메뉴 건너뛰기




Volumn 6, Issue 1, 2011, Pages 161-172

Safety and efficacy of silodosin for the treatment of benign prostatic hyperplasia

Author keywords

Benign prostatic hyperplasia; Lower urinary tract symptoms; Selective; Silodosin

Indexed keywords

ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1B ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; NAFTOPIDIL; PHENYLEPHRINE; PLACEBO; PRAZOSIN; SILODOSIN; TAMSULOSIN;

EID: 80755143278     PISSN: 11769092     EISSN: 11781998     Source Type: Journal    
DOI: 10.2147/cia.s13803     Document Type: Review
Times cited : (35)

References (44)
  • 1
    • 33645463258 scopus 로고    scopus 로고
    • American Urological Association Guideline: Management of benign prostatic hyperplasia (BPH), Available from:, Accessed May 13, 2011
    • American Urological Association Guideline: Management of benign prostatic hyperplasia (BPH). 2010. Chapter 1: Guideline on the management of benign prostatic hyperplasia (BPH). Available from: http://www.auanet.org/content/guidelines-and-quality-care/clinical-guidelines.cfm?subcbph. Accessed May 13, 2011.
    • (2010) Chapter 1: Guideline on the management of benign prostatic hyperplasia (BPH)
  • 2
    • 33749315428 scopus 로고    scopus 로고
    • Benign prostatic hyperplasia: A review and ultrasound classification
    • Wasserman NF. Benign prostatic hyperplasia: A review and ultrasound classification. Radiol Clin North Am. 2006:44:689-710.
    • (2006) Radiol Clin North Am , vol.44 , pp. 689-710
    • Wasserman, N.F.1
  • 3
    • 0037454386 scopus 로고    scopus 로고
    • Benign prostatic hyperplasia
    • Thorpe A, Neal D. Benign prostatic hyperplasia. Lancet. 2003;361:1359-1367.
    • (2003) Lancet , vol.361 , pp. 1359-1367
    • Thorpe, A.1    Neal, D.2
  • 4
    • 34547798149 scopus 로고    scopus 로고
    • Benign prostatic hyperplasia: Etiology, pathophysiology, epidemiology, and natural history
    • In: Wein AJ, Kavoussi LR, Novick AC, et al, editors, 9th ed. Philadelphia, PA: WB Saunders
    • Roehrborn CG, McConnell JD. Benign prostatic hyperplasia: Etiology, pathophysiology, epidemiology, and natural history. In: Wein AJ, Kavoussi LR, Novick AC, et al, editors. Campbell-Walsh Urology. 9th ed. Philadelphia, PA: WB Saunders; 2007.
    • (2007) Campbell-Walsh Urology
    • Roehrborn, C.G.1    McConnell, J.D.2
  • 5
    • 44849136157 scopus 로고    scopus 로고
    • Benign prostatic hyperplasia as a progressive disease: A guide to the risk factors and options for medical management
    • Emberton M, Cornel EB, Bassi PF, et al. Benign prostatic hyperplasia as a progressive disease: A guide to the risk factors and options for medical management. Int J Clin Pract. 2008;62:1076-1086.
    • (2008) Int J Clin Pract , vol.62 , pp. 1076-1086
    • Emberton, M.1    Cornel, E.B.2    Bassi, P.F.3
  • 6
    • 48249138056 scopus 로고    scopus 로고
    • Alpha-adrenergic receptor antagonists in older patients with benign prostatic hyperplasia: Issues and potential complications
    • Fine SR, Ginsberg P. Alpha-adrenergic receptor antagonists in older patients with benign prostatic hyperplasia: Issues and potential complications. J Am Osteopath Assoc. 2008;108:333-337.
    • (2008) J Am Osteopath Assoc , vol.108 , pp. 333-337
    • Fine, S.R.1    Ginsberg, P.2
  • 7
    • 0032101088 scopus 로고    scopus 로고
    • Alpha-blockade therapy for benign prostatic hyperplasia: From a nonselective to a more selective alpha1A-adrenergic antagonist
    • Beduschi MC, Beduschi R, Oesterling JE. Alpha-blockade therapy for benign prostatic hyperplasia: From a nonselective to a more selective alpha1A-adrenergic antagonist. Urology. 1998;51:861-872.
    • (1998) Urology , vol.51 , pp. 861-872
    • Beduschi, M.C.1    Beduschi, R.2    Oesterling, J.E.3
  • 8
    • 0041382438 scopus 로고    scopus 로고
    • Lower urinary tract symptoms/benign prostatic hyperplasia: Maintaining symptom control and reducing complications
    • O'Leary MP. Lower urinary tract symptoms/benign prostatic hyperplasia: Maintaining symptom control and reducing complications. Urology. 2003;62 Suppl 1:15-23.
    • (2003) Urology , vol.62 , Issue.SUPPL. 1 , pp. 15-23
    • O'Leary, M.P.1
  • 9
    • 45549091557 scopus 로고    scopus 로고
    • Diagnosis and management of benign prostatic hyperplasia
    • Edwards JL. Diagnosis and management of benign prostatic hyperplasia. Am Fam Physician. 2008;77:1403-1410.
    • (2008) Am Fam Physician , vol.77 , pp. 1403-1410
    • Edwards, J.L.1
  • 10
    • 39849096422 scopus 로고    scopus 로고
    • Alpha1-adrenoceptor subtypes and lower urinary tract symptoms
    • Schwinn DA, Roehrborn CG. Alpha1-adrenoceptor subtypes and lower urinary tract symptoms. Int J Urol. 2008;15:193-199.
    • (2008) Int J Urol , vol.15 , pp. 193-199
    • Schwinn, D.A.1    Roehrborn, C.G.2
  • 11
    • 0029072209 scopus 로고
    • International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: Consensus update
    • Hieble JP, Bylund DB, Clarke DE, et al. International Union of Pharmacology. X. Recommendation for nomenclature of alpha 1-adrenoceptors: consensus update. Pharmacol Rev. 1995;47:267-270.
    • (1995) Pharmacol Rev , vol.47 , pp. 267-270
    • Hieble, J.P.1    Bylund, D.B.2    Clarke, D.E.3
  • 12
    • 0028815402 scopus 로고
    • Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: Sequence corrections and direct comparison with other species homologues
    • Schwinn DA, Johnston GI, Page SO, et al. Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: Sequence corrections and direct comparison with other species homologues. J Pharmacol Exp Ther. 1995;272:134-142.
    • (1995) J Pharmacol Exp Ther , vol.272 , pp. 134-142
    • Schwinn, D.A.1    Johnston, G.I.2    Page, S.O.3
  • 13
    • 4344572783 scopus 로고    scopus 로고
    • Update on human alpha1-adrenoceptor subtype signaling and genomic organization
    • Hawrylyshyn KA, Michelotti GA, Coge F, et al. Update on human alpha1-adrenoceptor subtype signaling and genomic organization. Trends Pharmacol Sci. 2004;25:449-455.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 449-455
    • Hawrylyshyn, K.A.1    Michelotti, G.A.2    Coge, F.3
  • 14
    • 0027976374 scopus 로고
    • Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: Implications for human alpha-adrenergic physiology
    • Price DT, Lefkowitz RJ, Caron MG, et al. Localization of mRNA for three distinct alpha 1-adrenergic receptor subtypes in human tissues: Implications for human alpha-adrenergic physiology. Mol Pharmacol. 1994;45:171-175.
    • (1994) Mol Pharmacol , vol.45 , pp. 171-175
    • Price, D.T.1    Lefkowitz, R.J.2    Caron, M.G.3
  • 15
    • 0027326003 scopus 로고
    • Identification, quantification, and localization of mRNA for three distinct alpha 1 adrenergic receptor subtypes in human prostate
    • Price DT, Schwinn DA, Lomasney JW, et al. Identification, quantification, and localization of mRNA for three distinct alpha 1 adrenergic receptor subtypes in human prostate. J Urol. 1993;150:546-551.
    • (1993) J Urol , vol.150 , pp. 546-551
    • Price, D.T.1    Schwinn, D.A.2    Lomasney, J.W.3
  • 16
    • 0030969734 scopus 로고    scopus 로고
    • Prostatic alpha 1-adrenoceptors and uroselectivity
    • Andersson KE, Lepor H, Wyllie MG. Prostatic alpha 1-adrenoceptors and uroselectivity. Prostate. 1997;30:202-215.
    • (1997) Prostate , vol.30 , pp. 202-215
    • Andersson, K.E.1    Lepor, H.2    Wyllie, M.G.3
  • 17
    • 0027326003 scopus 로고
    • Identification, quantification, and localization of mRNA for three distinct alpha 1 adrenergic receptor subtypes in human prostate
    • Price DT, Schwinn DA, Lomasney JW, Allen LF, Caron MG, Lefkowitz RJ. Identification, quantification, and localization of mRNA for three distinct alpha 1 adrenergic receptor subtypes in human prostate. J Urol. 1993;150:546-551.
    • (1993) J Urol , vol.150 , pp. 546-551
    • Price, D.T.1    Schwinn, D.A.2    Lomasney, J.W.3    Allen, L.F.4    Caron, M.G.5    Lefkowitz, R.J.6
  • 18
    • 0031596558 scopus 로고    scopus 로고
    • 1-adrenoceptor subtype mRNAs in human proximal urethra
    • 1-adrenoceptor subtype mRNAs in human proximal urethra. Br J Pharmacol. 1998;123:1289-1293.
    • (1998) Br J Pharmacol , vol.123 , pp. 1289-1293
    • Nasu, K.1    Moriyama, N.2    Fukasawa, R.3
  • 22
    • 40949149171 scopus 로고    scopus 로고
    • Development of silodosin
    • Yamazaki Y. Development of silodosin. Yakugaku Zasshi. 2006;126:207-208.
    • (2006) Yakugaku Zasshi , vol.126 , pp. 207-208
    • Yamazaki, Y.1
  • 23
    • 33645002966 scopus 로고    scopus 로고
    • 1-Adrenoceptor subtype selectivity and organ specificity of Silodosin (KMD-3213)
    • 1-Adrenoceptor subtype selectivity and organ specificity of Silodosin (KMD-3213). Yakugaku Zasshi. 2006;126:209-216.
    • (2006) Yakugaku Zasshi , vol.126 , pp. 209-216
    • Tatemichi, S.1    Kobayashi, K.2    Maezawa, M.3
  • 25
    • 33644998013 scopus 로고    scopus 로고
    • Effects of silodosin (KMD-3213) on phenylephrine-induced increase in intraurethral pressure and blood pressure in rats-study of the selectivity for lower urinary tract
    • Tatemichi S, Kobayashi K, Maruyama I, et al. Effects of silodosin (KMD-3213) on phenylephrine-induced increase in intraurethral pressure and blood pressure in rats-study of the selectivity for lower urinary tract. Yakugaku Zasshi. 2006;126:217-223.
    • (2006) Yakugaku Zasshi , vol.126 , pp. 217-223
    • Tatemichi, S.1    Kobayashi, K.2    Maruyama, I.3
  • 27
    • 33749572713 scopus 로고    scopus 로고
    • 1A-adrenoceptor selective antagonist for treating benign prostatic hyperplasia: Results of a Phase III randomized, placebo-controlled, double-blind study in Japanese men
    • 1A-adrenoceptor selective antagonist for treating benign prostatic hyperplasia: Results of a Phase III randomized, placebo-controlled, double-blind study in Japanese men. BJU Int. 2006;98:1019-1024.
    • (2006) BJU Int , vol.98 , pp. 1019-1024
    • Kawabe, K.1    Yoshida, M.2    Homma, Y.3
  • 28
    • 67349102059 scopus 로고    scopus 로고
    • Rapid efficacy of the highly selective alpha1 A-adrenoceptor antagonist silodosin in men with signs and symptoms of benign prostatic hyperplasia: Pooled results of 2 Phase III studies
    • Marks LS, Gittelman MC, Hill LA, Volinn W, Hoel G. Rapid efficacy of the highly selective alpha1 A-adrenoceptor antagonist silodosin in men with signs and symptoms of benign prostatic hyperplasia: Pooled results of 2 Phase III studies. J Urol. 2009;181:2634-2640.
    • (2009) J Urol , vol.181 , pp. 2634-2640
    • Marks, L.S.1    Gittelman, M.C.2    Hill, L.A.3    Volinn, W.4    Hoel, G.5
  • 29
    • 79551473561 scopus 로고    scopus 로고
    • Silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia: Results of an international, randomized, double-blind, placebo-and active-controlled clinical trial performed in Europe
    • European Silodosin Study Group
    • Chapple CR, Montorsi F, Tammela TJ, Wirth M, Koldewijn E, Fernandez EF; European Silodosin Study Group. Silodosin therapy for lower urinary tract symptoms in men with suspected benign prostatic hyperplasia: Results of an international, randomized, double-blind, placebo-and active-controlled clinical trial performed in Europe. Eur Urol. 2011;59:342-352.
    • (2011) Eur Urol , vol.59 , pp. 342-352
    • Chapple, C.R.1    Montorsi, F.2    Tammela, T.J.3    Wirth, M.4    Koldewijn, E.5    Fernandez, E.F.6
  • 30
    • 33751014241 scopus 로고    scopus 로고
    • 1A-adrenoceptor selective antagonist for the treatment of benign prostatic hyperplasia: Phase III long-term study
    • Silodosin Clinical Study Group
    • 1A-adrenoceptor selective antagonist for the treatment of benign prostatic hyperplasia: Phase III long-term study. Jap J Urol Surg. 2006;19:153-164.
    • (2006) Jap J Urol Surg , vol.19 , pp. 153-164
    • Kawabe, K.1    Yoshida, M.2    Arakawa, S.3    Takeuchi, H.4
  • 31
    • 70849089430 scopus 로고    scopus 로고
    • Silodosin in the treatment of the signs and symptoms of benign prostatic hyperplasia: A 9-month, open-label extension study
    • Marks LS, Gittelman MC, Hill LA, Volinn W, Hoel G. Silodosin in the treatment of the signs and symptoms of benign prostatic hyperplasia: A 9-month, open-label extension study. Urology. 2009;74:1318-1322.
    • (2009) Urology , vol.74 , pp. 1318-1322
    • Marks, L.S.1    Gittelman, M.C.2    Hill, L.A.3    Volinn, W.4    Hoel, G.5
  • 33
    • 71849107978 scopus 로고    scopus 로고
    • Efficacy of silodosin for relieving benign prostatic obstruction: Prospective pressure flow study
    • Matsukawa Y, Gotoh M, Komatsu T, Funahashi Y, Sassa N, Hattori R. Efficacy of silodosin for relieving benign prostatic obstruction: Prospective pressure flow study. J Urol. 2009;182:2831-2835.
    • (2009) J Urol , vol.182 , pp. 2831-2835
    • Matsukawa, Y.1    Gotoh, M.2    Komatsu, T.3    Funahashi, Y.4    Sassa, N.5    Hattori, R.6
  • 34
    • 77957285079 scopus 로고    scopus 로고
    • Short-term effects of crossover treatment with silodosin and tamsulosin hydrochloride for lower urinary tract symptoms associated with benign prostatic hyperplasia
    • Miyakita H, Yokoyama E, Onodera Y, et al. Short-term effects of crossover treatment with silodosin and tamsulosin hydrochloride for lower urinary tract symptoms associated with benign prostatic hyperplasia. Int J Urol. 2010;17:869-875.
    • (2010) Int J Urol , vol.17 , pp. 869-875
    • Miyakita, H.1    Yokoyama, E.2    Onodera, Y.3
  • 35
    • 34848818085 scopus 로고    scopus 로고
    • 1-Adrenoceptors and ejaculatory function
    • 1-Adrenoceptors and ejaculatory function. Br J Pharmacol. 2007;152:289-290.
    • (2007) Br J Pharmacol , vol.152 , pp. 289-290
    • Michel, M.C.1
  • 37
    • 0042885514 scopus 로고    scopus 로고
    • Lower urinary tract symptoms/benign prostatic hyperplasia: Minimizing morbidity caused by treatment
    • Schulman CC. Lower urinary tract symptoms/benign prostatic hyperplasia: Minimizing morbidity caused by treatment. Urology. 2003;62 Suppl 3A:24-33.
    • (2003) Urology , vol.62 , Issue.SUPPL. 3A , pp. 24-33
    • Schulman, C.C.1
  • 38
    • 34848847899 scopus 로고    scopus 로고
    • 1-Adrenoceptors are required for normal male sexual function
    • 1-Adrenoceptors are required for normal male sexual function. Br J Pharmacol. 2007;152:332-340.
    • (2007) Br J Pharmacol , vol.152 , pp. 332-340
    • Sanbe, A.1    Tanaka, Y.2    Fujiwara, Y.3
  • 39
    • 33749031267 scopus 로고    scopus 로고
    • Ejaculatory disorder caused by alpha-1adrenoceptor antagonists is not retrograde ejaculation but a loss of seminal emission
    • Hisasue S, Furuya R, Itoh N, Kobayashi K, Furuya S, Tsukamoto T. Ejaculatory disorder caused by alpha-1adrenoceptor antagonists is not retrograde ejaculation but a loss of seminal emission. Int J Urol. 2006;13:1311-1316.
    • (2006) Int J Urol , vol.13 , pp. 1311-1316
    • Hisasue, S.1    Furuya, R.2    Itoh, N.3    Kobayashi, K.4    Furuya, S.5    Tsukamoto, T.6
  • 40
    • 79956156019 scopus 로고    scopus 로고
    • Symptomatic and urodynamic responses in patients with reduced or no seminal emission during silodosin treatment for LUTS and BPH
    • Roehrborn CG, Kaplan SA, Lepor H, Volinn W. Symptomatic and urodynamic responses in patients with reduced or no seminal emission during silodosin treatment for LUTS and BPH. Prostate Cancer Prostatic Dis. 2011;14:143-148.
    • (2011) Prostate Cancer Prostatic Dis , vol.14 , pp. 143-148
    • Roehrborn, C.G.1    Kaplan, S.A.2    Lepor, H.3    Volinn, W.4
  • 41
    • 78649920033 scopus 로고    scopus 로고
    • Ejaculation disorder is associated with increased efficacy of silodosin for benign prostatic hyperplasia
    • Homma Y, Kawabe K, Takeda M, Yoshida M. Ejaculation disorder is associated with increased efficacy of silodosin for benign prostatic hyperplasia. Urology. 2010;76:1446-1450.
    • (2010) Urology , vol.76 , pp. 1446-1450
    • Homma, Y.1    Kawabe, K.2    Takeda, M.3    Yoshida, M.4
  • 43
    • 33845502549 scopus 로고    scopus 로고
    • Incidence of intraoperative floppy iris syndrome in patients on either systemic or topical i1-adrenoceptor antagonist
    • Oshika T, Ohashi Y, Inamura M, et al. Incidence of intraoperative floppy iris syndrome in patients on either systemic or topical i1-adrenoceptor antagonist. Am J Ophthalmol. 2007;143:150-151.
    • (2007) Am J Ophthalmol , vol.143 , pp. 150-151
    • Oshika, T.1    Ohashi, Y.2    Inamura, M.3
  • 44
    • 84856310027 scopus 로고    scopus 로고
    • United State Food and Drug Administration/Center for Drug Evaluation and Research, Application No. 022206. Available from:, Accessed on April 1, 2011
    • United State Food and Drug Administration/Center for Drug Evaluation and Research. Drug Approval Package, RAPAFLO (silodosin) capsules, Application No. 022206. Available from: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/022206s000TOC.cfm. Accessed on April 1, 2011.
    • Drug Approval Package, RAPAFLO (silodosin) capsules


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.