High-resolution structure of a retroviral protease folded as a monomer

Acta Crystallographica Section D: Biological Crystallography

Volumn 67, Issue 11, 2011, Pages 907-914

  Gilski, Miroslaw ^a,b   Kazmierczyk, MacIej ^a   Krzywda, Szymon ^a   Zábranská, Helena ^c   Cooper, Seth ^d   Popović, Zoran ^d   Khatib, Firas ^e   Dimaio, Frank ^e   Thompson, James ^e   Baker, David ^e   Pichová, Iva ^c   Jaskolski, Mariusz ^a,b  

^a ADAM MICKIEWICZ UNIVERSITY   (Poland)

^b INSTITUTE OF BIOORGANIC CHEMISTRY   (Poland)

^c INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^d University of Washington   (United States)

^e UNIVERSITY OF WASHINGTON   (United States)

Author keywords

AIDS; dimerization inhibition; drug design targets; HIV 1; Mason Pfizer monkey virus; protein folding; retropepsins; retroviral proteases

Indexed keywords

ANTIRETROVIRUS AGENT; MASON PFIZER MONKEY VIRUS PROTEASE; MASON-PFIZER MONKEY VIRUS PROTEASE; PROTEINASE;

ANIMAL; ARTICLE; CHEMISTRY; COMPARATIVE STUDY; CRYSTALLIZATION; DIMERIZATION; DISEASE MODEL; DRUG EFFECT; ENZYMOLOGY; GENETICS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACACA; MASON PFIZER MONKEY VIRUS; METABOLISM; MOLECULARLY TARGETED THERAPY; MUTATION; PATHOGENICITY; PROTEIN CONFORMATION; PROTEIN FOLDING; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; VIROLOGY; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTI-RETROVIRAL AGENTS; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DISEASE MODELS, ANIMAL; ENDOPEPTIDASES; HIV INFECTIONS; HIV-1; HUMANS; MACACA; MASON-PFIZER MONKEY VIRUS; MOLECULAR TARGETED THERAPY; MUTATION; PROTEIN CONFORMATION; PROTEIN FOLDING; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME;

HUMAN IMMUNODEFICIENCY VIRUS 1; MACACA MULATTA; MASON-PFIZER MONKEY VIRUS; PAPAYA MOSAIC VIRUS; SIMIAE;

EID: 80955159982     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S0907444911035943     Document Type: Article

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