Gadolinium-containing inorganic nanostructures for biomedical applications: Cytotoxic aspects

ICONN 2010 - Proceedings of the 2010 International Conference on Nanoscience and Nanotechnology

Volumn , Issue , 2010, Pages 225-229

  Hemmer, Eva ^a   Yamano, Tomoyoshi ^a   Kishimoto, Hidehiro ^a   Soga, Kohei ^a  

^a TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Bioimaging; Cytotoxicity; Gadolinium oxide; Surface modification; Upconversion

Indexed keywords

BIO-IMAGING; BIOLOGICAL PHENOMENA; BIOMEDICAL APPLICATIONS; CYTOTOXIC; DIAGNOSTIC TOOLS; GADOLINIUM OXIDE; INORGANIC NANOSTRUCTURES; MORPHOLOGY EFFECT; UP-CONVERSION;

BIOCOMPATIBILITY; CYTOTOXICITY; ERBIUM; GADOLINIUM; MEDICAL APPLICATIONS; NANORODS; VISUALIZATION; YTTERBIUM;

NANOSCIENCE;

EID: 80555157652     PISSN: None     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1109/ICONN.2010.6045165     Document Type: Conference Paper

References (22)

1. V. Wagner, A. Dullaart, A.-K. Bock, and A. Zweck, "The emerging nanomedicine landscape," Nat. Biotechnol., vol. 24, pp. 1211-1217, 2006.
2. O. V. Salata, "Applications of nanoparticles in biology and medicine," J. Nanobiotechnol., vol. 2, 6 pp, 2004.
3. A. Doat, M. Fanjul, F. Pellé, E. Hollande, and A. Lebugle, "Europiumdoped bioapatite: a new photostable biological probe, internalizable by human cells," Biomaterials, vol. 24, pp. 3365-3371, 2003.
4. N. C. Shaner, M. Z. Lin, M. R. McKeown, P. A. Steinbach, K. L. Hazelwood, M. W. Davidson, and R. Y. Tsien, "Improving the photostability of bright monomeric orange and red fluorescent proteins," Nature Methods, vol. 5, pp. 545-551, 2008.
5. M. Kamimura, D. Miyamoto, Y. Saito, K. Soga, and Y. Nagasaki, "Design of poly(ethylene glycol)/streptavidin coimmobilized upconversion nanophosphors and their application to fluorescence biolabeling," Langmuir, vol. 24, pp. 8864-8870, 2008.
6. S. F. Lim, R. Riehn, W. S. Ryu, N. Khanarian, C. Tung, D. Tank, and R. H. Austin, "In vivo and scanning electron microscopy imaging of upconverting nanophosphors in caenorhabditis elegans," Nano Lett., vol. 6, pp. 169-174, 2006.
7. R. R. Anderson, and J. A. Parrish, "The optics of human skin," J. Invest. Dermatol., vol. 77, pp. 13-19, 1981.
8. O. R. Moss, "Insights into the health effects of nanoparticles: why numbers matter," Int. J. Nanotechnol., vol. 5, pp. 3-14, 2008.
9. C. M. Sayes, and D. B. Warheit, "An in vitro investigation of the differential cytotoxic responses of human and rat lung epithelial cell lines using TiO2 nanoparticles," Int. J. Nanotechnol., vol. 5, pp. 15-29, 2008.
10. K. Soto, K. M. Garza, and L. E. Murr, "Cytotoxic effects of aggregated nanomaterials," Acta Biomaterialia, vol. 3, pp. 351-358, 2007.
11. S. Hirano, and K. T. Suzuki, "Exposure, metabolism, and toxicity of rare earths and related compounds," Environ. Health Persp., vol. 104 [Supplement 1], pp. 85-95, 1996.
12. M. A. McDonald, and K. L. Watkin, "Small particulate gadolinium oxide and gadolinium oxide albumin microspheres as multimodal contrast and therapeutic agents," Invest. Radiol., vol. 38, pp. 305-310, 2003.
13. E. Hemmer, Y. Kohl, V. Colquhoun, H. Thielecke, K. Soga, and S. Mathur, "Probing cytotoxicity of Gd(OH)3 nanostructures", J. Phys. Chem. B, vol. 114, pp. 4358-365, 2010.
14. E. Matijevic, and W. P. Hsu, "Preparation and properties of monodispersed colloidal particles of lanthanide compounds," J. Colloid Interface Sci., vol. 118, pp 506-523, 1987.
15. I. Y. Park, D. Kim, J. Lee, S. H. Lee and K.-J. Kim, "Effects of urea concentration and reaction temperature on morphology of gadolinium compounds prepared by homogeneous precipitation," Mater. Chem. Phys., vol. 106, pp. 149-157, 2007.
16. V. Nallusamy, E. Hemmer, H. Hyodo, and K. Soga, "Facile surfactant assisted synthesis of Er3+ doped Y2O3 nanophosphors for upconversion bioimaging," unpublished.
17. E. Hemmer, T. Yamano, H. Kishimoto, and Kohei Soga, "Cytotoxicity of Gd2O3:Ln3+ nanostructures and their potential as biomarkers," Proc. 7th International Conference on f Elements, ICfE-7, G. Meyer, ed., 2009, Cologne, Germany, in press.
18. K. Soga, Y. Okumura, K. Tsuji, and N. Venkatachalam, "Effect of K3PO4 addition as sintering inhibitor during calcination of Y2O3 nanoparticles," J. Phys.: Conference Series,vol. 191, 012003, 7 pp, 2009.
19. K. Soga, Y. Saito, K. Shimizu, H. Nagata, T. Konishi, and Y. Nagasaki, "Preparation and surface modification of rare-earth doped ceramic nanophosphors for fluorescence bio imaging," MRS Fall Meeting Proc., MA.E2.3, 2006.
20. T. Zako, H. Nagata, N. Terada, M. Sakono, K. Soga, and M. Maeda, "Improvement of dispersion stability and characterization of upconversion nanophosphores covalently modified PEG as a fluorescence bioimaging probe," J. Mater. Sci. vol. 43, pp. 5325-5330, 2008.
21. M. Kamimura, D. Miyamoto, Y. Saito, K. Soga, and Y. Nagasaki, "Prepration of PEG and protein co-immobilized upconversion nanophosphores as near-infrared biolabeling materials," J. Photopolymer Sci Technol., vol. 21, pp. 183-187, 2008.
22. L. E. van Vlerken, T. K. Vyas, andM. M. Amiji, "Poly(ethylene glycol)-modified nanocarriers for tumor-targeted and intracellular delivery," Pharm. Res., vol. 24, pp. 1405-1414, 2007.