A role for the ubiquitin ligase Nedd4 in membrane sorting of LAPTM4 proteins

PLoS ONE

Volumn 6, Issue 11, 2011, Pages

  Milkereit, Ruth ^a   Rotin, Daniela ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 4A; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 4B; UBIQUITIN PROTEIN LIGASE NEDD4; UNCLASSIFIED DRUG; CARRIER PROTEIN; ESCRT PROTEIN; IMMEDIATE EARLY PROTEIN; LAPTM4A PROTEIN, HUMAN; LAPTM4A PROTEIN, MOUSE; LAPTM4B PROTEIN, HUMAN; LAPTM5 PROTEIN, HUMAN; LAPTM5 PROTEIN, MOUSE; MEMBRANE PROTEIN; NEDD4 UBIQUITIN PROTEIN LIGASES; ONCOPROTEIN; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FIBROBLAST; GENE OVEREXPRESSION; GENETIC CONSERVATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; KNOCKOUT MOUSE; LYSOSOME; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN TARGETING; AFFINITY CHROMATOGRAPHY; ANIMAL; CELL CULTURE; CELL LINE; CONFOCAL MICROSCOPY; GENETICS; METABOLISM; PHYSIOLOGY; PROTEIN TRANSPORT; UBIQUITINATION;

ANIMALS; CELL LINE; CELL MEMBRANE; CELLS, CULTURED; CHROMATOGRAPHY, AFFINITY; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; HUMANS; IMMEDIATE-EARLY PROTEINS; LYSOSOMES; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; MICROSCOPY, CONFOCAL; ONCOGENE PROTEINS; PROTEIN TRANSPORT; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 80855128821     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027478     Document Type: Article

References (50)

1. Shao GZ, Zhou RL, Zhang QY, Zhang Y, Liu JJ, et al. (2003) Molecular cloning and characterization of LAPTM4B, a novel gene upregulated in hepatocellular carcinoma. Oncogene 22: 5060-5069.
2. Hogue DL, Nash C, Ling V, Hobman TC, (2002) Lysosome-associated protein transmembrane 4 alpha (LAPTM4 alpha) requires two tandemly arranged tyrosine-based signals for sorting to lysosomes. Biochem J 365: 721-730.
3. Kasper G, Vogel A, Klaman I, Grone J, Petersen I, et al. (2005) The human LAPTM4b transcript is upregulated in various types of solid tumours and seems to play a dual functional role during tumour progression. Cancer Lett 224: 93-103.
4. Adra CN, Zhu S, Ko JL, Guillemot JC, Cuervo AM, et al. (1996) LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. Genomics 35: 328-337.
5. Hogue DL, Ellison MJ, Young JD, Cass CE, (1996) Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae. J Biol Chem 271: 9801-9808.
6. Cabrita MA, Hobman TC, Hogue DL, King KM, Cass CE, (1999) Mouse transporter protein, a membrane protein that regulates cellular multidrug resistance, is localized to lysosomes. Cancer Res 59: 4890-4897.
7. Hogue DL, Kerby L, Ling V, (1999) A mammalian lysosomal membrane protein confers multidrug resistance upon expression in Saccharomyces cerevisiae. J Biol Chem 274: 12877-12882.
8. Hayami Y, Iida S, Nakazawa N, Hanamura I, Kato M, et al. (2003) Inactivation of the E3/LAPTm5 gene by chromosomal rearrangement and DNA methylation in human multiple myeloma. Leukemia 17: 1650-1657.
9. Ouchida R, Yamasaki S, Hikida M, Masuda K, Kawamura K, et al. (2008) A lysosomal protein negatively regulates surface T cell antigen receptor expression by promoting CD3zeta-chain degradation. Immunity 29: 33-43.
10. Ouchida R, Kurosaki T, Wang JY, (2010) A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation. J Immunol 185: 294-301.
11. Li L, Wei XH, Pan YP, Li HC, Yang H, et al. (2010) LAPTM4B: a novel cancer-associated gene motivates multidrug resistance through efflux and activating PI3K/AKT signaling. Oncogene 29: 5785-5795.
12. Li Y, Zou L, Li Q, Haibe-Kains B, Tian R, et al. (2010) Amplification of LAPTM4B and YWHAZ contributes to chemotherapy resistance and recurrence of breast cancer. Nat Med 16: 214-218.
13. Peng C, Zhou RL, Shao GZ, Rui JA, Wang SB, et al. (2005) Expression of lysosome-associated protein transmembrane 4B-35 in cancer and its correlation with the differentiation status of hepatocellular carcinoma. World J Gastroenterol 11: 2704-2708.
14. Morris DG, Musat M, Czirjak S, Hanzely Z, Lillington DM, et al. (2005) Differential gene expression in pituitary adenomas by oligonucleotide array analysis. Eur J Endocrinol 153: 143-151.
15. Liu J, Zhou R, Zhang N, Rui J, Jin C, (2000) Biological function of a novel gene overexpressed in human hepatocellular carcinoma. Chin Med J (Engl) 113: 881-885.
16. Meng F, Luo C, Hu Y, Yin M, Lin M, et al. (2010) Overexpression of LAPTM4B-35 in cervical carcinoma: a clinicopathologic study. Int J Gynecol Pathol 29: 587-593.
17. Liu XR, Zhou RL, Zhang QY, Zhang Y, Jin YY, et al. (2004) Structure analysis and expressions of a novel tetratransmembrane protein, lysosoma-associated protein transmembrane 4 beta associated with hepatocellular carcinoma. World J Gastroenterol 10: 1555-1559.
18. Zhou L, He XD, Chen J, Cui QC, Qu Q, et al. (2007) Overexpression of LAPTM4B-35 closely correlated with clinicopathological features and post-resectional survival of gallbladder carcinoma. Eur J Cancer 43: 809-815.
19. Yang Y, Yang H, McNutt MA, Xiong F, Nie X, et al. (2008) LAPTM4B overexpression is an independent prognostic marker in ovarian carcinoma. Oncol Rep 20: 1077-1083.
20. Zhou L, He XD, Cui QC, Zhou WX, Qu Q, et al. (2008) Expression of LAPTM4B-35: a novel marker of progression, invasiveness and poor prognosis of extrahepatic cholangiocarcinoma. Cancer Lett 264: 209-217.
21. Yang H, Xiong F, Wei X, Yang Y, McNutt MA, et al. (2010) Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo. Cancer Lett.
22. Yang H, Xiong FX, Lin M, Yang Y, Nie X, et al. (2010) LAPTM4B-35 overexpression is a risk factor for tumor recurrence and poor prognosis in hepatocellular carcinoma. J Cancer Res Clin Oncol 136: 275-281.
23. He J, Shao G, Zhou R, (2003) Effects of the novel gene, LAPTM4B, highly expression in hepatocellular carcinoma on cell proliferation and tumorigenesis of NIH3T3 cells. Beijing Da Xue Xue Bao 35: 348-352.
24. Liu X, Xiong F, Wei X, Yang H, Zhou R, (2009) LAPTM4B-35, a novel tetratransmembrane protein and its PPRP motif play critical roles in proliferation and metastatic potential of hepatocellular carcinoma cells. Cancer Sci 100: 2335-2340.
25. Yin M, Xu Y, Lou G, Hou Y, Meng F, et al. (2010) LAPTM4B overexpression is a novel predictor of epithelial ovarian carcinoma metastasis. Int J Cancer.
26. Zhou L, He XD, Yu JC, Zhou RL, Yang H, et al. (2010) Overexpression of LAPTM4B promotes growth of gallbladder carcinoma cells in vitro. Am J Surg 199: 515-521.
27. Pak Y, Glowacka WK, Bruce MC, Pham N, Rotin D, (2006) Transport of LAPTM5 to lysosomes requires association with the ubiquitin ligase Nedd4, but not LAPTM5 ubiquitination. J Cell Biol 175: 631-645.
28. Bonifacino JS, Traub LM, (2003) Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu Rev Biochem 72: 395-447.
29. Boman AL, (2001) GGA proteins: new players in the sorting game. J Cell Sci 114: 3413-3418.
30. Edeling MA, Smith C, Owen D, (2006) Life of a clathrin coat: insights from clathrin and AP structures. Nat Rev Mol Cell Biol 7: 32-44.
31. Rotin D, Kumar S, (2009) Physiological functions of the HECT family of ubiquitin ligases. Nat Rev Mol Cell Biol 10: 398-409.
32. Stawiecka-Mirota M, Pokrzywa W, Morvan J, Zoladek T, Haguenauer-Tsapis R, et al. (2007) Targeting of Sna3p to the endosomal pathway depends on its interaction with Rsp5p and multivesicular body sorting on its ubiquitylation. Traffic 8: 1280-1296.
33. Fouladkou F, Landry T, Kawabe H, Neeb A, Lu C, et al. (2008) The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization. Proc Natl Acad Sci U S A 105: 8585-8590.
34. Liu X, Zhou R, Zhang Q, Zhang Y, Shao G, et al. (2003) [Identification and characterization of LAPTM4B encoded by a human hepatocellular carcinoma-associated novel gene]. Beijing Da Xue Xue Bao 35: 340-347.
35. Rajagopal A, Simon SM, (2003) Subcellular localization and activity of multidrug resistance proteins. Mol Biol Cell 14: 3389-3399.
36. Porcelli L, Lemos C, Peters GJ, Paradiso A, Azzariti A, (2009) Intracellular trafficking of MDR transporters and relevance of SNPs. Curr Top Med Chem 9: 197-208.
37. Yilmaz M, Christofori G, (2009) EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 28: 15-33.
38. Passey S, Pellegrin S, Mellor H, (2004) What is in a filopodium? Starfish versus hedgehogs. Biochem Soc Trans 32: 1115-1117.
39. Pollard TD, (2007) Regulation of actin filament assembly by Arp2/3 complex and formins. Annu Rev Biophys Biomol Struct 36: 451-477.
40. Helliwell SB, Losko S, Kaiser CA, (2001) Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease. J Cell Biol 153: 649-662.
41. Soetens O, De Craene JO, Andre B, (2001) Ubiquitin is required for sorting to the vacuole of the yeast general amino acid permease, Gap1. J Biol Chem 276: 43949-43957.
42. Steenhuis P, Herder S, Gelis S, Braulke T, Storch S, (2010) Lysosomal targeting of the CLN7 membrane glycoprotein and transport via the plasma membrane require a dileucine motif. Traffic 11: 987-1000.
43. Letourneur F, Klausner RD, (1992) A novel di-leucine motif and a tyrosine-based motif independently mediate lysosomal targeting and endocytosis of CD3 chains. Cell 69: 1143-1157.
44. Bagshaw RD, Mahuran DJ, Callahan JW, (2005) A proteomic analysis of lysosomal integral membrane proteins reveals the diverse composition of the organelle. Mol Cell Proteomics 4: 133-143.
45. Chen C, Okayama H, (1987) High-efficiency transformation of mammalian cells by plasmid DNA. Mol Cell Biol 7: 2745-2752.
46. Treier M, Staszewski LM, Bohmann D, (1994) Ubiquitin-dependent c-Jun degradation in vivo is mediated by the delta domain. Cell 78: 787-798.
47. Rodriguez-Paris JM, Nolta KV, Steck TL, (1993) Characterization of lysosomes isolated from Dictyostelium discoideum by magnetic fractionation. J Biol Chem 268: 9110-9116.
48. Diettrich O, Mills K, Johnson AW, Hasilik A, Winchester BG, (1998) Application of magnetic chromatography to the isolation of lysosomes from fibroblasts of patients with lysosomal storage disorders. FEBS Lett 441: 369-372.
49. Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, et al. (2007) ClustalW and ClustalX version 2. Bioinformatics 23: 2947-2948.
50. Letunic I, Doerks T, Bork P, (2009) SMART 6: recent updates and new developments. Nucleic Acids Res 37: D229-232.