Alterations in saliva steroid hormone levels after oral mifepristone administration in women with pregnancies of greater than 41 weeks' gestation

Reproductive Sciences

Volumn 15, Issue 4, 2008, Pages 394-399

  Fassett, Michael J ^a,d   Lachelin, Gillian C L ^b   McGarrigle, Hugh H G ^b   Wing, Deborah A ^c  

^a KAISER PERMANENTE MEDICAL CENTER   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d KAISER PERMANENTE   (United States)

Author keywords

Labor induction; Mifepristone; Saliva steroids

Indexed keywords

ESTRADIOL; ESTRIOL; HYDROCORTISONE; MIFEPRISTONE; PLACEBO; PROGESTERONE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEMOGRAPHY; DRUG MECHANISM; FEMALE; GESTATIONAL AGE; HORMONE DETERMINATION; HUMAN; HUMAN EXPERIMENT; LABOR INDUCTION; PREGNANCY; PRIORITY JOURNAL; PROLONGED PREGNANCY; RADIOIMMUNOASSAY; RANDOMIZED CONTROLLED TRIAL; SALIVA LEVEL; UTERINE CERVIX RIPENING;

ADMINISTRATION, ORAL; ADULT; CERVICAL RIPENING; ESTRADIOL; ESTRIOL; FEMALE; HUMANS; HYDROCORTISONE; LABOR, INDUCED; MIFEPRISTONE; PREGNANCY; PREGNANCY, PROLONGED; PROGESTERONE; RADIOIMMUNOASSAY; SALIVA; STATISTICS, NONPARAMETRIC;

EID: 43849106948     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719107310305     Document Type: Article

References (22)

1. Cabrol MD, Dubois MD, Cronje H., et al. Induction of labor with mifepristone (RU486) in intrauterine fetal death. Am J Obstet Gynecol. 1990 ; 163: 540-542.
2. Frydman R., Lelaidier C., Baton-Saint-Mleux C., et al. Labor induction in women at term with mifepristone (RU486): a double-blind, randomized, placebo-controlled study. Obstet Gynecol. 1992 ; 80: 972-975.
3. Stenlund PM, Edman G., Aedo AR, et al. Induction of labor with mifepristone-a randomized, double-blind study versus placebo. Acta Obstet Gynecol Scand. 1999 ; 78: 793-798.
4. Elliott CL, Brennand JE, Calder AA The effects of mifepristone of cervical ripening and labor induction in primigravidae. Obstet Gynecol. 1998 ; 92: 804-809.
5. Giacalone PL, Daures JP, Faure JM, et al. The effects of mifepristone on uterine sensitivity to oxytocin and on fetal heart rate patterns. Eur J Obstet Gynecol Reprod Biol. 2001 ; 97: 30-34.
6. Vining RF, McGinley, Symons RG. Hormones in saliva: mode of entry and consequent implications for clinical interpretation. Clin Chem. 1983 ; 29: 1752-1756.
7. Lachelin GCL, McGarrigle HHG. A comparison of saliva, plasma unconjugated and plasma total oestriol levels throughout normal pregnancy. Br J Obstet Gynecol. 1984 ; 91: 1203-1209.
8. Wing DA, Fassett MJ, Mishell DR Mifepristone for preinduction cervical ripening beyond 41 weeks' gestation: a randomized controlled trial. Obstet Gynecol. 2000 ; 96: 543-548.
9. Darne J., McGarrigle HHG, Lachelin GCL. Saliva oestriol, oestradiol, oestrone and progesterone levels in pregnancy: spontaneous labour at term is preceded by a rise in the saliva oestriol:progesterone ratio. Br J Obstet Gynaecol. 1987 ; 94: 227-235.
10. Scott EM, McGarrigle HHG, Lachelin GCL. The increase in plasma and saliva cortisol levels in pregnancy is not due to the increase in corticosteroids binding globulin levels. J Clin Endocrinol Metab. 1990 ; 71: 639-644.
11. Heikinheimo O. Clinical pharmacokinetics of mifepristone. Clin Pharmacokinet. 1997 ; 33: 7-17.
12. Heikinihemo O., Kekkonen R., Lahteenmaki P. The pharmacokinetics of mifepristone in humans reveal insights into differential mechanisms of antiprogestin action. Contraception. 2003 ; 68: 421-426.
13. Stjernholm YM, Sahlin L., Eriksson HA, et al. Cervical ripening after treatment with prostaglandin E2 or antiprogestin (RU486): possible mechanisms in relation to gonadal steroids. Eur J Obstet Gynecol Reprod Biol. 1999 ; 84: 83-88.
14. Weng L., Jiao L., Tang X. Histological study of the uterine cervix during termination of early pregnancy by mifepristone and prostaglandins. Chinese J Obstet Gynecol. 1995 ; 30: 522-525.
15. Di WL, Lachelin GC, McGarrigle HH, et al. Oestriol and oestradiol increase cell to cell communication and connexin43 protein expression in human myometrium. Mol Hum Reprod. 2001 ; 7: 671-679.
16. Dong YL, Yallampalli C. Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP2 and contractile FP receptors in the rat uterus. Biol Reprod. 2000 ; 62: 533-539.
17. Giacalone PL, Targosz V., Laffargue F., et al. Cervical ripening with mifepristone before labor induction: a randomized study. Obstet Gynecol. 1998 ; 92: 487-492.
18. Hill NC, Selinger M., Ferguson J., et al. The placental transfer of mifepristone (RU486) during the second trimester and its influence upon maternal and fetal steroid concentrations. Br J Obstet Gynaecol. 1990 ; 97: 406-411.
19. Norman JE, Kelly RW, Baird DT Uterine activity and decidual prostaglandin production in women in early pregnancy in response to mifepristone with or without indomethacin in vivo. Hum Rep. 1991 ; 6 (5). 740-744.
20. Karalis K., Goodwin G., Mazjoub JA Cortisol blockade of progesterone: a possible molecular mechanism involved in the initiation of human labor. Nat Med. 1996 ; 2: 556-560.
21. Darne J., McGarrigle HHG, Lachelin GCL. Increased saliva oestriol to progesterone ratio before idiopathic preterm delivery: a possible predictor for preterm labour ? BMJ. 1987 ; 294: 270-272.
22. Moran DJ, McGarrigle HHG, Lachelin GCL. Lack of normal increase in saliva estriol/progesterone ratio in women with labor induced at 42 weeks' gestation. Am J Obstet Gynecol. 1992 ; 167: 1563-1564.