Protein kinase C ζ is a positive modulator of canonical wnt signaling pathway in tumoral colon cell lines

Carcinogenesis

Volumn 32, Issue 11, 2011, Pages 1615-1624

  Luna ulloa, Luis Bernardo ^a   Hernández maqueda, José G ^a   Santoyo ramos, Paula ^a   Castaneda patlan M Cristina ^a   Robles flores, Martha ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; PROTEIN KINASE C ZETA; SMALL INTERFERING RNA; WNT PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENIC ACTIVITY; COLON TUMOR; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; BETA CATENIN; BLOTTING, WESTERN; CELL ADHESION; CELL MOVEMENT; CELL NUCLEUS; CELL PROLIFERATION; CELLS, CULTURED; COLON; COLONIC NEOPLASMS; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, DOMINANT; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; INTESTINES; LUCIFERASES; MICE; MICE, NUDE; PROTEIN KINASE C; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TRANSCRIPTIONAL ACTIVATION; WNT SIGNALING PATHWAY;

EID: 80755187835     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgr190     Document Type: Article

References (44)

1. Radtke,F. et al. (2005) Self-renewal and cancer of the gut: two sides of a coin. Science, 307, 1904-1909.
2. Logan,C. et al. (2004) The Wnt signaling pathway in development and disease. Ann. Rev. Cell Dev. Biol., 20, 781-810.
3. Katoh,M. et al. (2007) WNT signaling pathway and stem cell signaling network. Clin Cancer Res., 13, 4042-4045.
4. Slusarski,D.C. et al. (1997) Interaction of Wnt and a Frizzled homologue triggers G-proteinlinked phosphatidylinositol signalling. Nature, 390, 410-413.
5. Slusarski,D.C. et al. (1997) Modulation of embryonic intracellular Ca2+ signalling by Wnt-5A. Dev. Biol., 182, 114-120.
6. Sheldahl,L.C. et al. (1999) Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr. Biol., 9, 695-698.
7. Medina,A. et al. (2000) Xenopus frizzled 7 can act in canonical and noncanonical Wnt signalling pathways: implications on early patterning and morphogenesis. Mech. Dev., 92, 227-237.
8. Kuhl,M. et al. (2001) Antagonistic regulation of convergent extension movements in Xenopus by Wnt/_b-catenin and Wnt/Ca2+ signaling. Mech. Dev., 106, 61-76.
9. Kinoshita,N. et al. (2003) PKCd is essential for Dishevelled function in a noncanonical Wnt pathway that regulates Xenopus convergent extension movements. Genes Dev., 17, 1663-1676.
10. Goode,N. et al. (1992) Differential regulation of glycogen synthase kinase 3 by protein kinase C isotypes. J. Biol. Chem., 267, 16878-16882.
11. Cook,D. et al. (1996)Wingless inactivates GSK3 via an intracellular signaling pathway which involves a protein kinase C. EMBO J., 15, 4526-4536.
12. Orford,K. et al. (1997) Serine Phosphorylation-regulated Ubiquitination and Degradation of b-Catenin. J. Biol. Chem., 272, 24735-24738.
13. Hers,I. et al. (1999) The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity. FEBS Lett., 460, 433-436.
14. Fields,A.P. et al. (2003) Protein kinase C in disease: cancer. Methods Mol. Biol., 233, 519-537.
15. Gokmen-Polar,Y. et al. (2001) Elevated protein kinase C bII is an early promotive event in colon carcinogenesis. Cancer Res., 61, 1375-1381.
16. Zhang,J. et al. (2004) Protein kinase C (PKC) bII induces cell invasion trough a RasMek-, PKCi/Rac 1-dependent signaling pathway. J. Biol. Chem., 279, 22118-22123.
17. Ohno,S. et al. (2002) Protein kinase C isotypes and their specific functions: prologue. J. Biochem., 132, 509-511.
18. Nakanishi,H. et al. (1993) Activation of the f isozyme of protein kinase C by phosphatidylinositol 3, 4, 5-trisphosphate. J. Biol. Chem., 268, 13-16.
19. Akimoto,K. et al. (1996) EGF or PDGF receptors activate atypical PKCf through phosphatidylinositol 3-kinase. EMBO J., 15, 788-798.
20. Chou,M.M. et al. (1998) Regulation of protein kinase C zeta by PI 3-kinase and PDK-1. Curr. Biol., 8, 1069-1077.
21. Diaz-Meco,M.T. et al. (1996) The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell, 86, 777-786.
22. Hirai,T. et al. (2003) Protein kinase Cf (PKCf): activation mechanisms and cellular functions. J. Biochem., 133, 1-7.
23. Lin,D. et al. (2000) A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signaling and cell polarity. Nat. Cell Biol. 2, 540-547.
24. Berra,E. et al. (1995) Evidence for a role of MEK and MAPK during signal transduction by protein kinase Cf. EMBO J., 14, 6157-6163.
25. Schönwasser,D.C. et al. (1998) Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway by conventional, novel, and atypical protein kinase C isotypes. Mol. Cell. Biol., 18, 790-798.
26. Chou,M.M. et al. (1998) Regulation of protein kinase C zeta by PI3-kinase and PDK-1. Curr. Biol., 8, 1069-1077.
27. Kolligs,F.T. et al. (1999) Neoplastic transformation of RK3E by mutant beta-catenin requires deregulation of Tcf/Lef transcription but not activation of c-myc expression. Mol. Cell. Biol., 19, 5696-5706.
28. Storz,P. et al. (2004) Protein kinase C delta selectively regulates protein kinase D-dependent activation of NF-kappaB in oxidative stress signaling. Mol. Cell. Biol., 24, 2614-2626.
29. Reyland,M.E. (2009) Protein kinase C isoforms: multi-functional regulators of cell life and death. Front Biosci., 14, 2386-2399.
30. Baluch,D.P. et al. (2008) GSK3b mediates acentromeric spindle stabilization by activated PKCf. Dev. Biol., 317, 46-58.
31. Fagotto,F. et al. (1998) Nuclear localization signal-independent and importin/ karyopherin-independent nuclear import of b-catenin. Curr. Biol., 8, 181-190.
32. Kulay,U. et al. (1997) Dominant-negative mutants of importin-b block multiple pathways of import and export through the nuclear pore complex. EMBO J., 16, 1153-1163.
33. Henderson,B.R. et al. (2002) The ins and outs of APC and b-catenin nuclear transport. EMBO Rep., 3, 834-839.
34. Cong,F. et al. (2004) Nuclear-cytoplasmic shuttling of Axin regulates subcellular localization of beta-catenin. Proc. Natl Acad. Sci. USA, 101, 2882-2887.
35. Ki,H. et al. (2008) b-catenin can bind directly to CRM1 independently of adenomatous polyposis coli, which affects its nuclear localization and LEF-1/b-catenin-dependent gene expression. Cell Biol. Int., 32, 394-400.
36. Ki,H. et al. (2006) Overexpressed LEF-1 proteins display different nuclear localization patterns of beta-catenin in normal versus tumor cells. Cell Biol. Int., 30, 253-261.
37. Hendriksen,J. et al. (2005) RanBP3 enhances nuclear export of active b-catenin independently of CRM1. J. Cell Biol., 171, 785e97.
38. Takemaru,K. et al. (2009) Fine-tuning of nuclear-catenin by chibby and 14-3-3. Cell Cycle, 8, 210-213.
39. Zhang,X. et al. (2007) Dishevelled promotes axon differentiation by regulating atypical protein kinase C. Nat. Cell Biol., 9, 743-754.
40. Wolf,A.M. et al. (2008) Phosphatidylinositol-3-kinase-Atypical proteína kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance. J Neurosci., 28, 3456-3467.
41. Fields,A.P. et al. (2007) Protein kinase Ci: human oncogene, prognostic marker and therapeutic target. Pharmacol. Res., 55, 487-497.
42. Seth,R. et al. (2009) Concomitant mutations and splice variants in KS and BRAF demonstrate complex perturbation or the Ras/Raf signaling pathway in advanced colorectal cancer. Gut., 58, 1234-1241.
43. Sun,J. et al. (2008) Both Wnt and mTOR signaling pathways are involved in insulin-stimulated proto-oncogene expression in intestinal cells. Cell. Signal., 20, 219-229.
44. Phelps,R.A. et al. (2009) A two-step model for colon adenoma initiation and progression caused by APC loss. Cell, 137, 623-634.