Design, synthesis, and pharmacological evaluation of haloperidol derivatives as novel potent calcium channel blockers with vasodilator activity

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Chen, Yicun ^a   Zheng, Jinhong ^a   Zheng, Fuchun ^a   Wang, Jinzhi ^a   Zhang, Yanmei ^a   Gao, Fenfei ^a   Huang, Zhanqin ^a   Shi, Ganggang ^a  

^a SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; CALCIUM ION; HALOPERIDOL; N 4 TERT BUTYL BENZYL HALOPERIDOL CHLORIDE; UNCLASSIFIED DRUG; CALCIUM; DRUG DERIVATIVE; POTASSIUM CHLORIDE;

ANIMAL TISSUE; ARTICLE; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; EXTRACELLULAR CALCIUM; IC 50; INHIBITION KINETICS; NONHUMAN; PHYSICAL CHEMISTRY; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; THORACIC AORTA; VASCULAR SMOOTH MUSCLE; VASODILATATION; ANIMAL; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; DRUG EFFECT; EXTRACELLULAR SPACE; IN VITRO STUDY; INTRACELLULAR SPACE; MALE; METABOLISM; SYNTHESIS; WISTAR RAT;

RATTUS;

ANIMALS; AORTA, THORACIC; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; EXTRACELLULAR SPACE; HALOPERIDOL; INTRACELLULAR SPACE; MALE; MUSCLE, SMOOTH, VASCULAR; POTASSIUM CHLORIDE; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, WISTAR; VASODILATION;

EID: 81155137572     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027673     Document Type: Article

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