Efficacy of intravascular catheter lock solutions containing preservatives in the prevention of microbial colonization

Journal of Hospital Infection

Volumn 79, Issue 4, 2011, Pages 317-322

  Shenep, L E ^a   Shenep, M A ^a   Cheatham, W ^a   Hoffman, J M ^a   Hale, A ^a   Williams, B F ^a   Perkins, R ^a   Hewitt, C B ^a   Hayden, R T ^a   Shenep, J L ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Catheter related infection; Ethanol; Heparin; Preservatives

Indexed keywords

HEPARIN; SODIUM CHLORIDE;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS CEREUS; CANDIDA ALBICANS; CATHETER; CATHETER INFECTION; CONTROLLED STUDY; ESCHERICHIA COLI; INCIDENCE; INFECTION CONTROL; MEDICAL RECORD REVIEW; MICROBIAL COLONIZATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS;

BACTERIA; BENZYL ALCOHOL; CATHETER-RELATED INFECTIONS; CATHETERIZATION; CATHETERS; DISINFECTION; ETHANOL; HUMANS; INCIDENCE; MICROBIAL SENSITIVITY TESTS; PARABENS; PRESERVATIVES, PHARMACEUTICAL;

EID: 81055156871     PISSN: 01956701     EISSN: 15322939     Source Type: Journal    
DOI: 10.1016/j.jhin.2011.07.010     Document Type: Article

References (24)

1. Cardo D., Horan T., Andrus M., et al. National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control 2004, 32:470-485.
2. Slonim A.D., Kurtines H.C., Sprague B.M., Singh N. The costs associated with nosocomial bloodstream infections in the pediatric intensive care unit. Pediatr Crit Care Med 2001, 2:170-174.
3. Pronovost P., Needham D., Berenholtz S., et al. An intervention to decrease catheter-related bloodstream infections in the ICU. N Engl J Med 2006, 355:2725-2732.
4. Raad I.I., Hohn D.C., Gilbreath B.J., et al. Prevention of central venous catheter-related infections by using maximal sterile barrier precautions during insertion. Infect Control Hosp Epidemiol 1994, 15:231-238.
5. Maki D.G., Ringer M., Alvarado C.J. Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet 1991, 338:339-343.
6. Menyhay S.Z., Maki D.G. Preventing central venous catheter-associated bloodstream infections: development of an antiseptic barrier cap for needleless connectors. Am J Infect Control 2008, 36:S174-S175.
7. Essop A.R., Frolich J., Moosa M.R., Miller M., Ming R.C. Risk factors related to bacterial contamination of indwelling vascular catheters in non-infected hosts. Intensive Care Med 1984, 10:193-195.
8. Raad I. Intravascular-catheter-related infections. Lancet 1998, 351:893-898.
9. Donlan R.M., Costerton J.W. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev 2002, 15:167-193.
10. Farber B.F., Kaplan M.H., Clogston A.G. Staphylococcus epidermidis extracted slime inhibits the antimicrobial action of glycopeptide antibiotics. J Infect Dis 1990, 161:37-40.
11. Aslam S. Effect of antibacterials on biofilms. Am J Infect Control 2008, 36:S175-S211.
12. Wiernikowski J.T., Elder-Thornley D., Dawson S., Rothney M., Smith S. Bacterial colonization of tunneled right atrial catheters in pediatric oncology: a comparison of sterile saline and bacteriostatic saline flush solutions. Am J Pediatr Hematol Oncol 1991, 13:137-140.
13. Sherertz R.J., Boger M.S., Collins C.A., Mason L., Raad I.I. Comparative in vitro efficacies of various catheter lock solutions. Antimicrob Agents Chemother 2006, 50:1865-1868.
14. Sanders J., Pithie A., Ganly P., et al. A prospective double-blind randomized trial comparing intraluminal ethanol with heparinized saline for the prevention of catheter-associated bloodstream infection in immunosuppressed haematology patients. J Antimicrob Chemother 2008, 62:809-815.
15. O'Grady N.P., Alexander M., Dellinger E.P., et al. Guidelines for the prevention of intravascular catheter-related infections. Infect Control Hosp Epidemiol 2002, 23:759-769.
16. O'Grady N.P., Alexander M., Burns L.A., et al. Guidelines for the prevention of intravascular catheter-related infections. Clin Infect Dis 2011, 52:e162-e193.
17. Steczko J., Ash S.R., Nivens D.E., Brewer L., Winger R.K. Microbial inactivation properties of a new antimicrobial/antithrombotic catheter lock solution (citrate/methylene blue/parabens). Nephrol Dial Transplant 2009, 24:1937-1945.
18. Gershanik J., Boecler B., Ensley H., McCloskey S., George W. The gasping syndrome and benzyl alcohol poisoning. N Engl J Med 1982, 307:1384-1388.
19. Mermel L.A., Farr B.M., Sherertz R.J., et al. Guidelines for the management of intravascular catheter-related infections. Clin Infect Dis 2001, 32:1249-1272.
20. Rubin L.G., Shih S., Shende A., Karayalcin G., Lanzkowsky P. Cure of implantable venous port-associated bloodstream infections in pediatric hematology-oncology patients without catheter removal. Clin Infect Dis 1999, 29:102-105.
21. Ceri H., Olson M.E., Stremick C., Read R.R., Morck D., Buret A. The Calgary Biofilm Device: new technology for rapid determination of antibiotic susceptibilities of bacterial biofilms. J Clin Microbiol 1999, 37:1771-1776.
22. Kimura E.T., Darby T.D., Krause R.A., Brondyk H.D. Parenteral toxicity studies with benzyl alcohol. Toxicol Appl Pharmacol 1971, 18:60-68.
23. Darbre P.D., Harvey P.W. Paraben esters: review of recent studies of endocrine toxicity, absorption, esterase and human exposure, and discussion of potential human health risks. J Appl Toxicol 2008, 28:561-578.
24. Dannenberg C., Bierbach U., Rothe A., Beer J., Korholz D. Ethanol-lock technique in the treatment of bloodstream infections in pediatric oncology patients with Broviac catheter. J Pediatr Hematol Oncol 2003, 25:616-621.