Delta-cell-specific expression of hedgehog pathway Ptch1 receptor in murine and human endocrine pancreas

Diabetes/Metabolism Research and Reviews

Volumn 27, Issue 8, 2011, Pages 755-760

  Grieco, F A ^a,b   Moretti, M ^c   Sebastiani, G ^a,b   Galleri, L ^a,b   Spagnuolo, I ^a,b   Scafetta, G ^c   Gulino, A ^c   de Smaele, E ^d   Maroder, M ^d   Dotta, F ^a,b  

^a UNIVERSITY OF SIENA   (Italy)

^b Toscana Life Science Park   (Italy)

^c SAPIENZA UNIVERSITY OF ROME   (Italy)

^d SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Diabetes; Endocrine pancreas; Hedgehog pathway; Ptch1; Somatostatin

Indexed keywords

GLUCAGON; INSULIN; MESSENGER RNA; PARAFFIN; PROTEIN PATCHED 1; SOMATOSTATIN; STREPTOZOCIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONFOCAL MICROSCOPY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LASER CAPTURE MICRODISSECTION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; ORGAN DONOR; PANCREAS; PANCREAS ISLET DELTA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE SECTION;

ANIMALS; HUMANS; ISLETS OF LANGERHANS; MALE; MICE; MICE, INBRED C57BL; RECEPTORS, CELL SURFACE; SOMATOSTATIN-SECRETING CELLS;

EID: 80855131248     PISSN: 15207552     EISSN: 15207560     Source Type: Journal    
DOI: 10.1002/dmrr.1247     Document Type: Article

References (17)

1. McMahon AP, Ingham PW, Tabin CJ. Developmental roles and clinical significance of hedgehog signaling. Curr Top Dev Biol 2003; 53: 1-114.
2. Po A, Ferretti E, Miele E, et al. Hedgehog controls neural stem cells through p53-independent regulation of Nanog. Embo J 2010; 29(15): 2646-2658.
3. Ruiz i Altaba A, Mas C, Stecca B. The Gli code: an information nexus regulating cell fate, stemness and cancer. Trends Cell Biol 2007; 17(9): 438-447.
4. Gallo R, Grieco FA, Marselli L, et al. Hedgehog signaling during expansion of human pancreatic islet-derived precursors. Ann N Y Acad Sci 2008; 1150: 43-45.
5. Hebrok M, Kim KS, St-Jacques B, McMahon AP, Melton DA. Regulation of pancreas development by hedgehog signaling. Development 2000; 127(22): 4905-4913.
6. Kawahira H, Ma NH, Tzanakakis ES, McMahon AP, Chuang PT, Hebrok M. Combined activities of hedgehog signaling inhibitors regulate pancreas development. Development 2003; 130(20): 4871-4879.
7. Lau J, Kawahira H, Hebrok M. Hedgehog signaling in pancreas development and disease. Cell Mol Life Sci 2006; 63(6): 642-652.
8. Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat Genet 1997; 15(1): 106-110.
9. Jonsson J, Carlsson L, Edlund T, Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994; 371(6498): 606-609.
10. Thomas MK, Lee JH, Rastalsky N, Habener JF. Hedgehog signaling regulation of homeodomain protein islet duodenum homeobox-1 expression in pancreatic beta-cells. Endocrinology 2001; 142(3): 1033-1040.
11. Thomas MK, Rastalsky N, Lee JH, Habener JF. Hedgehog signaling regulation of insulin production by pancreatic beta-cells. Diabetes 2000; 49(12): 2039-2047.
12. Lau J, Hebrok M. Hedgehog signaling in pancreas epithelium regulates embryonic organ formation and adult beta-cell function. Diabetes 2010; 59(5): 1211-1221.
13. Apelqvist A, Ahlgren U, Edlund H. Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas. Curr Biol 1997; 7(10): 801-804.
14. Hebrok M, Kim SK, Melton DA. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev 1998; 12(11): 1705-1713.
15. Goodrich LV, Milenkovi' L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science 1997; 277(5329): 1109-1113.
16. Chen Y, Struhl G. Dual roles for patched in sequestering and transducing Hedgehog. Cell 1996; 87(3): 553-563.
17. Fernands A, King LC, Guz Y, Stein R, Wright CVE, Teitelman G. Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinolgy 1997; 138(4): 1750.