Estimating the pK a values of basic and acidic side chains in ion channels using electrophysiological recordings: A robust approach to an elusive problem

Proteins: Structure, Function and Bioinformatics

Volumn 79, Issue 12, 2011, Pages 3485-3493

  Cymes, Gisela D ^a   Grosman, Claudio ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Electrostatics; Nicotinic acetylcholine receptor; Patch clamp technique; PH; Proton transfer; Single channel kinetics

Indexed keywords

BASE; CATION; HISTIDINE; ION CHANNEL; LYSINE; NICOTINIC RECEPTOR; PROTON; ACID; AMINO ACID; PROTEIN;

ACIDITY; ALPHA HELIX; ARTICLE; CONDUCTANCE; ELECTROPHYSIOLOGY; ION PERMEABILITY; ION TRANSPORT; MUTAGENESIS; NONHUMAN; PH; PKA; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; PROTON TRANSPORT; STATIC ELECTRICITY; CELL LINE; CELL STRAIN HEK293; CHEMISTRY; HUMAN; METABOLISM; PATCH CLAMP; PROTEIN SUBUNIT;

ACIDS; AMINO ACIDS; CATIONS; CELL LINE; ELECTROPHYSIOLOGICAL PHENOMENA; HEK293 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; ION CHANNELS; PATCH-CLAMP TECHNIQUES; PROTEIN SUBUNITS; PROTEINS; PROTONS; RECEPTORS, NICOTINIC; STATIC ELECTRICITY;

EID: 81055157089     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.23087     Document Type: Article

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