Comorbidity and the rate of cognitive decline in patients with Alzheimer dementia

International Journal of Geriatric Psychiatry

Volumn 26, Issue 12, 2011, Pages 1244-1251

  Solomon, Alina ^a,b   Dobranici, Letitia ^c,d   Kareholt, Ingemar ^b   Tudose, Cǎtǎlina ^e,f   Lǎzǎrescu, Mircea ^g,h  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c CF2 Hospital   (Romania)

^d SPIRU HARET UNIVERSITY   (Romania)

^e Alexandru Obregia Psychiatric Hospital Bucharest   (Romania)

^f CAROL DAVILA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^g Eduard Pamfil Psychiatric Hospital   (Romania)

^h VICTOR BABES UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

Author keywords

Alzheimer; CIRS G; cognitive decline; comorbidity

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; COGNITIVE DEFECT; COMORBIDITY; CONTROLLED STUDY; DAILY LIFE ACTIVITY; DISEASE ASSOCIATION; DISEASE SEVERITY; FEMALE; FOLLOW UP; HUMAN; MAJOR CLINICAL STUDY; MALE;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; COGNITION DISORDERS; COMORBIDITY; DISABILITY EVALUATION; FEMALE; GERIATRIC ASSESSMENT; HUMANS; MALE; PSYCHIATRIC STATUS RATING SCALES; ROMANIA; SEVERITY OF ILLNESS INDEX;

EID: 80855130338     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.2670     Document Type: Article

References (44)

1. Aguero-Torres H, Thomas VS, Winblad B, Fratiglioni L., 2002. The impact of somatic and cognitive disorders on the functional status of the elderly. J Clin Epidemiol 55: 1007-1012. (Pubitemid 36018865)
2. Appelman AP, Vincken KL, van der Graaf Y, et al,. 2010. White matter lesions and lacunar infarcts are independently and differently associated with brain atrophy: the SMART-MR study. Cerebrovasc Dis 29 (1): 28-35.
3. Artaz MA, Boddaert J, Hériche-Taillandier E, et al,. 2006. Medical comorbidity in Alzheimer's disease: baseline characteristics of the REAL.FR Cohort. Rev Med Interne 27 (2): 91-97. (Pubitemid 43188738)
4. Bellew KM, Pigeon JG, Stang PE, et al,. 2004. Hypertension and the rate of cognitive decline in patients with dementia of the Alzheimer type. Alzheimer Dis Assoc Disord 18 (4): 208-213. (Pubitemid 40076150)
5. Bhargava D, Weiner MF, Hynan LS, Diaz-Arrastia R, Lipton AM., 2006. Vascular disease and risk factors, rate of progression, and survival in Alzheimer's disease. J Geriatr Psychiatry Neurol 19 (2): 78-82. (Pubitemid 43726026)
6. Cechetto DF, Hachinski V, Whitehead SN., 2008. Vascular risk factors and Alzheimer's disease. Expert Rev Neurother 8 (5): 743-750. (Pubitemid 351656825)
7. Doraiswamy PM, Leon J, Cummings JL, Marin D, Neumann PJ., 2002. Prevalence and impact of medical comorbidity in Alzheimer's disease. J Gerontol Med Sci 87: M173-M77.
8. Folstein MF, Folstein SE, McHugh PR., 1975. " Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189-198.
9. Fong TG, Jones RN, Shi P, et al,. 2009. Delirium accelerates cognitive decline in Alzheimer disease. Neurology 72 (18): 1570-1575.
10. Fotuhi M, Hachinski V, Whitehouse PJ., 2009. Changing perspectives regarding late-life dementia. Nat Rev Neurol 5 (12): 649-658.
11. Helzner EP, Luchsinger JA, Scarmeas N, et al,. 2009. Contribution of vascular risk factors to the progression in Alzheimer disease. Arch Neurol 66 (3): 343-348.
12. Heyman A, Fillenbaum GG, Welsh-Bohmer KA, et al,. 1998. Cerebral infarcts in patients with autopsy-proven Alzheimer's disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer's Disease. Neurology 51: 159-162. (Pubitemid 28345377)
13. Iadecola C., 2010. The overlap between neurodegenerative and vascular factors in the pathogenesis of dementia. Acta Neuropathol 120 (3): 287-296.
14. Katz S, Ford AB, Moskowitz RW, et al,. 1963. The index of ADL: a standardised measure of biological and psychosocial function. J Am Med Assoc 185: 914-919.
15. Kuo TC, Zhao Y, Weir S, Kramer MS, Ash AS., 2008. Implications of comorbidity on costs for patients with Alzheimer disease. Med Care 46 (8): 839-846.
16. Lawton MP, Brody EM., 1969. Assessment of older people: self-maintaining and instrumental activities of daily living. Gerontologist 9: 179-186.
17. Linn ES, Linn MW, Gurel L., 1968. Cumulative illness rating scale. J Am Geriatr Soc 16: 622-626.
18. Lyketsos CG, Toone L, Tschanz J, et al,. 2005. Population-based study of medical comorbidity in early dementia and "cognitive impairment, no dementia" (CIND). Association with functional and cognitive impairment: The Cache County Study. Am J Geriatr Psychiatr 13: 656-664. (Pubitemid 41197236)
19. Malone DC, McLaughlin TP, Wahl PM, et al,. 2009. Burden of Alzheimer's disease and association with negative health outcomes. Am J Manag Care 15 (8): 481-488.
20. Marengoni A., 2008. Prevalence and impact of chronic diseases and multimorbidity in the aging population: A clinical and Epidemiological approach. Doctoral Thesis, Karolinska Institutet, Stockholm, Sweden.
21. Marengoni A, Rizzuto D, Wang HX, Winblad B, Fratiglioni L., 2009. Patterns of chronic multimorbidity in the elderly population. J Am Geriatr Soc 57 (2): 225-230.
22. McCormick WC, Kukull WA, Van Belle G, et al,. 1994. Symptom patterns and comorbidity in the early stages of Alzheimer's disease. J Am Geriatr Soc 42: 517-521. (Pubitemid 24145304)
23. McKhann G, Drachman D, Folstein M, et al,. 1984. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease. Neurology 34: 939-944. (Pubitemid 14076461)
24. Middleton LE, Yaffe K., 2009. Promising strategies for the prevention of dementia. Arch Neurol 66 (10): 1210-1215.
25. Mielke MM, Rosenberg PB, Tschanz J, et al,. 2007. Vascular factors predict rate of progression in Alzheimer disease. Neurology 69 (19): 1850-1858. (Pubitemid 350071146)
26. Miller MD, Towers A., 1991. A Manual of Guidelines for Scoring the Cumulative Illness Rating Scale for Geriatrics (CIRS-G). University of Pittsburgh: Pittsburg, PA.
27. Morris JC., 1993. The Clinical Dementia Rating (CDR): current version and scoring rules. Neurology 43: 2412-2414. (Pubitemid 23346995)
28. Musicco M, Palmer K, Salamone G, et al,. 2009. Predictors of progression of cognitive decline in Alzheimer's disease: the role of vascular and sociodemographic factors. J Neurol 256 (8): 1288-1295.
29. Portet F, Scarmeas N, Cosentino S, Helzner EP, Stern Y., 2009. Extrapyramidal signs before and after diagnosis of incident Alzheimer disease in a prospective population study. Arch Neurol 66 (9): 1120-1126.
30. Regan C, Katona C, Walker Z, et al,. 2006. Relationship of vascular risk to the progression of Alzheimer disease. Neurology 67 (8): 1357-1362. (Pubitemid 44632057)
31. Riccio D, Solinas A, Astara G, Mantovani G., 2007. Comprehensive geriatric assessment in female elderly patients with Alzheimer disease and other types of dementia. Arch Gerontol Geriatr 44 (Suppl 1): 343-353. (Pubitemid 46273732)
32. Roselli F, Tartaglione B, Federico F, et al,. 2009. Rate of MMSE score change in Alzheimer's disease: influence of education and vascular risk factors. Clin Neurol Neurosurg 111 (4): 327-330.
33. Sanderson M, Wang J, Davis DR, et al,. 2002. Co-morbidity associated with dementia. Am J Alzheimers Dis Other Demen 17 (2): 73-78. (Pubitemid 34754509)
34. Sanz C, Andrieu S, Sinclair A, et al,. 2009. Diabetes is associated with a slower rate of cognitive decline in Alzheimer disease. Neurology 73 (17): 1359-1366.
35. Scarmeas N, Albert M, Brandt J, et al,. 2005. Motor signs predict poor outcomes in Alzheimer disease. Neurology 64 (10): 1696-1703. (Pubitemid 40695800)
36. Schubert CC, Boustani M, Callahan CM, et al,. 2006. Comorbidity profile of dementia patients in primary care: are they sicker ? J Am Geriatr Soc 54 (1): 104-109.
37. Silvestrini M, Gobbi B, Pasqualetti P, et al,. 2009. Carotid atherosclerosis and cognitive decline in patients with Alzheimer's disease. Neurobiol Aging 30 (8): 1177-1183.
38. Silvestrini M, Pasqualetti P, Baruffaldi R, et al,. 2006. Cerebrovascular reactivity and cognitive decline in patients with Alzheimer disease. Stroke 37 (4): 1010-1015.
39. Snowdon DA, Greiner LH, Mortimer JA, et al,. 1997. Brain infarction and the clinical expression of Alzheimer disease. The Nun Study. J Am Med Assoc 277: 813-817. (Pubitemid 27111317)
40. Tekin S, Fairbanks LA, O'Connor S, Rosenberg S, Cummings JL., 2001. Activities of daily living in Alzheimer's disease: neuropsychiatric, cognitive, and medical illness influences. Am J Geriatr Psychiatr 9 (1): 81-86. (Pubitemid 32062077)
41. Tudose C., 2006. Boala Alzheimer ën România rezultatele unui studiu de marketing research. Revista Romana de Psihiatrie 1-2.
42. van Dijk PT, Dippel DW, Van Der Meulen JH, Habbema JD., 1996. Comorbidity and its effect on mortality in nursing home patients with dementia. J Nerv Ment Dis 184: 180-187. (Pubitemid 26112936)
43. Wolf-Klein GP, Silverstone FA, Brod MS, et al,. 1998. Are Alzheimer patients healthier ? J Am Geriatr Soc 36: 219-224.
44. World Health Organization. 1993. ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research. Geneva WHO.