Acute and multiple-dose studies to determine the safety, tolerability, and pharmacokinetic profile of advantame in healthy volunteers

Food and Chemical Toxicology

Volumn 49, Issue SUPPL. 1, 2011, Pages

  Warrington, S ^a   Lee, C ^b   Otabe, A ^c   Narita, T ^d   Polnjak, O ^e   Pirags, V ^e   Krievins, D ^e  

^a Hammersmith Medicines Research Limited and Trio Medicines Limited   (United Kingdom)

^b Deva Medical Consulting   (United Kingdom)

^c AJINOMOTO CO INC   (Japan)

^d Ajinomoto Pharmaceuticals Europe Ltd   (United Kingdom)

^e PAULS STRADINS CLINICAL UNIVERSITY HOSPITAL   (Latvia)

Author keywords

Advantame; Artificial sweetener; Man; Pharmacokinetics; Safety; Toxicokinetics

Indexed keywords

ADVANTAME; PLACEBO; SWEETENING AGENT; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; FEMALE; HALF LIFE TIME; HEADACHE; HUMAN; HUMAN EXPERIMENT; LIMIT OF QUANTITATION; MALE; NORMAL HUMAN; OPEN STUDY; PHARYNGITIS; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SAFETY; SORE THROAT; STEADY STATE; TOXICOKINETICS; UPPER RESPIRATORY TRACT INFECTION; VIRAL RESPIRATORY TRACT INFECTION;

ADULT; AREA UNDER CURVE; DIPEPTIDES; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; FEMALE; HALF-LIFE; HUMANS; MALE; SWEETENING AGENTS; YOUNG ADULT;

EID: 80755126863     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.06.043     Document Type: Article

References (2)

1. Amino Y., Mori K., Tomiyama Y., Sakata H., Fujieda T. Development of a new, low calorie sweetener: new aspartame derivative. Sweetness and Sweeteners: Biology, Chemistry and Psychophysics (ACS Symposium Series 979) 2008, 463-480. American Chemical Society (ACS), Washington, DC. K.W. Deepthi, G. DuBois (Eds.).
2. Ubukata, K., Nakayama, A., Mihara, R., 2011. Pharmacokinetics and metabolism of N [N[3-(3-hydroxy-4-methoxyphenyl) propyl]-α-aspartyl]-l-phenylalanine 1 methyl ester, monohydrate (advantame) in the rat, dog, and man. Food Chem. Toxicol.