Endogenous testosterone and brachial artery endothelial function in middle-aged men with symptoms of late-onset hypogonadism

Aging Male

Volumn 14, Issue 4, 2011, Pages 237-242

  Mäkinen, Juuso I ^a,b   Perheentupa, Antti ^a   Irjala, Kerttu ^a   Pöllänen, Pasi ^a   Mäkinen, Juha ^a   Huhtaniemi, Ilpo ^a,c   Raitakari, Olli T ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b UNIVERSITY OF TURKU   (Finland)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

atherosclerosis; endothelial function; Late onset hypogonadism; testosterone

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LUTEINIZING HORMONE; NITRATE; TESTOSTERONE; TRIACYLGLYCEROL;

ADULT; AGE; AGED; ALCOHOL CONSUMPTION; ANDROPAUSE; ARTERIAL WALL THICKNESS; ARTERY BLOOD FLOW; ARTERY DIAMETER; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTERY FLOW MEDIATED DILATATION; ARTERY INTIMA; ARTICLE; BODY MASS; BRACHIAL ARTERY; CARDIOVASCULAR DISEASE; CAROTID ARTERY; CHOLESTEROL BLOOD LEVEL; CLINICAL FEATURE; DIASTOLIC BLOOD PRESSURE; FINLAND; HUMAN; HYPOGONADISM; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; PRIORITY JOURNAL; SMOKING; SYSTOLIC BLOOD PRESSURE; TESTOSTERONE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL; ULTRASOUND;

ADULT; AGE OF ONSET; AGED; AGING; ALCOHOL DRINKING; BODY MASS INDEX; BRACHIAL ARTERY; CARDIOVASCULAR DISEASES; CAROTID INTIMA-MEDIA THICKNESS; CHOLESTEROL, HDL; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; HYPOGONADISM; LIPIDS; LUTEINIZING HORMONE; MALE; MIDDLE AGED; REGIONAL BLOOD FLOW; SMOKING; TESTOSTERONE;

EID: 80955142344     PISSN: 13685538     EISSN: 14730790     Source Type: Journal    
DOI: 10.3109/13685538.2011.593655     Document Type: Article

References (41)

1. Tunstall-Pedoe H, Kuulasmaa K, Amouyel P, Arveiler D, Rajakangas AM, Pajak A. Myocardial infarction and coronary deaths in the World Health Organization MONICA Project. Registration procedures, event rates, and case-fatality rates in 38 populations from 21 countries in four continents. Circulation 1994;90:583-612.
2. Celermajer DS. Endothelial dysfunction: Does it matter? Is it reversible? J Am Coll Cardiol 1997;30:325-333. (Pubitemid 27339309)
3. Neunteufl T, Katzenschlager R, Hassan A, Klaar U, Schwarzacher S, Glogar D, Bauer P, Weidinger F. Systemic endothelial dysfunction is related to the extent and severity of coronary artery disease. Atherosclerosis 1997;129:111-118. (Pubitemid 27104258)
4. Yeboah J, Crouse JR, Hsu FC, Burke GL, Herrington DM. Brachial flow-mediated dilation predicts incident cardiovascular events in older adults: The Cardiovascular Health Study. Circulation 2007;115:2390-2397. (Pubitemid 46717961)
5. Chan SY, Mancini GB, Kuramoto L, Schulzer M, Frohlich J, Ignaszewski A. The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease. J Am Coll Cardiol 2003;42:1037-1043. (Pubitemid 37108590)
6. Adams MR, Robinson J, McCredie R, Seale JP, Sorensen KE, Deanfield JE, Celermajer DS. Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilation in adults at risk of atherosclerosis. J Am Coll Cardiol 1998;32:123-127. (Pubitemid 28351052)
7. Raitakari OT, Seale JP, Celermajer DS. Impaired vascular responses to nitroglycerin in subjects with coronary atherosclerosis. Am J Cardiol 2001;87:217-9, A8. (Pubitemid 32057237)
8. Losordo DW, Kearney M, Kim EA, Jekanowski J, Isner JM. Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women. Circulation 1994;89:1501-1510. (Pubitemid 24114224)
9. Fujimoto R, Morimoto I, Morita E, Sugimoto H, Ito Y, Eto S. Androgen receptors, 5 alpha-reductase activity and androgen-dependent proliferation of vascular smooth muscle cells. J Steroid Biochem Mol Biol 1994;50:169-174. (Pubitemid 24265230)
10. Karakitsos D, Patrianakos AP, De Groot E, Boletis J, Karabinis A, Kyriazis J, Samonis G, et al. Androgen deficiency and endothelial dysfunction in men with end-stage kidney disease receiving maintenance hemodialysis. Am J Nephrol 2006;26:536-543. (Pubitemid 46143875)
11. Herman SM, Robinson JT, McCredie RJ, Adams MR, Boyer MJ, Celermajer DS. Androgen deprivation is associated with enhanced endothelium-dependent dilatation in adult men. Arterioscler Thromb Vasc Biol 1997;17:2004-2009. (Pubitemid 28057101)
12. Zitzmann M, Brune M, Nieschlag E. Vascular reactivity in hypogonadal men is reduced by androgen substitution. J Clin Endocrinol Metab 2002;87:5030-5037. (Pubitemid 35316342)
13. Sader MA, Griffiths KA, Skilton MR, Wishart SM, Handelsman DJ, Celermajer DS. Physiological testosterone replacement and arterial endothelial function in men. Clin Endocrinol (Oxf) 2003;59:62-67. (Pubitemid 36774109)
14. Kang SM, Jang Y, Kim JY, Chung N, Cho SY, Chae JS, Lee JH. Effect of oral administration of testosterone on brachial arterial vasoreactivity in men with coronary artery disease. Am J Cardiol 2002;89:862-864. (Pubitemid 34241469)
15. Webb CM, McNeill JG, Hayward CS, de Zeigler D, Collins P. Effects of testosterone on coronary vasomotor regulation in men with coronary heart disease. Circulation 1999;100:1690-1696. (Pubitemid 29485250)
16. Worboys S, Kotsopoulos D, Teede H, McGrath B, Davis SR. Evidence that parenteral testosterone therapy may improve endothelium- dependent and -independent vasodilation in postmenopausal women already receiving estrogen. J Clin Endocrinol Metab 2001;86:158-161. (Pubitemid 32109790)
17. Rosano GM, Leonardo F, Pagnotta P, Pelliccia F, Panina G, Cerquetani E, della Monica PL, et al. Acute anti-ischemic effect of testosterone in men with coronary artery disease. Circulation 1999;99:1666-1670. (Pubitemid 29162477)
18. Yue P, Chatterjee K, Beale C, Poole-Wilson PA, Collins P. Testosterone relaxes rabbit coronary arteries and aorta. Circulation 1995;91:1154-1160.
19. Ebenbichler CF, Sturm W, Gänzer H, Bodner J, Mangweth B, Ritsch A, Sandhofer A, et al. Flow-mediated, endothelium-dependent vasodilatation is impaired in male body builders taking anabolic-androgenic steroids. Atherosclerosis 2001;158:483-490. (Pubitemid 32913661)
20. Sullivan ML, Martinez CM, Gennis P, Gallagher EJ. The cardiac toxicity of anabolic steroids. Prog Cardiovasc Dis 1998;41:1-15. (Pubitemid 28385246)
21. Mäkinen J, Järvisalo MJ, Pöllänen P, Perheentupa A, Irjala K, Koskenvuo M, Mäkinen J, et al. Increased carotid atherosclerosis in andropausal middle-aged men. J Am Coll Cardiol 2005;45:1603-1608. (Pubitemid 40704493)
22. Mäkinen JI, Perheentupa A, Irjala K, Pöllänen P, Mäkinen J, Huhtaniemi I, Raitakari OT. Endogenous testosterone and serum lipids in middle-aged men. Atherosclerosis 2008;197:688-693. (Pubitemid 351417865)
23. Heinemann LAJ, Zimmermann T, Vermeulen A, Thiel C. A New " Aging Male's Symptoms" (AMS) Rating Scale. Aging Male 1999;2:105-114. (Pubitemid 29411279)
24. Koivumaa-Honkanen H, Honkanen R, Viinamäki H, Heikkilä K, Kaprio J, Koskenvuo M. Self-reported life satisfaction and 20-year mortality in healthy Finnish adults. Am J Epidemiol 2000;152:983-991.
25. Juonala M, Viikari JS, Laitinen T, Marniemi J, Helenius H, Rönnemaa T, Raitakari OT. Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: The cardiovascular risk in young Finns study. Circulation 2004;110:2918-2923. (Pubitemid 39473618)
26. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972;18:499-502.
27. Akishita M, Hashimoto M, Ohike Y, Ogawa S, Iijima K, Eto M, Ouchi Y. Low testosterone level is an independent determinant of endothelial dysfunction in men. Hypertens Res 2007;30:1029-1034.
28. Yildiz O, Seyrek M. Vasodilating mechanisms of testosterone. Exp Clin Endocrinol Diabetes 2007;115:1-6. (Pubitemid 46293403)
29. Mullen MJ, Kharbanda RK, Cross J, Donald AE, Taylor M, Vallance P, Deanfield JE, MacAllister RJ. Heterogenous nature of flow-mediated dilatation in human conduit arteries in vivo: Relevance to endothelial dysfunction in hypercholesterolemia. Circ Res 2001;88:145-151. (Pubitemid 32147301)
30. Costarella CE, Stallone JN, Rutecki GW, Whittier FC. Testosterone causes direct relaxation of rat thoracic aorta. J Pharmacol Exp Ther 1996;277:34-39. (Pubitemid 27169040)
31. Sader MA, McCredie RJ, Griffiths KA, Wishart SM, Handelsman DJ, Celermajer DS. Oestradiol improves arterial endothelial function in healthy men receiving testosterone. Clin Endocrinol (Oxf) 2001;54:175-181. (Pubitemid 32193518)
32. Lew R, Komesaroff P, Williams M, Dawood T, Sudhir K. Endogenous estrogens influence endothelial function in young men. Circ Res 2003;93:1127-1133. (Pubitemid 37485045)
33. Nathan L, Shi W, Dinh H, Mukherjee TK, Wang X, Lusis AJ, Chaudhuri G. Testosterone inhibits early atherogenesis by conversion to estradiol: Critical role of aromatase. Proc Natl Acad Sci USA 2001;98:3589-3593. (Pubitemid 32220889)
34. Diano S, Horvath TL, Mor G, Register T, Adams M, Harada N, Naftolin F. Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects. Menopause 1999;6:21-28. (Pubitemid 29131755)
35. Friedl R, Brunner M, Moeslinger T, Spieckermann PG. Testosterone inhibits expression of inducible nitric oxide synthase in murine macrophages. Life Sci 2000;68:417-429. (Pubitemid 32011894)
36. English KM, Jones RD, Jones TH, Morice AH, Channer KS. Testosterone acts as a coronary vasodilator by a calcium antagonistic action. J Endocrinol Invest 2002;25:455-458. (Pubitemid 34516593)
37. Williams MR, Dawood T, Ling S, Dai A, Lew R, Myles K, Funder JW, et al. Dehydroepiandrosterone increases endothelial cell proliferation in vitro and improves endothelial function in vivo by mechanisms independent of androgen and estrogen receptors. J Clin Endocrinol Metab 2004;89:4708-4715. (Pubitemid 39244492)
38. Sakabe K, Fukuda N, Wakayama K, Nada T, Shinohara H, Tamura Y. Lipid-altering changes and pleiotropic effects of atorvastatin in patients with hypercholesterolemia. Am J Cardiol 2004;94:497-500. (Pubitemid 39120004)
39. English KM, Mandour O, Steeds RP, Diver MJ, Jones TH, Channer KS. Men with coronary artery disease have lower levels of androgens than men with normal coronary angiograms. Eur Heart J 2000;21:890-894. (Pubitemid 30307417)
40. Cunningham GR. Testosterone replacement therapy for late-onset hypogonadism. Nat Clin Pract Urol 2006;3:260-267. (Pubitemid 43738868)
41. Pitteloud N, Mootha VK, Dwyer AA, Hardin M, Lee H, Eriksson KF, Tripathy D, et al. Relationship between testosterone levels, insulin sensitivity, and mitochondrial function in men. Diabetes Care 2005;28:1636-1642. (Pubitemid 41340902)