Measurement of ocular surface protection under natural blink conditions

Clinical Ophthalmology

Volumn 5, Issue 1, 2011, Pages 1349-1357

  Abelson, Richard ^a,b   Lane, Keith J ^c   Angjeli, Endri ^c   Johnston, Patrick ^c   Ousler, George ^c   Montgomery, Douglas ^a  

^a ARIZONA STATE UNIVERSITY   (United States)

^b Statistics and Data Corporation   (United States)

^c Ora Inc   (United States)

Author keywords

Forced stare; Interblink interval; Ocular protection index; Tear film breakup time

Indexed keywords

ARTIFICIAL TEAR; EYE DROPS; FLUORESCEIN SODIUM; LIQUIGEL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG INSTILLATION; DRY EYE; EYE EXAMINATION; EYELID REFLEX; FEMALE; FLUORESCENCE ANALYSIS; FORCED STARE; HUMAN; INTERBLINK INTERVAL; INTERMETHOD COMPARISON; MALE; METHODOLOGY; PILOT STUDY; RETROSPECTIVE STUDY; SLIT LAMP; STAINING; TEAR FILM; TEAR FILM BREAKUP AREA; TEAR FILM BREAKUP TIME; TELEVISION VIEWING; TREATMENT OUTCOME; VIDEO CAPTURE MANUAL ANALYSIS; VIDEORECORDING;

EID: 81055125673     PISSN: 11775467     EISSN: 11775483     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Ousler GW, Gomes PJ, Welch D, Abelson MB. Methodologies for the study of ocular surface disease. Ocul Surf. 2005;3:143-154.
2. Rolando M, Zierhut M. The ocular surface and tear film and their dysfunction in dry eye disease. Surv Ophthalmol. 2001;45(Suppl 2): S203-S210.
3. Rolando M, Refojo MF, Kenyon KR. Tear water evaporation and eye surface diseases. Ophthalmologica. 1985;190(3):147-149.
4. Nguyen DH, Beuerman RW, Meneray MA, Maitchouk D. Sensory denervation leads to deregulated protein synthesis in the lacrimal gland. Adv Exp Med Biol. 1998;438:55-62.
5. Nagyova B, Tiffany JM. Components responsible for the surface tension of human tears. Curr Eye Res. 1999;19(1):4-11.
6. Mishima S, Maurice DM. The oily layer of the tear film and evaporation from the corneal surface. Exp Eye Res. 1961;1:39-45.
7. Chao CC, Vergnes JP, Freeman IL, Brown SI. Biosynthesis and partial characterization of tear film glycoproteins. Incorporation of radioactive precursors by human lacrimal gland explants in vitro. Exp Eye Res. 1980; 30(4):411-425.
8. Ousler GW 3rd, Hagberg KW, Schindelar M, Welch D, Abelson MB. The ocular protection index. Cornea. 2008;27(5):509-513.
9. Abelson MB, Ousler GW 3rd, Nally LA, Welch D, Krenzer K. Alternative reference values for tear film break up time in normal and dry eye populations. Adv Exp Med Biol. 2002;506(Pt B):1121-1125.
10. Holly FJ. Formation and rupture of the tear film. Exp Eye Res. 1973; 15(5):515-525.
11. Lemp MA. Breakup of the tear film. Int Ophthalmol Clin. 1973; 13(1):97-102.
12. Lemp MA, Goldberg M, Roddy MR. The effect of tear substitutes on tear film break-up time. Invest Ophthalmol. 1975;14(3):255-258.
13. Smith J, Nichols KK, Baldwin EK. Current patterns in the use of diagnostic tests in dry eye evaluation. Cornea. 2008;27(6):656-662.
14. Crampton HJ, Abelson MB, Ousler GW 3rd, et al. Correlation of the controlled adverse environment (CAE) model with a murine model of experimental dry eye in assessing the ability of topical doxycycline to prevent corneal barrier disruption. Invest Ophthalmol Vis Sci. 2007;48:E-abstract 402.
15. D'Arienzo P, Ousler GW 3rd, Schindelar MR. A comparison of two marketed artificial tears in improvement of tear film stability as measured by tear film break-up time (TFBUT) and ocular protection index (OPI) [Poster presentation]. Tear Film and Ocular Surface Society Meeting; 2007; Taormina, Sicily; 2007.
16. Ousler GW, Emory TB, Welch D, Abelson MB. Factors that influence the inter-blink interval (IBI) as measured by the ocular protection index (OPI). Invest Ophthalmol Vis Sci. 2002;43:E-abstract 56.
17. Wilcox Hagberg KA, Ousler GW 3rd, Casavant JS, Welch D, Abelson MB. Effects of menopause on the ocular protection index (OPI) in a population of dry eye patients of Ashkenazi Jewish descent. Invest Ophthalmol Vis Sci. 2005;45:E-abstract 79.
18. Ousler GW, Michaelson C, Christensen MT. An evaluation of tear film breakup time extension and ocular protection index scores among three marketed lubricant eye drops. Cornea. 2007;26(8):949-952.
19. ® 9.2. Cary, NC: SAS Institute Inc; 2009.
20. Begley CG, Himebaugh N, Renner D, et al. Tear breakup dynamics: a technique for quantifying tear film instability. Optom Vis Sci. 2006; 83(1):15-21.
21. Liu H, Begley CG, Chalmers R, Wilson G, Srinivas SP, Wilkinson JA. Temporal progression and spatial repeatability of tear breakup. Optom Vis Sci. 2006;83(10):723-730.