Sedation and weaning from mechanical ventilation: Linking spontaneous awakening trials and spontaneous breathing trials to improve patient outcomes

Anesthesiology Clinics

Volumn 29, Issue 4, 2011, Pages 651-661

  Hooper, Michael H ^a   Girard, Timothy D ^a,b  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Interruption of sedation; Sedation; Spontaneous awakening; Wake up and breathe; Weaning

Indexed keywords

SEDATIVE AGENT;

AGITATION; ANXIETY; ARTIFICIAL VENTILATION; BREATHING; CLINICAL PROTOCOL; CLINICAL TRIAL (TOPIC); CRITICALLY ILL PATIENT; DRUG WITHDRAWAL; HUMAN; INTENSIVE CARE; MEDICAL DECISION MAKING; PAIN; REVIEW; SEDATION; SIDE EFFECT; VENTILATED PATIENT; WAKEFULNESS;

EID: 81055131691     PISSN: 19322275     EISSN: 22103538     Source Type: Journal    
DOI: 10.1016/j.anclin.2011.09.005     Document Type: Review

References (25)

1. Zilberberg M.D., Luippold R.S., Sulsky S., et al. Prolonged acute mechanical ventilation, hospital resource utilization, and mortality in the United States. Crit Care Med 2008, 36(3):724-730.
2. Rashid A., Sattar K.A., Dar M.I., et al. Analyzing the outcome of early versus prolonged extubation following cardiac surgery. Ann Thorac Cardiovasc Surg 2008, 14(4):218-223.
3. Cook D.J., Walter S.D., Cook R.J., et al. Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med 1998, 129(6):433-440.
4. Pinhu L., Whitehead T., Evans T., et al. Ventilator-associated lung injury. Lancet 2003, 361(9354):332-340.
5. Brochard L., Rauss A., Benito S., et al. Comparison of three methods of gradual withdrawal from ventilatory support during weaning from mechanical ventilation. Am J Respir Crit Care Med 1994, 150(4):896-903.
6. Esteban A., Frutos F., Tobin M.J., et al. A comparison of four methods of weaning patients from mechanical ventilation. Spanish Lung Failure Collaborative Group. N Engl J Med 1995, 332(6):345-350.
7. Ely E.W., Baker A.M., Dunagan D.P., et al. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med 1996, 335(25):1864-1869.
8. MacIntyre N.R., Cook D.J., Ely E.W., et al. Evidence-based guidelines for weaning and discontinuing ventilatory support: a collective task force facilitated by the American College of Chest Physicians; the American Association for Respiratory Care; and the American College of Critical Care Medicine. Chest 2001, 120(6 Suppl):375S-395S.
9. Dellinger R.P., Levy M.M., Carlet J.M., et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock. Crit Care Med 2008, 36(1):296-327.
10. Boles J.M., Bion J., Connors A., et al. Weaning from mechanical ventilation. Eur Respir J 2007, 29(5):1033-1056.
11. Turner J.S., Briggs S.J., Springhorn H.E., et al. Patients' recollection of intensive care unit experience. Crit Care Med 1990, 18(9):966-968.
12. Kollef M.H., Levy N.T., Ahrens T.S., et al. The use of continuous i.v. sedation is associated with prolongation of mechanical ventilation. Chest 1998, 114(2):541-548.
13. Kress J.P., Pohlman A.S., O'Connor M.F., et al. Daily interruption of sedative infusions in critically ill patients undergoing mechanical ventilation. N Engl J Med 2000, 342(20):1471-1477.
14. Schweickert W.D., Gehlbach B.K., Pohlman A.S., et al. Daily interruption of sedative infusions and complications of critical illness in mechanically ventilated patients. Crit Care Med 2004, 32(6):1272-1276.
15. Martin J., Franck M., Sigel S., et al. Changes in sedation management in German intensive care units between 2002 and 2006: a national follow up survey. Crit Care 2007, 11(6):R124.
16. Mehta S., Burry L., Fischer S., et al. Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients. Crit Care Med 2006, 34(2):374-380.
17. Payen J.F., Chanques G., Mantz J., et al. Current practices in sedation and analgesia for mechanically ventilated critically ill patients: a prospective multicenter patient-based study. Anesthesiology 2007, 106(4):687-695.
18. Patel R.P., Gambrell M., Speroff T., et al. Delirium and sedation in the intensive care unit: survey of behaviors and attitudes of 1384 healthcare professionals. Crit Care Med 2009, 37(3):825-832.
19. Tanios M.A., deWit M., Epstein S.K., et al. Perceived barriers to the use of sedation protocols and daily sedation interruption: A multidisciplinary survey. J Crit Care 2009, 24:66-73.
20. Devlin J.W., Tanios M.A., Epstein S.K. Intensive care unit sedation: waking up clinicians to the gap between research and practice. Crit Care Med 2006, 34(2):556-557.
21. Hong J.J., Mazuski J.E., Shapiro M.J. Daily interruption of sedative infusions in critically ill patients. N Engl J Med 2000, 343(11):814-815.
22. Heffner J.E. A wake-up call in the intensive care unit. N Engl J Med 2000, 342(20):1520-1522.
23. Riker R.R. Neuromuscular blockade at the end of life. N Engl J Med 2000, 342:1921-1922.
24. Kress J.P., Gehlbach B., Lacy M., et al. The long-term psychological effects of daily sedative interruption on critically ill patients. Am J Respir Crit Care Med 2003, 168(12):1457-1461.
25. Girard T.D., Kress J.P., Fuchs B.D., et al. Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial. Lancet 2008, 371(9607):126-134.