PKR-dependent mechanisms of interferon-a for inhibiting hepatitis B virus replication

Molecules and Cells

Volumn 32, Issue 2, 2011, Pages 167-172

  Park, Il Hyun ^a   Baek, Kyung Won ^a   Cho, Eun Young ^a   Ahn, Byung Yoon ^a  

^a Korea University   (South Korea)

Author keywords

Antiviral mechanism; Hepatitis B virus; IFN a; PKR

Indexed keywords

ALPHA INTERFERON; INITIATION FACTOR 2ALPHA; PROTEIN KINASE R; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; GENETIC TRANSFECTION; HEPATITIS B VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RNA INTERFERENCE; VIRUS CAPSID; VIRUS GENOME; VIRUS INHIBITION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; CAPSID; CELL LINE, TUMOR; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; HEPATITIS B; HEPATITIS B VIRUS; HUMANS; INTERFERON-ALPHA; PHOSPHORYLATION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSGENES; VIRUS REPLICATION;

HEPATITIS B VIRUS; MIRIDAE;

EID: 81055157995     PISSN: 10168478     EISSN: 02191032     Source Type: Journal    
DOI: 10.1007/s10059-011-1059-6     Document Type: Article

References (23)

1. Cha, M.Y., Kim, C.M., Park, Y.M., and Ryu, W.S. (2004). Hepatitis B virus X protein is essential for the activation of Wnt/betacatenin signaling in hepatoma cells. Hepatology 39, 1683-1693.
2. Darnell, J.E., Jr. (1997). STATs and gene regulation. Science 277, 1630-1635. (Pubitemid 27446219)
3. Garcia, M.A., Meurs, E.F., and Esteban, M. (2007). The dsRNA protein kinase PKR: virus and cell control. Biochimie 89, 799-811. (Pubitemid 47001637)
4. Guidotti, L.G., Morris, A., Mendez, H., Koch, R., Silverman, R.H., Williams, B.R., and Chisari, F.V. (2002). Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice. J. Virol. 76, 2617-2621. (Pubitemid 34184846)
5. Hayashi, Y., and Koike, K. (1989). Interferon inhibits hepatitis B virus replication in a stable expression system of transfected viral DNA. J. Virol. 63, 2936-2940. (Pubitemid 19156012)
6. Hoofnagle, J.H., and di Bisceglie, A.M. (1997). The treatment of chronic viral hepatitis. N. Engl. J. Med. 336, 347-356.
7. Kang, J.I., Kwon, S.N., Park, S.H., Kim, Y.K., Choi, S.Y., Kim, J.P., and Ahn, B.Y. (2009). PKR protein kinase is activated by hepatitis C virus and inhibits viral replication through translational control. Virus Res. 142, 51-56.
8. Katze, M.G., He, Y., and Gale, M., Jr. (2002). Viruses and interferon: a fight for supremacy. Nat. Rev. Immunol. 2, 675-687. (Pubitemid 37328725)
9. Langland, J.O., Cameron, J.M., Heck, M.C., Jancovich, J.K., and Jacobs, B.L. (2006). Inhibition of PKR by RNA and DNA viruses. Virus Res. 119, 100-110. (Pubitemid 43765973)
10. Lok, A.S., and McMahon, B.J. (2007). Chronic hepatitis B. Hepatology 45, 507-539. (Pubitemid 46374607)
11. Ohata, K., Ichikawa, T., Nakao, K., Shigeno, M., Nishimura, D., Ishikawa, H., Hamasaki, K., and Eguchi, K. (2003). Interferon alpha inhibits the nuclear factor kappa B activation triggered by X gene product of hepatitis B virus in human hepatoma cells. FEBS Lett. 553, 304-308. (Pubitemid 37315621)
12. Pasquetto, V., Wieland, S.F., Uprichard, S.L., Tripodi, M., and Chisari, F.V. (2002). Cytokine-sensitive replication of hepatitis B virus in immortalized mouse hepatocyte cultures. J. Virol. 76, 5646-5653. (Pubitemid 34517915)
13. Proud, C.G. (1995). PKR: a new name and new roles. Trends Biochem. Sci. 20, 241-246.
14. Rang, A., Gunther, S., and Will, H. (1999). Effect of interferon alpha on hepatitis B virus replication and gene expression in transiently transfected human hepatoma cells. J. Hepatol. 31, 791-799. (Pubitemid 29514211)
15. Robek, M.D., Wieland, S.F., and Chisari, F.V. (2002). Inhibition of hepatitis B virus replication by interferon requires proteasome activity. J. Virol. 76, 3570-3574. (Pubitemid 34224559)
16. Samuel, C.E. (1993). The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans. J. Biol. Chem. 268, 7603-7606. (Pubitemid 23120319)
17. Seeger, C., Zoulim, F., and Mason, W.S. (2007). Hepadnaviruses. Field's virology, D.M., Knipe, and P.M. Howley, eds. (Philadelphia, USA: Lippincott Williams & Wilkins), pp. 2977-3029.
18. Sohn, S.Y., Kim, S.B., Kim, J., and Ahn, B.Y. (2006). Negative regulation of hepatitis B virus replication by cellular Hsp40/DnaJ proteins through destabilization of viral core and X proteins. J. Gen. Virol. 87, 1883-1891. (Pubitemid 43985871)
19. Su, H., and Yee, J.K. (1992). Regulation of hepatitis B virus gene expression by its two enhancers. Proc. Natl. Acad. Sci. USA 89, 2708-2712.
20. Uprichard, S.L., Wieland, S.F., Althage, A., and Chisari, F.V. (2003). Transcriptional and posttranscriptional control of hepatitis B virus gene expression. Proc. Natl. Acad. Sci. USA 100, 1310-1315. (Pubitemid 36183998)
21. Wieland, S.F., Guidotti, L.G., and Chisari, F.V. (2000). Intrahepatic induction of alpha/beta interferon eliminates viral RNA-containing capsids in hepatitis B virus transgenic mice. J. Virol. 74, 4165-4173. (Pubitemid 30214422)
22. Wieland, S.F., Eustaquio, A., Whitten-Bauer, C., Boyd, B., and Chisari, F.V. (2005). Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids. Proc. Natl. Acad. Sci. USA 102, 9913-9917. (Pubitemid 40993667)
23. Xu, C., Guo, H., Pan, X.B., Mao, R., Yu, W., Xu, X., Wei, L., Chang, J., Block, T.M., and Guo, J.T. (2010). Interferons accelerate decay of replication-competent nucleocapsids of hepatitis B virus. J. Virol. 84, 9332-9340.