Ribavirin enhances IFN-α signalling and MxA expression: A novel immune modulation mechanism during treatment of HCV

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Stevenson, Nigel J ^a   Murphy, Alison G ^a   Bourke, Nollaig M ^a   Keogh, Catherine A ^a   Hegarty, John E ^b   O'Farrelly, Cliona ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; CORE PROTEIN; MESSENGER RNA; MYXOVIRUS RESISTANCE PROTEIN A; RIBAVIRIN; STAT1 PROTEIN; STAT3 PROTEIN; ANTIVIRUS AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; MYXOVIRUS RESISTANCE PROTEINS; NUCLEOCAPSID PROTEIN, HEPATITIS C VIRUS; STAT1 PROTEIN, HUMAN; STAT3 PROTEIN, HUMAN;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HEPATITIS C; IMMUNOMODULATION; LIVER CELL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; CELL CULTURE; ENZYME IMMUNOASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HEPATITIS C VIRUS; HUMAN; IMMUNOLOGY; IMMUNOPRECIPITATION; METABOLISM; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; VIROLOGY; VIRUS REPLICATION; WESTERN BLOTTING;

HEPATITIS C VIRUS;

ANTIVIRAL AGENTS; BLOTTING, WESTERN; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE; GTP-BINDING PROTEINS; HEPACIVIRUS; HEPATITIS C; HEPATOCYTES; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; INTERFERON-ALPHA; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; RIBAVIRIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; VIRAL CORE PROTEINS; VIRUS REPLICATION;

EID: 81155131454     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027866     Document Type: Article

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