Chemoradiation treatment with gemcitabine plus Stereotactic Body Radiotherapy for unresectable, non-metastatic, locally advanced hilar cholangiocarcinoma. Results of a five year experience

Radiotherapy and Oncology

Volumn 99, Issue 2, 2011, Pages 120-123

  Polistina, Francesco Antonio ^a,b,e   Guglielmi, Rosabianca ^b   Baiocchi, Cristina ^b   Francescon, Paolo ^b   Scalchi, Paolo ^b   Febbraro, Antonio ^c   Costantin, Giorgio ^b   Ambrosino, Giovanni ^b,d  

^a Hospital of Dolo   (Italy)

^b SAN BORTOLO HOSPITAL   (Italy)

^c FATEBENEFRATELLI HOSPITAL   (Italy)

^d UNIVERSITY OF PADOVA   (Italy)

^e Ospedale di Dolo   (Italy)

Author keywords

Hilar cholangiocarcinoma; Klatskin tumor; Multimodal therapy; Radiochemotherapy; Stereotactic radiotherapy

Indexed keywords

GEMCITABINE;

ADULT; ADVANCED CANCER; AGED; ARTICLE; BILE DUCT CARCINOMA; CANCER COMBINATION CHEMOTHERAPY; CANCER GRADING; CHEMORADIOTHERAPY; CLINICAL ARTICLE; DISEASE COURSE; DISTANT METASTASIS; DRUG EFFICACY; DRUG SAFETY; DUODENUM BLEEDING; DUODENUM STENOSIS; DUODENUM ULCER; FEMALE; FOLLOW UP; GASTRITIS; HISTOPATHOLOGY; HUMAN; LEUKOPENIA; MALE; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; STEREOTACTIC BODY RADIATION THERAPY; SURVIVAL RATE; SURVIVAL TIME; TREATMENT RESPONSE; VOMITING;

AGED; ANTIMETABOLITES, ANTINEOPLASTIC; BILE DUCT NEOPLASMS; CHI-SQUARE DISTRIBUTION; CHOLANGIOCARCINOMA; COMBINED MODALITY THERAPY; CONTRAST MEDIA; DEOXYCYTIDINE; DOSE FRACTIONATION; FEMALE; HEPATIC DUCT, COMMON; HUMANS; KLATSKIN'S TUMOR; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; RADIOSURGERY; SURVIVAL ANALYSIS; TOMOGRAPHY, X-RAY COMPUTED; TREATMENT OUTCOME;

EID: 80955180566     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.05.016     Document Type: Article

References (33)

1. F. Ito, C.S. Cho, L.F. Rikkers, and S.M. Weber Hilar cholangiocarcinoma: current management Ann Surg 250 2009 210 218
2. B. Launois, J. Terblanche, and M. Lakehal Proximal bile duct cancer: high resectability rate and 5-year survival Ann Surg 230 1999 266 275 (Pubitemid 30191894)
3. H. Witzigmann, F. Berr, and U. Ringel Surgical and palliative management and outcome in 184 patients with hilar cholangiocarcinoma: palliative photodynamic therapy plus stenting is comparable to r1/r2 resection Ann Surg 244 2006 230 239 (Pubitemid 44305537)
4. A.C. Koong, Q.T. Le, and A. Ho Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer Int J Radiat Oncol Biol Phys 58 2004 1017 1021 (Pubitemid 38314781)
5. National Cancer Institute, Cancer Therapy Evaluation Program. Common Terminology Criteria for Adverse Events, version 3.0 (CTCAE). August 2006. Available at http://ctep.info,nih.gov/protocolDevelopment/electronic- applications/docs/ctcaev3.pdf. [accessed 18.01.2010].
6. P. Therasse, S.G. Arbuck, and E.A. Eisenhauer New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada J Natl Cancer Inst 92 2000 205 216
7. D.J. Rea, J.K. Heimbach, and C.B. Rosen Liver transplantation with neoadjuvant chemoradiation is more effective than resection for hilar cholangiocarcinoma Ann Surg 242 2005 451 458 discussion 458-61
8. M. Shimoda, D.G. Farmer, and S.D. Colquhoun Liver transplantation for cholangiocellular carcinoma: analysis of a single center experience and review of the literature Liver Transpl 7 2001 1023 1033 (Pubitemid 34023989)
9. F.L. Domoulin, E. Horst, T. Sauerbruch, and T. Gerhardt Palliative locoregional therapy for hilar cholangiocarcinoma: photodynamic therapy and brachytherapy Zentralbl Chir 132 2007 336 341
10. E.A. Rauws Photodynamic therapy and Klatskin tumor: an overview Scand J Gastroenterol Suppl 243 2006 135 138 (Pubitemid 43941076)
11. F. Pisello, G. Geraci, G. Modica, and C. Scium Cholangitis prevention in endoscopic Klatskin tumor palliation: air cholangiography technique Langenbecks Arch Surg 394 2009 1109 1114
12. S.H. Lee, J.K. Park, and W.J. Yoon Optimal biliary drainage for inoperable Klatskin's tumor based on Bismuth type World J Gastroenterol 13 2007 3948 3955 (Pubitemid 47272490)
13. H. Witzigmann, M. Wiedmann, C. Wittekind, J. Mössner, and J. Hauss Therapeutical concepts and results for Klatskin tumors Dtsch Arztebl 105 2008 156 161 (Pubitemid 351373528)
14. R. Golfieri, E. Giampalma, and M. Renzulli Unresectable hilar cholangiocarcinoma: multimodality approach with percutaneous treatment associated with radiotherapy and chemotherapy In Vivo 20 2006 757 760 (Pubitemid 46061616)
15. S. Kubicka, K.L. Rudolph, M.K. Tietze, M. Lorenz, and M. Manns Phase II study of systemic gemcitabine chemotherapy for nonresectable cholangiocarcinoma: a randomized prospective study Hepatogastroenterology 48 2001 783 789 (Pubitemid 32619681)
16. S.T. Kim, J.O. Park, and K.T. Lee A phase II study of gemcitabine and cisplatin in advanced biliary cancer Cancer 106 2006 1339 1346 (Pubitemid 43363912)
17. F. Polistina, G. Costantin, and F. Casamassima Unresectable locally advanced pancreatic cancer: a multimodal treatment using neoadjuvant chemoradiotherapy (gemcitabine plus stereotactic radiosurgery) and subsequent surgical exploration Ann Surg Oncol 17 2010 2092 2101
18. D.T. Chang, D. Shellenberg, and J. Shen Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas Cancer 115 2009 665 672
19. F. Momm, E. Shubert, and K. Henne Stereotactic fractionated radiotherapy for Klatskin tumours Radiother Oncol 95 2010 99 102
20. A. Niemierko Reporting and analyzing dose distributions: a concept of equivalent uniform dose Med Phys 24 1997 103 110 (Pubitemid 27051935)
21. A.R. Prideaux, H. Song, and R.F. Hobbs Three-dimensional radiobiologic dosimetry: application of radiobiologic modeling to patient-specific 3-dimensional imaging-based internal dosimetry J Nucl Med 48 2007 1008 1016 Epub 2007 May 15 (Pubitemid 46909931)
22. C.H. Crane, K.O. Macdonald, and J.N. Vauthey Limitations of conventional doses of chemoradiation for unresectable biliary cancer Int J Radiat Oncol Biol Phys 53 2002 969 974 (Pubitemid 34722643)
23. K.A. Vallis, I.S. Benjamin, and A.J. Munro External beam and intraluminal radiotherapy for locally advanced bile duct cancer: role and tolerability Radiother Oncol 41 1996 61 66 (Pubitemid 26396298)
24. A.G. Morganti, L. Trodella, and V. Valentini Combined modality treatment in unresectable extrahepatic biliary carcinoma Int J Radiat Oncol Biol Phys 46 2000 913 919 (Pubitemid 30114404)
25. N. Kopek, M.I. Holt, A.T. Hansen, and M. Hoyer Stereotactic body radiotherapy for unresectable cholangiocarcinoma Radiother Oncol 94 2010 47 52
26. M.A. Ben-David, K.A. Griffith, and E. Abu-Isa External beam radiotherapy for localized extrahepatic cholangiocarcinoma Int J Radiat Oncol Biol Phys 66 2006 772 779 (Pubitemid 44436705)
27. G. Costamagna, A. Tringali, L. Petruzziello, and C. Spada Hilar tumors Can J Gastroenterol 18 2004 451 454
28. M. Wiedmann, K. Caca, and F. Berr Neoadjuvant photodynamic therapy as a new approach to treating hilar cholangiocarcinoma: a phase II pilot study Cancer 97 2003 2783 2790 (Pubitemid 36605146)
29. R. Golfieri, E. Giampalma, and M. Renzulli Unresectable hilar cholangiocarcinoma: multimodality approach with percutaneus treatment associated with radiotherapy and chemotherapy In Vivo 20 2006 757 760 (Pubitemid 46061616)
30. J. Furuse, T. Okusaka, and A. Funakoshi Early phase II study of uraciltegafur plus doxorubicin in patients with unresectable advanced biliary tract cancer Jpn J Clin Oncol 36 2006 552 556 (Pubitemid 44593897)
31. S. Kubicka, K.L. Rudolph, M.K. Tietze, M. Lorenz, and M. Manns Phase II study of systemic gemcitabine chemotherapy for advanced unresectable hepatobiliary carcinomas Hepatogastroenterology 48 2001 783 789 (Pubitemid 32619681)
32. M. Aljiffry, M.J. Walsh, and M. Molinari Advances in diagnosis, treatment and palliation of cholangiocarcinoma: 1990-2009 World J Gastroenterol 15 2009 4240 4262
33. G. Becker, F. Momm, and H. Schwacha Klatskin tumor treated by inter-disciplinary therapies including stereotactic radiotherapy: a case report World J Gastroenterol 11 2005 4923 4926 (Pubitemid 41223313)