Rapid, non-invasive imaging of alphaviral brain infection: Reducing animal numbers and morbidity to identify efficacy of potential vaccines and antivirals

Vaccine

Volumn 29, Issue 50, 2011, Pages 9345-9351

  Patterson, Michael ^a   Poussard, Allison ^a   Taylor, Katherine ^a   Seregin, Alexey ^a   Smith, Jeanon ^a   Peng, Bi Hung ^a   Walker, Aida ^a   Linde, Jenna ^a   Smith, Jennifer ^a   Salazar, Milagros ^a   Paessler, Slobodan ^a,b  

^a Preclinical Studies Core at Galveston National Laboratory   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Encephalitis; In vivo; IVIS; Luciferase; Neuroinvasion; TC83; VEEV

Indexed keywords

ANTIVIRUS AGENT; LUCIFERASE; RINTATOLIMOD; VIRUS VACCINE;

ACCURACY; ALPHA VIRUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TESTING REDUCTION; ANIMAL TESTING REFINEMENT; ANIMAL TESTING REPLACEMENT; ARTICLE; BIOLUMINESCENCE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; IN VIVO STUDY; INOCULATION; MORBIDITY; MOUSE; NEUROIMAGING; NONHUMAN; PRIORITY JOURNAL; TECHNOLOGY; VENEZUELAN EQUINE ENCEPHALOMYELITIS ALPHAVIRUS; VIRUS ENCEPHALITIS; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; BRAIN; CENTRAL NERVOUS SYSTEM DISEASES; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, VENEZUELAN EQUINE; FEMALE; IMAGING, THREE-DIMENSIONAL; MICE; MICE, INBRED ICR; NEUROIMAGING; POLY I-C; POLY U;

EID: 80855143746     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.09.130     Document Type: Article

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