A mouse model for spatial and temporal expression of HGF in the heart

Transgenic Research

Volumn 20, Issue 6, 2011, Pages 1203-1216

  Riess, Ilan ^a   Sala, Valentina ^a   Leo, Christian ^a   Demaria, Marco ^a   Gatti, Stefano ^a   Gallo, Simona ^a   Fitou, Amandine ^a   Boero, Ombretta ^a   Levi, Renzo ^a   Cuccovillo, Ivan ^b   Molla, Fabiola ^b   de Angelis, Noeleen ^b   Staszewsky, Lidia ^b   Latini, Roberto ^b   Crepaldi, Tiziana ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

Author keywords

Heart; HGF; Myocardial infarction; Transgenic mice

Indexed keywords

COLLAGEN; DOXYCYCLINE; GREEN FLUORESCENT PROTEIN; HGF PROTEIN, MOUSE; SCATTER FACTOR;

ANIMAL; ANIMAL MODEL; ARTICLE; CELL LINE; CELL PROLIFERATION; CROSS BREEDING; CULTURE MEDIUM; DOG; DRUG EFFECT; ECHOCARDIOGRAPHY; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HEART; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; METABOLISM; MOUSE; PATHOPHYSIOLOGY; PREGNANCY; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL LINE; CELL PROLIFERATION; COLLAGEN; CROSSES, GENETIC; CULTURE MEDIA, CONDITIONED; DOGS; DOXYCYCLINE; ECHOCARDIOGRAPHY; FEMALE; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HEART; HEPATOCYTE GROWTH FACTOR; HETEROZYGOTE; IMMUNOHISTOCHEMISTRY; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; MYOCARDIAL REPERFUSION INJURY; PREGNANCY; REAL-TIME POLYMERASE CHAIN REACTION;

MUS MUSCULUS;

EID: 80855133463     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11248-011-9485-y     Document Type: Article

References (31)

1. Aoki M, Morishita R, Taniyama Y, Kida I, Moriguchi A, Matsumoto K, Nakamura T, Kaneda Y, Higaki J, Ogihara T (2000) Angiogenesis induced by hepatocyte growth factor in non-infarcted myocardium and infarcted myocardium: up-regulation of essential transcription factor for angiogenesis, ets. Gene Ther 7: 417-427.
2. Birchmeier C, Birchmeier W, Gherardi E, Vande Woude GF (2003) Met, metastasis, motility and more. Nat Rev Mol Cell Biol 4: 915-925.
3. Boccaccio C, Comoglio PM (2006) Invasive growth: a MET-driven genetic programme for cancer and stem cells. Nat Rev Cancer 6: 637-645.
4. Breckenridge RA, Zuberi Z, Gomes J, Orford R, Dupays L, Felkin LE, Clark JE, Magee AI, Ehler E, Birks EJ, Barton PJR, Tinker A, Mohun TJ (2009) Overexpression of the transcription factor Hand1 causes predisposition towards arrhythmia in mice. J Mol Cell Cardiol 47: 133-141.
5. Cheung PY, Sawicki G, Wozniak M, Wang W, Radomski MW, Schulz R (2000) Matrix metalloproteinase-2 contributes to ischemia-reperfusion injury in the heart. Circulation 101: 1833-1839.
6. Crepaldi T, Bersani F, Scuoppo C, Accornero P, Prunotto C, Taulli R, Forni PE, Leo C, Chiarle R, Griffiths J, Glass DJ, Ponzetto C (2007) Conditional activation of MET in differentiated skeletal muscle induces atrophy. J Biol Chem 282: 6812-6822.
7. Fishman Gl (1998) Timing is everything in life: conditional transgene expression in the cardiovascular system. Circ Res 82: 837-844.
8. Giacobini P, Messina A, Wray S, Giampietro C, Crepaldi T, Carmeliet P, Fasolo A (2007) Hepatocyte growth factor acts as a motogen and guidance signal for gonadotropin hormone-releasing hormone-1 neuronal migration. J Neurosci 27: 431-445.
9. Hayashi S, Morishita R, Nakamura S, Yamamoto K, Moriguchi A, Nagano T, Taiji M, Noguchi H, Matsumoto K, Nakamura T, Higaki J, Ogihara T (1999) Potential role of hepatocyte growth factor, a novel angiogenic growth factor, in peripheral arterial disease: downregulation of HGF in response to hypoxia in vascular cells. Circulation 100: 11301-11308.
10. Li Y, Joseph A, Bhargava MM, Rosen EM, Nakamura T, Goldberg I (1992) Effect of scatter factor and hepatocyte growth factor on motility and morphology of MDCK cells. In Vitro Cell Dev Biol 28A: 364-368.
11. Lyons GE, Schiaffino S, Sassoon D, Barton P, Buckingham M (1990) Developmental regulation of myosin gene expression in mouse cardiac muscle. J Cell Biol 111: 2427-2436.
12. McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ (2005) Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiol Genomics 22: 118-126.
13. Morishita R, Nakamura S, Hayashi S, Taniyama Y, Moriguchi A, Nagano T, Taiji M, Noguchi H, Takeshita S, Matsumoto K, Nakamura T, Higaki J, Ogihara T (1999) Therapeutic angiogenesis induced by human recombinant hepatocyte growth factor in rabbit hind limb ischemia model as cytokine supplement therapy. Hypertension 33: 1379-1384.
14. Moumen A, Ieraci A, Patane S, Sole C, Comella JX, Dono R, Maina F (2007) Met signals hepatocyte survival by preventing Fas-triggered FLIP degradation in a PI3 k-Akt-dependent manner. Hepatology 45: 1210-1217.
15. Nakamura T, Mizuno S, Matsumoto K, Sawa Y, Matsuda H, Nakamura T (2000) Myocardial protection from ischemia/reperfusion injury by endogenous and exogenous HGF. J Clin Invest 106: 1511-1519.
16. Rappolee DA, Iyer A, Patel Y (1996) Hepatocyte growth factor and its receptor are expressed in cardiac myocytes during early cardiogenesis. Circ Res 78: 1028-1036.
17. Redfern CH, Coward P, Degtyarev MY, Lee EK, Kwa AT, Hennighausen L, Bujard H, Fishman GI, Conklin BR (1999) Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat Biotechnol 17: 165-169.
18. Sanbe A, Gulick J, Hanks MC, Liang QR, Osinska H, Robbins J (2003) Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res 92: 609-616.
19. Siedner S, Kruger M, Schroeter M, Metzler D, Roell W, Fleischmann BK, Hescheler J, Pfitzer G, Stehle R (2003) Developmental changes in contractility and sarcomeric proteins from the early embryonic to the adult stage in the mouse heart. J Physiol 548: 493-505.
20. Song W, Majka SM, McGuire PG (1999) Hepatocyte growth factor expression in the developing myocardium: evidence for a role in the regulation of the mesenchymal cell phenotype and urokinase expression. Dev Dyn 214: 92-100.
21. Taniyama Y, Morishita R, Hiraoka K, Aoki M, Nakagami H, Yamasaki K, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T (2001) Therapeutic angiogenesis induced by human hepatocyte growth factor gene in rat diabetic hind limb ischemia model-Molecular mechanisms of delayed angiogenesis in diabetes. Circulation 104: 2344-2350.
22. Taniyama Y, Morishita R, Aoki M, Hiraoka K, Yamasaki K, Hashiya N, Matsumoto K, Nakamura T, Kaneda Y, Ogihara T (2002) Angiogenesis and antifibrotic action by hepatocyte growth factor in cardiomyopathy. Hypertension 40: 47-53.
23. Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ (2006) Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. Am J Physiol Heart Circ Physiol 290: H1103-H1109.
24. Ueda H, Sawa Y, Matsumoto K, Kitagawa-Sakakida S, Kawahira Y, Nakamura T, Kaneda Y, Matsuda H (1999) Gene transfection of hepatocyte growth factor attenuates reperfusion injury in the heart. Ann Thorac Surg 67: 1726-1731.
25. Ueda H, Nakamura T, Matsumoto K, Sawa Y, Matsuda H, Nakamura T (2001) A potential cardioprotective role of hepatocyte growth factor in myocardial infarction in rats. Cardiovasc Res 51: 41-50.
26. Urbanek K, Rota M, Cascapera S, Bearzi C, Nascimbene A, De Angelis A, Hosoda T, Chimenti S, Baker M, Limana F, Nurzynska D, Torella D, Rotatori F, Rastaldo R, Musso E, Quaini F, Leri A, Kajstura J, Anversa P (2005) Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ Res 97: 663-673.
27. Wang YG, Ahmad N, Wani MA, Ashraf M (2004) Hepatocyte growth factor prevents ventricular remodeling and dysfunction in mice via Akt pathway and angiogenesis. J Mol Cell Cardiol 37: 1041-1052.
28. Wang W, Yang ZJ, Ma DC, Wang LS, Xu SL, Zhang YR, Cao KJ, Zhang FM, Ma WZ (2006) Induction of collateral artery growth and improvement of post-infarct heart function by hepatocyte growth factor gene transfer. Acta Pharmacol Sin 27: 555-560.
29. Xiao GH, Jeffers M, Bellacosa A, Mitsuuchi Y, Vande Woude GF, Testa JR (2001) Anti-apoptotic signaling by hepatocyte growth factor/Met via the phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase pathways. Proc Natl Acad Sci USA 98: 247-252.
30. Yu Z, Redfern CS, Fishman GI (1996) Conditional transgene expression in the heart. Circ Res 79: 691-697.
31. Zammit PS, Kelly RG, Franco D, Brown N, Moorman AF, Buckingham ME (2000) Suppression of atrial myosin gene expression occurs independently in the left and right ventricles of the developing mouse heart. Dev Dyn 217: 75-85.