Host cytosolic phospholipase A2α contributes to group B streptococcus penetration of the blood-brain barrier

Infection and Immunity

Volumn 79, Issue 10, 2011, Pages 4088-4093

  Maruvada, Ravi ^a   Zhu, Longkun ^a   Pearce, Donna ^a   Sapirstein, Adam ^b   Kim, Kwang Sik ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Anesthesiology and Critical Care Medicine ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; CYTOSOLIC PHOSPHOLIPASE A2; CYTOSOLIC PHOSPHOLIPASE A2 ALPHA; MEMBRANE PHOSPHOLIPID; PEPTIDOLEUKOTRIENE; PROTEIN KINASE C ALPHA; UNCLASSIFIED DRUG;

ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BRAIN; CELL INVASION; CONTROLLED STUDY; DISEASE COURSE; ENZYME RELEASE; GENE DELETION; GROUP B STREPTOCOCCAL MENINGITIS; HOST; LIPID MONOLAYER; MICROVASCULAR ENDOTHELIAL CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECIES INVASION; STREPTOCOCCUS AGALACTIAE;

ARACHIDONIC ACID; BLOOD-BRAIN BARRIER; BRAIN; CELLS, CULTURED; CYSTEINE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HUMANS; LEUKOTRIENES; MICROCIRCULATION; PHOSPHOLIPASES A2, CYTOSOLIC; PROTEIN KINASE C-ALPHA; STREPTOCOCCUS AGALACTIAE;

EID: 80755180516     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.05506-11     Document Type: Article

References (41)

1. Anfuso, C. D., et al. 2007. Endothelial cell-pericyte cocultures induce PLA2 protein expression through activation of PKCα and the MAPK/ERK cascade. J. Lipid Res. 48:782-793.
2. Berman, P. H., and B. Q. Banker. 1966. Neonatal meningitis. A clinical and pathological study of 29 cases. Pediatrics 38:6-24.
3. Centers for Disease Control and Prevention. 1996. Postnatal causes of development disabilities in children aged 3-10 years, Atlanta, Georgia, 1991. MMWR Morb. Mortal. Wkly. Rep. 45:130-134.
4. Das, A., et al. 2001. Differential role of cytosolic phospholipase A2 in the invasion of brain microvascular endothelial cells by Escherichia cells and Listeria monocytogenes. J. Infect. Dis. 184:732-737.
5. de Louvois, J., S. Halket, and D. Harvey. 2004. Neonatal meningitis in England and Wales: sequelae at 5 years of age. Eur. J. Pediatr. 7:730-734.
6. Doctor, B. A., et al. 2001. Clinical outcomes of neonatal meningitis in verylow birth-weight infants. Clin. Pediatr. 40:473-480.
7. Doran, K. S., et al. 2005. Blood-brain barrier invasion by group B streptococcus depends upon proper cell-surface anchoring of lipoteichoic acid. J. Clin. Invest. 115:2499-2507.
8. Ferrieri, P., B. Burke, and J. Nelson. 1980. Production of bacteremia and meningitis in infant rats with group B streptococcal serotypes. Infect. Immun. 27:1023-1032.
9. Ghosh, M., D. E. Tucker, S. A. Burchett, and C. C. Leslie. 2006. Properties of the group IV phospholipase A2 family. Prog. Lipid Res. 45:487-510.
10. Glaser, P., et al. 2002. Genome sequence of Streptococcus agalactiae, a pathogen causing invasive neonatal disease. Mol. Microbiol. 45:1499-1513.
11. Hegen, M., et al. 2003. Cytosolic phospholipase A2alpha-deficient mice are resistant to collagen-induced arthritis. J. Exp. Med. 197:1297-1302.
12. Holt, D. E., S. Halket, J. de Louvois, and D. Harvey. 2001. Neonatal meningitis in England and Wales: 10 years on. Arch. Dis. Child. Fetal Neonatal Ed. 84:F85-F89.
13. Hristeva, L., R. Booy, I. Bowler, and A. R. Wilkinson. 1993. Prospective surveillance of neonatal meningitis. Arch. Dis. Child. 69:14-18.
14. Hryciw, D. H., C. A. Pollock, and P. Pronnik. 2005. PKCα-mediated remodeling of the actin cytoskeleton is involved in constitutive albumin uptake by proximal tubule cells. Am. J. Physiol. Renal Physiol. 288:F1227-F1235.
15. Ichinose, F., et al. 2002. Cytosolic phospholipase A(2) in hypoxic pulmonary vasoconstriction. J. Clin. Invest. 109:1493-1500.
16. Jones, N., et al. 2003. Multilocus sequence typing system for group B Streptococcus. J. Clin. Microbiol. 41:2530-2536.
17. Kim, K. S., and B. F. Anthony. 1981. Penicillin tolerance in group B streptococci isolated from septic newborn infants. J. Infect. Dis. 144:411-419.
18. Kim, K. S. 2003. Neurological diseases: pathogenesis of bacterial meningitis: from bacteremia to neuronal injury. Nat. Rev. Neurosci. 4:376-385.
19. Kim, K. S. 1987. Effect of antimicrobial therapy for experimental infections due to group B Streptococcus on mortality and clearance of bacteria. J. Infect. Dis. 155:1233-1241.
20. Kim, K. S. 2008. Mechanisms of microbial traversal of the blood-brain barrier. Nat. Rev. Microbiol. 6:625-634.
21. Kim, Y. V., F. DiCello, C. S. Hillaire, and K. S. Kim. 2004. Protease-activated receptors of human brain microvascular endothelial cells: expression and differential Ca2+ signaling induced by thrombin and protease-activated receptor-1 activating peptide. Am. J. Physiol. Cell Physiol. 286:C31-C42.
22. Klinger, G., C. N. Chin, J. Beyene, and M. Perlman. 2000. Predicting the outcome of neonatal bacterial meningitis. Pediatrics 106:477-482.
23. Lamy, M. C., et al. 2006. Rapid detection of the "highly virulent" group B Streptococcus ST-17 clone. Microbes Infect. 8:1714-1722.
24. Larsson, C. 2006. Protein kinase C and the regulation of the actin cytoskeleton. Cell. Signal. 18:276-284.
25. Levent, F., C. A. Baker, M. A. Rench, and M. S. Edwards. 2010. Early outcomes of group B streptococcal meningitis in the 21st century. Pediatr. Infect. Dis. J. 29:1009-1012.
26. Maisey, H. C., K. S. Doran, and V. Nizet. 2008. Recent advances in understanding the molecular basis of group B streptococcal virulence. Expert Rev. Mol. Med. 10:e27.
27. Manning, S. D., et al. 2009. Multilocus sequence types associated with neonatal group B streptococcal sepsis and meningitis in Canada. J. Clin. Microbiol. 47:1143-1148.
28. Miyaura, C., et al. 2003. An essential role of cytosolic phospholipase A2 in prostaglandin E2-mediated bone resorption associated with inflammation. J. Exp. Med. 197:1303-1310.
29. Musser, J. M., S. J. Mattingly, R. Quentin, A. Goudeau, and R. K. Selander. 1989. Identification of a high-virulence clone of type III Streptococcus agalactiae (group B Streptococcus) causing invasive neonatal disease. Proc. Natl. Acad. Sci. U. S. A. 86:4731-4735.
30. Nagase, T., et al. 2002. A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis. Nat. Med. 8:480-484.
31. Nizet, V., et al. 1997. Invasion of brain microvascular endothelial cells by group B streptococci. Infect. Immun. 65:5074-5081.
32. Pavicevic, Z., C. C. Leslie, and K. U. Malik. 2008. cPLA2 phosphorylation at serine-515 and serine-505 is required for arachidonic acid release in vascular smooth muscle cells. J. Lipid Res. 49:724-737.
33. Peters-Golden, M., and W. R. Henderson. 2007. Leukotrienes. N. Engl. J. Med. 357:1841-1854.
34. Ruffer, C., A. Strey, A. Janning, K. S. Kim, and V. Gerke. 2004. Cell-cell junctions of dermal microvascular endothelial cells contain tight and adherens junction proteins in spatial proximity. Biochemistry 43:5360-5369.
35. Shin, S., and K. S. Kim. 2006. RhoA and Rac1 contribute to type III group B streptococcal invasion of human brain microvascular endothelial cells. Biochem. Biophys. Res. Commun. 345:538-542.
36. Shin, S., P. Maneesh, J. Lee, L. Romer, and K. S. Kim. 2006. Focal adhesion kinase is involved in type III group B streptococcal invasion of human brain microvascular endothelial cells. Microb. Pathog. 41:168-173.
37. Stevens, J. P., et al. 2003. Long-term outcome of neonatal meningitis. Arch. Dis. Child. Fetal Neonatal Ed. 88:F179-F184.
38. Stins, M. F., F. Gilles, and K. S. Kim. 1997. Selective expression of adhesion molecules on human brain microvascular endothelial cells. J. Neuroimmunol. 76:81-90.
39. Tazi, A., et al. 2010. The surface protein HvgA mediates group B Streptococcus hypervirulence and meningeal tropism in neonates. J. Exp. Med. 207:2313-2322.
40. Tenenbaum, T., et al. 2007. Adherence to and invasion of human brain microvascular endothelial cells is promoted by the laminin-binding protein Lmb of Streptococcus agalactiae. Microbes Infect. 9:714-720.
41. Zhu, L., et al. 2010. Arachidonic acid metabolism regulates Escherichia coli penetration of the blood-brain barrier. Infect. Immun. 78:4302-4310.