Telomere shortening impairs regeneration of the olfactory epithelium in response to injury but not under homeostatic conditions

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Watabe Rudolph, Masami ^a   Begus Nahrmann, Yvonne ^a   Lechel, André ^a   Rolyan, Harshvardhan ^a   Scheithauer, Marc Oliver ^a   Rettinger, Gerhard ^a   Thal, Dietmar Rudolf ^a   Rudolph, Karl Lenhard ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1A; PROTEIN P21;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVITY; CELL AGING; CELL CYCLE ARREST; CELL CYCLE PROGRESSION; CELL FUNCTION; CELL PROLIFERATION; CHEMICAL INJURY; CHROMOSOME ANALYSIS; CHROMOSOME DELETION; CHROMOSOME SIZE; CHROMOSOMES AND CHROMOSOMAL PHENOMENA; CONTROLLED STUDY; HOMEOSTASIS; MOUSE; NONHUMAN; OLFACTORY EPITHELIUM; STRUCTURE ANALYSIS; TELOMERE SHORTENING; TISSUE INJURY; TISSUE REGENERATION; WILD TYPE; AGING; ANIMAL; DRUG EFFECT; GENE INACTIVATION; GENETICS; INJURY; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; REGENERATION;

MUS;

AGING; ANIMALS; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; GENE KNOCKOUT TECHNIQUES; HOMEOSTASIS; MICE; OLFACTORY MUCOSA; REGENERATION; TELOMERE SHORTENING;

EID: 81155128111     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027801     Document Type: Article

References (36)

1. Graziadei PP, Graziadei GA, (1979) Neurogenesis and neuron regeneration in the olfactory system of mammals. I. Morphological aspects of differentiation and structural organization of the olfactory sensory neurons. J Neurocytol 8: 1-18.
2. Graziadei PP, Levine RR, Graziadei GA, (1978) Regeneration of olfactory axons and synapse formation in the forebrain after bulbectomy in neonatal mice. Proc Natl Acad Sci U S A 75: 5230-5234.
3. De Lorenzo AJ, (1957) Electron microscopic observations of the olfactory mucosa and olfactory nerve. J Biophys Biochem Cytol 3: 839-850.
4. Matulionis DH, (1975) Ultrastructural study of mouse olfactory epithelium following destruction by ZnSO4 and its subsequent regeneration. Am J Anat 142: 67-89.
5. Graziadei GA, Graziadei PP, (1979) Neurogenesis and neuron regeneration in the olfactory system of mammals. II. Degeneration and reconstitution of the olfactory sensory neurons after axotomy. J Neurocytol 8: 197-213.
6. Schwartz Levey M, Chikaraishi DM, Kauer JS, (1991) Characterization of potential precursor populations in the mouse olfactory epithelium using immunocytochemistry and autoradiography. J Neurosci 11: 3556-3564.
7. Doty RL, (1979) A review of olfactory dysfunctions in man. Am J Otolaryngol 1: 57-79.
8. Welge-Lüssen A, (2009) Ageing, neurodegeneration, and olfactory and gustatory loss. B-ENT 5 (Suppl 13): 129-132.
9. Doty RL, (1991) Olfactory capacities in aging and Alzheimer's disease. Psychophysical and anatomic considerations 640: 20-27.
10. Wysocki CJ, Pelchat ML, (1992) The effects of aging on the human sense of smell and its relationship to food choice. Crit. Rev. Food Sci. Nutr 33: 63-82.
11. Sundermann EE, Gilbert PE, Murphy C, (2008) The effect of hormone therapy on olfactory sensitivity is dependent on apolipoprotein E genotype. Hormones and Behavior 54: 528-533.
12. Jenkin A, Renner D, Hahn F, Larsen J, (2000) A case of primary amenorrhea, diabetes and anosmia. Gynecol Endocrinol 14: 65-70.
13. Blackburn EH, (1991) Structure and function of telomeres. Nature 350: 569-573.
14. de Lange T, Shiue L, Myers RM, Cox DR, Naylor SL, et al. (1990) Structure and variability of human chromosome ends. Mol Cell Biol 10: 518-527.
15. Morin GB, (1989) The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats. Cell 59: 521-529.
16. Shay JW, Wright WE, (2004) Telomeres in dyskeratosis congenita. Nat Genet 36: 437-438.
17. Allsopp RC, Vaziri H, Patterson C, Goldstein S, Younglai EV, et al. (1992) Telomere length predicts replicative capacity of human fibroblasts. Proc Natl Acad Sci U S A 89: 10114-10118.
18. Ferrón SR, Marqués-Torrejón MA, Mira H, Flores I, Taylor K, et al. (2009) Telomere shortening in neural stem cells disrupts neuronal differentiation and neuritogenesis. J Neurosci 29: 14394-14407.
19. Frenck RW Jr, Blackburn EH, Shannon KM, (1998) The rate of telomere sequence loss in human leukocytes varies with age. Proc Natl Acad Sci U S A 95: 5607-5610.
20. Takubo K, Nakamura K, Izumiyama N, Furugori E, Sawabe M, et al. (2000) Telomere shortening with aging in human liver. J Gerontol A Biol Sci Med Sci. 55: B533-536.
21. Feng YR, Biggar RJ, Gee D, Norwood D, Zeichner SL, et al. (1999) Long-term telomere dynamics: modest increase of cell turnover in HIV-infected individuals followed for up to 14 years. Pathobiology 67: 34-38.
22. Greider CW, Blackburn EH, (1987) The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 51: 887-898.
23. Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, et al. (1997) hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90: 785-795.
24. Vaziri H, Benchimol S, (1999) Alternative pathways for the extension of cellular life span: inactivation of p53/pRb and expression of telomerase. Oncogene 18: 7676-7680.
25. Vulliamy T, Marrone A, Goldman F, Dearlove A, Bessler M, et al. (2001) Mason PJ, Dokal I. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 413: 432-435.
26. Armanios MY, Chen JJ, Cogan JD, Alder JK, Ingersoll RG, et al. (2007) Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med. 356: 1317-1326.
27. Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, et al. (1997) Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25-34.
28. Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, et al. (1999) Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96: 701-712.
29. Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, et al. (2007) Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet 39: 99-105.
30. Min YG, Kim JW, Hong SC, Dhong HJ, Jarin PR, et al. (2003) Pathogenetic mechanism of olfactory cell injury after exposure to sulfur dioxide in mice. Laryngoscope 113: 2157-2162.
31. Brown JP, Wei W, Sedivy JM, (1997) Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277: 831-834.
32. Begus-Nahrmann Y, Lechel A, Obenauf AC, Nalapareddy K, Peit E, et al. (2009) p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet 41: 1138-1143.
33. Kondo K, Suzukawa K, Sakamoto T, Watanabe K, Kanaya K, et al. (2010) Age-related changes in cell dynamics of the postnatal mouse olfactory neuroepithelium: cell proliferation, neuronal differentiation, and cell death. J Comp Neurol 518: 1962-1975.
34. Lee HW, Blasco MA, Gottlieb GJ, Horner JW 2nd, Greider CW, et al. (1998) Essential role of mouse telomerase in highly proliferative organs. Nature 392: 569-574.
35. Deng C, Zhang P, Harper JW, Elledge SJ, Leder P, (1995) Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82: 675-684.
36. Poon SS, Martens UM, Ward RK, Lansdorp PM, (1999) Telomere length measurements using digital fluorescence microscopy. Cytometry 36: 267-278.