Necessary and sufficient role for T helper cells to prevent fungal dissemination in allergic lung disease

Infection and Immunity

Volumn 79, Issue 11, 2011, Pages 4459-4471

  Porter, Paul C ^a   Roberts, Luz ^a   Fields, Anna ^a   Knight, Morgan ^a   Qian, Yuping ^a   Delclos, George L ^b   Han, Shuhua ^a   Kheradmand, Farrah ^a   Corry, David B ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 17;

ARTICLE; ASPERGILLUS FUMIGATUS; ASTHMA; BIOTRANSFORMATION; CELLULAR IMMUNITY; CONIDIUM; CURVULARIA LUNATA; HOST RESISTANCE; HOUSE DUST ALLERGY; HUMAN; INFECTION CONTROL; LYMPHOCYTE FUNCTION; MOUSE; MYCOSIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RESPIRATORY TRACT MUCOSA; TH1 CELL; TH2 CELL;

ANIMALS; B-LYMPHOCYTES; BRAIN DISEASES; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; DUST; FUNGI; HOMEODOMAIN PROTEINS; HUMANS; IMMUNITY, MUCOSAL; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYCOSES; RESPIRATORY HYPERSENSITIVITY; SPECIFIC PATHOGEN-FREE ORGANISMS; SPORES, FUNGAL; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 80855129263     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05209-11     Document Type: Article

References (63)

1. Adcock, I. M., P. A. Ford, P. Bhavsar, T. Ahmad, and K. F. Chung. 2008. Steroid resistance in asthma: mechanisms and treatment options. Curr. Allergy Asthma Rep. 8:171-178.
2. Agarwal, R., D. Gupta, A. N. Aggarwal, D. Behera, and S. K. Jindal. 2006. Allergic bronchopulmonary aspergillosis: lessons from 126 patients attending a chest clinic in north India. Chest 130:442-448.
3. Aimanianda, V., et al. 2009. Surface hydrophobin prevents immune recognition of airborne fungal spores. Nature 460:1117-1121.
4. Anand, R., and B. N. Tiwary. 2010. Th1 and Th2 cytokines in a self-healing primary pulmonary Aspergillus flavus infection in BALB/c mice. Cytokine 52:258-264.
5. Baddley, J. W., D. Salzman, and P. G. Pappas. 2002. Fungal brain abscess in transplant recipients: epidemiologic, microbiologic, and clinical features. Clin. Transplant. 16:419-424.
6. Beasley, R. 2002. The burden of asthma with specific reference to the United States. J. Allergy Clin. Immunol. 109:S482-S489.
7. Bjorgvinsdottir, H., et al. 1997. Retroviral-mediated gene transfer of gp91phox into bone marrow cells rescues defect in host defense against Aspergillus fumigatus in murine X-linked chronic granulomatous disease. Blood 89:41-48.
8. Carney, A. S., et al. 2006. Th2 immunological inflammation in allergic fungal sinusitis, nonallergic eosinophilic fungal sinusitis, and chronic rhinosinusitis. Am. J. Rhinol. 20:145-149.
9. Carter, E., and C. Boudreaux. 2004. Fatal cerebral phaeohyphomycosis due to Curvularia lunata in an immunocompetent patient. J. Clin. Microbiol. 42:5419-5423.
10. Cenci, E., et al. 1999. Interleukin-4 causes susceptibility to invasive pulmonary aspergillosis through suppression of protective type I responses. J. Infect. Dis. 180:1957-1968.
11. Cenci, E., et al. 1998. Cytokine- and T helper-dependent lung mucosal immunity in mice with invasive pulmonary aspergillosis. J. Infect. Dis. 178: 1750-1760.
12. Cenci, E., et al. 1997. Th1 and Th2 cytokines in mice with invasive aspergillosis. Infect. Immun. 65:564-570.
13. Corry, D. B., et al. 1996. Interleukin 4, but not interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity. J. Exp. Med. 183:109-117.
14. Corry, D. B., et al. 1998. Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient mice. Mol. Med. 4:344-355.
15. Denning, D. W., B. R. O'Driscoll, C. M. Hogaboam, P. Bowyer, and R. M. Niven. 2006. The link between fungi and severe asthma: a summary of the evidence. Eur. Respir. J. 27:615-626.
16. Denning, D. W., et al. 2009. Randomized controlled trial of oral antifungal treatment for severe asthma with fungal sensitization: the Fungal Asthma Sensitization Trial (FAST) study. Am. J. Respir. Crit. Care Med. 179:11-18.
17. Erbagci, Z. 2002. Deep dermatophytoses in association with atopy and diabetes mellitus: Majocchi's granuloma tricophyticum or dermatophytic pseudomycetoma? Mycopathologia 154:163-169.
18. Fahy, J. V., D. B. Corry, and H. A. Boushey. 2000. Airway inflammation and remodeling in asthma. Curr. Opin. Pulm. Med. 6:15-20.
19. Gerson, S. L., et al. 1984. Prolonged granulocytopenia: the major risk factor for invasive pulmonary aspergillosis in patients with acute leukemia. Ann. Intern. Med. 100:345-351.
20. Reference deleted
21. Hogaboam, C. M., et al. 2000. Chronic airway hyperreactivity, goblet cell hyperplasia, and peribronchial fibrosis during allergic airway disease induced by Aspergillus fumigatus. Am. J. Pathol. 156:723-732.
22. Katzenstein, A. L. 2000. Diagnostic features and differential diagnosis of Churg-Strauss syndrome in the lung. A review. Am. J. Clin. Pathol. 114:767-772.
23. Kauffman, H. F., J. F. Tomee, T. S. van der Werf, J. G. de Monchy, and G. K. Koeter. 1995. Review of fungus-induced asthmatic reactions. Am. J. Respir. Crit. Care Med. 151:2109-2115.
24. Kheradmand, F., et al. 2002. A protease-activated pathway underlying Th cell type 2 activation and allergic lung disease. J. Immunol. 169:5904-5911.
25. Kitamura, D., J. Roes, R. Kuhn, and K. Rajewsky. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350:423-426.
26. Kobayashi, T., et al. 2009. Asthma-related environmental fungus, Alternaria, activates dendritic cells and produces potent Th2 adjuvant activity. J. Immunol. 182:2502-2510.
27. Kozel, T. R., M. A. Wilson, T. P. Farrell, and S. M. Levitz. 1989. Activation of C3 and binding to Aspergillus fumigatus conidia and hyphae. Infect. Immun. 57:3412-3417.
28. Kruse, D., and G. T. Cole. 1990. Isolation of tube precipitin antibody-reactive fractions of Coccidioides immitis. Infect. Immun. 58:169-178.
29. Kurup, V. P., M. Ramasamy, P. A. Greenberger, and J. N. Fink. 1988. Isolation and characterization of a relevant Aspergillus fumigatus antigen with IgG- and IgE-binding activity. Int. Arch. Allergy Appl. Immunol. 86: 176-182.
30. Liang, S. C., et al. 2006. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203:2271-2279.
31. Luong, A., L. S. Davis, and B. F. Marple. 2009. Peripheral blood mononuclear cells from allergic fungal rhinosinusitis adults express a Th2 cytokine response to fungal antigens. Am. J. Rhinol. Allergy 23:281-287.
32. Luong, A., and B. Marple. 2005. The role of fungi in chronic rhinosinusitis. Otolaryngol. Clin. North Am. 38:1203-1213.
33. Luong, A., and B. F. Marple. 2004. Allergic fungal rhinosinusitis. Curr. Allergy Asthma Rep. 4:465-470.
34. Reference deleted
35. Marx, J. J., and D. K. Flaherty. 1976. Activation of the complement sequence by extracts of bacteria and fungi associated with hypersensitivity pneumonitis. J. Allergy Clin. Immunol. 57:328-334.
36. Mehrad, B., R. M. Strieter, and T. J. Standiford. 1999. Role of TNF-alpha in pulmonary host defense in murine invasive aspergillosis. J. Immunol. 162:1633-1640.
37. Mombaerts, P., et al. 1992. RAG-1-deficient mice have no mature B and T lymphocytes. Cell 68:869-877.
38. Morgenstern, D. E., M. A. Gifford, L. L. Li, C. M. Doerschuk, and M. C. Dinauer. 1997. Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus. J. Exp. Med. 185:207-218.
39. Murdock, B. J., et al. 2011. Coevolution of TH1, TH2, and TH17 responses during repeated pulmonary exposure to Aspergillus fumigatus conidia. Infect. Immun. 79:125-135.
40. Nurieva, R., et al. 2007. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448:480-483.
41. Pasqualotto, A. C., G. Powell, R. Niven, and D. W. Denning. 2009. The effects of antifungal therapy on severe asthma with fungal sensitization and allergic bronchopulmonary aspergillosis. Respirology 14:1121-1127.
42. Polak-Wyss, A. 1991. Protective effect of human granulocyte colony-stimulating factor (hG-CSF) on Cryptococcus and Aspergillus infections in normal and immunosuppressed mice. Mycoses 34:205-215.
43. Polikepahad, S., et al. 13 April 2010. A reversible, non-invasive method for airway resistance measurements and bronchoalveolar lavage fluid sampling in mice. J. Vis. Exp. doi:10.3791/1720.
44. Porter, P., et al. 2011. Respiratory tract allergic disease and atopy: experimental evidence for a fungal infectious etiology. Med. Mycol. 49(Suppl. 1):S158-S163.
45. Porter, P., et al. 2009. Link between allergic asthma and airway mucosal infection suggested by proteinase-secreting household fungi. Mucosal Immunol. 2:504-517.
46. Porter, P. C., V. Ongeri, A. Luong, F. Kheradmand, and D. B. Corry. 2011. Seeking common pathophysiology in asthma, atopy and sinusitis. Trends Immunol. 32:43-49.
47. Riley, D. J., J. W. Mackenzie, W. E. Uhlman, and N. H. Edelman. 1975. Allergic bronchopulmonary aspergillosis: evidence of limited tissue invasion. Am. Rev. Respir. Dis. 111:232-236.
48. Riscili, B. P., and K. L. Wood. 2009. Noninvasive pulmonary Aspergillus infections. Clin. Chest Med. 30:315-335.
49. Rivera, A., et al. 2006. Innate immune activation and CD4+ T cell priming during respiratory fungal infection. Immunity 25:665-675.
50. Romano, C., et al. 1997. Two cases of cutaneous phaeohyphomycosis by Alternaria alternata and Alternaria tenuissima. Mycopathologia 137:65-74.
51. Rosas, A. L., R. S. MacGill, J. D. Nosanchuk, T. R. Kozel, and A. Casadevall. 2002. Activation of the alternative complement pathway by fungal melanins. Clin. Diagn. Lab. Immunol. 9:144-148.
52. Sanchez, C., et al. 1995. Treatment of cerebral Aspergillosis with itraconazole: do high doses improve the prognosis? Clin. Infect. Dis. 21:1485-1487.
53. Sasada, M., and R. B. Johnston, Jr. 1980. Macrophage microbicidal activity. Correlation between phagocytosis-associated oxidative metabolism and the killing of Candida by macrophages. J. Exp. Med. 152:85-98.
54. Reference deleted
55. Schaffner, A., H. Douglas, and A. Braude. 1982. Selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to Aspergillus. Observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes. J. Clin. Invest. 69:617-631.
56. Schaffner, A., H. Douglas, A. I. Braude, and C. E. Davis. 1983. Killing of Aspergillus spores depends on the anatomical source of the macrophage. Infect. Immun. 42:1109-1115.
57. Reference deleted
58. Shoham, S., and S. M. Levitz. 2005. The immune response to fungal infections. Br. J. Haematol. 129:569-582.
59. Soubani, A. O., and P. H. Chandrasekar. 1988. The clinical spectrum of pulmonary aspergillosis. Chest 121:1988-1999.
60. Sturtevant, J. E., and J. P. Latge. 1992. Interactions between conidia of Aspergillus fumigatus and human complement component C3. Infect. Immun. 60:1913-1918.
61. Reference deleted
62. Vlahakis, N. E., and T. R. Aksamit. 2001. Diagnosis and treatment of allergic bronchopulmonary aspergillosis. Mayo Clin. Proc. 76:930-938.
63. Werner, J. L., et al. 2009. Requisite role for the dectin-1 beta-glucan receptor in pulmonary defense against Aspergillus fumigatus. J. Immunol. 182:4938-4946.