Verification of expressions of Kir2 as potential peripheral biomarkers in lymphocytes from patients with Parkinson's disease

Neuroscience Letters

Volumn 505, Issue 2, 2011, Pages 104-108

  Gui, Ya Xing ^a   Wan, Ying ^a   Xiao, Qin ^a   Wang, Ying ^a   Wang, Gang ^a   Chen, Sheng Di ^a,b  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Biomarker; Dopamine receptor; Inwardly rectifying potassium channel; Parkinson's disease; Peripheral blood lymphocytes

Indexed keywords

ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; BIOLOGICAL MARKER; DOPAMINE RECEPTOR; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; LEVODOPA; MESSENGER RNA; POTASSIUM CHANNEL; POTASSIUM CHANNEL KIR2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; LYMPHOCYTE; MALE; PARKINSON DISEASE; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION;

AGED; BIOLOGICAL MARKERS; FEMALE; GENE EXPRESSION REGULATION; HUMANS; LYMPHOCYTE SUBSETS; MALE; MIDDLE AGED; PARKINSON DISEASE; POTASSIUM CHANNELS, INWARDLY RECTIFYING; REPRODUCIBILITY OF RESULTS;

EID: 81055140153     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.09.070     Document Type: Article

References (24)

1. Baba Y., Kuroiwa A., Uitti R.J., Wszolek Z.K., Yamada T. Alterations of T-lymphocyte populations in Parkinson disease. Parkinsonism Relat. Disord. 2005, 11:493-498.
2. Dong Y., Cooper D., Nasif F., Hu X.T., White F.J. Dopamine modulates inwardly rectifying potassium currents in medial prefrontal cortex pyramidal neurons. J. Neurosci. 2004, 24:3077-3085.
3. Gregerson K.A., Flagg T.P., O'Neill T.J., Anderson M., Lauring O., Horel J.S., Welling P.A. Identification of G protein-coupled, inward rectifier potassium channel gene products from the rat anterior pituitary gland. Endocrinology 2001, 142:2820-2832.
4. Grunblatt E., Bartl J., Zehetmayer S., Ringel T.M., Bauer P., Riederer P., Jacob C.P. Gene expression as peripheral biomarkers for sporadic Alzheimer's disease. J. Alzheimers Dis. 2009, 16:627-634.
5. Hassan M.N., Thakar J.H. Dopamine receptors in Parkinson's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 1988, 12:173-182.
6. Inanobe A., Fujita A., Ito M., Tomoike H., Inageda K., Kurachi Y. Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses. Am. J. Physiol. Cell Physiol. 2002, 282:C1396-C1403.
7. Kaasinen V., Aalto S., N.A K., Hietala J., Sonninen P., Rinne J.O. Extrastriatal dopamine D(2) receptors in Parkinson's disease: a longitudinal study. J. Neural Transm. 2003, 110:591-601.
8. Karschin C., Dissmann E., Stuhmer W., Karschin A. IRK(1-3) and GIRK(1-4) inwardly rectifying K+ channel mRNAs are differentially expressed in the adult rat brain. J. Neurosci. 1996, 16:3559-3570.
9. 1H-3-benzaze pine hydrochloride (SCH23390) directly inhibits G protein-coupled inwardly rectifying potassium channels. Mol. Pharmacol. 2002, 62:119-126.
10. Liss B., Haeckel O., Wildmann J., Miki T., Seino S., Roeper J. K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nat. Neurosci. 2005, 8:1742-1751.
11. Mailman R., Huang X., Nichols D.E. Parkinson's disease and D1 dopamine receptors. Curr. Opin. Investig. Drugs 2001, 2:1582-1591.
12. Nagai Y., Ueno S., Saeki Y., Soga F., Hirano M., Yanagihara T. Decrease of the D3 dopamine receptor mRNA expression in lymphocytes from patients with Parkinson's disease. Neurology 1996, 46:791-795.
13. Perez M.F., White F.J., Hu X.T. Dopamine D(2) receptor modulation of K(+) channel activity regulates excitability of nucleus accumbens neurons at different membrane potentials. J. Neurophysiol. 2006, 96:2217-2228.
14. Pruss H., Wenzel M., Eulitz D., Thomzig A., Karschin A., Veh R.W. Kir2 potassium channels in rat striatum are strategically localized to control basal ganglia function. Brain Res. Mol. Brain Res. 2003, 110:203-219.
15. Pruss H., Derst C., Lommel R., Veh R.W. Differential distribution of individual subunits of strongly inwardly rectifying potassium channels (Kir2 family) in rat brain. Brain Res. Mol. Brain Res. 2005, 139:63-79.
16. Reale M., Iarlori C., Thomas A., Gambi D., Perfetti B., Di Nicola M., Onofrj M. Peripheral cytokines profile in Parkinson's disease. Brain Behav. Immun. 2009, 23:55-63.
17. Stoessl A.J., de la Fuente-Fernandez R. Dopamine receptors in Parkinson's disease: imaging studies. Adv. Neurol. 2003, 91:65-71.
18. Thomzig A., Laube G., Pruss H., Veh R.W. Pore-forming subunits of K-ATP channels, Kir6.1 and Kir6.2, display prominent differences in regional and cellular distribution in the rat brain. J. Comp. Neurol. 2005, 484:313-330.
19. Wang S., Hu L.F., Yang Y., Ding J.H., Hu G. Studies of ATP-sensitive potassium channels on 6-hydroxydopamine and haloperidol rat models of Parkinson's disease: implications for treating Parkinson's disease?. Neuropharmacology 2005, 48:984-992.
20. Wang G., Cheng Q., Zheng R., Tan Y.Y., Sun X.K., Zhou H.Y., Ye X.L., Wang Y., Wang Z., Sun B.M., Chen S.D. Economic burden of Parkinson's disease in a developing country: a retrospective cost analysis in Shanghai, China. Mov. Disord. 2006, 21:1439-1443.
21. Wang G., Zeng J., Ren R., Chen S. Potassium channels in the basal ganglia: promising new targets for the treatment of Parkinson's disease. Front. Biosci. 2008, 13:3825-3838.
22. Wang Y., Yang P.L., Tang J.F., Lin J.F., Cai X.H., Wang X.T., Zheng G.Q. Potassium channels: possible new therapeutic targets in Parkinson's disease. Med. Hypotheses 2008, 71:546-550.
23. Zeng J., Wang G., Chen S.D. ATP-sensitive potassium channels: novel potential roles in Parkinson's disease. Neurosci. Bull. 2007, 23:370-376.
24. Zvara A., Szekeres G., Janka Z., Kelemen J.Z., Cimmer C., Santha M., Puskas L.G. Over-expression of dopamine D2 receptor and inwardly rectifying potassium channel genes in drug-naive schizophrenic peripheral blood lymphocytes as potential diagnostic markers. Dis. Markers 2005, 21:61-69.