Surgically staged high-risk endometrial cancer: Randomized study of adjuvant radiotherapy alone vs. sequential chemo-radiotherapy

Gynecologic Oncology

Volumn 110, Issue 2, 2008, Pages 190-195

  Kuoppala, Tapio ^a   Mäenpää, Johanna ^a   Tomas, Eija ^a   Puistola, Ulla ^b   Salmi, Tuula ^c   Grenman, Seija ^c   Lehtovirta, Pentti ^d   Fors, Matti ^d   Luukkaala, Tiina ^e   Sipilä, Pirkko ^f  

^a TAMPERE UNIVERSITY HOSPITAL   (Finland)

^b OULU UNIVERSITY HOSPITAL   (Finland)

^c TURKU UNIVERSITY HOSPITAL   (Finland)

^d HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^e PIRKANMAA HOSPITAL DISTRICT   (Finland)

^f Gynegolocical Center in Oulu   (Finland)

Author keywords

Adjuvant radiotherapy; Adjuvant sequential chemo radiotherapy; High risk endometrial carcinoma

Indexed keywords

CISPLATIN; CYCLOPHOSPHAMIDE; EPIRUBICIN;

ABDOMINAL CRAMP; ABDOMINAL HYSTERECTOMY; ABDOMINAL PAIN; ACUTE TOXICITY; ADJUVANT THERAPY; ADULT; AGED; ALOPECIA; ANEMIA; ARTICLE; ASCITES FLUID CYTOLOGY; BLOOD TOXICITY; BONE NECROSIS; CANCER ADJUVANT THERAPY; CANCER COMBINATION CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RELAPSE; CANCER RISK; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CHEMOTHERAPY INDUCED EMESIS; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DISEASE FREE SURVIVAL; DRUG TREATMENT FAILURE; ENDOMETRIUM CARCINOMA; ENTEROPATHY; ERYTHROCYTE SEDIMENTATION RATE; FEMALE; FOLLOW UP; HIGH RISK PATIENT; HUMAN; INFECTION; INTERMETHOD COMPARISON; INTESTINE FISTULA; INTESTINE OBSTRUCTION; KIDNEY FUNCTION TEST; LEUKOPENIA; LIVER FUNCTION TEST; MAJOR CLINICAL STUDY; MALNUTRITION; MELENA; MULTIMODALITY CANCER THERAPY; MULTIPLE CYCLE TREATMENT; NAUSEA; OVERALL SURVIVAL; PELVIS LYMPHADENECTOMY; POSTOPERATIVE CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RECURRENCE RISK; RECURRENT CANCER; SALPINGOOOPHORECTOMY; SEPSIS; SIDE EFFECT; STOMACH ULCER; SURVIVAL RATE; URETER OBSTRUCTION;

AGED; AGED, 80 AND OVER; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; CISPLATIN; CYCLOPHOSPHAMIDE; ENDOMETRIAL NEOPLASMS; EPIRUBICIN; FEMALE; HUMANS; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; RADIOTHERAPY, ADJUVANT; RISK FACTORS; SURVIVAL RATE;

EID: 47349110637     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2008.03.020     Document Type: Article

References (43)

1. FIGO. Annual report (2001)
2. Smith M.R., Peters W.A., and Drescher C.W. Cisplatin, doxorubicin hydrochloride, and cyclophosphamide followed by radiotherapy in high-risk endometrial carcinoma. Am J Obstet Gynecol 170 (1994) 1677-1682
3. Boronow R.C., Morrow C.P., Creasman W.T., et al. Surgical staging in endometrial cancer: clinical-pathologic findings of a prospective study. Obstet Gynecol 63 (1984) 825-832
4. Sutton G.P., Geisler H.E., Stehman F.B., Young P.C.M., Kimes T.M., and Ehrlich. Features associated with survival and disease-free survival in early endometrial cancer. Am J Obstet Gynecol 160 (1989) 1385-1393
5. Wilson T.O., Podrats K.C., Gaffey T.A., Malkasian G.D., P.C. O.`B., and Maessens J.M. Evaluation of unfavourable histologic subtypes in endometrial adenocarcinoma. Am J Obstet Gynecol 162 (1990) 418-426
6. Ackerman I., Malone S., Thomas G., Fransse E., Balogh J., and Dembo A. Endometrial carcinoma-relative effectiveness of adjuvant irradiation vs therapy reserved for relapse. Gynecol Oncol 36 (1996) 166-171
7. Lybeert M.L.M., van Putten W.L.J., Brölmann H.A.M., and Coebergh J.W.W. Postoperative radiotherapy for endometrial carcinoma Stage I. Wide variation in referral patterns but no effect on long-term survival in a retrospective study in the southeast Netherlands. Eur J Cancer 34:4 (1998) 586-590
8. Berman M.L. Adjuvant radiotherapy following properly staged endometrial cancer: what role?. Gynecol Oncol 92:3 (2004) 737-739
9. Creutzberg C.L. GOG-99: ending the controversy regarding pelvic radiotherapy for endometrial carcinoma?. Gynecol Oncol 92 (2004) 3740-3743
10. Creutzberg C.L., van Putten W.L.J., Koper P.C.M., Lybeert M.L.M., Jobsen J.J., Warlam-Rodenhuis C.C., et al. Surgery and postoperative radiotherapy vs surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. Lancet 355 (2000) 1404-1411
11. Aalders J., Abeler V., Kolstad P., and Onsrud M. Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma. Obstet Gynecol 56 (1980) 419-427
12. Orr J.W., Holimon J.L., and Orr P.F. Stage I corpus cancer: is teletherapy necessary?. Am J Obstet Gynecol 176 (1997) 777-789
13. Potish R.A., and Dusenbery K.E. Enteric morbidity of postoperative pelvic external beam and brachytherapy for uterine cancer. Int J Radiat Oncol Biol Phys 18 (1990) 1005-1010
14. Burke T.W., Stringer C.A., Morris M., Freedman R.S., and Kavanagh J.J. Prospective treatment of advanced or recurrent endometrial carcinoma with cisplatin, doxorubicin, and cyclophosphamide. Gynecol Oncol 40 (1991) 264-267
15. Pustilnik T., and Burke T.W. Adjuvant chemotherapy for high-risk endometrial cancer. Seminars Radiat Oncol 10 1 (2000) 23-28
16. Randall M.E., and Reisinger S. Radiation therapy and combined chemo-irradiation in advanced and recurrent endometrial carcinoma. Seminars Oncol 21 1 (1994) 91-99
17. Reisinger S.A., Asbury R., Liao S.-Y., and Homesley H.D. A phase I study of weekly cisplatin and whole abdominal radiation for the treatment of Stage III and IV endometrial carcinoma: a Gynecologic Oncology Group pilot study. Gynecol Oncol 63 (1996) 299-303
18. Reisinger S.A., Asbury R., Liao S.-Y., and Homesley H.D. A phase I study of weekly cisplatin and whole abdominal radiation for the treatment of Stage III and IV endometrial carcinoma: a Gynecologic Oncology Group pilot study. Gynecol Oncol 63 (1996) 299-303
19. Hoskins P., Swenerton K., Pike J., Wong F., Acquino-Parsons C., and Lee N. Paclitaxel and carboplatin, alone or with radiation, in advanced or recurrent endometrial cancer: a phase II study. J Clin Oncol 19 (2001) 4048-4053
20. Dimopoulos M.A., Papadimitriou C.A., Georgoulias V., Moulopoulos L.A., Aravantinos G., Gika D., et al. Paclitaxel and cisplatin in advanced or recurrent carcinoma of the endometrium: long term results of a phase II multicenter study. Gynecol Oncol 78 (2000) 52-57
21. Soper J.T., Reisinger S.A., Ashburry R., Jones E., and Clarke-Pearson D.L. Feasibility study of concurrent weekly cisplatin and whole abdominopelvic irradiation followed by doxorubicin/cisplatin chemotherapy for advanced stage endometrial carcinoma: a Gynecologic Oncology Group trial. Gynecol Oncol 95 (2004) 95-100
22. Bruzzone M., Miglietta L., Franzone P., Gadducci A., and Boccardo F. Combined treatment with chemotherapy and radiotherapy in high-risk FIGO stage III-IV endometrial cancer patients. Gynecol Oncol 93 (2003) 345-352
23. Sagae S., Udagava Y., Susume, et al. Randomized phase III trial of whole pelvic radiotherapy vs cisplatin bases chemotherapy in patients with intermediate risk endometrial carcinoma. J Clin Oncol 23 suppl 16 (2005) 455s (Abstr. 50002)
24. Duska L.R., Berkowitz R., et al. A pilot trial of TAC (paclitaxel, doxorubicin and carboplatin) chemotherapy with filgastrim (r-metHUG-CSF) support followed by radiotherapy in patients with "high-risk" endometrial cancer. Gynecol Oncol 96 (2005) 198-203
25. Hoffman M.S., Roberts W.S., Cavanagh D., Praphat H., Solomon P., and Lyman G.H. Treatment of recurrent and metastatic endometrial cancer with cisplatin, doxorubicin, cyclophosphamide, and megestrol acetate. Gynecol Oncol 35 (1989) 75-77
26. Horton J., Elson P., Gordon P., Hahn R, and Greech R. Combination chemotherapy for advanced endometrial cancer. An evaluation of three regimens. Cancer 49 (1982) 2441-2445
27. Cohen C.J., Bruckner H.W., Deppe G., Blessing J.A., Homesley H., Lee J.H., et al. Multidrug treatment of advanced and recurrent endometrial carcinoma: a Gynecologic Oncology Group study. Obstet Gynecol 63 (1984) 719-726
28. Stringer C.A., Gershenson D.M., Burke T.W., Edwards C.L., Gordon A.L., and Wharton J.T. Adjuvant chemotherapy with cisplatin, doxorubicin and cyclophosphamide (PAC) for early-stage high-risk endometrial cancer: a preliminary analysis. Gynecol Oncol 38 (1990) 305-308
29. Burke T.W., Gershenson D.M., Morris M., Striger C.A., Levenback C., Tortolero-Luna G., et al. Postoperative adjuvant cisplatin, doxorubicin, and cyclophosphamide (PAC) chemotherapy in women with high-risk endometrial carcinoma. Gynecol Oncol 55 (1994) 47-50
30. Markman M., Kennedy A., Webster K., Kulp B., Peterson G., and Belinson J. Persistent chemosensitivity to platinum and/or paclitaxel in metastatic endometrial cancer. Gynecol Oncol 73 (1999) 422-423
31. Rufford B.D., and Lawton F.G. Endometrial cancer. Curr Obstet Gynaecol 11 (2001) 290-295
32. Kauppila A., Grönroos M., and Nieminen U. Clinical outcome in endometrial cancer. Obstet Gynecol 60 (1982) 473-479
33. Hernandez E. Endometrial adenocarcinoma. Obst Gyn Clin North Am 28 4 (2001) 743-757
34. Roberts J.A., Brunetto V.L., Keys H.M., et al. A phase III randomized study of surgery vs surgery plus adjunctive radiation therapy in intermediate risk endometrial adenocarcinoma (GOG). Gynecol Oncol 68 (1998) 135 (Abstr 258)
35. Irwin C., Levin W., Fyles A., Pintilie M., Manchul L., and Kirkbride P. The role of adjuvant radiotherapy in carcinoma of the endometrium - results in 550 patients with pathologic stage I disease. Gynecol Oncol 70 (1998) 247-254
36. Keyes H.M., Roberts J.A., Brunetto V.L., Zaino R.J., Spirtos N.M., Bloss J.D., et al. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 92 (2004) 744-751
37. Pustilnik T., and Burge T.W. Adjuvant chemotherapy for high-risk endometrial cancer. Seminars Radiat Oncol 10 1 (2000) 23-28
38. Frigerio L., Mangili G., Aletti G., Carnelli M., Caravaglia E., Beatrice S., et al. Concomitant radiotherapy and paclitaxel for high-risk endometrial cancer: first feasibility study. Gynecol Oncol 81 (2001) 53-57
39. Irvin W.P., Rice L.W., and Berkowitz R.S. Advances in the management of endometrial adenocarcinoma. J Reprod Med 47:3 (2002) 173-190
40. Hoskins P.J., Swenerton K.D., Pike J.A., Wong F., Lim P., Acquino-Parsons C., et al. Paclitaxel and carboplatin, alone or with irradiation in advanced or recurrent endometrial cancer: a phase II study. J Clin Oncol 19 (2001) 4048-4053
41. Morrow C.P., Bundy B.N., Homesley H.D., Creasman W.T., Hornback N.B., Kurman R., et al. Doxorubicin as an adjuvant following surgery and radiation therapy in patients with high-risk endometrial carcinoma, Stage I and occult Stage II: a Gynecologic Oncology Group study. Gynecol Oncol 36 (1990) 166-171
42. Sood B.M., Timmins P.F., Gorla G.R., Garg M., Anderson P.S., and Vikram B. Concomitant cisplatin and extended field radiation therapy in patients with cervical and endometrial cancer. Int J Gynecol Cancer 12 (2002) 459-464.
43. Högberg T, Rosenberg P, Kristensen G, de Oliveira CF, de Pont Christensen R, Sorbe B, Lundgren C, Salmi T, Andersson H, Reed NS. A randomized phase-III study on adjuvant treatment with radiation (RT)+-chemotherapy (CT) in early-stage high-risk endometrial cancer (NSGO-EC-9501/EORTC 55991). 43rd Annual meeting of the American Society of Clinical Oncology. Chicago, Illinois, USA. 2007, June 1-5, Abstr. 5503.