Enhanced transcription of estrogen receptor α and mitochondrial cytochrome b genes in uterine leiomyomas

Gynecological Endocrinology

Volumn 27, Issue 12, 2011, Pages 1094-1098

  Shaik, Noor Ahmad ^a,b,c   Lone, Waseem Gul ^b,d   Khan, Imran Ali ^a,d   Rao, Kaipa Prabhakar ^b   Kodati, Vijaya Lakshmi ^a   Hasan, Qurratulain ^a,d,e  

^a Vasavi Medical and Research Centre ^*  (India)

^b OSMANIA UNIVERSITY   (India)

^c KING SAUD UNIVERSITY   (Saudi Arabia)

^d KAMINENI HOSPITALS   (India)

^e Bhagwan Mahavir Hospital and Research Centre   (India)

Author keywords

estrogen receptor ; mitochondrial cytochrome b; real time PCR; Uterine leiomyomas

Indexed keywords

CYTOCHROME B; ESTROGEN RECEPTOR ALPHA;

ARTICLE; CARCINOGENESIS; CLINICAL ARTICLE; COMPARATIVE STUDY; DISEASE ASSOCIATION; DNA POLYMORPHISM; FEMALE; GENE OVEREXPRESSION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENOTYPE; HUMAN; HUMAN TISSUE; MITOCHONDRIAL GENE; MYOMETRIUM; PREMENOPAUSE; PRIORITY JOURNAL; UTERUS MYOMA;

ADULT; CASE-CONTROL STUDIES; CYTOCHROMES B; ESTROGEN RECEPTOR ALPHA; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, MITOCHONDRIAL; GENOTYPE; HUMANS; LEIOMYOMA; MITOCHONDRIA; MODELS, BIOLOGICAL; MYOMETRIUM; PREMENOPAUSE; TRANSCRIPTION, GENETIC; UP-REGULATION; UTERINE NEOPLASMS;

EID: 80955132900     PISSN: 09513590     EISSN: 14730766     Source Type: Journal    
DOI: 10.3109/09513590.2011.569610     Document Type: Article

References (30)

1. Vollenhoven BJ, Pearce P, Herington AC, Healy DL. Steroid receptor binding and messenger RNA expression in fibroids from untreated and gonadotrophin-releasing hormone agonist pretreated women. Clin Endocrinol (Oxf) 1994;40:537-544.
2. Parker WH. Etiology, symptomatology, and diagnosis of uterine myomas. Fertil Steril 2007;87:725-736.
3. Flake GP, Andersen J, Dixon D. Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect 2003;111:1037-1054.
4. Levin ER. Integration of the extranuclear and nuclear actions of estrogen. Mol Endocrinol 2005;19:1951-1959.
5. Hall JM, McDonnel DP. The estrogen β isoform (ERβ) of the human estrogen receptor modulates ERα transcriptional activity and is a key regulator of the cellular response to estrogens and antiestrogens. Endocrinology 1999;140: 5566-5578.
6. Benassayag C, Leroy MJ, Rigourd V, Robert B, Honore JC, Mignot TM, Vacher-Lavenu MC, Chapron C, Ferre F. Estrogen receptors (ERalpha;lpha/ ERbeta;eta) in normal and pathological growth of the human myometrium: pregnancy and leiomyoma. Am J Physiol l999;276:1112-1118.
7. Jakimiuk AJ, Bogusiewicz M, Tarkowski R, Dziduch P, Adamiak A, Wróbel A, Haczyński J, Magoffin DA, Jakowicki JA. Estrogen receptor alphα and βeta expression in uterine leiomyomas from premenopausal women. Fertil Steril 2004;82:1244-1249.
8. Wang H, Wu X, Englund K, Masironi K, Eriksson H, Sahlin L. Different expression of estrogen receptors α and bβ in human myometrium and leiomyoma during the prolifERαtive phase of the menstrual cycle and after GnRHa treatment. Gynecol Endocrinol 2001;15:443-452.
9. Bakas P, Liapis A, Vlahopoulos S, Giner M, Logotheti S, Creatsas G, Meligova AK, Alexis MN, Zoumpourlis V. Estrogen receptor alphα and βeta in uterine fibroids: a basis for altered estrogen responsiveness. Fertil Steril 2008;90: 1878-1885.
10. Chen JQ, Eshete M, Alworth WL, Yager JD. Binding of MCF 7 cell mitochondrial proteins and recombinant human estrogen receptor α and β to human mitochondrial DNA estrogen response elements. J cell Biochem 2004;93:358-373.
11. Felty Q, Roy D. Estrogen, mitochondria, and growth of cancer and non-cancer cells. J Carcinog 2005;4:1.
12. Demonacos CV, Karayanni N, Hatzoglou E, Tsiriyiotis C, Spandidos DA, Sekeris CE. Mitochondrial genes as sites of primary action of steroid hormones. Steroids 1996;61:226-232.
13. Chen JQ, Delannoy M, Cooke C, Yager JD. Mitochondrial localization of ERα and ERβ in human MCF7 cells. Am J Physiol Endocrinol Metab 2004;286:1011-1022.
14. Al-Hendy A, Salama A. Ethnic distribution of estrogen receptor-alpha polymorphism is associated with a higher prevalence of uterine leiomyomas in black Americans. Fertil Steril 2006;86:686-693.
15. Bhavani V, Srinivasulu M, Ahuja YR, Hasan Q. Role of BRCA1, HSD17B1 and HSD17B2 methylation in breast cancer tissue. Cancer Biomark 2009;5:279-287.
16. Jin SY, Hong SJ, Yang HI, Park SD, Yoo Mc, Lee HJ, Hong MS, Park HJ, Yoon SH, Kim BS, et al. Estrogen receptor-a gene haplotype is associated with primary knee osteoarthritis in Korean population. Arthritis Res Ther 2004;6: 415-421.
17. Haut S, Billette de Villemeur T, Brivet M, Guiochon- Mantel A, Boutron A, Rustin P, Legrand A, Slama A. The deleterious G15498A mutation in mitochondrial DNAencoded cytochrome b may remain clinically silent in homoplasmic carriers. Eur J Hum Genet 2004;12:220-224.
18. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29: 45.
19. Govindan S, Ahmad SN, Vedicherla B, Kodati V, Rao KP, Hasan Q. Estrogen receptor-a gene (T/C) Pvu II polymorphism in endometriosis and uterine fibroids. Dis Markers 2009;26:149-154.
20. Kitawaki J, Obayashi H, Ishihara H, Koshiba H, Kusuki I, Kado N, Tsukamoto K, Hasegawa G, Nakamura N, Honjo H. Oestrogen receptor-alpha gene polymorphism is associated with endometriosis, adenomyosis and leiomyomata. Hum Reprod 2001;16:51-55.
21. Bakas P, Liapis A, Vlahopoulos S, Giner M, Logotheti S, Creatsas G, Meligova A, Alexis M, Zoumpourlisv V. Estrogen receptor α and β in uterine fibroids: a basis for altered estrogen responsiveness. Fertil Steril 2007;90:1878-1885.
22. Englund K, Blanck A, Gustavsson I, Lundkvist U, Sjoblom P, Norgren A, Lindblom B. Sex steroid receptors in human myometrium and fibroids: changes during the menstrual cycle and gonadotropin-releasing hormone treatment. J Clin Endocrinol Metab 1998;83:4092-4096.
23. Lessl M, Klotzbuecher M, Schoen S, Reles A, Stockemann K, Fuhrmann U. Comparative messenger ribonucleic acid analysis of immediate early genes and sex steroid receptors in human leiomyoma and healthy myometrium. J Clin Endocrinol Metab 1997;82:2596-2600.
24. Nisolle M, Gillerot S, Casanas-Roux F, Squifflet J, Berliere M, Donnez J. Immunohistochemical study of the prolifERαtion index, oestrogen receptors and progesterone receptors α and β in leiomyomata and normal myometrium during the menstrual cycle and under gonadotrophin-releasing hormone agonist thERαpy. Hum Reprod 1999;14:2844-2850.
25. Kovacs KA, Oszter A, Gocze PM, Kornyei JL, Szabo I. Comparative analysis of cyclin D1 and oestrogen receptor (alphα and βeta) levels in human leiomyoma and adjacent myometrium. Mol Hum Reprod 2001;11:1085-1091.
26. Strissel PL, Swiatek J, Oppelt O, Renner PS, Beckmann MW, Strcik R. Transcriptional analysis of steroid hormone receptors in smooth muscle uterine leiomyoma tumors of postmenopausal patients. J Steroid Biochem Mol Biol 2007;107: 42-47.
27. Laurie CC, Stam LF. The effect of an intronic polymorphism on alcohol dehydrogenase expression in Drosophila melanogaster. Genetics 1994;138:379-385.
28. Chen JQ, Yager JD. Estrogen's effects on mitochondrial gene expression: mechanisms and potential contributions to estrogen carcinogenesis. Ann N Y Acad Sci 2004;1028:258-272.
29. Yager J, Chen J, Gokhale M, Li Y, Trush M. Enhanced levels of sevERαl mitochondrial mRNA transcripts and mitochondrial superoxide production during ethinyl estradiol-induced hepatocarcinogenesis and after estrogen treatment of HepG2 cells. Carcinogenesis 1998;19:2187-2193.
30. Yager JD, Chen JQ. Mitochondrial estrogen receptors-new insights into specific functions. Trends Endocrinol Metab 2007;18:88-91.