A possible role for long non-coding RNA in modulating signaling pathways

Medical Hypotheses

Volumn 77, Issue 6, 2011, Pages 962-965

  Rotblat, Barak ^a   Leprivier, Gabriel ^a   Sorensen, Poul H B ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P53; RAS PROTEIN; UNTRANSLATED RNA;

ARTICLE; BIOLOGICAL PHENOMENA AND FUNCTIONS CONCERNING THE ENTIRE ORGANISM; BREAST CARCINOMA; ENZYME ACTIVITY; EWING SARCOMA; GENE EXPRESSION; HUMAN; LUNG CARCINOMA; LUNG NON SMALL CELL CANCER; MUTANT; NEOPLASM; ONCOGENE RAS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

EVOLUTION, MOLECULAR; HUMANS; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; RAS PROTEINS; RNA, UNTRANSLATED; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 80755189026     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2011.08.020     Document Type: Article

References (37)

1. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
2. Cox A.D., Der C.J. The dark side of Ras: regulation of apoptosis. Oncogene 2003, 22:8999-9006.
3. Pe'er D., Hacohen N. Principles and strategies for developing network models in cancer. Cell 2011, 144:864-873.
4. Costa F.F. Non-coding RNAs: meet thy masters. Bioessays 2010, 32:599-608.
5. Ponting C.P., Oliver P.L., Reik W. Evolution and functions of long noncoding RNAs. Cell 2009, 136:629-641.
6. Gibb E.A., Brown C.J., Lam W.L. The functional role of long non-coding RNA in human carcinomas. Mol Cancer 2011, 10:38.
7. Ponjavic J., Ponting C.P., Lunter G. Functionality or transcriptional noise? Evidence for selection within long noncoding RNAs. Genome Res 2007, 17:556-565.
8. Campbell S.L., Khosravi-Far R., Rossman K.L., Clark G.J., Der C.J. Increasing complexity of Ras signaling. Oncogene 1998, 17:1395-1413.
9. Mitin N., Rossman K.L., Der C.J. Signaling interplay in Ras superfamily function. Curr Biol 2005, 15:R563-R574.
10. Karnoub A.E., Weinberg R.A. Ras oncogenes: split personalities. Nat Rev Mol Cell Biol 2008, 9:517-531.
11. Omerovic J., Laude A.J., Prior I.A. Ras proteins: paradigms for compartmentalised and isoform-specific signalling. Cell Mol Life Sci 2007, 64:2575-2589.
12. Goi T., Rusanescu G., Urano T., Feig L.A. Ral-specific guanine nucleotide exchange factor activity opposes other Ras effectors in PC12 cells by inhibiting neurite outgrowth. Mol Cell Biol 1999, 19:1731-1741.
13. Sternberg P.W., Horvitz H.R. The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans. Cell 1989, 58:679-693.
14. Zand T.P., Reiner D.J., Der C.J. Ras effector switching promotes divergent cell fates in C. elegans vulval patterning. Dev Cell 2011, 20:84-96.
15. Ozaki Y., Sasagawa S., Kuroda S. Dynamic characteristics of transient responses. J Biochem 2005, 137:659-663.
16. Claperon A., Therrien M. KSR and CNK: two scaffolds regulating RAS-mediated RAF activation. Oncogene 2007, 26:3143-3158.
17. Philips M.R. Compartmentalized signalling of Ras. Biochem Soc Trans 2005, 33:657-661.
18. Henis Y.I., Hancock J.F., Prior I.A. Ras acylation, compartmentalization and signaling nanoclusters (Review). Mol Membr Biol 2009, 26:80-92.
19. Ashery U., Yizhar O., Rotblat B., Kloog Y. Nonconventional trafficking of Ras associated with Ras signal organization. Traffic 2006, 7:119-126.
20. Eisenberg S., Shvartsman D.E., Ehrlich M., Henis Y.I. Clustering of raft-associated proteins in the external membrane leaflet modulates internal leaflet H-ras diffusion and signaling. Mol Cell Biol 2006, 26:7190-7200.
21. Elad-Sfadia G., Haklai R., Ballan E., Gabius H.J., Kloog Y. Galectin-1 augments Ras activation and diverts Ras signals to Raf-1 at the expense of phosphoinositide 3-kinase. J Biol Chem 2002, 277:37169-37175.
22. Nancy V., Callebaut I., El Marjou A., de Gunzburg J. The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. J Biol Chem 2002, 277:15076-15084.
23. Sasaki A.T., Carracedo A., Locasale J.W., et al. Ubiquitination of k-ras enhances activation and facilitates binding to select downstream effectors. Sci Signal 2011, 4:ra13.
24. Roy S., Plowman S., Rotblat B., et al. Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling. Mol Cell Biol 2005, 25:6722-6733.
25. Tsai M.C., Manor O., Wan Y., et al. Long noncoding RNA as modular scaffold of histone modification complexes. Science 2010, 329:689-693.
26. Wang X., Arai S., Song X., et al. Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature 2008, 454:126-130.
27. Boguski M.S., McCormick F. Proteins regulating Ras and its relatives. Nature 1993, 366:643-654.
28. Mayer G., Blind M., Nagel W., et al. Controlling small guanine-nucleotide-exchange factor function through cytoplasmic RNA intramers. Proc Natl Acad Sci USA 2001, 98:4961-4965.
29. Mattick J.S. Challenging the dogma: the hidden layer of non-protein-coding RNAs in complex organisms. Bioessays 2003, 25:930-939.
30. Guttman M., Amit I., Garber M., et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature 2009, 458:223-227.
31. Huarte M., Rinn J.L. Large non-coding RNAs: missing links in cancer?. Hum Mol Genet 2010, 19:R152-R161.
32. Kapranov P., St Laurent G., Raz T., et al. The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNA. BMC Biol 2010, 8:149.
33. Silva J.M., Perez D.S., Pritchett J.R., Halling M.L., Tang H., Smith D.I. Identification of long stress-induced non-coding transcripts that have altered expression in cancer. Genomics 2010, 95:355-362.
34. Ji P., Diederichs S., Wang W., et al. MALAT-1, a novel noncoding RNA, and thymosin beta4 predict metastasis and survival in early-stage non-small cell lung cancer. Oncogene 2003, 22:8031-8041.
35. Gupta R.A., Shah N., Wang K.C., et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 2010, 464:1071-1076.
36. Huarte M., Guttman M., Feldser D., et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 2010, 142:409-419.
37. Khalil A.M., Guttman M., Huarte M., et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci USA 2009, 106:11667-11672.