Expression of Wnt-1, TGF-β and related cell-cell adhesion components following radiotherapy in salivary glands of patients with manifested radiogenic xerostomia

Radiotherapy and Oncology

Volumn 101, Issue 1, 2011, Pages 93-99

  Hakim, Samer George ^a   Ribbat, Julika ^a   Berndt, Alexander ^b   Richter, Petra ^b   Kosmehl, Hartwig ^c   Benedek, Geza A ^a   Jacobsen, Hans Christian ^a   Trenkle, Thomas ^a   Sieg, Peter ^a   Rades, Dirk ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

^b FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^c HELIOS KLINIKUM ERFURT   (Germany)

Author keywords

Catenin; Cell adhesion; Radiation; Salivary glands; TGF ; Wnt pathway

Indexed keywords

BETA CATENIN; TENASCIN; TRANSFORMING GROWTH FACTOR BETA; WNT1 PROTEIN;

ACINAR CELL; ARTICLE; CANCER RADIOTHERAPY; CELL ADHESION; CELL DIFFERENTIATION; CELL VIABILITY; CLINICAL ARTICLE; EPITHELIUM; HEAD AND NECK CANCER; HUMAN; HUMAN TISSUE; IMMUNOHISTOLOGY; IRRADIATION; MESENCHYME; PAROTID GLAND; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIATION INJURY; SALIVARY GLAND; SALIVARY GLAND DISEASE; STROMA; UPREGULATION; XEROSTOMIA;

CADHERINS; CELL ADHESION MOLECULES; CROSS-SECTIONAL STUDIES; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; PROGNOSIS; RADIOTHERAPY; RADIOTHERAPY DOSAGE; RISK ASSESSMENT; SALIVARY GLAND NEOPLASMS; SALIVARY GLANDS; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME; UP-REGULATION; WNT1 PROTEIN; XEROSTOMIA;

EID: 80655149015     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.07.032     Document Type: Article

References (27)

1. S.G. Hakim, H. Kosmehl, I. Lauer, R. Nadrowitz, T. Wedel, and P. Sieg The role of myoepithelial cells in the short-term radiogenic impairment of salivary glands. An immunohistochemical, ultrastructural and scintigraphic study Anticancer Res 22 2002 4121 4128 (Pubitemid 36134443)
2. S.G. Hakim, H. Jacobsen, and D. Hermes Early immunohistochemical and functional markers indicating radiation damage of the parotid gland Clin Oral Investig 8 2004 30 35
3. L. Hinck, W.J. Nelson, and J. Papkoff Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin J Cell Biol 124 1994 729 741
4. A. Letamendia, E. Labbe, and L. Attisano Transcriptional regulation by Smads: crosstalk between the TGF-beta and Wnt pathways J Bone Joint Surg Am 83-A 2001 S31 S39
5. D.Y. Dao, X. Yang, D. Chen, M. Zuscik, and R.J. O'Keefe Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways Ann NY Acad Sci 1116 2007 82 99 (Pubitemid 350274352)
6. J.D. Cox, J. Stetz, and T.F. Pajak Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC) Int J Radiat Oncol Biol Phys 31 1995 1341 1346
7. T. Dijkema, C.P. Raaijmakers, and R.K. Ten Haken Parotid gland function after radiotherapy: the combined michigan and utrecht experience Int J Radiat Oncol Biol Phys 78 2010 449 453
8. L.B. Marks, E.D. Yorke, and A. Jackson Use of normal tissue complication probability models in the clinic Int J Radiat Oncol Biol Phys 76 2010 S10 19
9. S.G. Hakim, H. Kosmehl, I. Lauer, R. Nadrowitz, T. Wedel, and P. Sieg A comparative study on the protection profile of lidocaine, amifostine, and pilocarpin on the parotid gland during radiotherapy Cancer Res 65 2005 10486 10493 (Pubitemid 41743744)
10. L.C. Stephens, K.K. Ang, T.E. Schultheiss, G.K. King, W.A. Brock, and L.J. Peters Target cell and mode of radiation injury in rhesus salivary glands Radiother Oncol 7 1986 165 174 (Pubitemid 17180969)
11. S. Bartel-Friedrich, R.E. Friedrich, C. Lautenschlager, H.J. Holzhausen, and R. Moll Dose-response relationships on the expression profile of cytokeratins and vimentin in rat submandibular glands following fractionated irradiation Anticancer Res 20 2000 4917 4926 (Pubitemid 32319053)
12. S. Bartel-Friedrich, R.E. Friedrich, C. Lautenschlager, and H.J. Holzhausen Dose-response relationships and the effect of age and latency period on the expression profile of laminin in irradiated rat mandibular glands Anticancer Res 20 2000 5221 5228 (Pubitemid 32319111)
13. F. Wehrhan, F. Rodel, G.G. Grabenbauer, K. Amann, W. Bruckl, and S. Schultze-Mosgau Transforming growth factor beta 1 dependent regulation of Tenascin-C in radiation impaired wound healing Radiother Oncol 72 2004 297 303 (Pubitemid 39265383)
14. S. Maschler, S. Grunert, A. Danielopol, H. Beug, and G. Wirl Enhanced tenascin-C expression and matrix deposition during Ras/TGF-beta-induced progression of mammary tumor cells Oncogene 23 2004 3622 3633 (Pubitemid 38658429)
15. K. Beiter, E. Hiendlmeyer, and T. Brabletz Beta-Catenin regulates the expression of tenascin-C in human colorectal tumors Oncogene 24 2005 8200 8204 (Pubitemid 41759818)
16. A. Ben-Ze'ev, and B. Geiger Differential molecular interactions of beta-catenin and plakoglobin in adhesion, signaling and cancer Curr Opin Cell Biol 10 1998 629 639 (Pubitemid 28477022)
17. Y. Araki, S. Okamura, and S.P. Hussain Regulation of cyclooxygenase-2 expression by the Wnt and ras pathways Cancer Res 63 2003 728 734 (Pubitemid 36158154)
18. K. Orford, C.C. Orford, and S.W. Byers Exogenous expression of beta-catenin regulates contact inhibition, anchorage-independent growth, anoikis, and radiation-induced cell cycle arrest J Cell Biol 146 1999 855 868
19. M. Nakashima, S. Meirmanov, and R. Matsufuji Altered expression of beta-catenin during radiation-induced colonic carcinogenesis Pathol Res Pract 198 2002 717 724 (Pubitemid 36032880)
20. H.W. Chang, J.L. Roh, and E.J. Jeong Wnt signaling controls radiosensitivity via cyclooxygenase-2-mediated Ku expression in head and neck cancer Int J Cancer 122 2008 100 107
21. O.K. Rodningen, J. Overgaard, J. Alsner, T. Hastie, and A.L. Borresen-Dale Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblasts Radiother Oncol 77 2005 231 240 (Pubitemid 41785330)
22. K. Kusafuka, A. Yamaguchi, T. Kayano, and T. Takemura Immunohistochemical localization of members of the transforming growth factor (TGF)-beta superfamily in normal human salivary glands and pleomorphic adenomas J Oral Pathol Med 30 2001 413 420 (Pubitemid 32635623)
23. M. Franz, T. Hansen, and L. Borsi A quantitative co-localization analysis of large unspliced tenascin-C(L) and laminin-5/gamma2-chain in basement membranes of oral squamous cell carcinoma by confocal laser scanning microscopy J Oral Pathol Med 36 2007 6 11 (Pubitemid 44973981)
24. B. Hinz, G. Gabbiani, and C. Chaponnier The NH2-terminal peptide of alpha-smooth muscle actin inhibits force generation by the myofibroblast in vitro and in vivo J Cell Biol 157 2002 657 663 (Pubitemid 34839793)
25. B. Hinz, G. Celetta, J.J. Tomasek, G. Gabbiani, and C. Chaponnier Alpha-smooth muscle actin expression upregulates fibroblast contractile activity Mol Biol Cell 12 2001 2730 2741 (Pubitemid 33051938)
26. E.H. Jho, T. Zhang, C. Domon, C.K. Joo, J.N. Freund, and F. Costantini Wnt/beta-catenin/Tcf signaling induces the transcription of Axin2, a negative regulator of the signaling pathway Mol Cell Biol 22 2002 1172 1183 (Pubitemid 34094853)
27. J. Yarnold, and M.C. Brotons Pathogenetic mechanisms in radiation fibrosis Radiother Oncol 97 2010 149 161