Strained dimethyl 2-(bromoselanyl)-5-tert-butylisophthalate: A reactive precursor for the synthesis of ebselen analogs

Tetrahedron Letters

Volumn 52, Issue 50, 2011, Pages 6831-6834

  Selvakumar, Karuthapandi ^a   Singh, Harkesh B ^a   Butcher, Ray J ^b  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

^b HOWARD UNIVERSITY   (United States)

Author keywords

Ebselen; Glutathione peroxidase; Heterocycles; Selenenyl halides; Selenium

Indexed keywords

DIMETHYL 2 (BROMOSELANYL) 5 TERT BUTYLISOPHTHALATE; EBSELEN; ORGANIC COMPOUND; UNCLASSIFIED DRUG;

ARTICLE; SYNTHESIS;

EID: 80755135428     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2011.10.067     Document Type: Article

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38. 2: C, 51.70; H, 4.96; N, 4.31. Found: C, 49.56; H, 5.05; N, 4.40.
39. +(100%).
40. 4Se: C, 50.57; H, 5.38; N, 3.93. Found: C, 49.78; H, 5.83; N, 4.33.
41. 3Se: C, 43.98; H, 5.43; N, 6.03. Found: C, 44.03; H, 5.35; 6.23.
42. 3Se: C, 50.01; H, 4.98; N, 3.64. Found: C, 49.59; H, 5.13; N, 2.61.
43. 3Se: C, 48.08; H, 4.84; N, 3.74. Found: C, 47.93; H, 3.92; N, 4.32.
44. 3SSe: 374.99. Found: 377.89 (100%).
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46. 11 Therefore, we speculate that if the ester groups are modified to the amide group, the antioxidant activity of such compounds could be enhanced.