Influence of macrophage infiltration of herniated lumbar disc tissue on outcome after lumbar disc surgery

Spine

Volumn 25, Issue 7, 2000, Pages 871-875

  Woertgen, Chris ^a   Rothoerl, Ralf Dirk ^b   Brawanski, Alexander ^b  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b NONE

Author keywords

Inflammation; Lumbar disc herniation; Outcome; Surgery

Indexed keywords

ADULT; ARTICLE; CELL INFILTRATION; FEMALE; FOLLOW UP; HUMAN; IMMUNOHISTOCHEMISTRY; LUMBAR DISK HERNIA; MACROPHAGE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SPINE SURGERY; TREATMENT OUTCOME;

ADULT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; FEMALE; FOLLOW-UP STUDIES; FOREIGN-BODY REACTION; HUMANS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DISPLACEMENT; LUMBAR VERTEBRAE; MACROPHAGES; MALE; PAIN MEASUREMENT; PROSPECTIVE STUDIES; RADICULOPATHY; TREATMENT OUTCOME;

EID: 0033996351     PISSN: 03622436     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007632-200004010-00017     Document Type: Article

References (29)

1. Brown MD. The source of low back pain and sciatica. Semin Arthritis Rheum 1989;18(Suppl 2):67-72.
2. 2 on lumbar nerve root structure and function. Spine 1997; 22:1057-64.
3. Cornefjord M, Olmarker K, Farley D, Weinstein JN, Rydevik. Substance P and VIP in spinal roots after epidural application of autologous nucleus pulposus. Neuro-Orthop 1997;20:133-42.
4. Doita M, Kanatani T, Harada T, Mizuno K. Immunohistologic study of the ruptured intervertebral disc of the lumbar spine. Spine 1996;21:235-41.
5. 2 is inflammatory. Spine 1992;17(Suppl):S129-32.
6. Gertzbein SD, Tile M, Gross A, Falk R. Autoimmunity in degenerative disc disease of the lumbar spine. Orthop Clin North Am 1975;6:67-73.
7. Groenblad M, Virri J, Tolonen J, et al. A controlled immunohistochemical study of inflammatory cells in disc herniation tissue. Spine 1994;19:2744-51.
8. Guyton AC. The blood cells. In: Function of the Human Body. 3rd ed. Philadelphia: WB Saunders, 1969:85-98.
9. Hirotaka H, Shinomiya K, Komori H, et al. Upregulated expression of chemokines in herniated nucleus pulposus resorption. Spine 1996;21:1647-52.
10. Howe JF, Loeser JD, Calvin WH. Mechanosensitivity of dorsal root ganglia and chronically injured axons: A physiological basis for the radicular pain of nerve root compression. Pain 1977;3:25-41.
11. 2 and nitric oxide in pain-related behavior produced by an allograft of intervertebral disc material to the static nerve of the rat. Spine 1997; 22:1074-9.
12. Marshall LL, Trethewie ER, Curtain CC. Chemical radiculitis: A clinical, physiological, and immunological study. Clin Orthop 1977;129:61-7.
13. Mason DY, Cordell JL, Abdulaziz Z, Naiem M, Bordenhave G. Preparation of peroxidase-antiperoxidase (PAP) complexes for immunohistological labelling of monoclonal antibodies. J Histochem Cytochem 1982;30:1114-22.
14. McCarron RF, Wimpee MW, Hudkins PG, Laros GS. The inflammatory effect of nucleus pulposus: A possible element in the pathogenesis of low back pain. Spine 1987;12:760-4.
15. Meyers R, Saal JS, Franson R, Garfin SR. Human Disc PLA2 Induces Neural Injury: A Histomorphometric Study. Presented at the annual meeting of the International Society for the Study of the Lumbar Spine, Chicago, Illinois, 1992.
16. Mixter WJ, Barr JS. Rupture of the intervertebral disc with involvement of the spinal canal. N England J Med 1934;211:210-5.
17. Nachemson A. Intradiscal measurements of pH in patients with lumbar rhizopathies. Acta Orthop Scand 1969;40:23-42.
18. Rothoerl RD, Woertgen C, Holzschuh M, Breme K, Rueschoff J, Brawanski A. Macrophage tissue infiltration, clinical symptoms and signs in patients with lumbar disc herniations: A clinicopathological study on 179 patients. Acta Neurochir 1998;140:1245-8.
19. Rothoerl RD, Woertgen C, Holzschuh M, Rueschoff J, Brawanski A. Is there a clinical correlate to the histologic evidence of inflammation in herniated lumbar disc tissue? Spine 1998;23(11):1197-1201.
20. Rvdevik B, Garfin SR. Spinal nerve root compression. In: Szabo RM, ed. Nerve Compression Syndromes, Diagnosis, and Treatment. Thorofare, NJ: Slack, 1989:247-61.
21. Saal JS. The role of inflammation in lumbar pain. Spine 1995;20:1821-7.
22. 2 activity in lumbar disc herniations. Spine 1990;15:674-8.
23. Siddall PJ, Cousins MJ. Spinal pain mechanisms. Spine 1997;22:98-104.
24. Smyth MJ, Wright V. Sciatica and the intervertebral disc: An experimental study. J Bone Joint Surg [Am] 1958;40:1401-18.
25. Takahashi H, Suguro T, Okazima Y, Motegi M, Okada Y, Kakiuchi T. Inflammatory cytokines in the herniated disc of the lumbar spine. Spine 1996;21: 218-24.
26. Takino T, Takahashi K, Miyazaki T, Matsui T, Tomita K. An immunohistochemical study of inflammatory cells appearance in rabbits nucleus pulposus. Neuro-Orthop 1997;20:113-20.
27. Thelander U, Fagerlund M, Friberg S, Larsson S. Straight leg raising test versus radiological size, shape, and position of lumbar disc hernias. Spine 1992; 17:395-9.
28. Virri J, Sikk S, Groenblad M, et al. Concomitant immunocytochemical study of macrophage cells and blood vessels in disc herniation tissue. Eur Spine J 1994;3:336-41.
29. Weinstein JN. The role of neurogenic and nonneurogenic mediators as they relate to pain and the development of osteoarthritis. Spine 1992;17(Suppl):S356-61.