Simultaneous determination of nitrendipine and hydrochlorothiazide in spontaneously hypertensive rat plasma using HPLC with on-line solid-phase extraction

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 879, Issue 30, 2011, Pages 3459-3464

  Shang, Dewei ^a,b   Wang, Xipei ^b   Zhao, Xiutai ^c   Huang, Fengming ^b   Tian, Ganzhong ^a   Lu, Wei ^a,b   Zhou, Tianyan ^a,b  

^a PEKING UNIVERSITY   (China)

^b PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^c Dionex China Ltd   (China)

Author keywords

Hydrochlorothiazide; Nitrendipine; On line solid phase extraction; Pharmacokinetics; Spontaneously hypertensive rat

Indexed keywords

ACCEPTABLE LIMIT; ANALYTICAL COLUMNS; COLUMN TEMPERATURE; HIGH-ABUNDANCE PROTEINS; HPLC METHOD; HYDROCHLOROTHIAZIDE; LOWER LIMIT OF DETECTIONS; MATRIX; NITRENDIPINE; ON-LINE SOLID PHASE EXTRACTION; ON-LINE SPE; OPTIMAL DETECTION; PLASMA SAMPLES; RAT PLASMA; RUNTIMES; SIMULTANEOUS DETERMINATIONS; SPONTANEOUSLY HYPERTENSIVE RAT; SPONTANEOUSLY HYPERTENSIVE RATS; VALIDATION PERIODS;

CARBOXYLIC ACIDS; EXTRACTION; OILS AND FATS; PHARMACOKINETICS; PLASMAS; RATS;

PYRIDINE;

HYDROCHLOROTHIAZIDE; NITRENDIPINE;

ACCURACY; ARTICLE; DRUG BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIMIT OF DETECTION; LOWER LIMIT OF DETECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIVITY ANALYSIS; SOLID PHASE EXTRACTION; TEMPERATURE MEASUREMENT;

ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HYDROCHLOROTHIAZIDE; HYPERTENSION; LEAST-SQUARES ANALYSIS; NITRENDIPINE; RATS; RATS, INBRED SHR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TEMPERATURE;

RATTUS;

EID: 80555150614     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.09.025     Document Type: Article

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