A randomized study of the effect of mifepristone alone or in conjunction with ethinyl estradiol on ovarian function in women using the etonogestrel-releasing subdermal implant, Implanon®

Contraception

Volumn 84, Issue 6, 2011, Pages 600-608

  Weisberg, Edith ^a,b   Croxatto, Horatio B ^c   Findlay, John K ^d   Burger, Henry G ^d   Fraser, Ian S ^a,b  

^a FAMILY PLANNING NSW   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

^c CENTER FOR THE DEVELOPMENT OF NANOSCIENCE AND NANOTECHNOLOGY CEDENNA   (Chile)

^d HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Ethinyl estradiol; Etonogestrel; Implanon ; Mifepristone; Subdermal implant

Indexed keywords

ESTRADIOL; ETHINYLESTRADIOL; ETONOGESTREL; FOLLITROPIN; LUTEINIZING HORMONE; MIFEPRISTONE; PLACEBO; PROGESTERONE;

ADULT; ARTICLE; CLINICAL ARTICLE; DRUG IMPLANT; ESTRADIOL BLOOD LEVEL; FEMALE; FOLLITROPIN BLOOD LEVEL; HUMAN; LUTEINIZING HORMONE BLOOD LEVEL; OVARY FOLLICLE; OVARY FUNCTION; OVULATION; PROGESTERONE BLOOD LEVEL; TRANSVAGINAL ECHOGRAPHY; UTERINE CERVIX MUCUS; UTERUS BLEEDING;

ADOLESCENT; ADULT; CERVIX MUCUS; CONTRACEPTIVE AGENTS, FEMALE; DESOGESTREL; DOUBLE-BLIND METHOD; DRUG IMPLANTS; DRUG INTERACTIONS; DRUG THERAPY, COMBINATION; ESTRADIOL; ETHINYL ESTRADIOL; FEMALE; HUMANS; LUTEINIZATION; MENSTRUAL CYCLE; MIDDLE AGED; MIFEPRISTONE; OVARY; OVULATION INHIBITION; UTERINE HEMORRHAGE; VISCOSITY; YOUNG ADULT;

EID: 81155134643     PISSN: 00107824     EISSN: 18790518     Source Type: Journal    
DOI: 10.1016/j.contraception.2011.04.008     Document Type: Article

References (23)

1. United Nations Population Division World Contraceptive Use 2005. World Health Organization Surveys Information System http://www.un.org/esa/population/ publications/contraceptive2005/WCU2005.htm Accessed on 27-02-2010
2. C. D'Arcangues, V. Odlind, and I.S. Fraser Dysfunctional uterine bleeding induced by exogenous hormones M.J. Alexander, C. d'Arcangues, Steroid hormones and uterine bleeding 1992 AAAS Press Washington (DC) 81 106
3. L. Cheng, H. Zhu, A. Wanag, F. Ren, J. Chen, and A. Glasier Once a month administration of mifepristone improves bleeding patterns in women using subdermal contraceptive implants releasing levonorgestrel Hum Reprod 15 2000 1969 1972
4. M.R. Massie, M. Pavez, and B. Fuentealba Effect of intermittent treatment with mifepristone on bleeding patterns in Norplant implant users Contraception 70 2004 47 54 (Pubitemid 38781978)
5. I.S. Fraser, and M. Hickey Surface vascularisation and endometrial appearance in women with menorrhagia or using levonorgestrel implants. Implication for mechanisms of breakthrough bleeding Hum Reprod 17 2002 2428 2434 (Pubitemid 35021470)
6. A.F. Glasier, H. Wang, and J.E. Davie Administration of an antiprogesterone up-regulates estrogen receptors in the endometrium of women using Norplant: a pilot study Fertil Steril 77 2002 366 372 (Pubitemid 34086914)
7. C.J. Chuong, and P.F. Brenner Management of abnormal uterine bleeding Am J Obstet Gynecol 175 3 Pt 2 1996 787 792 (Pubitemid 26353241)
8. E. Weisberg, M. Hickey, D. Palmer, V. O'Connor, L.A. Salamonsen, and J.K. Findlay A pilot study to assess the effect of three short-term treatments on frequent and/or prolonged bleeding compared to placebo in women using Implanon Hum Reprod 21 2006 295 302 (Pubitemid 41794324)
9. K.R. Meckstroth, and P.D. Darney Implant contraception Semin Reprod Med 19 2001 339 354 (Pubitemid 34028422)
10. E. Weisberg, M. Hickey, D. Palmer, V. O'Connor, L.A. Salamonsen, and J.K. Findlay A randomized controlled trial of treatment options for troublesome uterine bleeding in Implanon users Hum Reprod 24 2009 1852 1861
11. L. Mäkäräinen, A. van Beek, L. Tuomivaara, B. Asplund, and H. Coelingh Bennink Ovarian function during the use of a single contraceptive implant: Implanon compared with Norplant Fertil Steril 69 1998 714 721 (Pubitemid 28188469)
12. World Health Organization WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction 4th ed. 1999 Cambridge University Press Cambridge, UK
13. N.N. Sakar Mifepristone: bioavailability, pharmacokinetics and use effectiveness Eur J Obstet Gynecol Reprod Biol 10 2002 113 120
14. O. Heikinheimo Clinical pharmacokinetics of mifepristone Clin Pharmacokinet 33 1997 7 17 (Pubitemid 27303114)
15. J. Parinaud, B. Perret, H. Ribbes, G. Vieitez, and E.E. Baulieu Effects of RU486 on progesterone secretion by human preovulatory granulosa cells in culture J Clin Endocrinol Metab 70 1990 1534 1537
16. H.B. Croxatto, A.M. Salvatierra, B. Fuentealba, and L. Leiva Follicle stimulating hormone-granulosa cell axis involvement in the antifolliculotrophic effect of low dose mifepristone (RU486) Hum Reprod 10 1995 1987 1991
17. E.V. Velasquez, S. Creus, R.V. Trigo, S.B. Cigorraga, E.H. Pellizzari, and H.B. Croxatto Pituitary-ovarian axis during lactational amenorrhoea. II. Longitudinal assessment of serum FSH polymorphism before and after recovery of menstrual cycles Hum Reprod 21 2006 916 923
18. E.V. Velasquez, R.V. Trigo, S. Creus, S. Campo, and H.B. Croxatto Pituitary-ovarian axis during lactational amenorrhoea. I. Longitudinal assessment of follicular growth, gonadotrophins, sex steroids and inhibin levels before and after recovery of menstrual cyclicity Hum Reprod. 21 2006 909 915
19. O. Heikinheimo, S. Ranta, S. Grinberg, and I.M. Spitz Alteration in sex steroids and gonadotrophins in post-menopausal women subsequent to long-term mifepristone administration Steroids 64 2000 831 836
20. G. Klinger, W. Carol, A. Börner, W. Michels, and K.R. Romero Hormone analytical and carrier protein alterations following administration of mifepristone (RU 486) for termination of early pregnancy Exp Clin Endocrinol 97 1991 63 67
21. H.B. Croxatto Progestin implants for female contraception Contraception 65 2002 15 19
22. J.-D. Wang, W.-L. Shi, G.-Q. Zhang, and X.-M. Bai Tissue and serum levels of steroid hormones and RU486 after administration of mifepristone Contraception 49 1994 245 253 (Pubitemid 124009887)
23. M.J. Fassett, G.C. Lachelin, H.H. McGarrigle, and D.A. Wing Alterations in saliva steroid hormone levels after oral mifepristone administration in women with pregnancies of greater than 41 weeks' gestation Reprod Sci 15 2008 394 399 (Pubitemid 351697331)