Synthesis and preliminary screening of novel a- and D-ring modified steroids as aromatase inhibitors

Letters in Drug Design and Discovery

Volumn 8, Issue 10, 2011, Pages 943-950

  Yadav, Mange Ram ^a   Sabale, Prafulla M ^a   Giridhar, Rajani ^a   Baria, Dharmendra ^a   Zimmer, Christina ^b   Hartmann, Rolf W ^b  

^a M S UNIVERSITY OF BARODA   (India)

^b SAARLAND UNIVERSITY   (Germany)

Author keywords

A D Heterosteroids; Androstanes; Aromatase; Aromatase Inhibitors; Azasteroids; Breast cancer

Indexed keywords

16,17A DIOXO 4 PHENYLTHIA 17 AZA DEXTRO HOMO 4 ANDROSTEN 3 ONE; 17A METHYL 4 PHENYLTHIA 17A AZA DEXTRO HOMO 4 ANDROSTEN 3 ONE; 17BETA HYDROXY 4 (4 FLUOROPHENYL) 4 AZA 5 ANDROSTEN 3 ONE; 17BETA HYDROXY 4 (4 TOLYL) 4 AZA 5 ANDROSTEN 3 ONE; 17BETA HYDROXY 4 AZA 5 ANDROSTEN 3 ONE; 17BETA HYDROXY 4 PHENYL 4 AZA 5 ANDROSTEN 3 ONE; 4 (4 AMINOPHENYLTHIA) 17 AZA DEXTRO HOMO 4 ANDROSTENE 3,16,17A TRIONE; 4 (4 AMINOPHENYLTHIA) 17A AZA DEXTRO HOMO 4 ANDROSTENE 3,17 DIONE; 4 HYDROXY 17 AZA DEXTRO HOMO 4 ANDROSTENE 3,16,17A TRIONE; 4 HYDROXY 17A AZA DEXTRO HOMO 4 ANDROSTENE 3,17 DIONE; 4 HYDROXY 17A METHYL 17A AZA DEXTRO HOMO 4 ANDROSTEN 3 ONE; 4 PHENYLTHIA 17A AZA DEXTRO HOMO 4 ANDROSTENE 3,17 DIONE; 4XI,5 OXIDO 17 AZA DEXTRO HOMO 5XI ANDROSTANE 3,16,17A TRIONE; AMINOGLUTETHIMIDE; ANDROGEN; ANDROSTENEDIONE DERIVATIVE; AROMATASE INHIBITOR; ESTROGEN; PYRIDOGLUTETHIMIDE; STEROID; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG CONFORMATION; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ASSAY; ENZYME BINDING; ENZYME INHIBITION; ENZYME MECHANISM; ESTROGEN SYNTHESIS; HUMAN; PRIORITY JOURNAL;

EID: 80655143437     PISSN: 15701808     EISSN: 1875628X     Source Type: Journal    
DOI: 10.2174/157018011797655322     Document Type: Article

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