The antifungal echinocandin caspofungin acetate kills growing cells of Aspergillus fumigatus in vitro

Antimicrobial Agents and Chemotherapy

Volumn 46, Issue 9, 2002, Pages 3001-3012

  Bowman, J C ^a   Hicks, P Scott ^a   Kurtz, M B ^a   Rosen, H ^a   Schmatz, D M ^a   Liberator, P A ^a   Douglas, Cameron M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; CASPOFUNGIN; ECHINOCANDIN; FLUCONAZOLE; ITRACONAZOLE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS; ASPERGILLUS FUMIGATUS; CELL DEATH; COLONY FORMING UNIT; CONTROLLED STUDY; DOSE RESPONSE; DRUG SENSITIVITY; FUNGAL CELL; NONHUMAN; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; ANTIBIOTICS, ANTIFUNGAL; ASPERGILLUS FUMIGATUS; CELL COUNT; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORESCENT DYES; FLUOROMETRY; MICROBIAL SENSITIVITY TESTS; PEPTIDES; PEPTIDES, CYCLIC;

EID: 0036720290     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.46.9.3001-3012.2002     Document Type: Article

References (40)

1. Evaluation of the echinocandin antifungal MK-0991 (L-743,872): Efficacies in mouse models of disseminated aspergillosis, candidiasis, and cryptococcosis
2. Efficacy of the echinocandin caspofungin against disseminated aspergillosis and candidiasis in cyclophosphamide-induced immunosuppressed mice
3. The production of conidiophores and conidia by newly germinated conidia of Aspergillus niger (microcycle conidiation)
4. Chitin biosynthesis in protoplasts and subcellular fractions of Aspergillus fumigatus
5. Heterologous protein secretion by Aspergillus niger growing in submerged culture as dispersed or aggregated mycelia
6. In vitro preclinical evaluation studies with the echinocandin antifungal MK-0991 (L-743,872)
7. Oxonol dyes as monitors of membrane potential: The effect of viruses and toxins on the plasma membrane potential of animal cells in monolayer culture and in suspension
8. The behavior of oxonol dyes in phospholipid dispersions
9. Glucan synthase complex of Aspergillus fumigatus
10. Microcycle conidiation by regenerating protoplasts of Aspergillus awamori
11. Quantitative PCR assay to measure Aspergillus fumigatus burden in a murine model of disseminated aspergillosis: Demonstration of efficacy of caspofungin acetate
12. Comparative measurements of membrane potentials with microelectrodes and voltage-sensitive dyes
13. Lysis of growing yeast-form cells of Candidas albicans by echinocandin: A cytological study
14. The interaction of human monocytes, monocyte-derived macrophages, and polymorphonuclear neutrophils with caspofungin (MK-0991), an echinocandin, for antifungal activity against Aspergillus fumigatus
15. Synergy, pharmacodynamics, and time-sequenced ultrastructural changes of the interaction between nikkomycin Z and the echinocandin FK463 against Aspergillus fumigatus
16. Yeast vitality during cider fermentation: Two approaches to the measurement of membrane potential
17. Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-β-D-glucan synthase inhibitors
18. The Saccharomyces cerevisiae FKS1 (ETGI) gene encodes an integral membrane protein which is a subunit of 1,3-β-D-glucan synthase
19. In vitro pharmacodynamic properties of MK-0991 determined by time-kill methods
20. Comparison of in vitro activities of the new triazole SCH56592 and the echinocandins MK-0991 (L-743,872) and LY303366 against opportunistic filamentous and dimorphic fungi and yeasts
21. Rapid determination of antifungal activity by flow cytometry
22. Form and function of septa in filamentous fungi
23. Dispersed growth of Streptomyces in liquid culture
24. Development of a robust flow cytometric assay for determining numbers of viable bacteria
25. Isolation of a gene involved in 1,3-β-glucan synthesis in Aspergillus nidulans and purification of the corresponding protein
26. Morphological effects of lipopeptides against Aspergillus fumigatus correlate with activities against (1,3)-β-D-glucan synthase
27. Studies of in vitro activities of voriconazole and itraconazole against Aspergillus hyphae using viability staining
28. Assessment of the effect of amphotericin B on the vitality of Candida albicans
29. Organism-dependent fungicidal activities of azoles
30. Early events in macrophage killing of Aspergillus fumigatus conidia: New flow cytometric viability assay
31. Aspergillus nidulans swo mutants show defects in polarity establishment, polarity maintenance and hyphal morphogenesis
32. Antifungal efficacy of caspofungin (MK-0991) in experimental pulmonary aspergillosis in persistently neutropenic rabbits: Pharmacokinetics, drug disposition, and relationship to galactomannan antigenemia
33. Antifungal efficacy, safety, and single-dose pharmacokinetics of LY303366, a novel echinocandin B, in experimental pulmonary aspergillosis in persistently neutropenic rabbits
34. In vitro activity of two echinocandin derivatives, LY303366 and MK-0991 (L-743,792), against clinical isolates of Aspergillus, Fusarium, Rhizopus, and other filamentous fungi
35. Fluorescence microscopy methods for yeast
36. A glucan synthase FKS1 homolog in Cryptococcus neoformans is single copy and encodes an essential function
37. Effect of Junlon on morphology of Aspergillus niger and its use in making turbidity measurements of fungal growth
38. The relevance of a study of a temperature-sensitive ballooning mutant of Aspergillus nidulans defective in mannose metabolism to our understanding of mannose as a wall component and carbon/energy source