A meta-analysis of polycystic ovary syndrome in women taking valproate for epilepsy

Epilepsy Research

Volumn 97, Issue 1-2, 2011, Pages 73-82

  Hu, Xiaowei ^a,b,c   Wang, Juan ^a   Dong, Wanli ^a   Fang, Qi ^a   Hu, Lifang ^b,c   Liu, Chunfeng ^b,c  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

Epilepsy; Polycystic ovary syndrome; Valproate

Indexed keywords

ANTICONVULSIVE AGENT; TESTOSTERONE; VALPROIC ACID;

ADULT; AMENORRHEA; ARTICLE; CHILD; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DISEASE ASSOCIATION; EPILEPSY; FEMALE; HUMAN; HYPERANDROGENISM; INCIDENCE; MAJOR CLINICAL STUDY; MENSTRUAL IRREGULARITY; MENSTRUATION DISORDER; META ANALYSIS; MONOTHERAPY; OLIGOMENORRHEA; OLIGOOVULATION; OUTCOME ASSESSMENT; OVARY INSUFFICIENCY; OVARY POLYCYSTIC DISEASE; POLYMENORRHEA; PRESCHOOL CHILD; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; TESTOSTERONE BLOOD LEVEL;

ANTICONVULSANTS; EPILEPSY; FEMALE; HUMANS; INCIDENCE; POLYCYSTIC OVARY SYNDROME; RISK FACTORS; VALPROIC ACID;

EID: 81055156252     PISSN: 09201211     EISSN: 18726844     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2011.07.006     Document Type: Article

References (38)

1. Bauer J., Jarre A., Klingüller D., Elger C.E. Polycystic ovary syndrome in patients with focal epilepsy: a study in 93 women. Epilepsy Res. 2000, 41:163-167.
2. Betts T., Yarrow H., Dutton N., Greenhill L., Rolfe T. A study of anticonvulsant medication on ovarian function in a group of women with epilepsy who have only ever taken one anticonvulsant compared with a group of women without epilepsy. Seizure 2003, 12:323-329.
3. Bilo L., Meo R., Valentino R., Buscaino G.A., Striano S., Nappi C. Abnormal pattern of luteinizing hormone pulsatility in women with epilepsy. Fertil. Steril. 1991, 55:705-711.
4. Bilo L., Meo R., Valentino R., Di Carlo C., Striano S., Nappi C. Characterization of the reproductive endocrine disorders in women with epilepsy. J. Clin. Endocrinol. Metab. 2001, 86:2950-2956.
5. Clayton R.N., Ogden V., Hodgkinson J., Wosswick L., Rodin D.A., Dyer S., et al. How common are polycystic ovaries in normal women and what is their significance for the fertility of the population?. Clin. Endocrinol. 1992, 37:127-134.
6. De Vries L., Karasik A., Landau Z., Phillip M., Kiviti S., Goldberg-Stern H., et al. Endocrine effects of valproate in adolescent girls with epilepsy. Epilepsia 2007, 48:470-477.
7. El-Khayat H.A., Abd El-Basset F.Z., Tomoum H.Y., Tohamy S.M., Zaky A.A., Mohamed M.S., et al. Physical growth and endocrinal disorders during pubertal maturation in girls with epilepsy. Epilepsia 2004, 45:1106-1115.
8. Farquhar C.M., Birdsall M., Manning P., Mitchell J.M., France J.T. The prevalence of polycystic ovaries on ultrasound scanning in a population of randomly selected women. Aust. N.Z. J. Obstet. Gynaecol. 1994, 34:67-72.
9. Fox R., Corrigan E., Thomas P.A., Hull M.G.R. The diagnosis of polycystic ovaries in women with oligo-amenorrhoea: predictive power of endocrine tests. Clin. Endocrinol. 1991, 34:127-131.
10. Gorkemli H., Genc B.O., Dogan E.A., Genc E., Ozdemir S. Long-term effects of valproic acid on reproductive endocrine functions in Turkish women with epilepsy. Gynecol. Obstet. Invest. 2009, 67:223-227.
11. Gungor N., Saad R., Janosky J., Arslanian S. Validation of surrogate estimates of insulin sensitivity and insulin secretion in children and adolescents. J. Pediatr. 2004, 144:47-55.
12. Gustavsen M.W., von Krogh K., Tauboll E., Zimmer K.E., Dahl E., Olsaker I., et al. Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta Neurol. Scand. 2009, 189(Suppl.):14-21.
13. Harden C.L. Polycystic ovaries and polycystic ovary syndrome in epilepsy: Evidence for neurogonadal disease. Epilepsy Curr. 2005, 5:142-146.
14. Herzog A.G., Seibel M.M., Schomer D., Vaitukaitis J.L., Geshwind N. Temporal lobe epilepsy: an extrahypothalamic pathogenesis for polycystic ovary syndrome?. Neurology 1984, 34:1389-1393.
15. Herzog A.G., Seibel M.M., Schomer D.L., Vaitukaitis J.L., Geschwind N. Reproductive endocrine disorders in women with partial seizures of temporal lobe origin. Arch. Neurol. 1986, 43:341-346.
16. Herzog A.G. Temporolimbic epilepsy and polycystic ovary syndrome. Fertil. Steril. 1996, 65:210-211.
17. Herzog A.G. Disorders of reproduction and fertility. Epilepsy: A Comprehensive Textbook 1997, 2013-2026. Lippincott-Raven, Philadelphia, PA. J. Engel, T.A. Pedley (Eds.).
18. Ilic A.Z. The occurrence of polycystic ovary syndrome in women with epilepsy. Eur. J. Neurol. 2010, 17(Suppl. 3):448.
19. Isojärvi J.I., Laatikainen T.J., Pakarinen A.J., Juntunen K.T.S., Myllyla V.V. Polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy. N. Engl. J. Med. 1993, 329:1383-1388.
20. Isojärvi J.I., Laatikainen T.J., Knip M., Pakarinen A.J., Juntunen K.T., Myllylä V.V. Obesity and endocrine disorders in women taking valproate for epilepsy. Ann. Neurol. 1996, 39:579-584.
21. Isojärvi J.I., Taubøll E., Pakarinen A.J., van Parys J., Rättyä J., Harbo H.F., et al. Altered ovarian function and cardiovascular risk factors in valproate-treated women. Am. J. Med. 2001, 111:290-296.
22. Lagace D.C., Nachtigal M.W. Valproic acid fails to induce polycystic ovary syndrome in female rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 2003, 27:587-594.
23. Löfgren E., Tapanainen J.S., Koivunen R., Pakarinen A., Isojärvi J.I. Effects of carbamazepine and oxcarbazepine on the reproductive endocrine function in women with epilepsy. Epilepsia 2006, 47:1441-1446.
24. Löfgren E., Mikkonen K., Tolonen U., Pakarinen A., Koivunen R., Myllyla V.V., et al. Reproductive endocrine function in women with epilepsy: The role of epilepsy type and medication. Epilepsy. Behav. 2007, 10:77-83.
25. Luef G., Abraham I., Trinka E., Alge A., Windisch J., Daxenbichler G., et al. Hyperandrogenism, postprandial hyperinsulinism and the risk of PCOS in a cross sectional study of women with epilepsy treated with valproate. Epilepsy Res. 2002, 48:91-102.
26. Meo R., Bilo L., Nappi C., Tommaselli A.P., Valentino R., Nocerino C., et al. Derangement of the hypothalamic GnRH pulse generator in women with epilepsy. Seizure 1993, 2:241-252.
27. Mikkonen K., Vainionpaa L.K., Pakarinen A.J., Knip M., Jarvela I.Y., Tapanainen J.S., et al. Long-term reproductive endocrine health in young women with epilepsy during puberty. Neurology 2004, 62:445-450.
28. Morrell M.J., Giudice L., Flynn K.L., Seale C.G., Paulson A.J., Doñe S., et al. Predictors of ovulatory failure in women with epilepsy. Ann. Neurol. 2002, 52:704-711.
29. Morrell M.J., Isojärvi J., Taylor A.E., Dam M., Ayala R., Gomez G., et al. Higher androgens and weight gain with valproate compared with lamotrigine for epilepsy. Epilepsy Res. 2003, 54:189-199.
30. Morrell M.J., Hayes F.J., Sluss P.M., Adams J.M., Bhatt M., Ozkara C., et al. Hyperandrogenism, ovulatory dysfunction, and PCOS with valproate vs lamotrigine. Ann. Neurol. 2008, 64:200-211.
31. Murialdo G., Galimberti C.A., Magri F., Sampaolo P., Copello F., Gianelli M.V., et al. Menstrual cycle and ovary alterations in women with epilepsy on antiepileptic therapy. J. Endocrinol. Invest. 1997, 20:519-526.
32. Nelson-DeGrave V.L., Wickenheisser J.K., Cockrell J.E., Wood J.R., Legro R.S., Strauss J.F., et al. Valproate potentiates androgen biosynthesis in human ovarian theca cells. Endocrinology 2004, 145:799-808.
33. Røste L.S., Taubøll E., Berner A.A., Isojärvi J.I.T., Gjerstad L. Valproate, but not lamotrigine, induces ovarian morphological changes in Wistar rats. Exp. Toxicol. Pathol. 2001, 52:545-552.
34. Røste L.S., Tauboll E., Isojarvi J.I., Pakarinen A.J., Huhtaniemi I.T., Knip M., et al. Effects of chronic valproate treatment on reproductive endocrine hormones in female and male Wistar rats. Reprod. Toxicol. 2002, 16:767-773.
35. Svalheim S., Tauboll E., Bjornenak T., Roste L.S., Morland T., Saetre E.R., et al. Do women with epilepsy have increased frequency of menstrual disturbances?. Seizure 2003, 12:529-533.
36. Tauboll E., Gregoaszczuk E.L., Kolodziej A., Katja M., Ropstad E. Valproate inhibits the conversion of testosterone to estradiol and acts as an apoptotic agent in growing porcine ovarian follicular cells. Epilepsia 2003, 44:1014-1021.
37. Vainionpää L.K., Rättyä J., Knip M., Tapanainen J.S., Pakarinen A.J., Lanning P., et al. Valproate-induced hyperandrogenism during pubertal maturation in girls with epilepsy. Ann. Neurol. 1999, 45:444-450.
38. Zawadski J.K., Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. Polycystic Ovary Syndrome 1992, 377-384. Blackwell Scientific, Oxford. A. Dunaif, J.R. Givens, F.P. Haseltine (Eds.).