Fibrinolysis is down-regulated in mouse collagen-induced arthritis, but its normalization does not alleviate the course of disease

Inflammation Research

Volumn 60, Issue 11, 2011, Pages 1021-1029

  Kwieciński, Jakub ^a   Josefsson, Elisabet ^a   Jin, Tao ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Collagen induced arthritis; Fibrinolysis; Plasmin; Rheumatoid arthritis; tPA; uPA

Indexed keywords

ALTEPLASE; D DIMER; FIBRIN; INTERLEUKIN 6; LOW MOLECULAR WEIGHT HEPARIN; PLASMIN; PLASMINOGEN ACTIVATOR; PLASMINOGEN ACTIVATOR INHIBITOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; DISEASE SEVERITY; DOWN REGULATION; DRUG EFFECT; ENZYME ACTIVITY; FIBRIN DEPOSITION; FIBRINOLYSIS; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; MALE; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; MOUSE; NONHUMAN; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

ANIMALS; ARTHRITIS, RHEUMATOID; COLLAGEN; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FIBRIN; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; FIBRINOLYSIN; FIBRINOLYSIS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6; MALE; MICE; MICE, INBRED DBA; PLASMINOGEN ACTIVATOR INHIBITOR 1; TISSUE PLASMINOGEN ACTIVATOR; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 80855138661     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-011-0363-0     Document Type: Article

References (42)

1. N Busso JA Hamilton 2002 Extravascular coagulation and the plasminogen activator/plasmin system in rheumatoid arthritis Arthritis Rheum 46 9 2268 2279 10.1002/art.10498 12355473 10.1002/art.10498 1:CAS:528:DC%2BD38XosVGjtbs%3D
2. JA Hamilton 2008 Plasminogen activator/plasmin system in arthritis and inflammation: friend or foe? Arthritis Rheum 58 3 645 648 10.1002/art.23269 18311800 10.1002/art.23269 (Pubitemid 351364861)
3. EJ Brommer G Dooijewaard BA Dijkmans FC Breedveld 1992 Plasminogen activators in synovial fluid and plasma from patients with arthritis Ann Rheum Dis 51 8 965 968 1417121 10.1136/ard.51.8.965 1:STN:280:DyaK3s%2FjslKltQ%3D%3D
4. N Busso V Peclat A So AP Sappino 1997 Plasminogen activation in synovial tissues: differences between normal, osteoarthritis, and rheumatoid arthritis joints Ann Rheum Dis 56 9 550 557 9370880 10.1136/ard.56.9.550 1:STN:280:DyaK1c%2FjvVaitg%3D%3D (Pubitemid 27428478)
5. HK Ronday HH Smits GN Van Muijen MS Pruszczynski RJ Dolhain EJ Van Langelaan, et al. 1996 Difference in expression of the plasminogen activation system in synovial tissue of patients with rheumatoid arthritis and osteoarthritis Br J Rheumatol 35 5 416 423 8646430 10.1093/rheumatology/35.5.416 1:STN:280:DyaK283jsFSquw%3D%3D
6. S Wallberg-Jonsson S Rantapaa-Dahlqvist L Nordmark M Ranby 1996 Mobilization of fibrinolytic enzymes in synovial fluid and plasma of rheumatoid arthritis and spondyloarthropathy and their relation to radiological destruction J Rheumatol 23 10 1704 1709 8895144 1:STN:280:DyaK2s%2FltVCitA%3D%3D (Pubitemid 26342438)
7. C Belcher F Fawthrop R Bunning M Doherty 1996 Plasminogen activators and their inhibitors in synovial fluids from normal, osteoarthritis, and rheumatoid arthritis knees Ann Rheum Dis 55 4 230 236 8733439 10.1136/ard.55.4.230 1:STN:280:DyaK283pslehuw%3D%3D
8. EJ Brommer G Dooijewaard BA Dijkmans FC Breedveld 1992 Depression of tissue-type plasminogen activator and enhancement of urokinase-type plasminogen activator as an expression of local inflammation Thromb Haemost 68 2 180 184 1412164 1:CAS:528:DyaK3sXltVCg
9. T Jin A Tarkowski P Carmeliet M Bokarewa 2003 Urokinase, a constitutive component of the inflamed synovial fluid, induces arthritis Arthritis Res Ther 5 1 R9 R17 12716448 10.1186/ar606 1:CAS:528:DC%2BD38XpsFWlsLg%3D
10. JA Kummer JJ Abbink JP de Boer D Roem EJ Nieuwenhuys AM Kamp, et al. 1992 Analysis of intraarticular fibrinolytic pathways in patients with inflammatory and noninflammatory joint diseases Arthritis Rheum 35 8 884 893 1379429 10.1002/art.1780350806 1:STN:280:DyaK38zlt1Ckuw%3D%3D
11. T Saxne I Lecander P Geborek 1993 Plasminogen activators and plasminogen activator inhibitors in synovial fluid. Difference between inflammatory joint disorders and osteoarthritis J Rheumatol 20 1 91 96 8441174 1:CAS:528: DyaK3sXksVKrs70%3D (Pubitemid 23049189)
12. JB Weinberg AM Pippen CS Greenberg 1991 Extravascular fibrin formation and dissolution in synovial tissue of patients with osteoarthritis and rheumatoid arthritis Arthritis Rheum 34 8 996 1005 1677574 10.1002/art. 1780340809 1:STN:280:DyaK3MzhsFKgtg%3D%3D
13. F Carmassi F De Negri M Morale R Puccetti SI Chung 1994 Elastase- and plasmin-mediated fibrinolysis in rheumatoid arthritis Int J Tissue React 16 2 89 93 7960505 1:STN:280:DyaK2M%2FkvFWktA%3D%3D (Pubitemid 24232667)
14. LT Kopeikina EF Kamper V Koutsoukos Y Bassiakos I Stavridis 1997 Imbalance of tissue-type plasminogen activator (t-PA) and its specific inhibitor (PAI-1) in patients with rheumatoid arthritis associated with disease activity Clin Rheumatol 16 3 254 260 9184262 10.1007/BF02238960 1:STN:280: DyaK2szislGqtw%3D%3D (Pubitemid 27273171)
15. MI Barnhart JM Riddle GB Bluhm C Quintana 1967 Fibrin promotion and lysis in arthritic joints Ann Rheum Dis 26 3 206 218 6026169 10.1136/ard.26.3.206 1:CAS:528:DyaF2sXkslWru7g%3D
16. I Clemmensen B Holund RB Andersen 1983 Fibrin and fibronectin in rheumatoid synovial membrane and rheumatoid synovial fluid Arthritis Rheum 26 4 479 485 6340698 10.1002/art.1780260405 1:CAS:528:DyaL3sXhvFGqtbk%3D (Pubitemid 13120236)
17. LR Zacharski FE Brown VA Memoli W Kisiel BJ Kudryk SM Rousseau, et al. 1992 Pathways of coagulation activation in situ in rheumatoid synovial tissue Clin Immunol Immunopathol 63 2 155 162 1611717 10.1016/0090-1229(92)90008-C 1:STN:280:DyaK38zgs1eksg%3D%3D
18. O Sanchez-Pernaute R Largo E Calvo MA Alvarez-Soria J Egido G Herrero-Beaumont 2003 A fibrin based model for rheumatoid synovitis Ann Rheum Dis 62 12 1135 1138 14644849 10.1136/ard.2003.011767 1:STN:280: DC%2BD3srmsVKhtQ%3D%3D (Pubitemid 37500617)
19. C Masson-Bessiere M Sebbag E Girbal-Neuhauser L Nogueira C Vincent T Senshu, et al. 2001 The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the alpha- and beta-chains of fibrin J Immunol 166 6 4177 4184 11238669 1:CAS:528:DC%2BD3MXitVGmtr8%3D (Pubitemid 32224951)
20. N Busso V Peclat K Van Ness E Kolodziesczyk J Degen T Bugge, et al. 1998 Exacerbation of antigen-induced arthritis in urokinase-deficient mice J Clin Invest 102 1 41 50 10.1172/JCI2312 9649555 10.1172/JCI2312 1:CAS:528: DyaK1cXktlWhtrY%3D (Pubitemid 28323828)
21. MJ Flick CM LaJeunesse KE Talmage DP Witte JS Palumbo MD Pinkerton, et al. 2007 Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif J Clin Invest 117 11 3224 3235 10.1172/JCI30134 17932565 10.1172/JCI30134 1:CAS:528:DC%2BD2sXht12isr3O (Pubitemid 350096980)
22. DD Brand AH Kang EF Rosloniec 2003 Immunopathogenesis of collagen arthritis Springer Semin Immunopathol 25 1 3 18 10.1007/s00281-003-0127-1 12904888 10.1007/s00281-003-0127-1 (Pubitemid 37000035)
23. YG Cho ML Cho SY Min HY Kim 2007 Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis Autoimmun Rev 7 1 65 70 10.1016/j.autrev.2007.08.001 17967728 10.1016/j.autrev.2007.08.001 1:CAS:528:DC%2BD1cXitVWntg%3D%3D (Pubitemid 350011068)
24. R Salvi V Peclat A So N Busso 2000 Enhanced expression of genes involved in coagulation and fibrinolysis in murine arthritis Arthritis Res 2 6 504 512 11056680 10.1186/ar132 1:CAS:528:DC%2BD3cXoslelsb0%3D (Pubitemid 32223798)
25. M Verdrengh IM Jonsson R Holmdahl A Tarkowski 2003 Genistein as an anti-inflammatory agent Inflamm Res 52 8 341 346 10.1007/s00011-003-1182-8 14504672 10.1007/s00011-003-1182-8 1:CAS:528:DC%2BD3sXntlShsr8%3D (Pubitemid 36995159)
26. CT Esmon 2004 Crosstalk between inflammation and thrombosis Maturitas 47 4 305 314 10.1016/j.maturitas.2003.10.015 15063484 10.1016/j.maturitas.2003.10. 015 1:CAS:528:DC%2BD2cXivVWmtLs%3D (Pubitemid 38520117)
27. A Sagripanti M Morganti A Carpi A Cupisti A Nicolini M Barsotti, et al. 1998 Uremic medium increases cytokine-induced PAI-1 secretion by cultured endothelial cells Biomed Pharmacother 52 7-8 298 302 9809172 10.1016/S0753-3322(98)80024-3 1:CAS:528:DyaK1cXntl2htr0%3D (Pubitemid 29155310)
28. VW van Hinsbergh EA van den Berg W Fiers G Dooijewaard 1990 Tumor necrosis factor induces the production of urokinase-type plasminogen activator by human endothelial cells Blood 75 10 1991 1998 2140060 (Pubitemid 20180288)
29. F Ingegnoli F Fantini EG Favalli A Soldi S Griffini V Galbiati, et al. 2008 Inflammatory and prothrombotic biomarkers in patients with rheumatoid arthritis: effects of tumor necrosis factor-alpha blockade J Autoimmun 31 2 175 179 10.1016/j.jaut.2008.07.002 18707846 10.1016/j.jaut.2008.07.002 1:CAS:528:DC%2BD1cXhtVymsb3M
30. T Jin M Bokarewa S Amu A Tarkowski 2009 Impact of short-term therapies with biologics on prothrombotic biomarkers in rheumatoid arthritis Clin Exp Rheumatol 27 3 491 494 2631[pii] 19604443 1:STN:280:DC%2BD1Mvoslajuw%3D%3D
31. PA Varisco V Peclat K van Ness A Bischof-Delaloye A So N Busso 2000 Effect of thrombin inhibition on synovial inflammation in antigen induced arthritis Ann Rheum Dis 59 10 781 787 11005778 10.1136/ard.59.10.781 1:CAS:528:DC%2BD3cXnslCitLw%3D
32. J Li Y Guo R Holmdahl T Ny 2005 Contrasting roles of plasminogen deficiency in different rheumatoid arthritis models Arthritis Rheum 52 8 2541 2548 10.1002/art.21229 16052596 10.1002/art.21229 1:CAS:528:DC%2BD2MXpslGht7c%3D (Pubitemid 41117443)
33. K Van Ness V Chobaz-Peclat M Castellucci A So N Busso 2002 Plasminogen activator inhibitor type-1 deficiency attenuates murine antigen-induced arthritis Rheumatology (Oxford) 41 2 136 141 10.1093/rheumatology/41.2.136 (Pubitemid 34537888)
34. YH Yang P Carmeliet JA Hamilton 2001 Tissue-type plasminogen activator deficiency exacerbates arthritis J Immunol 167 2 1047 1052 11441114 1:CAS:528:DC%2BD3MXotFWktbw%3D (Pubitemid 32660863)
35. Y Guo J Li E Hagstrom T Ny 2008 Protective effects of plasmin(ogen) in a mouse model of Staphylococcus aureus-induced arthritis Arthritis Rheum 58 3 764 772 10.1002/art.23263 18311818 10.1002/art.23263 1:CAS:528:DC%2BD1cXjslWqu78%3D (Pubitemid 351364874)
36. I Marty V Peclat G Kirdaite R Salvi A So N Busso 2001 Amelioration of collagen-induced arthritis by thrombin inhibition J Clin Invest 107 5 631 640 10.1172/JCI11064 11238564 10.1172/JCI11064 1:CAS:528:DC%2BD3MXhs12nsLw%3D (Pubitemid 32205184)
37. AD Cook EL Braine IK Campbell JA Hamilton 2002 Differing roles for urokinase and tissue-type plasminogen activator in collagen-induced arthritis Am J Pathol 160 3 917 926 11891190 10.1016/S0002-9440(10)64914-0 1:CAS:528:DC%2BD38XisVemtrc%3D (Pubitemid 34224581)
38. AD Cook CM De Nardo EL Braine AL Turner R Vlahos KJ Way, et al. 2010 Urokinase-type plasminogen activator and arthritis progression: role in systemic disease with immune complex involvement Arthritis Res Ther 12 2 R37 10.1186/ar2946 20196869 10.1186/ar2946
39. J Li A Ny G Leonardsson KS Nandakumar R Holmdahl T Ny 2005 The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritis Am J Pathol 166 3 783 792 166/3/783[pii] 15743790 10.1016/S0002-9440(10)62299-7 1:CAS:528: DC%2BD2MXivVOmsLs%3D (Pubitemid 40315635)
40. M Calabozo I Aretxabala A Alonso-Ruiz F Perez-Ruiz E Fraiz E Ruiz-Lucea, et al. 1998 Intraarticular urokinase: a new drainage technique for synovial effusions with rice bodies J Rheumatol 25 2 394 395 9489845 1:STN:280: DyaK1c7kvFCruw%3D%3D (Pubitemid 128753752)
41. RD Sturrock C Watkin T Williamson WC Dick 1974 Intra-articular urokinase in rheumatoid arthritis Ann Rheum Dis 33 2 124 125 4821384 10.1136/ard.33.2.124 1:STN:280:DyaE2c7ktVWksg%3D%3D
42. J Imiela J Nosarzewski A Górski 1995 Oral heparin in the treatment of rheumatoid arthritis Arch Immunol Ther Exp (Warsz) 43 5-6 313 315 1:STN:280:DyaK28zisl2qsg%3D%3D (Pubitemid 26066893)