메뉴 건너뛰기




Volumn 85, Issue 5, 2011, Pages 895-906

Bezafibrate restores the inhibition of FSH-induced follicular development and steroidogenesis by tumor necrosis factor-alpha through peroxisome proliferator-activated receptor-gamma pathway in an in vitro mouse preantral follicle culture

Author keywords

Bezafibrate; Follicle; Follicle culture; Follicular development; Granulosa cells; Ovary; Polycystic ovary syndrome; Pparg; Tnf

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; BEZAFIBRATE; CHORIONIC GONADOTROPIN; ESTRADIOL; FOLLITROPIN; N (2 BENZOYLPHENYL) O [2 (METHYL 2 PYRIDINYLAMINO)ETHYL]TYROSINE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TUMOR NECROSIS FACTOR ALPHA;

EID: 81055126925     PISSN: 00063363     EISSN: 15297268     Source Type: Journal    
DOI: 10.1095/biolreprod.111.090738     Document Type: Article
Times cited : (10)

References (69)
  • 2
    • 15444366255 scopus 로고    scopus 로고
    • Polycystic ovary syndrome
    • Ehrmann DA. Polycystic ovary syndrome. N Engl J Med 2005; 352:1223-1236.
    • (2005) N Engl J Med , vol.352 , pp. 1223-1236
    • Ehrmann, D.A.1
  • 3
    • 0031456016 scopus 로고    scopus 로고
    • Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis
    • Dunaif A. Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr Rev 1997; 18:774-800.
    • (1997) Endocr Rev , vol.18 , pp. 774-800
    • Dunaif, A.1
  • 4
    • 18144395497 scopus 로고    scopus 로고
    • Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment
    • DeUgarte CM, Bartolucci AA, Azziz R. Prevalence of insulin resistance in the polycystic ovary syndrome using the homeostasis model assessment. Fertil Steril 2005; 83:1454-1460.
    • (2005) Fertil Steril , vol.83 , pp. 1454-1460
    • DeUgarte, C.M.1    Bartolucci, A.A.2    Azziz, R.3
  • 5
    • 0022081697 scopus 로고
    • Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function
    • Adashi EY, Resnick CE, D'Ercole AJ, Svoboda ME, Van Wyk JJ. Insulin-like growth factors as intraovarian regulators of granulosa cell growth and function. Endocr Rev 1985; 6:400-420.
    • (1985) Endocr Rev , vol.6 , pp. 400-420
    • Adashi, E.Y.1    Resnick, C.E.2    D'Ercole, A.J.3    Svoboda, M.E.4    Van Wyk, J.J.5
  • 7
    • 60549105378 scopus 로고    scopus 로고
    • Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review
    • Palomba S, Falbo A, Zullo F, Orio F Jr. Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review. Endocr Rev 2009; 30:1-50.
    • (2009) Endocr Rev , vol.30 , pp. 1-50
    • Palomba, S.1    Falbo, A.2    Zullo, F.3    Orio Jr., F.4
  • 8
    • 0029842832 scopus 로고    scopus 로고
    • A mechanism for the suppression of estrogen production in polycystic ovary syndrome
    • Agarwal SK, Judd HL, Magoffin DA. A mechanism for the suppression of estrogen production in polycystic ovary syndrome. J Clin Endocrinol Metab 1996; 81:3686-3691.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 3686-3691
    • Agarwal, S.K.1    Judd, H.L.2    Magoffin, D.A.3
  • 10
    • 0034713161 scopus 로고    scopus 로고
    • Follicular dynamics in the polycystic ovary syndrome
    • Franks S, Mason H, Willis D. Follicular dynamics in the polycystic ovary syndrome. Mol Cell Endocrinol 2000; 163:49-52.
    • (2000) Mol Cell Endocrinol , vol.163 , pp. 49-52
    • Franks, S.1    Mason, H.2    Willis, D.3
  • 11
    • 0028354802 scopus 로고
    • Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis
    • Hillier SG. Current concepts of the roles of follicle stimulating hormone and luteinizing hormone in folliculogenesis. Hum Reprod 1994; 9:188-191.
    • (1994) Hum Reprod , vol.9 , pp. 188-191
    • Hillier, S.G.1
  • 12
    • 0030710606 scopus 로고    scopus 로고
    • Ontogeny of follicle-stimulating hormone receptor gene expression in isolated human ovarian follicles
    • Oktay K, Briggs D, Gosden RG. Ontogeny of follicle-stimulating hormone receptor gene expression in isolated human ovarian follicles. J Clin Endocrinol Metab 1997; 82:3748-3751.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 3748-3751
    • Oktay, K.1    Briggs, D.2    Gosden, R.G.3
  • 13
    • 0033034125 scopus 로고    scopus 로고
    • Effects of follicle-stimulating hormone and serum substitution on the in-vitro growth of human ovarian follicles
    • Wright CS, Hovatta O, Margara R, Trew G, Winston RM, Franks S, Hardy K. Effects of follicle-stimulating hormone and serum substitution on the in-vitro growth of human ovarian follicles. Hum Reprod 1999; 14:1555-1562.
    • (1999) Hum Reprod , vol.14 , pp. 1555-1562
    • Wright, C.S.1    Hovatta, O.2    Margara, R.3    Trew, G.4    Winston, R.M.5    Franks, S.6    Hardy, K.7
  • 15
    • 0032587240 scopus 로고    scopus 로고
    • The role of TNFalpha and TNF receptors in obesity and insulin resistance
    • Hotamisligil GS. The role of TNFalpha and TNF receptors in obesity and insulin resistance. J Intern Med 1999; 245:621-625.
    • (1999) J Intern Med , vol.245 , pp. 621-625
    • Hotamisligil, G.S.1
  • 17
    • 0032936968 scopus 로고    scopus 로고
    • Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome
    • Gonzalez F, Thusu K, Abdel-Rahman E, Prabhala A, Tomani M, Dandona P. Elevated serum levels of tumor necrosis factor alpha in normal-weight women with polycystic ovary syndrome. Metabolism 1999; 48:437-441.
    • (1999) Metabolism , vol.48 , pp. 437-441
    • Gonzalez, F.1    Thusu, K.2    Abdel-Rahman, E.3    Prabhala, A.4    Tomani, M.5    Dandona, P.6
  • 18
    • 33746422560 scopus 로고    scopus 로고
    • Association between circulating tumor necrosis factor-alpha, interleukin-6, and insulin resistance in normal-weight women with polycystic ovary syndrome
    • Tarkun I, Cetinarslan B, Turemen E, Canturk Z, Biyikli M. Association between circulating tumor necrosis factor-alpha, interleukin-6, and insulin resistance in normal-weight women with polycystic ovary syndrome. Metab Syndr Relat Disord 2006; 4:122-128.
    • (2006) Metab Syndr Relat Disord , vol.4 , pp. 122-128
    • Tarkun, I.1    Cetinarslan, B.2    Turemen, E.3    Canturk, Z.4    Biyikli, M.5
  • 19
    • 0029066697 scopus 로고
    • Contenders in FasL/TNF death signaling
    • Cleveland JL, Ihle JN. Contenders in FasL/TNF death signaling. Cell 1995; 81:479-482.
    • (1995) Cell , vol.81 , pp. 479-482
    • Cleveland, J.L.1    Ihle, J.N.2
  • 20
    • 0036157884 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha enhances oocyte/follicle apoptosis in the neonatal rat ovary
    • Morrison LJ, Marcinkiewicz JL. Tumor necrosis factor alpha enhances oocyte/follicle apoptosis in the neonatal rat ovary. Biol Reprod 2002; 66:450-457.
    • (2002) Biol Reprod , vol.66 , pp. 450-457
    • Morrison, L.J.1    Marcinkiewicz, J.L.2
  • 21
    • 21244480038 scopus 로고    scopus 로고
    • Apoptosis in the ovary: molecular mechanisms
    • Hussein MR. Apoptosis in the ovary: molecular mechanisms. Hum Reprod Update 2005; 11:162-177.
    • (2005) Hum Reprod Update , vol.11 , pp. 162-177
    • Hussein, M.R.1
  • 22
    • 0036057490 scopus 로고    scopus 로고
    • Steroidogenesis, proliferation and apoptosis in bovine granulosa cells: role of tumour necrosis factor-alpha and its possible signalling mechanisms
    • Basini G, Mainardi GL, Bussolati S, Tamanini C. Steroidogenesis, proliferation and apoptosis in bovine granulosa cells: role of tumour necrosis factor-alpha and its possible signalling mechanisms. Reprod Fertil Dev 2002; 14:141-150.
    • (2002) Reprod Fertil Dev , vol.14 , pp. 141-150
    • Basini, G.1    Mainardi, G.L.2    Bussolati, S.3    Tamanini, C.4
  • 23
    • 0347093365 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha (TNF alpha) inhibits progesterone and estradiol-17beta production from cultured granulosa cells: presence of TNFalpha receptors in bovine granulosa and theca cells
    • Sakumoto R, Shibaya M, Okuda K. Tumor necrosis factor-alpha (TNF alpha) inhibits progesterone and estradiol-17beta production from cultured granulosa cells: presence of TNFalpha receptors in bovine granulosa and theca cells. J Reprod Dev 2003; 49:441-449.
    • (2003) J Reprod Dev , vol.49 , pp. 441-449
    • Sakumoto, R.1    Shibaya, M.2    Okuda, K.3
  • 24
    • 0026636043 scopus 로고
    • Factors influencing the rate of preantral and antral growth of mouse ovarian follicles in vitro
    • Nayudu PL, Osborn SM. Factors influencing the rate of preantral and antral growth of mouse ovarian follicles in vitro. J Reprod Fertil 1992; 95:349-362.
    • (1992) J Reprod Fertil , vol.95 , pp. 349-362
    • Nayudu, P.L.1    Osborn, S.M.2
  • 25
    • 0031008691 scopus 로고    scopus 로고
    • In vitro culture of ovarian follicles
    • Hartshorne GM. In vitro culture of ovarian follicles. Rev Reprod 1997; 2:94-104.
    • (1997) Rev Reprod , vol.2 , pp. 94-104
    • Hartshorne, G.M.1
  • 26
    • 65249190781 scopus 로고    scopus 로고
    • Functional AR signaling is evident in an in vitro mouse follicle culture bioassay that encompasses most stages of folliculogenesis
    • Lenie S, Smitz J. Functional AR signaling is evident in an in vitro mouse follicle culture bioassay that encompasses most stages of folliculogenesis. Biol Reprod 2009; 80:685-695.
    • (2009) Biol Reprod , vol.80 , pp. 685-695
    • Lenie, S.1    Smitz, J.2
  • 27
    • 77953606706 scopus 로고    scopus 로고
    • Usefulness of bezafibrate for ovulation induction in clomiphene citrate-resistant polycystic ovary syndrome patients with dyslipidemia: a prospective pilot study of seven cases
    • Hara S, Takahashi T, Amita M, Igarashi H, Kurachi H. Usefulness of bezafibrate for ovulation induction in clomiphene citrate-resistant polycystic ovary syndrome patients with dyslipidemia: a prospective pilot study of seven cases. Gynecol Obstet Invest 2010; 70:166-172.
    • (2010) Gynecol Obstet Invest , vol.70 , pp. 166-172
    • Hara, S.1    Takahashi, T.2    Amita, M.3    Igarashi, H.4    Kurachi, H.5
  • 30
    • 0034751344 scopus 로고    scopus 로고
    • Expression and localization of PPARs in the rat ovary during follicular development and the periovulatory period
    • Komar CM, Braissant O, Wahli W, Curry TE Jr. Expression and localization of PPARs in the rat ovary during follicular development and the periovulatory period. Endocrinology 2001; 142:4831-4838.
    • (2001) Endocrinology , vol.142 , pp. 4831-4838
    • Komar, C.M.1    Braissant, O.2    Wahli, W.3    Curry Jr., T.E.4
  • 31
    • 0036234471 scopus 로고    scopus 로고
    • Localization and expression of messenger RNAs for the peroxisome proliferator-activated receptors in ovarian tissue from naturally cycling and pseudopregnant rats
    • Komar CM, Curry TE Jr. Localization and expression of messenger RNAs for the peroxisome proliferator-activated receptors in ovarian tissue from naturally cycling and pseudopregnant rats. Biol Reprod 2002; 66:1531-1539.
    • (2002) Biol Reprod , vol.66 , pp. 1531-1539
    • Komar, C.M.1    Curry Jr., T.E.2
  • 32
    • 33646810470 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in reproductive tissues: from gametogenesis to parturition
    • Froment P, Gizard F, Defever D, Staels B, Dupont J, Monget P. Peroxisome proliferator-activated receptors in reproductive tissues: from gametogenesis to parturition. J Endocrinol 2006; 189:199-209.
    • (2006) J Endocrinol , vol.189 , pp. 199-209
    • Froment, P.1    Gizard, F.2    Defever, D.3    Staels, B.4    Dupont, J.5    Monget, P.6
  • 33
    • 27544433196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors (PPARs) and ovarian function-implications for regulating steroidogenesis, differentiation, and tissue remodeling
    • Komar CM. Peroxisome proliferator-activated receptors (PPARs) and ovarian function-implications for regulating steroidogenesis, differentiation, and tissue remodeling. Reprod Biol Endocrinol 2005; 3:41.
    • (2005) Reprod Biol Endocrinol , vol.3 , pp. 41
    • Komar, C.M.1
  • 34
    • 0014384203 scopus 로고
    • Proposal for a classification of oocytes and follicles in the mouse ovary
    • Pedersen T, Peters H. Proposal for a classification of oocytes and follicles in the mouse ovary. J Reprod Fertil 1968; 17:555-557.
    • (1968) J Reprod Fertil , vol.17 , pp. 555-557
    • Pedersen, T.1    Peters, H.2
  • 35
    • 65949086999 scopus 로고    scopus 로고
    • Differences in collagen expression in cumulus cells after exposure to highly purified menotropin or recombinant follicle-stimulating hormone in a mouse follicle culture model
    • Adriaenssens T, Mazoyer C, Segers I, Wathlet S, Smitz J. Differences in collagen expression in cumulus cells after exposure to highly purified menotropin or recombinant follicle-stimulating hormone in a mouse follicle culture model. Biol Reprod 2009; 80:1015-1025.
    • (2009) Biol Reprod , vol.80 , pp. 1015-1025
    • Adriaenssens, T.1    Mazoyer, C.2    Segers, I.3    Wathlet, S.4    Smitz, J.5
  • 36
    • 6344235365 scopus 로고    scopus 로고
    • A reproducible two-step culture system for isolated primary mouse ovarian follicles as single functional units
    • Lenie S, Cortvrindt R, Adriaenssens T, Smitz J. A reproducible two-step culture system for isolated primary mouse ovarian follicles as single functional units. Biol Reprod 2004; 71:1730-1738.
    • (2004) Biol Reprod , vol.71 , pp. 1730-1738
    • Lenie, S.1    Cortvrindt, R.2    Adriaenssens, T.3    Smitz, J.4
  • 37
    • 1242341389 scopus 로고    scopus 로고
    • Differential FSH exposure in preantral follicle culture has marked effects on folliculogenesis and oocyte developmental competence
    • Adriaens I, Cortvrindt R, Smitz J. Differential FSH exposure in preantral follicle culture has marked effects on folliculogenesis and oocyte developmental competence. Hum Reprod 2004; 19:398-408.
    • (2004) Hum Reprod , vol.19 , pp. 398-408
    • Adriaens, I.1    Cortvrindt, R.2    Smitz, J.3
  • 38
    • 0025945981 scopus 로고
    • Ovarian actions of tumor necrosis factor-alpha (TNF alpha): pleiotropic effects of TNF alpha on differentiated functions of untransformed swine granulosa cells
    • Veldhuis JD, Garmey JC, Urban RJ, Demers LM, Aggarwal BB. Ovarian actions of tumor necrosis factor-alpha (TNF alpha): pleiotropic effects of TNF alpha on differentiated functions of untransformed swine granulosa cells. Endocrinology 1991; 129:641-648.
    • (1991) Endocrinology , vol.129 , pp. 641-648
    • Veldhuis, J.D.1    Garmey, J.C.2    Urban, R.J.3    Demers, L.M.4    Aggarwal, B.B.5
  • 39
    • 33846868371 scopus 로고    scopus 로고
    • Tumor necrosis factor (TNF) receptor type 2 is an important mediator of TNF alpha function in the mouse ovary
    • Greenfeld CR, Roby KF, Pepling ME, Babus JK, Terranova PF, Flaws JA. Tumor necrosis factor (TNF) receptor type 2 is an important mediator of TNF alpha function in the mouse ovary. Biol Reprod 2007; 76:224-231.
    • (2007) Biol Reprod , vol.76 , pp. 224-231
    • Greenfeld, C.R.1    Roby, K.F.2    Pepling, M.E.3    Babus, J.K.4    Terranova, P.F.5    Flaws, J.A.6
  • 40
    • 8944243076 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha inhibits follicle-stimulating hormone-induced granulosa cell oestradiol secretion in the human: dependence on size of follicle
    • Rice VM, Williams VR, Limback SD, Terranova PF. Tumour necrosis factor-alpha inhibits follicle-stimulating hormone-induced granulosa cell oestradiol secretion in the human: dependence on size of follicle. Hum Reprod 1996; 11:1256-1261.
    • (1996) Hum Reprod , vol.11 , pp. 1256-1261
    • Rice, V.M.1    Williams, V.R.2    Limback, S.D.3    Terranova, P.F.4
  • 41
    • 62149122199 scopus 로고    scopus 로고
    • Poor embryo development in mouse oocytes aged in vitro is associated with impaired calcium homeostasis
    • Takahashi T, Igarashi H, Kawagoe J, Amita M, Hara S, Kurachi H. Poor embryo development in mouse oocytes aged in vitro is associated with impaired calcium homeostasis. Biol Reprod 2009; 80:493-502.
    • (2009) Biol Reprod , vol.80 , pp. 493-502
    • Takahashi, T.1    Igarashi, H.2    Kawagoe, J.3    Amita, M.4    Hara, S.5    Kurachi, H.6
  • 43
    • 40749134638 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma is a target of progesterone regulation in the preovulatory follicles and controls ovulation in mice
    • Kim J, Sato M, Li Q, Lydon JP, Demayo FJ, Bagchi IC, Bagchi MK. Peroxisome proliferator-activated receptor gamma is a target of progesterone regulation in the preovulatory follicles and controls ovulation in mice. Mol Cell Biol 2008; 28:1770-1782.
    • (2008) Mol Cell Biol , vol.28 , pp. 1770-1782
    • Kim, J.1    Sato, M.2    Li, Q.3    Lydon, J.P.4    Demayo, F.J.5    Bagchi, I.C.6    Bagchi, M.K.7
  • 44
    • 58749109423 scopus 로고    scopus 로고
    • Effects of diethylstilbestrol on ovarian follicle development in neonatal mice
    • Kim H, Hayashi S, Chambon P, Watanabe H, Iguchi T, Sato T. Effects of diethylstilbestrol on ovarian follicle development in neonatal mice. Reprod Toxicol 2009; 27:55-62.
    • (2009) Reprod Toxicol , vol.27 , pp. 55-62
    • Kim, H.1    Hayashi, S.2    Chambon, P.3    Watanabe, H.4    Iguchi, T.5    Sato, T.6
  • 45
    • 0033976886 scopus 로고    scopus 로고
    • Effects of recombinant human FSH (rhFSH), urinary purified FSH (uFSH), and hMG on small preantral follicles and tertiary follicles from normal adult and androgen-sterilized female mice
    • Liu X, Andoh K, Mizunuma H, Kamijo T, Kikuchi N, Yamada K, Ibuki Y. Effects of recombinant human FSH (rhFSH), urinary purified FSH (uFSH), and hMG on small preantral follicles and tertiary follicles from normal adult and androgen-sterilized female mice. Fertil Steril 2000; 73:372-380.
    • (2000) Fertil Steril , vol.73 , pp. 372-380
    • Liu, X.1    Andoh, K.2    Mizunuma, H.3    Kamijo, T.4    Kikuchi, N.5    Yamada, K.6    Ibuki, Y.7
  • 46
    • 0035984989 scopus 로고    scopus 로고
    • Follicle culture in reproductive toxicology: a tool for in-vitro testing of ovarian function?
    • Cortvrindt RG, Smitz JE. Follicle culture in reproductive toxicology: a tool for in-vitro testing of ovarian function? Hum Reprod Update 2002; 8:243-254.
    • (2002) Hum Reprod Update , vol.8 , pp. 243-254
    • Cortvrindt, R.G.1    Smitz, J.E.2
  • 47
    • 0347090325 scopus 로고    scopus 로고
    • Preantral follicle culture as a novel in vitro assay in reproductive toxicology testing in mammalian oocytes
    • Sun F, Betzendahl I, Shen Y, Cortvrindt R, Smitz J, Eichenlaub-Ritter U. Preantral follicle culture as a novel in vitro assay in reproductive toxicology testing in mammalian oocytes. Mutagenesis 2004; 19:13-25.
    • (2004) Mutagenesis , vol.19 , pp. 13-25
    • Sun, F.1    Betzendahl, I.2    Shen, Y.3    Cortvrindt, R.4    Smitz, J.5    Eichenlaub-Ritter, U.6
  • 50
    • 0028284312 scopus 로고
    • Oocytic tumor necrosis factor alpha: localization in the neonatal ovary and throughout follicular development in the adult rat
    • Marcinkiewicz JL, Krishna A, Cheung CM, Terranova PF. Oocytic tumor necrosis factor alpha: localization in the neonatal ovary and throughout follicular development in the adult rat. Biol Reprod 1994; 50:1251-1260.
    • (1994) Biol Reprod , vol.50 , pp. 1251-1260
    • Marcinkiewicz, J.L.1    Krishna, A.2    Cheung, C.M.3    Terranova, P.F.4
  • 51
    • 0025220006 scopus 로고
    • Tumor necrosis factor production and accumulation of inflammatory cells in the corpus luteum of pseudopregnancy and pregnancy in rabbits
    • Bagavandoss P, Wiggins RC, Kunkel SL, Remick DG, Keyes PL. Tumor necrosis factor production and accumulation of inflammatory cells in the corpus luteum of pseudopregnancy and pregnancy in rabbits. Biol Reprod 1990; 42:367-376.
    • (1990) Biol Reprod , vol.42 , pp. 367-376
    • Bagavandoss, P.1    Wiggins, R.C.2    Kunkel, S.L.3    Remick, D.G.4    Keyes, P.L.5
  • 52
    • 0025184072 scopus 로고
    • Immunological evidence for a human ovarian tumor necrosis factor-alpha
    • Roby KF, Weed J, Lyles R, Terranova PF. Immunological evidence for a human ovarian tumor necrosis factor-alpha. J Clin Endocrinol Metab 1990; 71:1096-1102.
    • (1990) J Clin Endocrinol Metab , vol.71 , pp. 1096-1102
    • Roby, K.F.1    Weed, J.2    Lyles, R.3    Terranova, P.F.4
  • 53
    • 0031053479 scopus 로고    scopus 로고
    • Potential roles of tumor necrosis factor-alpha in follicular development, ovulation, and the life span of the corpus luteum
    • Terranova PF. Potential roles of tumor necrosis factor-alpha in follicular development, ovulation, and the life span of the corpus luteum. Domest Anim Endocrinol 1997; 14:1-15.
    • (1997) Domest Anim Endocrinol , vol.14 , pp. 1-15
    • Terranova, P.F.1
  • 54
    • 0036717801 scopus 로고    scopus 로고
    • The involvement of tumor necrosis factor-alpha (TNF) as an intraovarian regulator of oocyte apoptosis in the neonatal rat
    • Marcinkiewicz JL, Balchak SK, Morrison LJ. The involvement of tumor necrosis factor-alpha (TNF) as an intraovarian regulator of oocyte apoptosis in the neonatal rat. Front Biosci 2002; 7:d1997-d2005.
    • (2002) Front Biosci , vol.7
    • Marcinkiewicz, J.L.1    Balchak, S.K.2    Morrison, L.J.3
  • 55
    • 0032728688 scopus 로고    scopus 로고
    • Alterations of events related to ovarian function in tumor necrosis factor receptor type I knockout mice
    • Roby KF, Son DS, Terranova PF. Alterations of events related to ovarian function in tumor necrosis factor receptor type I knockout mice. Biol Reprod 1999; 61:1616-1621.
    • (1999) Biol Reprod , vol.61 , pp. 1616-1621
    • Roby, K.F.1    Son, D.S.2    Terranova, P.F.3
  • 56
    • 0035813225 scopus 로고    scopus 로고
    • Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants
    • Ameloot P, Fiers W, De Bleser P, Ware CF, Vandenabeele P, Brouckaert P. Identification of tumor necrosis factor (TNF) amino acids crucial for binding to the murine p75 TNF receptor and construction of receptor-selective mutants. J Biol Chem 2001; 276:37426-37430.
    • (2001) J Biol Chem , vol.276 , pp. 37426-37430
    • Ameloot, P.1    Fiers, W.2    De Bleser, P.3    Ware, C.F.4    Vandenabeele, P.5    Brouckaert, P.6
  • 57
    • 0034111902 scopus 로고    scopus 로고
    • Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome
    • Kolodziejczyk B, Duleba AJ, Spaczynski RZ, Pawelczyk L. Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome. Fertil Steril 2000; 73:1149-1154.
    • (2000) Fertil Steril , vol.73 , pp. 1149-1154
    • Kolodziejczyk, B.1    Duleba, A.J.2    Spaczynski, R.Z.3    Pawelczyk, L.4
  • 58
    • 0030855145 scopus 로고    scopus 로고
    • Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome
    • Ehrmann DA, Schneider DJ, Sobel BE, Cavaghan MK, Imperial J, Rosenfield RL, Polonsky KS. Troglitazone improves defects in insulin action, insulin secretion, ovarian steroidogenesis, and fibrinolysis in women with polycystic ovary syndrome. J Clin Endocrinol Metab 1997; 82:2108-2116.
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 2108-2116
    • Ehrmann, D.A.1    Schneider, D.J.2    Sobel, B.E.3    Cavaghan, M.K.4    Imperial, J.5    Rosenfield, R.L.6    Polonsky, K.S.7
  • 59
    • 4043100289 scopus 로고    scopus 로고
    • Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome
    • Brettenthaler N, De Geyter C, Huber PR, Keller U. Effect of the insulin sensitizer pioglitazone on insulin resistance, hyperandrogenism, and ovulatory dysfunction in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2004; 89:3835-3840.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3835-3840
    • Brettenthaler, N.1    De Geyter, C.2    Huber, P.R.3    Keller, U.4
  • 60
    • 12244251426 scopus 로고    scopus 로고
    • Effects of rosiglitazone in obese women with polycystic ovary syndrome and severe insulin resistance
    • Sepilian V, Nagamani M. Effects of rosiglitazone in obese women with polycystic ovary syndrome and severe insulin resistance. J Clin Endocrinol Metab 2005; 90:60-65.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 60-65
    • Sepilian, V.1    Nagamani, M.2
  • 62
  • 63
    • 0036962952 scopus 로고    scopus 로고
    • Troglitazone, an insulin-sensitizing thiazolidinedione, represses combined stimulation by LH and insulin of de novo androgen biosynthesis by thecal cells in vitro
    • Veldhuis JD, Zhang G, Garmey JC. Troglitazone, an insulin-sensitizing thiazolidinedione, represses combined stimulation by LH and insulin of de novo androgen biosynthesis by thecal cells in vitro. J Clin Endocrinol Metab 2002; 87:1129-1133.
    • (2002) J Clin Endocrinol Metab , vol.87 , pp. 1129-1133
    • Veldhuis, J.D.1    Zhang, G.2    Garmey, J.C.3
  • 64
    • 0036905306 scopus 로고    scopus 로고
    • Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome
    • la Marca A, Morgante G, Palumbo M, Cianci A, Petraglia F, De Leo V. Insulin-lowering treatment reduces aromatase activity in response to follicle-stimulating hormone in women with polycystic ovary syndrome. Fertil Steril 2002; 78:1234-1239.
    • (2002) Fertil Steril , vol.78 , pp. 1234-1239
    • La Marca, A.1    Morgante, G.2    Palumbo, M.3    Cianci, A.4    Petraglia, F.5    De Leo, V.6
  • 65
    • 0036136904 scopus 로고    scopus 로고
    • Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells
    • Schoppee PD, Garmey JC, Veldhuis JD. Putative activation of the peroxisome proliferator-activated receptor gamma impairs androgen and enhances progesterone biosynthesis in primary cultures of porcine theca cells. Biol Reprod 2002; 66:190-198.
    • (2002) Biol Reprod , vol.66 , pp. 190-198
    • Schoppee, P.D.1    Garmey, J.C.2    Veldhuis, J.D.3
  • 66
    • 0242361748 scopus 로고    scopus 로고
    • Expression and functional role of peroxisome proliferator-activated receptor-gamma in ovarian folliculogenesis in the sheep
    • Froment P, Fabre S, Dupont J, Pisselet C, Chesneau D, Staels B, Monget P. Expression and functional role of peroxisome proliferator-activated receptor-gamma in ovarian folliculogenesis in the sheep. Biol Reprod 2003; 69:1665-1674.
    • (2003) Biol Reprod , vol.69 , pp. 1665-1674
    • Froment, P.1    Fabre, S.2    Dupont, J.3    Pisselet, C.4    Chesneau, D.5    Staels, B.6    Monget, P.7
  • 67
    • 0037124098 scopus 로고    scopus 로고
    • Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma) does not affect mammary development and propensity for tumor formation but leads to reduced fertility
    • Cui Y, Miyoshi K, Claudio E, Siebenlist UK, Gonzalez FJ, Flaws J, Wagner KU, Hennighausen L. Loss of the peroxisome proliferation-activated receptor gamma (PPARgamma) does not affect mammary development and propensity for tumor formation but leads to reduced fertility. J Biol Chem 2002; 277:17830-17835.
    • (2002) J Biol Chem , vol.277 , pp. 17830-17835
    • Cui, Y.1    Miyoshi, K.2    Claudio, E.3    Siebenlist, U.K.4    Gonzalez, F.J.5    Flaws, J.6    Wagner, K.U.7    Hennighausen, L.8
  • 68
    • 6944239803 scopus 로고    scopus 로고
    • Identification of a functional peroxisome proliferator activated receptor response element in the 3′ untranslated region of the human bcl-2 gene
    • Butts BD, Tran NL, Briehl MM. Identification of a functional peroxisome proliferator activated receptor response element in the 3′ untranslated region of the human bcl-2 gene. Int J Oncol 2004; 24:1305-1310.
    • (2004) Int J Oncol , vol.24 , pp. 1305-1310
    • Butts, B.D.1    Tran, N.L.2    Briehl, M.M.3
  • 69
    • 17644391409 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor gamma ligand troglitazone induces apoptosis and p53 in rat granulosa cells
    • Lovekamp-Swan T, Chaffin CL. The peroxisome proliferator-activated receptor gamma ligand troglitazone induces apoptosis and p53 in rat granulosa cells. Mol Cell Endocrinol 2005; 233:15-24.
    • (2005) Mol Cell Endocrinol , vol.233 , pp. 15-24
    • Lovekamp-Swan, T.1    Chaffin, C.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.