What is the role of chemotherapy in endometrial cancer?

Current Oncology Reports

Volumn 13, Issue 6, 2011, Pages 433-441

  Hogberg, Thomas ^a  

^a LUND UNIVERSITY   (Sweden)

Author keywords

Antineoplastic agents; Carcinoma drug therapy; Chemotherapy, adjuvant; Drug therapy; Endometrial neoplasms; Radiotherapy; Randomized controlled trials as topic; Therapeutic use; Treatment outcome

Indexed keywords

CARBOPLATIN; CISPLATIN; CYCLOPHOSPHAMIDE; DOXORUBICIN; EPIRUBICIN; PACLITAXEL; TRASTUZUMAB;

ACUTE GRANULOCYTIC LEUKEMIA; ADVANCED CANCER; ANEMIA; ARTICLE; BONE MARROW SUPPRESSION; BONE MARROW TOXICITY; BRACHYTHERAPY; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RISK; CANCER SURVIVAL; CAUSE OF DEATH; CYSTITIS; DIARRHEA; DISEASE FREE SURVIVAL; DOSE RESPONSE; DRUG EFFICACY; DRUG FATALITY; DRUG SAFETY; DRUG TOLERABILITY; ENDOMETRIUM CANCER; ENDOMETRIUM CARCINOMA; EXTERNAL BEAM RADIOTHERAPY; FEBRILE NEUTROPENIA; GASTROINTESTINAL SYMPTOM; GYNECOLOGIC CANCER; HEART DISEASE; HEMATOLOGIC DISEASE; HUMAN; HYSTERECTOMY; INTERMETHOD COMPARISON; INTESTINE OBSTRUCTION; MULTIPLE CYCLE TREATMENT; NAUSEA AND VOMITING; NEUROLOGIC DISEASE; NEUROTOXICITY; NEUTROPENIA; OVARY CANCER; OVERALL SURVIVAL; PROGRESSION FREE SURVIVAL; RADIATION INJURY; RECURRENT CANCER; RISK ASSESSMENT; SALPINGOOOPHORECTOMY; THROMBOCYTOPENIA; URINARY TRACT INFECTION; WHOLE BODY RADIATION;

ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; ENDOMETRIAL NEOPLASMS; FEMALE; HUMANS; RANDOMIZED CONTROLLED TRIALS AS TOPIC;

EID: 81155133815     PISSN: 15233790     EISSN: 15346269     Source Type: Journal    
DOI: 10.1007/s11912-011-0192-x     Document Type: Article

References (47)

1. GLOBOCAN. Available at: www-dep.iarc.fr, 2011.
2. NORDCAN. Available at: www-dep.iarc.fr/NORDCAN/SW/frame.asp, 2011.
3. WT Creasman F Odicino P Maisonneuve MA Quinn U Beller JL Benedet, et al. 2006 Carcinoma of the corpus uteri. FIGO 26th Annual Report on the Results of Treatment in Gynecological Cancer Int J Gynaecol Obstet 95 Suppl 1 S105 S143 17161155 10.1016/S0020-7292(06)60031-3 (Pubitemid 44854931)
4. LM Landrum KN Moore TK Myers GS Lanneau Jr DS McMeekin JL Walker, et al. 2009 Stage IVB endometrial cancer: does applying an ovarian cancer treatment paradigm result in similar outcomes? A case-control analysis Gynecol Oncol 112 2 337 341 19041126 10.1016/j.ygyno.2008.10.009
5. JV Bokhman 1983 Two pathogenetic types of endometrial carcinoma Gynecol Oncol 15 1 10 17 6822361 10.1016/0090-8258(83)90111-7 1:STN:280: DyaL3s7gs1KktA%3D%3D (Pubitemid 13194678)
6. N Bansal V Yendluri RM Wenham 2009 The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies Canc Contr 16 1 8 13
7. IB Engelsen LA Akslen HB Salvesen 2009 Biologic markers in endometrial cancer treatment APMIS 117 10 693 707 19775337 10.1111/j.1600-0463.2009.02467.x 1:CAS:528:DC%2BD1MXhtlGgtbzK An extensive review on molecular mechanisms and putative targets for targeted therapy in endometrial cancer
8. J Aalders V Abeler P Kolstad M Onsrud 1980 Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients Obstet Gynecol 56 4 419 427 6999399 1:STN:280:DyaL3M%2FjtFChsQ%3D%3D (Pubitemid 10018299)
9. P Blake AM Swart J Orton H Kitchener T Whelan H Lukka, et al. 2009 Adjuvant external beam radiotherapy in the treatment of endometrial cancer (MRC ASTEC and NCIC CTG EN.5 randomised trials): pooled trial results, systematic review, and meta-analysis Lancet 373 9658 137 146 19070891 10.1016/S0140- 6736(08)61767-5 1:STN:280:DC%2BD1M%2Fmt1yrtQ%3D%3D
10. CL Creutzberg WL van Putten PC Koper ML Lybeert JJ Jobsen CC Warlam-Rodenhuis, et al. 2000 Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma Lancet 355 9213 1404 1411 10791524 10.1016/S0140-6736(00) 02139-5 1:STN:280:DC%2BD3c3ltVWlsQ%3D%3D (Pubitemid 30215963)
11. HM Keys JA Roberts VL Brunetto RJ Zaino NM Spirtos JD Bloss, et al. 2004 A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study Gynecol Oncol 92 3 744 751 14984936 10.1016/j.ygyno.2003. 11.048 (Pubitemid 38251372)
12. Kong AA, Johnson N, Cornes P, Simera I, Collingwood M, Williams C, et al. Adjuvant radiotherapy for stage I endometrial cancer (review). The Cochrane Library 2009;(Issue 1):Available at: http://www.thecochranelibrary.com.
13. DS McMeekin 2009 Where is the future of endometrial cancer therapy? Ann Oncol 20 11 1757 1761 19861581 10.1093/annonc/mdp493 1:STN:280: DC%2BD1MjitVejuw%3D%3D An interesting editorial by one of the key persons in the endometrial cancer group of GOG discussing the present status and possible future of chemotherapy in endometrial cancer
14. CE Humber JF Tierney RP Symonds M Collingwood J Kirwan C Williams, et al. 2007 Chemotherapy for advanced, recurrent or metastatic endometrial cancer: a systematic review of Cochrane collaboration Ann Oncol 18 3 409 420 17150999 10.1093/annonc/mdl417 1:STN:280:DC%2BD2s7hsVCiuw%3D%3D (Pubitemid 46359618)
15. SM Temkin G Fleming 2009 Current treatment of metastatic endometrial cancer Canc Contr 16 1 38 45
16. MS Aapro FH Van Wijk G Bolis B Chevallier ME van der Burg A Poveda, et al. 2003 Doxorubicin versus doxorubicin and cisplatin in endometrial carcinoma: definitive results of a randomised study (55872) by the EORTC Gynaecological Cancer Group Ann Oncol 14 3 441 448 12598351 10.1093/annonc/mdg112 1:STN:280:DC%2BD3s%2Fos1Glsg%3D%3D (Pubitemid 36367423)
17. JT Thigpen MF Brady HD Homesley J Malfetano B Dubeshter RA Burger, et al. 2004 Phase III trial of doxorubicin with or without cisplatin in advanced endometrial carcinoma: a gynecologic oncology group study J Clin Oncol 22 19 3902 3908 15459211 10.1200/JCO.2004.02.088 1:CAS:528:DC%2BD2cXpsVKitr8%3D (Pubitemid 41079871)
18. GF Fleming VL Brunetto D Cella KY Look GC Reid AR Munkarah, et al. 2004 Phase III trial of doxorubicin plus cisplatin with or without paclitaxel plus filgrastim in advanced endometrial carcinoma: A Gynecologic Oncology Group study J Clin Oncol 22 11 2159 2166 15169803 10.1200/JCO.2004.07.184 1:CAS:528:DC%2BD2cXpsVWltrw%3D (Pubitemid 41095150)
19. PJ Hoskins KD Swenerton JA Pike F Wong P Lim C Acquino-Parsons, et al. 2001 Paclitaxel and carboplatin, alone or with irradiation, in advanced or recurrent endometrial cancer: a phase II study J Clin Oncol 19 20 4048 4053 11600606 1:CAS:528:DC%2BD3MXotVakt7w%3D (Pubitemid 32976691)
20. B Sorbe H Andersson K Boman P Rosenberg M Kalling 2008 Treatment of primary advanced and recurrent endometrial carcinoma with a combination of carboplatin and paclitaxel-long-term follow-up Int J Gynecol Canc 18 4 803 808 10.1111/j.1525-1438.2007.01094.x 1:STN:280:DC%2BD1crisl2nug%3D%3D (Pubitemid 352020182)
21. T Akram P Maseelall J Fanning 2005 Carboplatin and paclitaxel for the treatment of advanced or recurrent endometrial cancer Am J Obstet Gynecol 192 5 1365 1367 15902110 10.1016/j.ajog.2004.12.032 1:CAS:528:DC%2BD2MXlslWgurg%3D
22. CM Michener G Peterson B Kulp KD Webster M Markman 2005 Carboplatin plus paclitaxel in the treatment of advanced or recurrent endometrial carcinoma J Canc Res Clin Oncol 131 9 581 584 10.1007/s00432-005-0676-x 1:CAS:528: DC%2BD2MXhtFGlt7nL (Pubitemid 41558550)
23. SA Scudder PY Liu SP Wilczynski HO Smith C Jiang AV Hallum III, et al. 2005 Paclitaxel and carboplatin with amifostine in advanced, recurrent, or refractory endometrial adenocarcinoma: a phase II study of the Southwest Oncology Group Gynecol Oncol 96 3 610 615 15721401 10.1016/j.ygyno.2004.11.024 1:CAS:528:DC%2BD2MXhsVOjsr4%3D (Pubitemid 40255477)
24. T Arimoto S Nakagawa T Yasugi H Yoshikawa K Kawana T Yano, et al. 2007 Treatment with paclitaxel plus carboplatin, alone or with irradiation, of advanced or recurrent endometrial carcinoma Gynecol Oncol 104 1 32 35 16996113 10.1016/j.ygyno.2006.07.038 1:CAS:528:DC%2BD2sXkvF2kug%3D%3D (Pubitemid 46054110)
25. MA Sovak J Dupont ML Hensley N Ishill S Gerst N Abu-Rustum, et al. 2007 Paclitaxel and carboplatin in the treatment of advanced or recurrent endometrial cancer: a large retrospective study Int J Gynecol Canc 17 1 197 203 10.1111/j.1525-1438.2006.00746.x 1:STN:280:DC%2BD2s%2FpsVChtw%3D%3D (Pubitemid 46213991)
26. FM Muggia JA Blessing J Sorosky GC Reid 2002 Phase II trial of the pegylated liposomal doxorubicin in previously treated metastatic endometrial cancer: a Gynecologic Oncology Group study J Clin Oncol 20 9 2360 2364 11981008 10.1200/JCO.2002.08.171 1:CAS:528:DC%2BD38XktVKrs7Y%3D (Pubitemid 34441664)
27. HD Homesley JA Blessing J Sorosky G Reid KY Look 2005 Phase II trial of liposomal doxorubicin at 40 mg/m(2) every 4 weeks in endometrial carcinoma: a Gynecologic Oncology Group Study Gynecol Oncol 98 2 294 298 15975638 10.1016/j.ygyno.2005.05.016 1:CAS:528:DC%2BD2MXmsVWgtbc%3D (Pubitemid 41019119)
28. G Balbi S Visconti A Monteverde MA Manganaro A Cardone 2007 Liposomal doxorubicin: a phase II trial Acta Biomed 78 3 210 213 18330081 1:CAS:528:DC%2BD1cXosFWgtLw%3D (Pubitemid 351599001)
29. E Pujade-Lauraine U Wagner E Aavall-Lundqvist V Gebski M Heywood PA Vasey, et al. 2010 Pegylated liposomal doxorubicin and carboplatin compared with paclitaxel and carboplatin for patients with platinum-sensitive ovarian cancer in late relapse J Clin Oncol 28 20 3323 3329 20498395 10.1200/JCO.2009.25.7519 1:CAS:528:DC%2BC3cXhtVajurrL
30. A du Bois J Pfisterer N Burchardi S Loibl J Huober P Wimberger, et al. 2007 Combination therapy with pegylated liposomal doxorubicin and carboplatin in gynecologic malignancies: a prospective phase II study of the Arbeitsgemeinschaft Gynaekologische Onkologie Studiengruppe Ovarialkarzinom (AGO-OVAR) and Kommission Uterus (AGO-K-Ut) Gynecol Oncol 107 3 518 525 17910981 10.1016/j.ygyno.2007.08.008 (Pubitemid 350160867)
31. S Pignata G Scambia C Pisano E Breda MM Di S Greggi, et al. 2007 A multicentre phase II study of carboplatin plus pegylated liposomal doxorubicin as first-line chemotherapy for patients with advanced or recurrent endometrial carcinoma: the END-1 study of the MITO (Multicentre Italian Trials in Ovarian Cancer and Gynecologic Malignancies) group Br J Canc 96 11 1639 1643 10.1038/sj.bjc.6603787 1:CAS:528:DC%2BD2sXlvVShtr0%3D (Pubitemid 46847208)
32. ME Randall VL Filiaci H Muss NM Spirtos RS Mannel J Fowler, et al. 2006 Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma: a Gynecologic Oncology Group Study J Clin Oncol 24 1 36 44 16330675 10.1200/JCO.2004.00.7617 1:CAS:528:DC%2BD28Xot1Chug%3D%3D (Pubitemid 46630491)
33. I Vandenput CB Van A Capoen K Leunen P Berteloot P Neven, et al. 2009 Neoadjuvant chemotherapy followed by interval debulking surgery in patients with serous endometrial cancer with transperitoneal spread (stage IV): a new preferred treatment? Br J Canc 101 2 244 249 10.1038/sj.bjc.6605157 1:CAS:528:DC%2BD1MXoslOmu78%3D
34. CP Morrow BN Bundy HD Homesley WT Creasman ND Hornback R Kurman, et al. 1990 Doxorubicine as an adjuvant following surgery and radiation therapy in patients with high-risk endometrial carcinoma, stage I and occult stage II: a GYnecologic Oncology Group study Gynecol Oncol 36 166 171 2298404 10.1016/0090-8258(90)90166-I 1:STN:280:DyaK3c7ivVCgtQ%3D%3D (Pubitemid 20061279)
35. R Maggi A Lissoni F Spina M Melpignano P Zola G Favalli, et al. 2006 Adjuvant chemotherapy vs radiotherapy in high-risk endometrial carcinoma: results of a randomised trial Br J Canc 95 3 266 271 10.1038/sj.bjc.6603279 1:STN:280:DC%2BD28vovV2kug%3D%3D (Pubitemid 44187586)
36. N Susumu S Sagae Y Udagawa K Niwa H Kuramoto S Satoh, et al. 2008 Randomized phase III trial of pelvic radiotherapy versus cisplatin-based combined chemotherapy in patients with intermediate- and high-risk endometrial cancer: a Japanese Gynecologic Oncology Group study Gynecol Oncol 108 1 226 233 17996926 10.1016/j.ygyno.2007.09.029 1:CAS:528:DC%2BD1cXhtlShsw%3D%3D (Pubitemid 350299451)
37. T Hogberg M Signorelli CF de Oliveira R Fossati AA Lissoni B Sorbe, et al. 2010 Sequential adjuvant chemotherapy and radiotherapy in endometrial cancer-results from two randomised studies Eur J Canc 46 13 2422 2431 10.1016/j.ejca.2010.06.002 1:CAS:528:DC%2BC3cXhtVGrtb3F
38. T Kuoppala J Maenpaa E Tomas U Puistola T Salmi S Grenman, et al. 2008 Surgically staged high-risk endometrial cancer: randomized study of adjuvant radiotherapy alone vs. sequential chemo-radiotherapy Gynecol Oncol 110 2 190 195 18534669 10.1016/j.ygyno.2008.03.020
39. K Greven K Winter K Underhill J Fontenesci J Cooper T Burke 2006 Final analysis of RTOG 9708: adjuvant postoperative irradiation combined with cisplatin/paclitaxel chemotherapy following surgery for patients with high-risk endometrial cancer Gynecol Oncol 103 1 155 159 16545437 10.1016/j.ygyno.2006.02. 007 1:CAS:528:DC%2BD28Xps1Wmsr8%3D (Pubitemid 44374683)
40. PORTEC 3. Available at: http://www.clinicalresearch.nl/portec3, 2011.
41. GOG-249. Available at: http://www.cancer.gov/clinicaltrials/search/view? cdrid=629591&version=HealthProfessional&protocolsearchid=9204275, 2011.
42. GOG-258. Available at: http://www.clinicaltrials.gov/ct2/show/ NCT00942357?term=GOG&rank=102, 2011.
43. AK Sood RL Coleman 2010 Targeted therapy in gynecologic oncology: biology, strategy, and assessment Gynecol Oncol 116 2 155 156 20109724 10.1016/j.ygyno.2009.12.009
44. J Bergh 2009 Quo vadis with targeted drugs in the 21st century? J Clin Oncol 27 1 2 5 19047306 10.1200/JCO.2008.18.8342
45. DJ Slamon B Leyland-Jones S Shak H Fuchs V Paton A Bajamonde, et al. 2001 Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2 New Engl J Med 344 11 783 792 11248153 10.1056/NEJM200103153441101 1:CAS:528:DC%2BD3MXisVGktrc%3D (Pubitemid 32222155)
46. R Simon A Maitournam 2004 Evaluating the efficiency of targeted designs for randomized clinical trials Clin Canc Res 10 20 6759 6763 10.1158/1078-0432.CCR-04-0496 1:CAS:528:DC%2BD2cXpslGlt7g%3D (Pubitemid 39383023)
47. KJ Dedes D Wetterskog A Ashworth SB Kaye JS Reis-Filho 2011 Emerging therapeutic targets in endometrial cancer Nat Rev Clin Oncol 8 5 261 271 21221135 10.1038/nrclinonc.2010.216 1:CAS:528:DC%2BC3MXltl2qsbw%3D A comprehensive and up-to-date review on current status of targeted therapy in endometrial cancer