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Volumn 5, Issue 3, 2011, Pages 113-119

Echinocandin-resistant Candida: Molecular methods and phenotypes

Author keywords

Anidulafungin; Candida albicans; Candida glabrata; Caspofungin; Clinical breakpoint; Echinocandins; Epidemiologic cutoff value; FKS; Glucan synthase; Micafungin; Resistance

Indexed keywords

ANIDULAFUNGIN; CASPOFUNGIN; ECHINOCANDIN; GLUCAN SYNTHASE; MICAFUNGIN;

EID: 80755153763     PISSN: 19363761     EISSN: 1936377X     Source Type: Journal    
DOI: 10.1007/s12281-011-0054-x     Document Type: Review
Times cited : (16)

References (50)
  • 5
    • 77953677793 scopus 로고    scopus 로고
    • Caspofungin use in daily clinical practice for treatment of invasive aspergillosis: Results of a prospective observational registry
    • Maertens J, Egerer G, Shin WS, et al. Caspofungin use in daily clinical practice for treatment of invasive aspergillosis: results of a prospective observational registry. BMC Infect Dis. 2010;10:182.
    • (2010) BMC Infect Dis , vol.10 , pp. 182
    • Maertens, J.1    Egerer, G.2    Shin, W.S.3
  • 6
    • 77955112550 scopus 로고    scopus 로고
    • Micafungin: A brief review of pharmacology, safety, and antifungal efficacy in pediatric patients
    • Lehrnbecher T, Groll AH. Micafungin: a brief review of pharmacology, safety, and antifungal efficacy in pediatric patients. Pediatr Blood Cancer. 2010;55:229-32.
    • (2010) Pediatr Blood Cancer , vol.55 , pp. 229-32
    • Lehrnbecher, T.1    Groll, A.H.2
  • 8
    • 33750553597 scopus 로고    scopus 로고
    • The safety of anidulafungin
    • DOI 10.1517/14740338.5.6.751
    • Vazquez JA. The safety of anidulafungin. Expert Opin Drug Saf. 2006;5:751-8. (Pubitemid 44669490)
    • (2006) Expert Opinion on Drug Safety , vol.5 , Issue.6 , pp. 751-758
    • Vazquez, J.A.1
  • 10
    • 0036720290 scopus 로고    scopus 로고
    • The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitro
    • Bowman JC, Hicks PS, Kurtz MB, et al. The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitro. Antimicrob Agents Chemother. 2002;46:3001-12.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 3001-12
    • Bowman, J.C.1    Hicks, P.S.2    Kurtz, M.B.3
  • 12
    • 0036266003 scopus 로고    scopus 로고
    • In vitro activity of caspofungin (MK-0991) against Candida albicans clinical isolates displaying different mechanisms of azole resistance
    • DOI 10.1128/JCM.40.6.2228-2230.2002
    • Bachmann SP, Patterson TF, Lopez-Ribot JL. In vitro activity of caspofungin (MK-0991) against Candida albicans clinical isolates displaying different mechanisms of azole resistance. J Clin Microbiol. 2002;40:2228-30. (Pubitemid 34596413)
    • (2002) Journal of Clinical Microbiology , vol.40 , Issue.6 , pp. 2228-2230
    • Bachmann, S.P.1    Patterson, T.F.2    Lopez-Ribot, J.L.3
  • 14
    • 0141863188 scopus 로고    scopus 로고
    • Echinocandin antifungal drugs
    • DOI 10.1016/S0140-6736(03)14472-8
    • DenningDW. Echinocandin antifungal drugs. Lancet. 2003;362:1142-51. (Pubitemid 37222342)
    • (2003) Lancet , vol.362 , Issue.9390 , pp. 1142-1151
    • Denning, D.W.1
  • 15
    • 34447105864 scopus 로고    scopus 로고
    • Resistance to echinocandin-class antifungal drugs
    • DOI 10.1016/j.drup.2007.04.002, PII S1368764607000404
    • Perlin DS. Resistance to echinocandin-class antifungal drugs. Drug Resist Updat. 2007;10:121-30. (Pubitemid 47031054)
    • (2007) Drug Resistance Updates , vol.10 , Issue.3 , pp. 121-130
    • Perlin, D.S.1
  • 16
    • 79955538785 scopus 로고    scopus 로고
    • Clinical breakpoints for the echinocandins and Candida revisited: Integration of molecular, clinical, and microbiological data to arrive at speciesspecific interpretive criteria
    • Feb 23 (Epub ahead of print). This critical report summarizes data used by the CLSI to establish revised clinical breakpoints for echinocandin susceptibility and resistance
    • Pfaller MA, Diekema DJ, Andes D, et al. Clinical breakpoints for the echinocandins and Candida revisited: Integration of molecular, clinical, and microbiological data to arrive at speciesspecific interpretive criteria. Drug Resist Updat. 2011, Feb 23 (Epub ahead of print). This critical report summarizes data used by the CLSI to establish revised clinical breakpoints for echinocandin susceptibility and resistance.
    • (2011) Drug Resist Updat
    • Pfaller, M.A.1    Diekema, D.J.2    Andes, D.3
  • 17
    • 79955625171 scopus 로고    scopus 로고
    • Current perspectives on echinocandin class drugs
    • Perlin DS. Current perspectives on echinocandin class drugs. Future Microbiol. 2011;6:441-57.
    • (2011) Future Microbiol , vol.6 , pp. 441-57
    • Perlin, D.S.1
  • 18
    • 38149134281 scopus 로고    scopus 로고
    • In vitro susceptibility of invasive isolates of Candida spp. to anidulafungin, caspofungin, and micafungin: Six years of global surveillance
    • Pfaller MA, Boyken L, Hollis RJ, et al. In vitro susceptibility of invasive isolates of Candida spp. to anidulafungin, caspofungin, and micafungin: six years of global surveillance. J Clin Microbiol. 2008;46:150-6.
    • (2008) J Clin Microbiol , vol.46 , pp. 150-6
    • Pfaller, M.A.1    Boyken, L.2    Hollis, R.J.3
  • 19
    • 73949126140 scopus 로고    scopus 로고
    • Wild-type MIC distributions and epidemiological cutoff values for the echinocandins and Candida spp
    • Pfaller MA, Boyken L, Hollis RJ, et al. Wild-type MIC distributions and epidemiological cutoff values for the echinocandins and Candida spp. J Clin Microbiol. 2010;48:52-6.
    • (2010) J Clin Microbiol , vol.48 , pp. 52-6
    • Pfaller, M.A.1    Boyken, L.2    Hollis, R.J.3
  • 20
    • 53149145998 scopus 로고    scopus 로고
    • Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin, and micafungin: Analysis and proposal for interpretive MIC breakpoints
    • Pfaller MA, Diekema DJ, Ostrosky-Zeichner L, et al. Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin, and micafungin: analysis and proposal for interpretive MIC breakpoints. J Clin Microbiol. 2008;46:2620-9.
    • (2008) J Clin Microbiol , vol.46 , pp. 2620-9
    • Pfaller, M.A.1    Diekema, D.J.2    Ostrosky-Zeichner, L.3
  • 21
    • 79951502711 scopus 로고    scopus 로고
    • Use of epidemiological cutoff values to examine 9-year trends in susceptibility of Candida species to anidulafungin, caspofungin, and micafungin
    • Pfaller M, Boyken L, Hollis R, Kroeger J, Messer S, Tendolkar S, et al. Use of epidemiological cutoff values to examine 9-year trends in susceptibility of Candida species to anidulafungin, caspofungin, and micafungin. J Clin Microbiol. 2011;49(2):624.
    • (2011) J Clin Microbiol , vol.49 , Issue.2 , pp. 624
    • Pfaller, M.1    Boyken, L.2    Hollis, R.3    Kroeger, J.4    Messer, S.5    Tendolkar, S.6
  • 22
    • 80755174636 scopus 로고    scopus 로고
    • This is a comprehensive global surveillance study identifying non-wild-type clinical isolates by species and drug
    • This is a comprehensive global surveillance study identifying non-wild-type clinical isolates by species and drug.
  • 23
    • 78650859229 scopus 로고    scopus 로고
    • National surveillance of fungemia in Denmark (2004 to 2009)
    • Arendrup MC, Bruun B, Christensen JJ, et al. National surveillance of fungemia in Denmark (2004 to 2009). J Clin Microbiol. 2011;49:325-34.
    • (2011) J Clin Microbiol , vol.49 , pp. 325-34
    • Arendrup, M.C.1    Bruun, B.2    Christensen, J.J.3
  • 24
    • 78751679700 scopus 로고    scopus 로고
    • Candida bloodstream infections: Comparison of species distributions and antifungal resistance patterns in community-onset and nosocomial isolates in the SENTRY Antimicrobial Surveillance Program, 2008-2009
    • Pfaller MA, Moet GJ, Messer SA, et al. Candida bloodstream infections: comparison of species distributions and antifungal resistance patterns in community-onset and nosocomial isolates in the SENTRY Antimicrobial Surveillance Program, 2008-2009. Antimicrob Agents Chemother. 2011;55:561-6.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 561-6
    • Pfaller, M.A.1    Moet, G.J.2    Messer, S.A.3
  • 25
    • 78649671319 scopus 로고    scopus 로고
    • FKS mutations and elevated echinocandin MIC values among Candida glabrata isolates from U.S. population-based surveillance
    • Zimbeck AJ, Iqbal N, Ahlquist AM, et al. FKS mutations and elevated echinocandin MIC values among Candida glabrata isolates from U.S. population-based surveillance. Antimicrob Agents Chemother. 2010;54:5042-7.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 5042-7
    • Zimbeck, A.J.1    Iqbal, N.2    Ahlquist, A.M.3
  • 26
    • 77952648499 scopus 로고    scopus 로고
    • Low prevalence of fks1 hot spot 1 mutations in a worldwide collection of Candida strains
    • Castanheira M, Woosley LN, Diekema DJ, et al. Low prevalence of fks1 hot spot 1 mutations in a worldwide collection of Candida strains. Antimicrob Agents Chemother. 2010;54:2655-9.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 2655-9
    • Castanheira, M.1    Woosley, L.N.2    Diekema, D.J.3
  • 27
    • 0028568052 scopus 로고
    • The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1, 3-beta-D-glucan synthase
    • Douglas CM, Foor F, Marrinan JA, et al. The Saccharomyces cerevisiae FKS1 (ETG1) gene encodes an integral membrane protein which is a subunit of 1, 3-beta-D-glucan synthase. Proc Natl Acad Sci USA. 1994;91:12907-11.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 12907-11
    • Douglas, C.M.1    Foor, F.2    Marrinan, J.A.3
  • 28
    • 0029128074 scopus 로고
    • Differential expression and function of two homologous subunits of yeast 1, 3-beta-D-glucan synthase
    • Mazur P, Morin N, Baginsky W, et al. Differential expression and function of two homologous subunits of yeast 1, 3-beta-D-glucan synthase. Mol Cell Biol. 1995;15:5671-81.
    • (1995) Mol Cell Biol , vol.15 , pp. 5671-81
    • Mazur, P.1    Morin, N.2    Baginsky, W.3
  • 29
    • 70349127708 scopus 로고    scopus 로고
    • Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1, 3-beta-D-glucan synthase: Implication for the existing susceptibility breakpoint
    • Garcia-Effron G, Lee S, Park S, et al. Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1, 3-beta-D-glucan synthase: implication for the existing susceptibility breakpoint. Antimicrob Agents Chemother. 2009;53:3690-9.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 3690-9
    • Garcia-Effron, G.1    Lee, S.2    Park, S.3
  • 30
    • 15844412765 scopus 로고    scopus 로고
    • In vitro activity of 1,3-beta-D-glucan synthase requires the GTP-binding protein Rho1
    • DOI 10.1074/jbc.271.24.14604
    • Mazur P, Baginsky W. In vitro activity of 1, 3-beta-D-glucan synthase requires the GTP-binding protein Rho1. J Biol Chem. 1996;271:14604-9. (Pubitemid 26190367)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.24 , pp. 14604-14609
    • Mazur, P.1    Baginsky, W.2
  • 31
    • 0031017918 scopus 로고    scopus 로고
    • Partial purification of (1,3)-beta-glucan synthase from Candida albicans
    • DOI 10.1016/S0378-1097(96)00485-5, PII S0378109796004855
    • Frost D, Brandt K, Estill C, et al. Partial purification of (1, 3)-beta-glucan synthase from Candida albicans. FEMS Microbiol Lett. 1997;146:255-61. (Pubitemid 27057731)
    • (1997) FEMS Microbiology Letters , vol.146 , Issue.2 , pp. 255-261
    • Frost, D.1    Brandt, K.2    Estill, C.3    Goldman, R.4
  • 32
    • 59749090444 scopus 로고    scopus 로고
    • Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: Implications for interpretive breakpoints
    • This comprehensive evaluation of fks mutant genotypes, MIC, and kinetic inhibition of glucan synthase from C. albicans reveals the need to reassess the initial clinical breakpoint
    • Garcia-Effron G, Park S, Perlin DS. Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: implications for interpretive breakpoints. Antimicrob Agents Chemother. 2009;53:112-22. This comprehensive evaluation of fks mutant genotypes, MIC, and kinetic inhibition of glucan synthase from C. albicans reveals the need to reassess the initial clinical breakpoint.
    • (2009) Antimicrob Agents Chemother , vol.53 , pp. 112-22
    • Garcia-Effron, G.1    Park, S.2    Perlin, D.S.3
  • 34
    • 4644370711 scopus 로고    scopus 로고
    • Caspofungin uptake is mediated by a high-affinity transporter in Candida albicans
    • DOI 10.1128/AAC.48.10.3845-3849.2004
    • Paderu P, Park S, Perlin DS. Caspofungin uptake is mediated by a high-affinity transporter in Candida albicans. Antimicrob Agents Chemother. 2004;48:3845-9. (Pubitemid 39304613)
    • (2004) Antimicrobial Agents and Chemotherapy , vol.48 , Issue.10 , pp. 3845-3849
    • Paderu, P.1    Park, S.2    Perlin, D.S.3
  • 35
    • 70049108302 scopus 로고    scopus 로고
    • Hsp90 orchestrates stress response signaling governing fungal drug resistance
    • Cowen LE. Hsp90 orchestrates stress response signaling governing fungal drug resistance. PLoS Pathog. 2009;5:e1000471.
    • (2009) PLoS Pathog , vol.5
    • Cowen, L.E.1
  • 36
    • 24144492350 scopus 로고    scopus 로고
    • Caspofungin susceptibility testing of isolates from patients with esophageal candidiasis or invasive candidiasis: Relationship of MIC to treatment outcome
    • DOI 10.1128/AAC.49.9.3616-3623.2005
    • Kartsonis N, Killar J, Mixson L, et al. Caspofungin susceptibility testing of isolates from patients with esophageal candidiasis or invasive candidiasis: relationship of MIC to treatment outcome. Antimicrob Agents Chemother. 2005;49:3616-23. (Pubitemid 41233008)
    • (2005) Antimicrobial Agents and Chemotherapy , vol.49 , Issue.9 , pp. 3616-3623
    • Kartsonis, N.1    Killar, J.2    Mixson, L.3    Hoe, C.-M.4    Sable, C.5    Bartizal, K.6    Motyl, M.7
  • 39
    • 33746922380 scopus 로고    scopus 로고
    • Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility
    • DOI 10.1128/AAC.00349-06
    • Katiyar S, Pfaller M, Edlind T. Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility. Antimicrob Agents Chemother. 2006;50:2892-4. (Pubitemid 44198725)
    • (2006) Antimicrobial Agents and Chemotherapy , vol.50 , Issue.8 , pp. 2892-2894
    • Katiyar, S.1    Pfaller, M.2    Edlind, T.3
  • 40
    • 79959192938 scopus 로고    scopus 로고
    • Disseminated candidiasis caused by Candida albicans with amino acid substitutions in Fks1 at position Ser645 cannot be successfully treated with micafungin
    • in press
    • Slater JL, Howard SJ, Sharp A, et al. Disseminated candidiasis caused by Candida albicans with amino acid substitutions in Fks1 at position Ser645 cannot be successfully treated with micafungin. Antimicrob Agents Chemother. 2011, in press.
    • (2011) Antimicrob Agents Chemother
    • Slater, J.L.1    Howard, S.J.2    Sharp, A.3
  • 41
    • 54049088997 scopus 로고    scopus 로고
    • Vivo pharmacodynamic target investigation for micafungin against Candida albicans and C. glabrata in a neutropenic murine candidiasis model
    • Andes DR, Diekema DJ, Pfaller MA, et al. In vivo pharmacodynamic target investigation for micafungin against Candida albicans and C. glabrata in a neutropenic murine candidiasis model. Antimicrob Agents Chemother. 2008;52:3497-503.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3497-503
    • Andes, D.R.1    Diekema, D.J.2    Pfaller, M.A.3
  • 42
    • 79955539687 scopus 로고    scopus 로고
    • Use of pharmacokineticpharmacodynamic analyses to optimize therapy with the systemic antifungal, micafungin, for invasive candidiasis or candidemia
    • Andes D, Ambrose PG, Hammel JP, et al. Use of pharmacokineticpharmacodynamic analyses to optimize therapy with the systemic antifungal, micafungin, for invasive candidiasis or candidemia. Antimicrob Agents Chemother. 2011;55:2113-21.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 2113-21
    • Andes, D.1    Ambrose, P.G.2    Hammel, J.P.3
  • 43
    • 77952620735 scopus 로고    scopus 로고
    • In vivo comparison of the pharmacodynamic targets for echinocandin drugs against Candida species
    • Andes D, Diekema DJ, Pfaller MA, et al. In vivo comparison of the pharmacodynamic targets for echinocandin drugs against Candida species. Antimicrob Agents Chemother. 2010;54:2497-506.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 2497-506
    • Andes, D.1    Diekema, D.J.2    Pfaller, M.A.3
  • 44
    • 50949119381 scopus 로고    scopus 로고
    • Mutations in the fks1 gene in Candida albicans C. tropicalis and C. krusei correlate with elevated caspofungin MICs uncovered in AM3 medium using the method of the European Committee on Antibiotic Susceptibility Testing
    • Desnos-Ollivier M, Bretagne S, Raoux D, et al. Mutations in the fks1 gene in Candida albicans, C. tropicalis, and C. krusei correlate with elevated caspofungin MICs uncovered in AM3 medium using the method of the European Committee on Antibiotic Susceptibility Testing. Antimicrob Agents Chemother. 2008;52:3092-8.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 3092-8
    • Desnos-Ollivier, M.1    Bretagne, S.2    Raoux, D.3
  • 45
    • 79955525326 scopus 로고    scopus 로고
    • Evaluation of caspofungin and micafungin CLSI M44-A2 Disk Diffusion and associated breakpoints testing using a well characterized panel of wild type and fks hot spot mutant Candida isolates
    • Arendrup MC, Park S, Brown S, et al. Evaluation of caspofungin and micafungin CLSI M44-A2 Disk Diffusion and associated breakpoints testing using a well characterized panel of wild type and fks hot spot mutant Candida isolates. Antimicrob Agents Chemother. 2011;55:1891-5.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 1891-5
    • Arendrup, M.C.1    Park, S.2    Brown, S.3
  • 46
    • 79955549399 scopus 로고    scopus 로고
    • Improved detection of Candida spp. fks hot spot mutants using the CLSI M27-A3 Document by the addition of Bovine Serum Albumin (BSA)
    • Garcia-Effron G, Park S, Perlin DS. Improved detection of Candida spp. fks hot spot mutants using the CLSI M27-A3 Document by the addition of Bovine Serum Albumin (BSA). Antimicrob Agents Chemother. 2011;55:2245-55.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 2245-55
    • Garcia-Effron, G.1    Park, S.2    Perlin, D.S.3
  • 47
    • 79953206974 scopus 로고    scopus 로고
    • Echinocandin susceptibility testing of Candida spp. using EUCAST EDef 7.1 and CLSI M27-A3 standard procedures: Analysis of the influence of bovine serum albumin supplementation, storage time, and drug lots
    • Arendrup MC, Rodriguez-Tudela JL, Park S, et al. Echinocandin susceptibility testing of Candida spp. using EUCAST EDef 7.1 and CLSI M27-A3 standard procedures: analysis of the influence of bovine serum albumin supplementation, storage time, and drug lots. Antimicrob Agents Chemother. 2011;55:1580-7.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 1580-7
    • Arendrup, M.C.1    Rodriguez-Tudela, J.L.2    Park, S.3
  • 48
    • 70350536660 scopus 로고    scopus 로고
    • Antifungal drug resistance: Do molecular methods provide a way forward?
    • Perlin DS. Antifungal drug resistance: do molecular methods provide a way forward? Curr Opin Infect Dis. 2009;22:568-73.
    • (2009) Curr Opin Infect Dis , vol.22 , pp. 568-73
    • Perlin, D.S.1
  • 49
    • 33744504444 scopus 로고    scopus 로고
    • Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FKS1
    • DOI 10.1128/AAC.01653-05
    • Balashov SV, Park S, Perlin DS. Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FKS1. Antimicrob Agents Chemother. 2006;50:2058-63. (Pubitemid 43807526)
    • (2006) Antimicrobial Agents and Chemotherapy , vol.50 , Issue.6 , pp. 2058-2063
    • Balashov, S.V.1    Park, S.2    Perlin, D.S.3
  • 50
    • 79960884598 scopus 로고    scopus 로고
    • Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance
    • in press
    • Ben-Ami R, Garcia-Effron G, Lewis RE, et al. Fitness and virulence costs of Candida albicans FKS1 hot spot mutations associated with echinocandin resistance. J Infect Dis. 2011, in press.
    • (2011) J Infect Dis
    • Ben-Ami, R.1    Garcia-Effron, G.2    Lewis, R.E.3


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