2,4-Dichlorophenoxyacetic acid effects on nephrotoxicity in rats during late pregnancy and early postnatal periods

Ecotoxicology and Environmental Safety

Volumn 74, Issue 8, 2011, Pages 2316-2323

  Troudi, Afef ^a   Soudani, Nejla ^a   Mahjoubi Samet, Amira ^a   Ben Amara, Ibtissem ^a   Zeghal, Najiba ^a  

^a Faculté des Sciences de Sfax   (Tunisia)

Author keywords

2,4 D; Antioxidant status; Histological changes; Malondialdehyde; Nephrotoxicity; Suckling rats

Indexed keywords

2,4 DICHLOROPHENOXYACETIC ACID; ASCORBIC ACID; BIOLOGICAL MARKER; CATALASE; DRINKING WATER; GLUTATHIONE; GLUTATHIONE PEROXIDASE; MEMBRANE PROTEIN; PROTEIN CARBONYL; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ACETIC ACID; ANTIOXIDANT; ENZYME ACTIVITY; HISTOLOGY; PHYSIOLOGICAL RESPONSE; POLLUTION EFFECT; PREGNANCY; RODENT; TOXICITY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BOWMAN CAPSULE; CELL DEGENERATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; ENZYME KIDNEY LEVEL; FEMALE; FIRST TRIMESTER PREGNANCY; HISTOPATHOLOGY; KIDNEY TUBULE CELL; LIPID PEROXIDATION; NEPHROTOXICITY; NONHUMAN; PERINATAL PERIOD; PROTEIN CONTENT; PROTEIN KIDNEY LEVEL; RAT; SUCKLING; THIRD TRIMESTER PREGNANCY; TISSUE LEVEL; TOXICITY TESTING; VITAMIN KIDNEY LEVEL;

2,4-DICHLOROPHENOXYACETIC ACID; ANIMALS; ASCORBIC ACID; CATALASE; FEMALE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HERBICIDES; KIDNEY; PREGNANCY; RATS; RATS, WISTAR; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCES; TUNISIA;

RATTUS; RATTUS NORVEGICUS;

EID: 80755130468     PISSN: 01476513     EISSN: 10902414     Source Type: Journal    
DOI: 10.1016/j.ecoenv.2011.07.032     Document Type: Article

References (56)

1. Aebi H. Catalase in vitro. Methods Enzymol. 1984, 105:121-126.
2. Agrahari S., Pandy C.K., Gopal K. Biochemical alteration induced by monocrotophos in the blood plasma of fish, Channa punctatus (Bloch). Pest. Biochem. Physiol. 2007, 88:268-272.
3. Amer S.M., Aly F.A.E. Genotoxic effect of 2,4-dichlorophenoxyacetic acid and its metabolite 2,4-dichlorophenol in mouse. Mutat. Res. 2001, 494:1-12.
4. Balague C.E., Ruiz C.S., Rey R. Effect of herbicide 2,4-dichlorophenoxyacetic acid on uropathogenic Escherichia coli virulence factors. Toxicology 2002, 177:143-155.
5. Beauchamp C., Fridovich I. Superoxide dismutase: improved assays and an assay applicable to acrylamide gel. Anal. Biochem. 1971, 44:276-287.
6. Bortolozzi A., Duffard R., Evangelista de Duffard A.M. Behavioral alteration induced in rats by pre- and postnatal exposure to 2,4-dichlorophenoxyacetic acid. Neurotoxicol. Teratol. 1999, 21:451-465.
7. Bradberry S.M., Watt B.E., Proudfoot A.T., Vale J.A. Mechanism of toxicity, clinical features and management of acute chlorophenoxy herbicide poisoning: a review. Clin. Toxicol. 2000, 38:111-114.
8. Brand R.M., Spalding M., Mueller C. Sunscreens can increase dermal penetration of 2,4-dichlorophenoxyacetic acid. Clin. Toxicol. 2002, 40:827-831.
9. Brusco A., Pecci-Saavedra J., Garcia G., Tagliaferro P., Evangelista de Duffard A.M., Duffard R. 2,4-Dichlorophenoxyacetic acid through lactation induces astrogliosis in rat brain. Mol. Chem. Neuropathol. 1997, 30:175-185.
10. Bukowska B. Effects of 2,4-D and its metabolite 2,4dichlorophenol on antioxidant enzymes and level of glutathione in human erythrocytes. Comp. Biochem. Physiol. 2003, part C(135):435-441.
11. Celik I., Tuluce Y., Isik I. Influence of subacute treatment of some plant growth regulators on serum marker enzymes and erythrocyte and tissue antioxidant defense and lipidperoxidation in rats. J. Biochem. Mol. Toxicol. 2006, 20:174-182.
12. Celik I., Tuluce Y. Determination of toxicity of subacute treatment of some plant growth regulators on rats. Environ. Toxicol. 2007, 22:613-619.
13. Charles J.M., Hanley T.R., Wilson R.D., Van Raven B., Bus J.S. Developmental toxicity studies in rats and rabbits on 2,4-dichlorophenoxyacetic acid and its forms. Toxicol. Sci. 2001, 60:121-131.
14. Charrel, M., 1991. Urée et créatinine, in: Sémiologie biochimique (Urea and Creatinin), Ellipses Publisher, Paris, pp. 124-128.
15. Council of European Communities Council Instructions about the Protection of Living Animals used in Scientific Investigations 1986, Official Journal of the European Communities, (JO 86/609/CEE), 1-18).
16. Donadio C., Lucchesi A., Tramonti G., Bianchi C. Creatinine clearance predicted from body cells mass is a good indicator of renal function. Kidney Int. 1997, 52:166-168.
17. Draper H.H., Hadley M. Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol. 1990, 186:421-431.
18. Duffard R., Garcia G., Rosso S., Bortolozzi A., Madariaga M., Di Paolo O., Evangelista de Duff{ligature}ard A.M. Central Nervous System myelin defi{ligature}cit in rats exposed to 2,4-dichlorophenoxyacetic acid throughout lactation. Neurotoxicol. Teratol. 1996, 18:691-696.
19. Ellman G.L. Tissue sulfhydryl groups. Arch. Biochem. Biophys. 1959, 82:70-77.
20. Evangelista de Duffard A.M., Brusco A., Duffard R., Garcia G. Changes in serotonin-immunoactivity in the dorsal and median raphe nuclei of rats exposed to 2,4-dichlorophenoxyacetic acid through lactation. Mol. Chem. Neuropathol. 1995, 26:187-193.
21. Ferri A., Bortolozzi A., Duffard R., Evangelista de Duffard A.M. Monoamine levels in neonate rats lactationally exposed to 2,4dichlorophenoxyacetic acid. Biogen. Amines 2000, 16:73-100.
22. Ferri A., Duffard R., Stürtz N., Evangelista de Duffard A.M. Iron, zinc and copper levels in brain, serum and liver of neonates exposed to 2,4-dichorophenoxyacetic acid. Neurotoxicol. Teratol. 2003, 25:607-613.
23. Fishbeck K.L., Rasmussen K.M. Effect of repeated cycles on maternal nutritional status lactational performance and litter growth in ad libitum-fed and chronically food-restricted rats. J. Nutr. 1987, 117:1967-1975.
24. Flohe L., Gunzler W.A. Assays of glutathione peroxidase. Methods Enzymol. 1984, 105:114-121.
25. Garebrant D.H., Phtibert M.A. Review of 2,4-dichlorophenoxyacetic acid (2,4-D) epidemiology and toxicology. Crit. Rev. Toxicol. 2002, 32:233-236.
26. Gorzinski S.J., Kociba R.J., Cambell R.A., Smith F.A., Nolan R.J., Eisenbrandt D.L. Acute, pharmacokinetic and subchronic toxicological studies of 2,4-dichlorophenoxyacetic acid. Fundamental Appl. Toxicol. 1987, 9:423-435.
27. Halliwell B., Gutteridge J.M.C. Free Radicals in Biology and Medicine 1999, vol. 35. Oxford Science Publications, (Free Rad. Biol. Med. 117-132).
28. Halliwell B., Gutteridge J.M.C. Detection of free radicals and other reactive species: trapping and fingerprinting. Free Radicals in Biology and Medicine 2001, 351-425. Oxford University Press, Oxford.
29. Hooper D.C., Spitsin S., Kean R.B., Champion J.M., Dickson G.M., Chaudhry I. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl. Acad. Sci. USA 1998, 95:675-680.
30. Jacques-Silva M.C., Nogueira C.W., Broch L.C. Diphenyl diselenide and ascorbic acid changes deposition of selenium and ascorbic acid in liver and brain of mice. Pharm. Toxicol. 2001, 88:119-125.
31. Jollow D.J., Mitchell J.R., Zampaglione N., Gillete J.R. Bromobenzene induced liver necrosis: protective role of glutathione and evidence for 3,4-bromobenzeneoxide as the hepatotoxic intermediate. Pharmacology 1974, 11:151-169.
32. Kaczor J.J., Ziolkowski W., Popinigis J., Tarnopolsky M. Anaerobic and aerobic enzyme activities in human skeletal muscle from children and adults. Pediat. Res. 2005, 57:331-335.
33. Kalender S., Kalender Y., Ogutcu A., Uzunhisarcikli M. Endosulfan-induced cardiotoxicity and free radical metabolism in rats: the protective effect of Vitamin E. Toxicology 2004, 202:227-235.
34. Khera K.S., McKinley W.P. Pre and postnatal studies on 2,4,5trichlorophenoxy acid, 2,4-dichlorophenoxyacetic acid and their derivatives in rats. Toxicol. Appl. Pharmacol. 1972, 22:14-28.
35. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193:265-275.
36. Madrigal-Bujaidar E., Hernandez-Ceruelos A., Chamorro G. Induction of sister chromatid exchanges by 2,4-dichlorophenoxyacetic acid in somatic and germ cells of mice exposed in vivo. Food Chem. Toxicol. 2001, 39:941-948.
37. 3 on mice. Environ. Toxicol. Pharmacol. 2009, 27:259-263.
38. Padh H. Vitamin C: newer insights into its biochemical functions. Cell Mol. Biol. Lett. 2005, 10:255-264.
39. Palmeira A.J., Moreno V.M.C., Madeira A. Thiols metabolism is altered by the herbicides paraquat, dinoseb and 2,4-D: a study in isolated hepatocytes. Toxicol. Lett. 1995, 81:115-123.
40. Palmeira C.M., Moreno A.J., Madeira V.M.C. Interactions of herbicides 2,4-D and Dinoseb with liver mitochondrial bioenergetics. Toxicol. Appl. Pharmacol. 1994, (127):50-57.
41. Reznick A.Z., Packer L. Oxidative damage to proteins: spectrophotometric method for carbonyl. Methods in Enzymology 1994, Academic Press, New York, (pp. 357-359).
42. Romão P.R., Tovar J., Fonseca S.G., Moraes R.H. Glutathione and the redox control system trypanothione/trypanothione reductase are involved in the protection of Leishmania spp. against nitrosothiol-induced cytotoxicity. Braz. J. Med. Biol. Res. 2006, 39:355-363.
43. Romero-Puertas I., Mccarthy M., Gomez L.M., Sandalio F.J. Reactive oxygen species-mediated enzymatic systems involved in the oxidative action of 2,4-dichlorophenoxyacetic acid. Plant Cell Environ. 2004, 27:1135-1148.
44. Ruilope L.M., Garcia-Puig J. Hyperuricemia and renal function. Circulation 2007, 115:593-599.
45. Schwartz D. Méthodes statistiques à l'usage des médecins et des biologistes [Statistical Methods for Doctor and Biologist's Use] 1963, Flammarion Publishers, Paris.
46. Schwetz B.A., Sparschu G.L., Gehring P.J. The effect of 2,4-D on rat embryonal, foetal and neonatal growth and development. Food Cosmet. Toxicol. 1971, 9:801-817.
47. Stohs S.J., Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Rad. Biol. Med. 1995, 18:321-336.
48. Stürtz N., Bongiovanni B., Rassetto M., Ferri A., Evangelista de Duffard A.M., Duffard R. Detection of 2,4-dichlorophenoxyacetic acid in rat milk of dams exposed during lactation and milk analysis of their major components. Food Chem. Toxicol. 2006, 44:8-16.
49. Tripathi G., Shukla S.P. Malate and lactate dehydrogenases of a freshwater cat fish impact of endosulfan. Biomed. Environ. Sci. 1990, 3:52-58.
50. Troudi A., Ben Amara I., Samet A.M., Zeghal N. Oxidative stress induced by 2,4-phenoxyacetic acid in liver of female rats and their progeny: biochemical and histopathological studies. Environ. Toxicol 2010, 10.1002/tox.20624.
51. Uyanikgil Y., Ateş U., Baka M., Biçer S., Oztaş E., Ergen G. Immunohistochemical and histopathological evaluation of 2,4-dichlorophenoxyacetic acid-induced changes in rat kidney cortex. Bull. Environ. Contam. Toxicol. 2009, 82:749-755.
52. Van Der R.O., Jonny B., Vermeulen N.P.E. Fish accumulation and biomarkers in environnemental risk assessment: a review. Environ. Toxicol. Pharmacol. 2003, 13:57-149.
53. Verma R.S., Mhta A., Srivastava N. In vivo chlorpyrifos induced oxidative stress: attenuation by antioxidant vitamins. Pest. Biochem. Physiol. 2007, 88:191-196.
54. Wauchope R.D., Buttler T.M., Hornsby A.G., Augustijn-Beckers P.M. Pesticide properties database for environmental decision making. Rev. Environ. Contam. Toxicol. 1992, 123:7-22.
55. Yadav P., Sarkar S., Rhatnagar D. Action of Capparis deciduas against alloxan- induced oxidative stress and diabetes in rat tissues. Pharm. Res. 1997, 36:221-228.
56. Yu F., Wang Z., Ju B., Wang Y., Wang J., Bai D. Apoptotic effect of organophosphorus insecticide chlorpyrifos on mouse retina in vivo via oxidative stress and protection of combination of vitamin C and E. Exp. Toxicol. Pathol. 2008, 59:415-423.