Interleukin-10 promoter polymorphisms associated with susceptibility to lumbar disc degeneration in a Chinese cohort

Genetics and Molecular Research

Volumn 10, Issue 3, 2011, Pages 1719-1727

  Lin, W P ^a   Lin, J H ^a   Chen, X W ^a   Wu, C Y ^a   Zhang, L Q ^a   Huang, Z D ^a   Lai, J M ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Interleukin 10; Lumbar disc degeneration; Polymorphisms; Susceptibility

Indexed keywords

INTERLEUKIN 10; MESSENGER RNA;

ADULT; ALLELE; ARTICLE; CASE CONTROL STUDY; CHINESE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE LOCUS; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HETEROZYGOTE; HUMAN; INTERVERTEBRAL DISK DEGENERATION; LUMBAR DISK DEGENERATION; LUMBAR DISK HERNIA; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; POLYMERASE CHAIN REACTION; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; COHORT STUDIES; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-10; INTERVERTEBRAL DISC DEGENERATION; LOGISTIC MODELS; LUMBAR VERTEBRAE; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROMOTER REGIONS, GENETIC; RNA, MESSENGER;

EID: 80955124642     PISSN: None     EISSN: 16765680     Source Type: Journal    
DOI: 10.4238/vol10-3gmr1283     Document Type: Article

References (24)

1. Ahn SH, Cho YW, Ahn MW, Jang SH, et al. (2002). mRNA expression of cytokines and chemokines in herniated lumbar intervertebral discs. Spine 27: 911-917.
2. Akyol S, Eraslan BS, Etyemez H and Tanriverdi T (2010). Catabolic cytokine expressions in patients with degenerative disc disease. Turk. Neurosurg. 20: 492-499.
3. Battie MC, Videman T and Parent E (2004). Lumbar disc degeneration: epidemiology and genetic influences. Spine 29: 2679-2690.
4. Claudino M, Trombone AP, Cardoso CR, Ferreira SB Jr, et al. (2008). The broad effects of the functional IL-10 promoter-592 polymorphism: modulation of IL-10, TIMP-3, and OPG expression and their association with periodontal disease outcome. J. Leukoc. Biol. 84: 1565-1573.
5. Hassett G, Hart DJ, Manek NJ, Doyle DV, et al. (2003). Risk factors for progression of lumbar spine disc degeneration: the Chingford Study. Arthritis Rheum. 48: 3112-3117.
6. Holm S, Mackiewicz Z, Holm AK, Konttinen YT, et al. (2009). Pro-inflammatory, pleiotropic, and anti-inflammatory TNF-alpha, IL-6, and IL-10 in experimental porcine intervertebral disk degeneration. Vet. Pathol. 46: 1292-1300.
7. Igarashi A, Kikuchi S, Konno S and Olmarker K (2004). Inflammatory cytokines released from the facet joint tissue in degenerative lumbar spinal disorders. Spine 29: 2091-2095.
8. Iguchi T, Kanemura A, Kasahara K, Kurihara A, et al. (2003). Age distribution of three radiologic factors for lumbar instability: probable aging process of the instability with disc degeneration. Spine 28: 2628-2633.
9. Kawaguchi S, Yamashita T, Yokogushi K, Murakami T, et al. (2001). Immunophenotypic analysis of the inflammatory infiltrates in herniated intervertebral discs. Spine 26: 1209-1214.
10. Kawaguchi S, Yamashita T, Katahira G, Yokozawa H, et al. (2002). Chemokine profile of herniated intervertebral discs infiltrated with monocytes and macrophages. Spine 27: 1511-1516.
11. Kurreeman FA, Schonkeren JJ, Heijmans BT, Toes RE, et al. (2004). Transcription of the IL10 gene reveals allele-specific regulation at the mRNA level. Hum. Mol. Genet. 13: 1755-1762.
12. Lalani I, Bhol K and Ahmed AR (1997). Interleukin-10: biology, role in inflammation and autoimmunity. Ann. Allergy Asthma Immunol. 79: 469-483.
13. Ma SL, Tang NL, Lam LC and Chiu HF (2005). The association between promoter polymorphism of the interleukin-10 gene and Alzheimer's disease. Neurobiol. Aging 26: 1005-1010.
14. Matsui H, Kanamori M, Ishihara H, Yudoh K, et al. (1998). Familial predisposition for lumbar degenerative disc disease. A case-control study. Spine 23: 1029-1034.
15. Park BL, Han IK, Lee HS, Kim LH, et al. (2004). Association of interleukin 10 haplotype with low bone mineral density in Korean postmenopausal women. J. Biochem. Mol. Biol. 37: 691-699.
16. Pye SR, Reid DM, Adams JE, Silman AJ, et al. (2006). Radiographic features of lumbar disc degeneration and bone mineral density in men and women. Ann. Rheum. Dis. 65: 234-238.
17. Rees LE, Wood NA, Gillespie KM, Lai KN, et al. (2002). The interleukin-10-1082 G/A polymorphism: allele frequency in different populations and functional significance. Cell. Mol. Life Sci. 59: 560-569.
18. Reuss E, Fimmers R, Kruger A, Becker C, et al. (2002). Differential regulation of interleukin-10 production by genetic and environmental factors - a twin study. Genes Immun. 3: 407-413.
19. Sambrook PN, MacGregor AJ and Spector TD (1999). Genetic influences on cervical and lumbar disc degeneration: a magnetic resonance imaging study in twins. Arthritis Rheum. 42: 366-372.
20. Scuderi GJ, Brusovanik GV, Anderson DG, Dunham CJ, et al. (2006). Cytokine assay of the epidural space lavage in patients with lumbar intervertebral disk herniation and radiculopathy. J. Spinal Disord. Tech. 19: 266-269.
21. Solovieva S, Lohiniva J, Leino-Arjas P, Raininko R, et al. (2006). Intervertebral disc degeneration in relation to the COL9A3 and the IL-1ss gene polymorphisms. Eur. Spine J. 15: 613-619.
22. Tworek D and Kuna P (2005). The role of interleukin 10 in allergic inflammation. Pol. Merkur Lekarski. 18: 125-128.
23. Valdes AM, Hassett G, Hart DJ and Spector TD (2005). Radiographic progression of lumbar spine disc degeneration is influenced by variation at inflammatory genes: a candidate SNP association study in the Chingford cohort. Spine 30: 2445-2451.
24. Woertgen C, Rothoerl RD and Brawanski A (2000). Influence of macrophage infiltration of herniated lumbar disc tissue on outcome after lumbar disc surgery. Spine 25: 871-875.