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Volumn 85, Issue 22, 2011, Pages 11916-11927

Roles of the envelope proteins in the amplification of covalently closed circular dna and completion of synthesis of the plus-strand DNA in hepatitis B virus

Author keywords

[No Author keywords available]

Indexed keywords

COVALENTLY CLOSED CIRCULAR DNA; DIHYDROLIPOAMIDE DEHYDROGENASE; M PROTEIN; PLUS STRAND DNA; UNCLASSIFIED DRUG; VIRUS DNA; VIRUS ENVELOPE PROTEIN; VITRONECTIN;

EID: 80655146213     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.05373-11     Document Type: Article
Times cited : (67)

References (57)
  • 1
    • 48949100877 scopus 로고    scopus 로고
    • Characterization of the contribution of spliced RNAs of hepatitis B virus to DNA synthesis in transfected cultures of Huh7 and HepG2 cells
    • Abraham, T. M., E. B. Lewellyn, K. M. Haines, and D. D. Loeb. 2008. Characterization of the contribution of spliced RNAs of hepatitis B virus to DNA synthesis in transfected cultures of Huh7 and HepG2 cells. Virology 379:30-37.
    • (2008) Virology , vol.379 , pp. 30-37
    • Abraham, T.M.1    Lewellyn, E.B.2    Haines, K.M.3    Loeb, D.D.4
  • 2
    • 0028095561 scopus 로고
    • Hepatitis B virus genome is organized into nucleosomes in the nucleus of the infected cell
    • Bock, C. T., P. Schranz, C. H. Schroder, and H. Zentgraf. 1994. Hepatitis B virus genome is organized into nucleosomes in the nucleus of the infected cell. Virus Genes 8:215-229.
    • (1994) Virus Genes , vol.8 , pp. 215-229
    • Bock, C.T.1    Schranz, P.2    Schroder, C.H.3    Zentgraf, H.4
  • 3
    • 0019887744 scopus 로고
    • Phase separation of integral membrane proteins in Triton X-114 solution
    • Bordier, C. 1981. Phase separation of integral membrane proteins in Triton X-114 solution. J. Biol. Chem. 256:1604-1607.
    • (1981) J. Biol. Chem. , vol.256 , pp. 1604-1607
    • Bordier, C.1
  • 4
    • 33845722719 scopus 로고    scopus 로고
    • Quantitative analysis of HBV cccDNA from clinical specimens: correlation with clinical and virological response during antiviral therapy
    • Bourne, E. J., et al. 2007. Quantitative analysis of HBV cccDNA from clinical specimens: correlation with clinical and virological response during antiviral therapy. J. Viral Hepat. 14:55-63.
    • (2007) J. Viral Hepat. , vol.14 , pp. 55-63
    • Bourne, E.J.1
  • 5
    • 9644260511 scopus 로고    scopus 로고
    • Envelopment of the hepatitis B virus nucleocapsid
    • Bruss, V. 2004. Envelopment of the hepatitis B virus nucleocapsid. Virus Res. 106:199-209.
    • (2004) Virus Res , vol.106 , pp. 199-209
    • Bruss, V.1
  • 6
    • 0030731672 scopus 로고    scopus 로고
    • A short linear sequence in the pre-S domain of the large hepatitis B virus envelope protein required for virion formation
    • Bruss, V. 1997. A short linear sequence in the pre-S domain of the large hepatitis B virus envelope protein required for virion formation. J. Virol. 71:9350-9357.
    • (1997) J. Virol. , vol.71 , pp. 9350-9357
    • Bruss, V.1
  • 7
    • 0026034960 scopus 로고
    • The role of envelope proteins in hepatitis B virus assembly
    • Bruss, V., and D. Ganem. 1991. The role of envelope proteins in hepatitis B virus assembly. Proc. Natl. Acad. Sci. U. S. A. 88:1059-1063.
    • (1991) Proc. Natl. Acad. Sci. U. S. A. , vol.88 , pp. 1059-1063
    • Bruss, V.1    Ganem, D.2
  • 8
    • 0028236042 scopus 로고
    • Post-translational alterations in transmembrane topology of the hepatitis B virus large envelope protein
    • Bruss, V., X. Lu, R. Thomssen, and W. H. Gerlich. 1994. Post-translational alterations in transmembrane topology of the hepatitis B virus large envelope protein. EMBO J. 13:2273-2279.
    • (1994) EMBO J , vol.13 , pp. 2273-2279
    • Bruss, V.1    Lu, X.2    Thomssen, R.3    Gerlich, W.H.4
  • 9
    • 0028013056 scopus 로고
    • Mapping a region of the large envelope protein required for hepatitis B virion maturation
    • Bruss, V., and R. Thomssen. 1994. Mapping a region of the large envelope protein required for hepatitis B virion maturation. J. Virol. 68:1643-1650.
    • (1994) J. Virol. , vol.68 , pp. 1643-1650
    • Bruss, V.1    Thomssen, R.2
  • 10
    • 13744253278 scopus 로고    scopus 로고
    • Evaluation of transcriptional efficiency of hepatitis B virus covalently closed circular DNA by reverse transcription-PCR combined with the restriction enzyme digestion method
    • Chou, Y. C., et al. 2005. Evaluation of transcriptional efficiency of hepatitis B virus covalently closed circular DNA by reverse transcription-PCR combined with the restriction enzyme digestion method. J. Virol. 79:1813-1823.
    • (2005) J. Virol. , vol.79 , pp. 1813-1823
    • Chou, Y.C.1
  • 11
    • 0020316090 scopus 로고
    • Electron microscopy of hepatitis B core antigen synthesized in E. coli
    • Cohen, B. J., and J. E. Richmond. 1982. Electron microscopy of hepatitis B core antigen synthesized in E. coli. Nature 296:677-679.
    • (1982) Nature , vol.296 , pp. 677-679
    • Cohen, B.J.1    Richmond, J.E.2
  • 12
  • 13
    • 0023428332 scopus 로고
    • Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen
    • Eble, B. E., D. R. MacRae, V. R. Lingappa, and D. Ganem. 1987. Multiple topogenic sequences determine the transmembrane orientation of the hepatitis B surface antigen. Mol. Cell. Biol. 7:3591-3601.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 3591-3601
    • Eble, B.E.1    MacRae, D.R.2    Lingappa, V.R.3    Ganem, D.4
  • 14
    • 0004250845 scopus 로고    scopus 로고
    • 5th ed. Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia, PA
    • Fields, B. N., D. M. Knipe, and P. M. Howley. 2007. Fields virology, 5th ed. Wolters Kluwer Health/Lippincott Williams & Wilkins, Philadelphia, PA.
    • (2007) Fields virology
    • Fields, B.N.1    Knipe, D.M.2    Howley, P.M.3
  • 15
    • 34249945560 scopus 로고    scopus 로고
    • Formation of hepatitis B virus covalently closed circular DNA: removal of genome-linked protein
    • Gao, W., and J. Hu. 2007. Formation of hepatitis B virus covalently closed circular DNA: removal of genome-linked protein. J. Virol. 81:6164-6174.
    • (2007) J. Virol. , vol.81 , pp. 6164-6174
    • Gao, W.1    Hu, J.2
  • 16
    • 70350328693 scopus 로고    scopus 로고
    • Drastic reduction in the production of subviral particles does not impair hepatitis B virus virion secretion
    • Garcia, T., et al. 2009. Drastic reduction in the production of subviral particles does not impair hepatitis B virus virion secretion. J. Virol. 83: 11152-11165.
    • (2009) J. Virol. , vol.83 , pp. 11152-11165
    • Garcia, T.1
  • 17
    • 0018937889 scopus 로고
    • Hepatitis B virus contains protein attached to the 5' terminus of its complete DNA strand
    • Gerlich, W. H., and W. S. Robinson. 1980. Hepatitis B virus contains protein attached to the 5' terminus of its complete DNA strand. Cell 21:801-809.
    • (1980) Cell , vol.21 , pp. 801-809
    • Gerlich, W.H.1    Robinson, W.S.2
  • 18
    • 36049013787 scopus 로고    scopus 로고
    • Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation
    • Guo, H., et al. 2007. Characterization of the intracellular deproteinized relaxed circular DNA of hepatitis B virus: an intermediate of covalently closed circular DNA formation. J. Virol. 81:12472-12484.
    • (2007) J. Virol. , vol.81 , pp. 12472-12484
    • Guo, H.1
  • 19
    • 72849136702 scopus 로고    scopus 로고
    • Production and function of the cytoplasmic deproteinized relaxed circular DNA of hepadnaviruses
    • Guo, H., R. Mao, T. M. Block, and J. T. Guo. 2010. Production and function of the cytoplasmic deproteinized relaxed circular DNA of hepadnaviruses. J. Virol. 84:387-396.
    • (2010) J. Virol. , vol.84 , pp. 387-396
    • Guo, H.1    Mao, R.2    Block, T.M.3    Guo, J.T.4
  • 20
    • 59849105037 scopus 로고    scopus 로고
    • Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells
    • Hantz, O., et al. 2009. Persistence of the hepatitis B virus covalently closed circular DNA in HepaRG human hepatocyte-like cells. J. Gen. Virol. 90: 127-135.
    • (2009) J. Gen. Virol. , vol.90 , pp. 127-135
    • Hantz, O.1
  • 21
    • 0021710644 scopus 로고
    • Large surface proteins of hepatitis B virus containing the pre-s sequence
    • Heermann, K. H., et al. 1984. Large surface proteins of hepatitis B virus containing the pre-s sequence. J. Virol. 52:396-402.
    • (1984) J. Virol. , vol.52 , pp. 396-402
    • Heermann, K.H.1
  • 22
    • 0025238448 scopus 로고
    • Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as well as for reverse transcription
    • Hirsch, R. C., J. E. Lavine, L. J. Chang, H. E. Varmus, and D. Ganem. 1990. Polymerase gene products of hepatitis B viruses are required for genomic RNA packaging as well as for reverse transcription. Nature 344:552-555.
    • (1990) Nature , vol.344 , pp. 552-555
    • Hirsch, R.C.1    Lavine, J.E.2    Chang, L.J.3    Varmus, H.E.4    Ganem, D.5
  • 24
    • 78149319907 scopus 로고    scopus 로고
    • Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner
    • Kock, J., et al. 2010. Generation of covalently closed circular DNA of hepatitis B viruses via intracellular recycling is regulated in a virus specific manner. PLoS Pathog. 6:e1001082.
    • (2010) PLoS Pathog , vol.6
    • Kock, J.1
  • 25
    • 0033987064 scopus 로고    scopus 로고
    • Hepatitis B virus core gene mutations which block nucleocapsid envelopment
    • Koschel, M., D. Oed, T. Gerelsaikhan, R. Thomssen, and V. Bruss. 2000. Hepatitis B virus core gene mutations which block nucleocapsid envelopment. J. Virol. 74:1-7.
    • (2000) J. Virol. , vol.74 , pp. 1-7
    • Koschel, M.1    Oed, D.2    Gerelsaikhan, T.3    Thomssen, R.4    Bruss, V.5
  • 26
    • 0035933758 scopus 로고    scopus 로고
    • Dual topology of the hepatitis B virus large envelope protein: determinants influencing post-translational pre-S translocation
    • Lambert, C., and R. Prange. 2001. Dual topology of the hepatitis B virus large envelope protein: determinants influencing post-translational pre-S translocation. J. Biol. Chem. 276:22265-22272.
    • (2001) J. Biol. Chem. , vol.276 , pp. 22265-22272
    • Lambert, C.1    Prange, R.2
  • 27
    • 0017756176 scopus 로고
    • Structure of hepatitis B Dane particle DNA and nature of the endogenous DNA polymerase reaction
    • Landers, T. A., H. B. Greenberg, and W. S. Robinson. 1977. Structure of hepatitis B Dane particle DNA and nature of the endogenous DNA polymerase reaction. J. Virol. 23:368-376.
    • (1977) J. Virol. , vol.23 , pp. 368-376
    • Landers, T.A.1    Greenberg, H.B.2    Robinson, W.S.3
  • 28
    • 33748939050 scopus 로고    scopus 로고
    • Intrahepatic levels and replicative activity of covalently closed circular hepatitis B virus DNA in chronically infected patients
    • Laras, A., J. Koskinas, E. Dimou, A. Kostamena, and S. J. Hadziyannis. 2006. Intrahepatic levels and replicative activity of covalently closed circular hepatitis B virus DNA in chronically infected patients. Hepatology 44:694-702.
    • (2006) Hepatology , vol.44 , pp. 694-702
    • Laras, A.1    Koskinas, J.2    Dimou, E.3    Kostamena, A.4    Hadziyannis, S.J.5
  • 29
    • 0020554617 scopus 로고
    • Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region
    • Laub, O., et al. 1983. Synthesis of hepatitis B surface antigen in mammalian cells: expression of the entire gene and the coding region. J. Virol. 48:271-280.
    • (1983) J. Virol. , vol.48 , pp. 271-280
    • Laub, O.1
  • 30
    • 0028145857 scopus 로고
    • Construction of avian hepadnavirus variants with enhanced replication and cytopathicity in primary hepatocytes
    • Lenhoff, R. J., and J. Summers. 1994. Construction of avian hepadnavirus variants with enhanced replication and cytopathicity in primary hepatocytes. J. Virol. 68:5706-5713.
    • (1994) J. Virol. , vol.68 , pp. 5706-5713
    • Lenhoff, R.J.1    Summers, J.2
  • 31
    • 0028334395 scopus 로고
    • Coordinate regulation of replication and virus assembly by the large envelope protein of an avian hepadnavirus
    • Lenhoff, R. J., and J. Summers. 1994. Coordinate regulation of replication and virus assembly by the large envelope protein of an avian hepadnavirus. J. Virol. 68:4565-4571.
    • (1994) J. Virol. , vol.68 , pp. 4565-4571
    • Lenhoff, R.J.1    Summers, J.2
  • 32
    • 77956188163 scopus 로고    scopus 로고
    • Development of cell cultures that express hepatitis B virus to high levels and accumulate cccDNA
    • Lentz, T. B., and D. D. Loeb. 2010. Development of cell cultures that express hepatitis B virus to high levels and accumulate cccDNA. J. Virol. Methods 169:52-60.
    • (2010) J. Virol. Methods , vol.169 , pp. 52-60
    • Lentz, T.B.1    Loeb, D.D.2
  • 33
    • 34447279278 scopus 로고    scopus 로고
    • The translocation motif of hepatitis B virus envelope proteins is dispensable for infectivity
    • Lepere, C., M. Regeard, J. Le Seyec, and P. Gripon. 2007. The translocation motif of hepatitis B virus envelope proteins is dispensable for infectivity. J. Virol. 81:7816-7818.
    • (2007) J. Virol. , vol.81 , pp. 7816-7818
    • Lepere, C.1    Regeard, M.2    Le Seyec, J.3    Gripon, P.4
  • 34
    • 0032981014 scopus 로고    scopus 로고
    • Infection process of the hepatitis B virus depends on the presence of a defined sequence in the pre-S1 domain
    • Le Seyec, J., P. Chouteau, I. Cannie, C. Guguen-Guillouzo, and P. Gripon. 1999. Infection process of the hepatitis B virus depends on the presence of a defined sequence in the pre-S1 domain. J. Virol. 73:2052-2057.
    • (1999) J. Virol. , vol.73 , pp. 2052-2057
    • Le Seyec, J.1    Chouteau, P.2    Cannie, I.3    Guguen-Guillouzo, C.4    Gripon, P.5
  • 35
    • 0031745654 scopus 로고    scopus 로고
    • Role of the pre-S2 domain of the large envelope protein in hepatitis B virus assembly and infectivity
    • Le Seyec, J., P. Chouteau, I. Cannie, C. Guguen-Guillouzo, and P. Gripon. 1998. Role of the pre-S2 domain of the large envelope protein in hepatitis B virus assembly and infectivity. J. Virol. 72:5573-5578.
    • (1998) J. Virol. , vol.72 , pp. 5573-5578
    • Le Seyec, J.1    Chouteau, P.2    Cannie, I.3    Guguen-Guillouzo, C.4    Gripon, P.5
  • 36
    • 0030916598 scopus 로고    scopus 로고
    • Production of hepatitis B virus covalently closed circular DNA in transfected cells is independent of surface antigen synthesis
    • Ling, R., and T. J. Harrison. 1997. Production of hepatitis B virus covalently closed circular DNA in transfected cells is independent of surface antigen synthesis. J. Gen. Virol. 78:1463-1467.
    • (1997) J. Gen. Virol. , vol.78 , pp. 1463-1467
    • Ling, R.1    Harrison, T.J.2
  • 37
    • 0038547689 scopus 로고    scopus 로고
    • Hepatitis B virus assembly is sensitive to changes in the cytosolic S loop of the envelope proteins
    • Loffler-Mary, H., J. Dumortier, C. Klentsch-Zimmer, and R. Prange. 2000. Hepatitis B virus assembly is sensitive to changes in the cytosolic S loop of the envelope proteins. Virology 270:358-367.
    • (2000) Virology , vol.270 , pp. 358-367
    • Loffler-Mary, H.1    Dumortier, J.2    Klentsch-Zimmer, C.3    Prange, R.4
  • 38
    • 0021075142 scopus 로고
    • Experimental transmission of duck hepatitis B virus
    • Mason, W. S., et al. 1983. Experimental transmission of duck hepatitis B virus. Virology 131:375-384.
    • (1983) Virology , vol.131 , pp. 375-384
    • Mason, W.S.1
  • 39
    • 35448950014 scopus 로고    scopus 로고
    • Hepatocyte turnover in transient and chronic hepadnavirus infections
    • Mason, W. S., S. Litwin, C. Xu, and A. R. Jilbert. 2007. Hepatocyte turnover in transient and chronic hepadnavirus infections. J. Viral Hepat. 14(Suppl. 1):22-28.
    • (2007) J. Viral Hepat. , vol.14 , Issue.SUPPL. 1 , pp. 22-28
    • Mason, W.S.1    Litwin, S.2    Xu, C.3    Jilbert, A.R.4
  • 40
    • 0021180942 scopus 로고
    • Hepatitis B virus DNA forms in nuclear and cytoplasmic fractions of infected human liver
    • Miller, R. H., and W. S. Robinson. 1984. Hepatitis B virus DNA forms in nuclear and cytoplasmic fractions of infected human liver. Virology 137:390- 399.
    • (1984) Virology , vol.137 , pp. 390-399
    • Miller, R.H.1    Robinson, W.S.2
  • 41
    • 77950490084 scopus 로고    scopus 로고
    • The pre-s2 domain of the hepatitis B virus is dispensable for infectivity but serves a spacer function for L-protein-connected virus assembly
    • Ni, Y., J. Sonnabend, S. Seitz, and S. Urban. 2010. The pre-s2 domain of the hepatitis B virus is dispensable for infectivity but serves a spacer function for L-protein-connected virus assembly. J. Virol. 84:3879-3888.
    • (2010) J. Virol. , vol.84 , pp. 3879-3888
    • Ni, Y.1    Sonnabend, J.2    Seitz, S.3    Urban, S.4
  • 42
    • 0028265897 scopus 로고
    • A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis
    • Ostapchuk, P., P. Hearing, and D. Ganem. 1994. A dramatic shift in the transmembrane topology of a viral envelope glycoprotein accompanies hepatitis B viral morphogenesis. EMBO J. 13:1048-1057.
    • (1994) EMBO J , vol.13 , pp. 1048-1057
    • Ostapchuk, P.1    Hearing, P.2    Ganem, D.3
  • 43
    • 0028859149 scopus 로고
    • Novel transmembrane topology of the hepatitis B virus envelope proteins
    • Prange, R., and R. E. Streeck. 1995. Novel transmembrane topology of the hepatitis B virus envelope proteins. EMBO J. 14:247-256.
    • (1995) EMBO J , vol.14 , pp. 247-256
    • Prange, R.1    Streeck, R.E.2
  • 44
    • 0016245955 scopus 로고
    • DNA of a human hepatitis B virus candidate
    • Robinson, W. S., D. A. Clayton, and R. L. Greenman. 1974. DNA of a human hepatitis B virus candidate. J. Virol. 14:384-391.
    • (1974) J. Virol. , vol.14 , pp. 384-391
    • Robinson, W.S.1    Clayton, D.A.2    Greenman, R.L.3
  • 45
    • 0018690283 scopus 로고
    • Hepatitis B viral DNA molecules have cohesive ends
    • Sattler, F., and W. S. Robinson. 1979. Hepatitis B viral DNA molecules have cohesive ends. J. Virol. 32:226-233.
    • (1979) J. Virol. , vol.32 , pp. 226-233
    • Sattler, F.1    Robinson, W.S.2
  • 46
    • 0035033218 scopus 로고    scopus 로고
    • Transfer of hepatitis B virus genome by adenovirus vectors into cultured cells and mice: crossing the species barrier
    • Sprinzl, M. F., H. Oberwinkler, H. Schaller, and U. Protzer. 2001. Transfer of hepatitis B virus genome by adenovirus vectors into cultured cells and mice: crossing the species barrier. J. Virol. 75:5108-5118.
    • (2001) J. Virol. , vol.75 , pp. 5108-5118
    • Sprinzl, M.F.1    Oberwinkler, H.2    Schaller, H.3    Protzer, U.4
  • 47
    • 0019949367 scopus 로고
    • Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate
    • Summers, J., and W. S. Mason. 1982. Replication of the genome of a hepatitis B-like virus by reverse transcription of an RNA intermediate. Cell 29:403-415.
    • (1982) Cell , vol.29 , pp. 403-415
    • Summers, J.1    Mason, W.S.2
  • 48
    • 0016818908 scopus 로고
    • Genome of hepatitis B virus: restriction enzyme cleavage and structure of DNA extracted from Dane particles
    • Summers, J., A. O'Connell, and I. Millman. 1975. Genome of hepatitis B virus: restriction enzyme cleavage and structure of DNA extracted from Dane particles. Proc. Natl. Acad. Sci. U. S. A. 72:4597-4601.
    • (1975) Proc. Natl. Acad. Sci. U. S. A. , vol.72 , pp. 4597-4601
    • Summers, J.1    O'Connell, A.2    Millman, I.3
  • 49
    • 0025334855 scopus 로고
    • Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification
    • Summers, J., P. M. Smith, and A. L. Horwich. 1990. Hepadnavirus envelope proteins regulate covalently closed circular DNA amplification. J. Virol. 64:2819-2824.
    • (1990) J. Virol. , vol.64 , pp. 2819-2824
    • Summers, J.1    Smith, P.M.2    Horwich, A.L.3
  • 50
    • 0025980689 scopus 로고
    • Morphogenetic and regulatory effects of mutations in the envelope proteins of an avian hepadnavirus
    • Summers, J., P. M. Smith, M. J. Huang, and M. S. Yu. 1991. Morphogenetic and regulatory effects of mutations in the envelope proteins of an avian hepadnavirus. J. Virol. 65:1310-1317.
    • (1991) J. Virol. , vol.65 , pp. 1310-1317
    • Summers, J.1    Smith, P.M.2    Huang, M.J.3    Yu, M.S.4
  • 51
    • 0023028191 scopus 로고
    • Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells
    • Tuttleman, J. S., C. Pourcel, and J. Summers. 1986. Formation of the pool of covalently closed circular viral DNA in hepadnavirus-infected cells. Cell 47:451-460.
    • (1986) Cell , vol.47 , pp. 451-460
    • Tuttleman, J.S.1    Pourcel, C.2    Summers, J.3
  • 52
    • 0025879364 scopus 로고
    • Three envelope proteins of hepatitis B virus: large S, middle S, and major S proteins needed for the formation of Dane particles
    • Ueda, K., T. Tsurimoto, and K. Matsubara. 1991. Three envelope proteins of hepatitis B virus: large S, middle S, and major S proteins needed for the formation of Dane particles. J. Virol. 65:3521-3529.
    • (1991) J. Virol. , vol.65 , pp. 3521-3529
    • Ueda, K.1    Tsurimoto, T.2    Matsubara, K.3
  • 53
    • 2942532722 scopus 로고    scopus 로고
    • Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy
    • Werle-Lapostolle, B., et al. 2004. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology 126:1750-1758.
    • (2004) Gastroenterology , vol.126 , pp. 1750-1758
    • Werle-Lapostolle, B.1
  • 55
    • 4644296081 scopus 로고    scopus 로고
    • Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients
    • Wong, D. K., et al. 2004. Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients. Hepatology 40:727-737.
    • (2004) Hepatology , vol.40 , pp. 727-737
    • Wong, D.K.1
  • 56
    • 0025329760 scopus 로고
    • In hepatocytes infected with duck hepatitis B virus, the template for viral RNA synthesis is amplified by an intracellular pathway
    • Wu, T. T., L. Coates, C. E. Aldrich, J. Summers, and W. S. Mason. 1990. In hepatocytes infected with duck hepatitis B virus, the template for viral RNA synthesis is amplified by an intracellular pathway. Virology 175:255-261.
    • (1990) Virology , vol.175 , pp. 255-261
    • Wu, T.T.1    Coates, L.2    Aldrich, C.E.3    Summers, J.4    Mason, W.S.5
  • 57
    • 13844250599 scopus 로고    scopus 로고
    • New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA
    • Zoulim, F. 2005. New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA. J. Hepatol. 42:302-308.
    • (2005) J. Hepatol. , vol.42 , pp. 302-308
    • Zoulim, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.