakura C, Yoneda S. 1998. Binding sites for the (Hg-Se) complex on selenoprotein P. Biochim Biophys Acta 1429: 102-112.
33. Yoneda S, Suzuki KT. 1997. Equimolar Hg-Se complex binds to selenoprotein P. Biochem Biophys Res Commun 231: 7-11.
34. Gailer J, George GN, Pickering IJ, Madden S, Prince RC, Yu EY, Denton MB, Younis HS, Aposhian HV. 2000. Structure basis of the antagonism between inorganic mercury and selenium in mammals. Chem Res Toxicol 13: 1135-1142.
35. Pearson RG. 1963. Hard and soft acids and bases. J Am Chem Soc 85: 3533-3539.
36. Fasman GD. 1989. Prediction of Protein Structure and the Principles of Protein Conformation. Plenum, New York, NY, USA.