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Volumn 4, Issue 1, 2011, Pages 163-172

Update on the management of inflammatory bowel disease: Specific role of adalimumab

Author keywords

Adalimumab; Anti TNF ; Crohn's disease; Ulcerative colitis

Indexed keywords

ADALIMUMAB; IMMUNOSTIMULATING AGENT; INFLIXIMAB; LAMIVUDINE; PLACEBO; STEROID; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

EID: 80955123985     PISSN: None     EISSN: 11787023     Source Type: Journal    
DOI: 10.2147/CEG.S14558     Document Type: Review
Times cited : (31)

References (48)
  • 1
    • 34248136828 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Cause and immunobiology
    • Baumgart DC, Carding SR. Inflammatory bowel disease: cause and immunobiology. Lancet. 2007;369:1627-1640.
    • (2007) Lancet , vol.369 , pp. 1627-1640
    • Baumgart, D.C.1    Carding, S.R.2
  • 2
    • 75149161836 scopus 로고    scopus 로고
    • The second European evidenced-based consensus on the diagnosis and management of Crohn's disease: Current management
    • Dignass A, Van Assche G, Lindsay JO, et al. The second European evidenced-based consensus on the diagnosis and management of Crohn's disease: current management. J Crohns Colitis. 2010;4:28-62.
    • (2010) J Crohns Colitis , vol.4 , pp. 28-62
    • Dignass, A.1    van Assche, G.2    Lindsay, J.O.3
  • 3
    • 59749093368 scopus 로고    scopus 로고
    • Practice Parameters Committee of the American College of Gastroenterology. Management of Crohn's disease in adults
    • Lichtenstein GR, Hanauer SB, Sandborn WJ. Practice Parameters Committee of the American College of Gastroenterology. Management of Crohn's disease in adults. Am J Gastroenterol. 2009;104:465-483.
    • (2009) Am J Gastroenterol , vol.104 , pp. 465-483
    • Lichtenstein, G.R.1    Hanauer, S.B.2    Sandborn, W.J.3
  • 4
    • 38749095183 scopus 로고    scopus 로고
    • European evidenced-based consensus on the management of ulcerative colitis: Current management
    • Travis S P, Stange EF, Lemann L, et al. European evidenced-based consensus on the management of ulcerative colitis: current management. J Crohn's Colitis. 2008;2:24-62.
    • (2008) J Crohn's Colitis , vol.2 , pp. 24-62
    • Travis, S.P.1    Stange, E.F.2    Lemann, L.3
  • 5
    • 77949271455 scopus 로고    scopus 로고
    • Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee
    • Kornbluth A, Sachar D, et al. Ulcerative Colitis Practice Guidelines in Adults: American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol. 2010;105:501-523.
    • (2010) Am J Gastroenterol , vol.105 , pp. 501-523
    • Kornbluth, A.1    Sachar, D.2
  • 6
    • 80955162460 scopus 로고    scopus 로고
    • ® Product monograph, Abbott Laboratories, Abbott Park, IL
    • ® Product monograph, Abbott Laboratories, Abbott Park, IL.
  • 7
    • 32044451548 scopus 로고    scopus 로고
    • Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: The CLASSIC-I trial
    • Hanauer SB, Sandborn WJ, Rutgeerts P, et al. Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial. Gastroenterology. 2006;130:323-333.
    • (2006) Gastroenterology , vol.130 , pp. 323-333
    • Hanauer, S.B.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 8
    • 34249281002 scopus 로고    scopus 로고
    • Adalimumab for maintenance treatment of Crohn's disease: Results of the CLASSIC II trial
    • Sandborn WJ, Hanauer SB, Rutgeerts P, et al. Adalimumab for maintenance treatment of Crohn's disease: results of the CLASSIC II trial. Gut. 2007;56:1232-1239.
    • (2007) Gut , vol.56 , pp. 1232-1239
    • Sandborn, W.J.1    Hanauer, S.B.2    Rutgeerts, P.3
  • 9
    • 33846242958 scopus 로고    scopus 로고
    • Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: The CHARM trial
    • Colombel J-F, Sandborn WJ, Rutgeerts P, et al. Adalimumab for maintenance of clinical response and remission in patients with Crohn's disease: the CHARM trial. Gastroenterology. 2007;132:52-65.
    • (2007) Gastroenterology , vol.132 , pp. 52-65
    • Colombel, J.-F.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 10
    • 55449098725 scopus 로고    scopus 로고
    • Effects of adalimumab therapy on incidence of hospitalization and surgery in Crohn's disease: Results from the CHARM study
    • Feagan BG, Panaccione R, Sandborn WJ, et al. Effects of adalimumab therapy on incidence of hospitalization and surgery in Crohn's disease: results from the CHARM study. Gastroenterology. 2008; 135:1493-1499.
    • (2008) Gastroenterology , vol.135 , pp. 1493-1499
    • Feagan, B.G.1    Panaccione, R.2    Sandborn, W.J.3
  • 11
    • 66949133561 scopus 로고    scopus 로고
    • Comparison of two adalimumab treatment schedule strategies for moderate-to-severe Crohn's disease: Results from the CHARM trial
    • Colombel JF, Sandborn WJ, Rutgeerts P, et al. Comparison of two adalimumab treatment schedule strategies for moderate-to-severe Crohn's disease: results from the CHARM trial. Am J Gastroenterol. 2009;104:1170-1179.
    • (2009) Am J Gastroenterol , vol.104 , pp. 1170-1179
    • Colombel, J.F.1    Sandborn, W.J.2    Rutgeerts, P.3
  • 12
    • 78650159235 scopus 로고    scopus 로고
    • Dosage adjustment during long-term adalimumab treatment for Crohn's disease:Clinical efficacy and pharmacoeconomics
    • Sandborn WJ, Colombel J F, Schreiber S, et al. Dosage adjustment during long-term adalimumab treatment for Crohn's disease:clinical efficacy and pharmacoeconomics. Infamm Bowel Dis. 2011;17:141-151.
    • (2011) Infamm Bowel Dis , vol.17 , pp. 141-151
    • Sandborn, W.J.1    Colombel, J.F.2    Schreiber, S.3
  • 13
    • 77952748486 scopus 로고    scopus 로고
    • Adalimumab sustains clinical remission and overall clinical beneft after 2 years of therapy for Crohn's disease
    • Panaccione R, Colombel JF, Sandborn WJ, et al. Adalimumab sustains clinical remission and overall clinical beneft after 2 years of therapy for Crohn's disease. Aliment Pharmacol Ther. 2010;31:1296-1309.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 1296-1309
    • Panaccione, R.1    Colombel, J.F.2    Sandborn, W.J.3
  • 14
    • 80051826949 scopus 로고    scopus 로고
    • Adalimumab produces clinical remission and reduces extraintestinal manifestations in Crohn's disease: Results from CARE
    • Lofberg R, Louis E, Reinisch W, et al. Adalimumab produces clinical remission and reduces extraintestinal manifestations in Crohn's disease: results from CARE. Infamm Bowel Dis. 2011.
    • (2011) Infamm Bowel Dis
    • Lofberg, R.1    Louis, E.2    Reinisch, W.3
  • 15
    • 79953786419 scopus 로고    scopus 로고
    • Loss of response and need for Adalimumab dose intensifcation in Crohn's disease: A systematic review
    • Billioud V, Sandborn WJ, Peyrin-Biroulet L. Loss of response and need for Adalimumab dose intensifcation in Crohn's disease: a systematic review. Am J Gastroenterol. 2011;106:674-684.
    • (2011) Am J Gastroenterol , vol.106 , pp. 674-684
    • Billioud, V.1    Sandborn, W.J.2    Peyrin-Biroulet, L.3
  • 16
    • 67649662356 scopus 로고    scopus 로고
    • Adalimumab for the treatment of fistulas in patients with Crohn's disease
    • Colombel J F, Schwarts DA, Sandborn WJ, et al. Adalimumab for the treatment of fistulas in patients with Crohn's disease. Gut. 2009; 58:940-948.
    • (2009) Gut , vol.58 , pp. 940-948
    • Colombel, J.F.1    Schwarts, D.A.2    Sandborn, W.J.3
  • 17
    • 78249282645 scopus 로고    scopus 로고
    • The CHOICE trial: Adalimumab demonstrates safety, fistula healing, improved quality of life and increased work productivity in patients with Crohn's disease who failed prior inf-liximab therapy
    • Lichtiger S, Binion DG, Wolf DC, et al. The CHOICE trial: adalimumab demonstrates safety, fistula healing, improved quality of life and increased work productivity in patients with Crohn's disease who failed prior inf-liximab therapy. Aliment Pharmacol Ther. 2010;32:1228-1239.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 1228-1239
    • Lichtiger, S.1    Binion, D.G.2    Wolf, D.C.3
  • 18
    • 34347402306 scopus 로고    scopus 로고
    • Adalimumab induction therapy for Crohn disease previously treated with infliximab: A randomized trial
    • Sandborn WJ, Rutgeerts P, Enns R, et al. Adalimumab induction therapy for Crohn disease previously treated with infliximab: a randomized trial. Ann Intern Med. 2007;146:829-838.
    • (2007) Ann Intern Med , vol.146 , pp. 829-838
    • Sandborn, W.J.1    Rutgeerts, P.2    Enns, R.3
  • 19
    • 46749092439 scopus 로고    scopus 로고
    • Adalimumab maintains long-term remission in moderately to severely active Crohn's disease after infliximab failure: 1-year follow-up of GAIN trial. [abstract]
    • Panaccione R, Sandborn WJ, D'Haens G, et al. Adalimumab maintains long-term remission in moderately to severely active Crohn's disease after infliximab failure: 1-year follow-up of GAIN trial. [abstract] Gastroenterolog y. 2008;134:A133.
    • (2008) Gastroenterolog Y , vol.134
    • Panaccione, R.1    Sandborn, W.J.2    D'haens, G.3
  • 20
    • 71949105445 scopus 로고    scopus 로고
    • Systematic review: The short-term and long-term efficacy of adalimumab following discontinuation of infliximab
    • Ma C, Panaccione R, Heitman SJ, et al. Systematic review: the short-term and long-term efficacy of adalimumab following discontinuation of infliximab. Aliment Pharmacol Ther. 2009;15(30):977-986.
    • (2009) Aliment Pharmacol Ther , vol.15 , Issue.30 , pp. 977-986
    • Ma, C.1    Panaccione, R.2    Heitman, S.J.3
  • 21
    • 79953307015 scopus 로고    scopus 로고
    • Deep remission for adalimumab-treated patients with moderate to severe ileocolonic Crohn's disease: Results from EXTEND [abstract]
    • Colombel JF, Rutgeerts P, Sandborn WJ. Deep remission for adalimumab-treated patients with moderate to severe ileocolonic Crohn's disease: results from EXTEND [abstract]. J Crohns Colitis. 2010;4:S10.
    • (2010) J Crohns Colitis , vol.4
    • Colombel, J.F.1    Rutgeerts, P.2    Sandborn, W.J.3
  • 22
    • 78650751328 scopus 로고    scopus 로고
    • Deep remission predicts long-term outcomes for Adalimumab-treated patients with Crohn's disease: Data from EXTEND [abstract]
    • Colombel J F, Rutgeerts P, Sandborn WJ. Deep remission predicts long-term outcomes for Adalimumab-treated patients with Crohn's disease: data from EXTEND [abstract]. Gut. 2010;59(Suppl 3):A80.
    • (2010) Gut , vol.59 , Issue.SUPPL. 3
    • Colombel, J.F.1    Rutgeerts, P.2    Sandborn, W.J.3
  • 23
    • 72949114290 scopus 로고    scopus 로고
    • Retrospective Evaluation of the Safety and Effect of Adalimumab Therapy (RESEAT) in pediatric crohn's disease
    • Rosh JR, Lerer T, Markowitz J, et al. Retrospective Evaluation of the Safety and Effect of Adalimumab Therapy (RESEAT) in pediatric crohn's disease. Am J Gastroenterol. 2009;104:3042-3049.
    • (2009) Am J Gastroenterol , vol.104 , pp. 3042-3049
    • Rosh, J.R.1    Lerer, T.2    Markowitz, J.3
  • 24
    • 79952803048 scopus 로고    scopus 로고
    • A British Society of Paediatric Gastroenterology, Hepatology and Nutrition survey of the effectiveness and safety of adalimumab in children with inflammatory bowel disease
    • Russell RK, Wilson ML, Loganathan S, et al. A British Society of Paediatric Gastroenterology, Hepatology and Nutrition survey of the effectiveness and safety of adalimumab in children with inflammatory bowel disease. Aliment Pharmacol Ther. 2011;33:946-953.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 946-953
    • Russell, R.K.1    Wilson, M.L.2    Loganathan, S.3
  • 25
    • 80955150065 scopus 로고    scopus 로고
    • Induction and maintenance adalimumab therapy for the treatment of moderate to severe Crohn's disease in children [abstract]
    • Hyams JS, Griffths AM, Markowitz J, et al. Induction and maintenance adalimumab therapy for the treatment of moderate to severe Crohn's disease in children [abstract]. Gastroenterology. 2011;140(Suppl 1): S90.
    • (2011) Gastroenterology , vol.140 , Issue.SUPPL. 1
    • Hyams, J.S.1    Griffths, A.M.2    Markowitz, J.3
  • 26
    • 34249857135 scopus 로고    scopus 로고
    • Adalimumab induction therapy for ulcerative colitis with intolerance or lost response to infliximab: An open-label study
    • Peyrin-Biroulet L, Laclotte C, Roblin X, et al. Adalimumab induction therapy for ulcerative colitis with intolerance or lost response to infliximab: an open-label study. World J Gastroenterol. 2007; 13:2328-2332.
    • (2007) World J Gastroenterol , vol.13 , pp. 2328-2332
    • Peyrin-Biroulet, L.1    Laclotte, C.2    Roblin, X.3
  • 27
    • 52149104260 scopus 로고    scopus 로고
    • Long-term outcome of adalimumab therapy for ulcerative colitis with intolerance or lost response to infliximab: A single-centre experience
    • Oussalah A, Laclotte C, Chevaux JB, et al. Long-term outcome of adalimumab therapy for ulcerative colitis with intolerance or lost response to infliximab: a single-centre experience. Aliment Pharmacol Ther. 2008;28:966-972.
    • (2008) Aliment Pharmacol Ther , vol.28 , pp. 966-972
    • Oussalah, A.1    Laclotte, C.2    Chevaux, J.B.3
  • 28
    • 70449727863 scopus 로고    scopus 로고
    • Open-label study of adali-mumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab
    • Aff W, Leighton JA, Hanauer SB, et al. Open-label study of adali-mumab in patients with ulcerative colitis including those with prior loss of response or intolerance to infliximab. Infamm Bowel Dis. 2009;15:1302-1307.
    • (2009) Infamm Bowel Dis , vol.15 , pp. 1302-1307
    • Aff, W.1    Leighton, J.A.2    Hanauer, S.B.3
  • 29
    • 77954752112 scopus 로고    scopus 로고
    • Treatment of ulcerative colitis with adalimumab or infliximab: Long-term follow-up of a single-centre cohort
    • Gies N, Kroeker KI, Wong K, et al. Treatment of ulcerative colitis with adalimumab or infliximab: long-term follow-up of a single-centre cohort. Aliment Pharmacol Ther. 2010;32:522-528.
    • (2010) Aliment Pharmacol Ther , vol.32 , pp. 522-528
    • Gies, N.1    Kroeker, K.I.2    Wong, K.3
  • 30
    • 78650892656 scopus 로고    scopus 로고
    • Adalimumab for ulcerative colitis patients previously treated with infliximab: Outcomes at short and long term and predictors of response
    • Taxonera C, Estellés J, Blanco I, et al. Adalimumab for ulcerative colitis patients previously treated with infliximab: outcomes at short and long term and predictors of response. Aliment Pharmacol Ther. 2011;33:340-348.
    • (2011) Aliment Pharmacol Ther , vol.33 , pp. 340-348
    • Taxonera, C.1    Estellés, J.2    Blanco, I.3
  • 31
    • 78650063811 scopus 로고    scopus 로고
    • The outcome of active ulcer-ative colitis treated with adalimumab [abstract]
    • Hudis N, Rajca B, Polyak S, et al. The outcome of active ulcer-ative colitis treated with adalimumab [abstract]. Gastroenterology. 2009;136:A661.
    • (2009) Gastroenterology , vol.136
    • Hudis, N.1    Rajca, B.2    Polyak, S.3
  • 32
    • 78650068536 scopus 로고    scopus 로고
    • Efficacy of adalimumab in the treatment of ulcerative colitis [abstract]
    • García-Bosch O, Aceituno M, Perez J, et al. Efficacy of adalimumab in the treatment of ulcerative colitis [abstract]. J Crohns Colitis. 2010;4:S55.
    • (2010) J Crohns Colitis , vol.4
    • García-Bosch, O.1    Aceituno, M.2    Perez, J.3
  • 33
    • 79955859430 scopus 로고    scopus 로고
    • Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: Results of a randomised controlled trial
    • Reinisch W, Sandborn WJ, Hommes DW, et al. Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial. Gut. 2011;60:780-787.
    • (2011) Gut , vol.60 , pp. 780-787
    • Reinisch, W.1    Sandborn, W.J.2    Hommes, D.W.3
  • 34
    • 79958248492 scopus 로고    scopus 로고
    • 52-week clinical efficacy with adalimumab in patients with moderately to severely active ulcer-ative colitis who failed corticosteroids and/or immunosoppresants [abstract]
    • Reinisch W, Sandborn WJ, Kumar A, et al. 52-week clinical efficacy with adalimumab in patients with moderately to severely active ulcer-ative colitis who failed corticosteroids and/or immunosoppresants [abstract]. J Crohns Colitis. 2011;5:S10.
    • (2011) J Crohns Colitis , vol.5
    • Reinisch, W.1    Sandborn, W.J.2    Kumar, A.3
  • 35
    • 80955150068 scopus 로고    scopus 로고
    • Adalimumab improves health-related quality of life for 52 weeks in patients with ulcerative colitis [abstract]
    • Sandborn WJ, Van Assche G, Thakkar RB, et al. Adalimumab improves health-related quality of life for 52 weeks in patients with ulcerative colitis [abstract]. J Crohns Colitis. 2011;5:S87.
    • (2011) J Crohns Colitis , vol.5
    • Sandborn, W.J.1    van Assche, G.2    Thakkar, R.B.3
  • 36
    • 80955162453 scopus 로고    scopus 로고
    • Induction and maintenance of clinical remission by adalimumab in patients with moderate-to-severe ulcerative colitis [abstract]
    • Sandborn WJ, Va n Assche GA, Reinisch W, et al. Induction and maintenance of clinical remission by adalimumab in patients with moderate-to-severe ulcerative colitis [abstract]. Gastroenterology. 2011;140(5 Suppl 1):S123-S124.
    • (2011) Gastroenterology , vol.140 , Issue.5 SUPPL. 1
    • Sandborn, W.J.1    van Assche, G.A.2    Reinisch, W.3
  • 37
    • 70349707016 scopus 로고    scopus 로고
    • Adalimumab safety in global clinical trials of patients with Crohn's disease
    • Colombel JF, Sandborn WJ, Panaccione R, et al. Adalimumab safety in global clinical trials of patients with Crohn's disease. Infamm Bowel Dis. 2009;15:1308-1319.
    • (2009) Infamm Bowel Dis , vol.15 , pp. 1308-1319
    • Colombel, J.F.1    Sandborn, W.J.2    Panaccione, R.3
  • 38
    • 71449093991 scopus 로고    scopus 로고
    • Review article: Chronic viral infection in the anti-tumour necrosis factor therapy era in inflammatory bowel disease
    • Shale MJ, Seow CH, Coffn S, et al. Review article: chronic viral infection in the anti-tumour necrosis factor therapy era in inflammatory bowel disease. Aliment Pharmacol Ther. 2010;31:20-34.
    • (2010) Aliment Pharmacol Ther , vol.31 , pp. 20-34
    • Shale, M.J.1    Seow, C.H.2    Coffn, S.3
  • 39
    • 78649661962 scopus 로고    scopus 로고
    • Advanced age is an independent risk factor for severe infections and mortality in patients given anti- tumor necrosis factor therapy for inflammatory bowel disease
    • Cottone M, Kohn A, Daperno M, et al. Advanced age is an independent risk factor for severe infections and mortality in patients given anti- tumor necrosis factor therapy for inflammatory bowel disease. Clin Gastroenterol Hepatol. 2011;9:30-35.
    • (2011) Clin Gastroenterol Hepatol , vol.9 , pp. 30-35
    • Cottone, M.1    Kohn, A.2    Daperno, M.3
  • 40
    • 63849102069 scopus 로고    scopus 로고
    • Review article: TNFα induced psoriasis in patients with inflammatory bowel disease
    • Fiorino G, Allez M, Malesci A, et al. Review article: TNFα induced psoriasis in patients with inflammatory bowel disease. Aliment Pharmacol Ther. 2009;29:921-927.
    • (2009) Aliment Pharmacol Ther , vol.29 , pp. 921-927
    • Fiorino, G.1    Allez, M.2    Malesci, A.3
  • 41
    • 70350130547 scopus 로고    scopus 로고
    • Infuence of trough serum levels and immunogenicity on long-term outcome of adalimumab therapy in Crohn's disease
    • Karmiris K, Paintaud G, Noman M, et al. Infuence of trough serum levels and immunogenicity on long-term outcome of adalimumab therapy in Crohn's disease. Gastroenterology. 2009;137:1628-1640.
    • (2009) Gastroenterology , vol.137 , pp. 1628-1640
    • Karmiris, K.1    Paintaud, G.2    Noman, M.3
  • 42
    • 80955128411 scopus 로고    scopus 로고
    • Adalimumab levels detected in cord blood and infants exposed in utero [abstract]
    • Mahadevan U, Miller JK, Wolf DC. Adalimumab levels detected in cord blood and infants exposed in utero [abstract]. Gastroenterology. 2011;140(5 Suppl 1):S61-S62.
    • (2011) Gastroenterology , vol.140 , Issue.5 SUPPL. 1
    • Mahadevan, U.1    Miller, J.K.2    Wolf, D.C.3
  • 43
    • 75149157977 scopus 로고    scopus 로고
    • Pregnancy outcome in women exposed to adalimumab: The OTIS autoimmune disease in pregnancy project [abstract]
    • Johnson DL, Jones KL, Chambers CD, et al. Pregnancy outcome in women exposed to adalimumab: the OTIS autoimmune disease in pregnancy project [abstract]. Gastroenterology. 2009;136(5 Suppl 1):A27.
    • (2009) Gastroenterology , vol.136 , Issue.5 SUPPL. 1
    • Johnson, D.L.1    Jones, K.L.2    Chambers, C.D.3
  • 44
    • 80955157132 scopus 로고    scopus 로고
    • Anti-TNF therapy and fetal risk: A systematic review of the literature [abstract]
    • Marchioni RM, Kerner C, Lichtenstein GR. Anti-TNF therapy and fetal risk: a systematic review of the literature [abstract]. Gastroenterology. 2011;140(5 Suppl 1):S772.
    • (2011) Gastroenterology , vol.140 , Issue.5 SUPPL. 1
    • Marchioni, R.M.1    Kerner, C.2    Lichtenstein, G.R.3
  • 46
    • 39449085441 scopus 로고    scopus 로고
    • Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: An open randomised trial
    • Belgian Inflammatory Bowel Disease Research Group, North-Holland Gut Club
    • D'Haens G, Baert F, Van Assche G, et al. Belgian Inflammatory Bowel Disease Research Group; North-Holland Gut Club. Early combined immunosuppression or conventional management in patients with newly diagnosed Crohn's disease: an open randomised trial. Lancet. 2008;371:660-667.
    • (2008) Lancet , vol.371 , pp. 660-667
    • D'haens, G.1    Baert, F.2    van Assche, G.3
  • 47
    • 77950988234 scopus 로고    scopus 로고
    • Infliximab, azathioprine, or combination therapy for Crohn's disease
    • Colombel JF, Sandborn WJ, Reinisch W, et al. Infliximab, azathioprine, or combination therapy for Crohn's disease. N Engl J Med. 2010; 362:1383-1395.
    • (2010) N Engl J Med , vol.362 , pp. 1383-1395
    • Colombel, J.F.1    Sandborn, W.J.2    Reinisch, W.3
  • 48
    • 84872494012 scopus 로고    scopus 로고
    • Crohn's disease patients treated with adalimumab beneft from co-treatment with immunomodulators: Results from a nationwide study in the Netherlands [abstract]
    • van der Valk ME, van Oijen MG, Siersema PD, et al. Crohn's disease patients treated with adalimumab beneft from co-treatment with immunomodulators: results from a nationwide study in the Netherlands [abstract]. Gastroenterology. 2011;140(5 Suppl 1):S264.
    • (2011) Gastroenterology , vol.140 , Issue.5 SUPPL. 1
    • van der Valk, M.E.1    van Oijen, M.G.2    Siersema, P.D.3


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