Proteolytic targeting of Rab29 by an effector protein distinguishes the intracellular compartments of human-adapted and broad-host Salmonella

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 45, 2011, Pages 18418-18423

  Spanò, Stefania ^a   Liu, Xiaoyun ^a   Galán, Jorge E ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Bacterial pathogenesis; Cysteine proteases; Vesicular traffic

Indexed keywords

BACTERIAL TOXIN; RAB PROTEIN; RAB29 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL DIVISION; CELL VACUOLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTRACELLULAR SPACE; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN TARGETING; SALMONELLA ENTERICA; SALMONELLA PARATYPHI; SALMONELLA TYPHI; SEROTYPE;

ADAPTATION, PHYSIOLOGICAL; AMINO ACID SEQUENCE; ANIMALS; CELL COMPARTMENTATION; CERCOPITHECUS AETHIOPS; COS CELLS; HELA CELLS; HUMANS; MOLECULAR SEQUENCE DATA; PROTEOLYSIS; RAB GTP-BINDING PROTEINS; SALMONELLA;

BACTERIA (MICROORGANISMS); SALMONELLA; SALMONELLA ENTERICA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHI; SALMONELLA PARATYPHI; SALMONELLA TYPHI;

EID: 81055130099     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1111959108     Document Type: Article

References (32)

1. Pang T, Levine MM, Ivanoff B, Wain J, Finlay BB (1998) Typhoid fever-important issues still remain. Trends Microbiol 6:131-133.
2. Crump JA, Mintz ED (2010) Global trends in typhoid and paratyphoid fever. Clin Infect Dis 50:241-246.
3. Parry CM, Hien TT, Dougan G, White NJ, Farrar JJ (2002) Typhoid fever. N Engl J Med 347:1770-1782. (Pubitemid 35375617)
4. Hohmann EL (2001) Nontyphoidal salmonellosis. Clin Infect Dis 32:263-269.
5. Sabbagh SC, Forest CG, Lepage C, Leclerc JM, Daigle F (2010) So similar, yet so different: Uncovering distinctive features in the genomes of Salmonella enterica serovars Typhimurium and Typhi. FEMS Microbiol Lett 305:1-13.
6. Spanò S, Ugalde JE, Galán JE (2008) Delivery of a Salmonella Typhi exotoxin from a host intracellular compartment. Cell Host Microbe 3:30-38.
7. Haghjoo E, Galán JE (2004) Salmonella typhi encodes a functional cytolethal distending toxin that is delivered into host cells by a bacterial-internalization pathway. Proc Natl Acad Sci USA 101:4614-4619. (Pubitemid 38437459)
8. Song J, et al. (2010) A mouse model for the human pathogen Salmonella typhi. Cell Host Microbe 8:369-376.
9. Brighouse A, Dacks JB, Field MC (2010) Rab protein evolution and the history of the eukaryotic endomembrane system. Cell Mol Life Sci 67:3449-3465.
10. Stenmark H (2009) Rab GTPases as coordinators of vesicle traffic. Nat Rev Mol Cell Biol 10:513-525.
11. Méresse S, Steele-Mortimer O, Finlay BB, Gorvel JP (1999) The rab7 GTPase controls the maturation of Salmonella typhimurium-containing vacuoles in HeLa cells. EMBO J 18:4394-4403. (Pubitemid 29391249)
12. Wasmeier C, et al. (2006) Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes. J Cell Biol 175:271-281. (Pubitemid 44631421)
13. Galán JE (2001) Salmonella interactions with host cells: Type III secretion at work. Annu Rev Cell Dev Biol 17:53-86.
14. Waterman SR, Holden DW (2003) Functions and effectors of the Salmonella pathogenicity island 2 type III secretion system. Cell Microbiol 5:501-511. (Pubitemid 36939590)
15. Ibarra JA, Steele-Mortimer O (2009) Salmonella-the ultimate insider. Salmonella virulence factors that modulate intracellular survival. Cell Microbiol 11:1579-1586.
16. Zhou D, Chen LM, Hernandez L, Shears SB, Galán JE (2001) A Salmonella inositol polyphosphatase acts in conjunction with other bacterial effectors to promote host cell actin cytoskeleton rearrangements and bacterial internalization. Mol Microbiol 39:248-259. (Pubitemid 32113499)
17. Hernandez LD, Pypaert M, Flavell RA, Galán JE (2003) A Salmonella protein causes macrophage cell death by inducing autophagy. J Cell Biol 163:1123-1131. (Pubitemid 37541887)
18. Marlovits TC, et al. (2006) Assembly of the inner rod determines needle length in the type III secretion injectisome. Nature 441:637-640. (Pubitemid 43927295)
19. Kubori T, Sukhan A, Aizawa SI, Galán JE (2000) Molecular characterization and assembly of the needle complex of the Salmonella typhimurium type III protein secretion system. Proc Natl Acad Sci USA 97:10225-10230.
20. Wood MW, et al. (1998) Identification of a pathogenicity island required for Salmonella enteropathogenicity. Mol Microbiol 29:883-891. (Pubitemid 28365473)
21. Knodler LA, et al. (2003) Salmonella type III effectors PipB and PipB2 are targeted to detergent-resistant microdomains on internal host cell membranes. Mol Microbiol 49: 685-704. (Pubitemid 36918689)
22. Ho TD, et al. (2002) Identification of GtgE, a novel virulence factor encoded on the Gifsy-2 bacteriophage of Salmonella enterica serovar Typhimurium. J Bacteriol 184: 5234-5239. (Pubitemid 35024368)
23. McClelland M, et al. (2004) Comparison of genome degradation in Paratyphi A and Typhi, human-restricted serovars of Salmonella enterica that cause typhoid. Nat Genet 36:1268-1274. (Pubitemid 39577934)
24. Parkhill J, et al. (2001) Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18. Nature 413:848-852. (Pubitemid 33026852)
25. Buchko GW, et al. (2010) A multi-pronged search for a common structural motif in the secretion signal of Salmonella enterica serovar Typhimurium type III effector proteins. Mol Biosyst 6:2448-2458.
26. Ostermeier C, Brunger AT (1999) Structural basis of Rab effector specificity: crystal structure of the small G protein Rab3A complexed with the effector domain of rabphilin-3A. Cell 96:363-374. (Pubitemid 29077590)
27. Lee MT, Mishra A, Lambright DG (2009) Structural mechanisms for regulation of membrane traffic by rab GTPases. Traffic 10:1377-1389.
28. Montecucco C, Schiavo G (1993) Tetanus and botulism neurotoxins: A new group of zinc proteases. Trends Biochem Sci 18:324-327. (Pubitemid 23258286)
29. Galán JE, Curtiss R, 3rd (1991) Distribution of the invA, -B, -C, and -D genes of Salmonella typhimurium among other Salmonella serovars: invA mutants of Salmonella typhi are deficient for entry into mammalian cells. Infect Immun 59:2901-2908.
30. Hoiseth SK, Stocker BA (1981) Aromatic-dependent Salmonella typhimurium are nonvirulent and effective as live vaccines. Nature 291:238-239. (Pubitemid 11081517)
31. Kaniga K, Bossio JC, Galán JE (1994) The Salmonella typhimurium invasion genes invF and invG encode homologues of the AraC and PulD family of proteins. Mol Microbiol 13:555-568.
32. Lara-Tejero M, Kato J, Wagner S, Liu X, Galán JE (2011) A sorting platform determines the order of protein secretion in bacterial type III systems. Science 331:1188-1191.