Embryonic exposure to thimerosal, an organomercury compound, causes abnormal early development of serotonergic neurons

Neuroscience Letters

Volumn 505, Issue 2, 2011, Pages 61-64

  Ida Eto, Michiru ^a   Oyabu, Akiko ^a   Ohkawara, Takeshi ^a   Tashiro, Yasura ^a   Narita, Naoko ^b   Narita, Masaaki ^a  

^a MIE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b BUNKYO UNIVERSITY   (Japan)

Author keywords

Development; Embryonic exposure; Serotonergic neuron; Thimerosal

Indexed keywords

SEROTONIN; THIOMERSAL;

ANTERIOR HYPOTHALAMUS; BRAIN NERVE CELL; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GESTATIONAL AGE; IMMUNOHISTOCHEMISTRY; NONHUMAN; NOTE; PRIORITY JOURNAL; RAPHE NUCLEUS; RAT; SEROTONINERGIC SYSTEM;

ANIMALS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; FEMALE; NERVOUS SYSTEM MALFORMATIONS; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PRESERVATIVES, PHARMACEUTICAL; RAPHE NUCLEI; RATS; RATS, WISTAR; SEROTONERGIC NEURONS; THIMEROSAL;

EID: 81055158010     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.05.053     Document Type: Note

References (26)

1. Aitken A.R., Törk I. Early development of serotonin-containing neurons and pathways as seen in wholemount preparations of the fetal rat brain. J. Comp. Neurol. 1988, 274:32-47.
2. Ball L.K., Ball R., Pratt R.D. An assessment of thimerosal use in childhood vaccines. Pediatrics 2001, 107:1147-1154.
3. Centers for Disease Control and Prevention (CDC), Notice to readers: thimerosal in vaccines: a joint statement of the American Academy of Pediatrics and the Public Health Service, Morb. Mort. Wkly. Rep. 48 (1999) 563-565.
4. Clarkson T.W., Magos L. The toxicology of mercury and its chemical compounds. Crit. Rev. Toxicol. 2006, 36:609-662.
5. Counter S.A., Buchanan L.H. Mercury exposure in children: a review. Toxicol. Appl. Pharmacol. 2004, 198:209-230.
6. Davies F.C.W. Minamata disease: a 1989 update on the mercury poisoning epidemic in Japan. Environ. Geochem. Health 1991, 13:35-38.
7. Díez S. Human health effects of methylmercury exposure. Rev. Environ. Contam. Toxicol. 2009, 198:111-132.
8. Jacobs B.L., Azmitia E.C. Structure and function of the brain serotonin system. Physiol. Rev. 1992, 72:165-229.
9. König N., Wilkie M.B., Lauder J.M. Tyrosine hydroxylase and serotonin containing cells in embryonic rat rhombencephalon: a whole-mount immunocytochemical study. J. Neurosci. Res. 1988, 20:212-223.
10. Lauder J.M., Bloom F.E. Ontogeny of monoamine neurons in the locus coeruleus, Raphe nuclei and substantia nigra of the rat. I. Cell differentiation. J. Comp. Neurol. 1974, 155:469-481.
11. Lawton M., Iqbal M., Kontovraki M., Lloyd Mills C., Hargreaves A.J. Reduced tubulin tyrosination as an early marker of mercury toxicity in differentiating N2a cells. Toxicol. In Vitro 2007, 21:1258-1261.
12. Magos L. Review on the toxicity of ethylmercury, including its presence as a preservative in biological and pharmaceutical products, J. Appl. Toxicol. 2001, 21:1-5.
13. Miyazaki K., Narita N., Narita M. Maternal administration of thalidomide or valproic acid causes abnormal serotonergic neurons in the offspring: implication for pathogenesis of autism. Int. J. Dev. Neurosci. 2005, 23:287-297.
14. Muguruma K., Watanabe Y. Early development of catecholaminergic and serotonergic neurons and their axonal projections in the fetal rat brain. Neurosci. Res. Suppl. 1998, 22:S295.
15. Narita N., Kato M., Tazoe M., Miyazaki K., Narita M., Okado N. Increased monoamine concentration in the brain and blood of fetal thalidomide- and valproic acid-exposed rat: putative animal models for autism. Pediatr. Res. 2002, 52:576-579.
16. Olczak M., Duszczyk M., Mierzejewski P., Majewska M.D. Neonatal administration of a vaccine preservative, thimerosal, produces lasting impairment of nociception and apparent activation of opioid system in rats. Brain Res. 2009, 1301:143-151.
17. Olczak M, Duszczyk M., Mierzejewski P., Bobrowicz T., Majewska M.D. Neonatal administration of thimerosal causes persistent changes in mu opioid receptors in the rat brain. Neurochem. Res. 2010, 35:1840-1847.
18. Olson L., Seiger A. Early prenatal ontogeny of central monoamine neurons in the rat: fluorescence histochemical observations. Z. Anat. Entwicklungsgesch. 1972, 137:301-316.
19. Qvarnström J., Lambertsson L., Havarinasab S., Hultman P., Frech W. Determination of methylmercury, ethylmercury, and inorganic mercury in mouse tissues, following administration of thimerosal, by species-specific isotope dilution GC-inductively coupled plasma-MS. Anal. Chem. 2003, 75:4120-4124.
20. Tan M., Parkin J.E. Route of decomposition of thiomersal (thimerosal). Int. J. Pharm. 2000, 208:23-34.
21. Tashiro Y., Endo T., Shirasaki R., Miyahara M., Heizmann C.W., Murakami F. Afferents of cranial sensory ganglia pathfind to their target independent of the site of entry into the hindbrain. J. Comp. Neurol. 2000, 417:491-500.
22. Tashiro Y., Yanagawa Y., Obata K., Murakami F. Development and migration of GABAergic neurons in the mouse myelencephalon. J. Comp. Neurol. 2007, 503:260-269.
23. The European Agency for the Evaluation of Medicinal Products (EMEA), EMEA public statement on thiomersal in vaccines for human use-recent evidence supports safety of thiomersal-containing vaccines, London, 24 March 2004, Doc.Ref EMEA/CPMP/VEG/1194/Adopted, Available from: http://www.ema.europa.eu/pdfs/human/press/pus/119404en.pdf.
24. Watanabe T., Mataga N., Muguruma K., Shiomitsu T., Imamura K. Synaptic plasticity in the visual cortex enhanced by 6R-tetrahydrobiopterin treatment. Chemistry and Biology of Pteridines and Folates 1997 1997, 755-758. Blackwell Science, Berlin. W. Pfleiderer, H. Rokos (Eds.).
25. Ye W., Shimamura K., Rubenstein J.L., Hynes M.A., Rosenthal A. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 1998, 93:755-766.
26. Young H.A., Geier D.A., Geier M.R. Thimerosal exposure in infants and neurodevelopmental disorders: an assessment of computerized medical records in the vaccine safety datalink. J. Neurol. Sci. 2008, 271:110-118.