Quantitative determination of nitrendipine and its metabolite dehydronitrendipine in human plasma using liquid chromatography-tandem mass spectrometry

Biomedical Chromatography

Volumn 15, Issue 8, 2001, Pages 518-524

  Chen, Xiaoyan ^a   Zhong, Dafang ^a   Yang, Hanyu ^a   Luan, Yan ^a   Xu, Haiyan ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ATMOSPHERIC IONIZATION; ATMOSPHERIC PRESSURE; DATA ACQUISITION; DATA HANDLING; DRUG PRODUCTS; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN); PYRIDINE;

ANALYTES; HIGH-THROUGHPUT; HUMAN PLASMAS; LC-MS-MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; NIFEDIPINE; NITRENDIPINE; QUANTITATIVE DETERMINATIONS; SIMULTANEOUS DETERMINATIONS;

METABOLITES;

DRUG METABOLITE; NIFEDIPINE; NITRENDIPINE;

ACCURACY; ANALYTIC METHOD; ARTICLE; CHEMICAL REACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; HUMAN; HUMAN EXPERIMENT; INFORMATION PROCESSING; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETER; MASS SPECTROMETRY; NORMAL HUMAN; STANDARD; TANDEM MASS SPECTROMETRY; TIME; VOLUNTEER;

EID: 0035668229     PISSN: 02693879     EISSN: None     Source Type: Journal    
DOI: 10.1002/bmc.104     Document Type: Article

References (9)

1. Quantification of nitrendipine in plasma by a capillary column gas chromatographic-mass spectrometric method
2. High-performance liquid chromatography of the metabolites of nitrendipine and investigation into the metabolic pathways of this dihydropyridine
3. Bioequivalence and metabolism of nitrendipine administered orally to healthy volunteers
4. 14C-nitrendipine in healthy volunteers
5. Nitrendipine: Identification and synthesis of main metabolites
6. Application of stable isotope methodology to study the pharmacokinetics, bioavailability and metabolism of nitrendipine after i.v. and p.o. administration
7. Gas chromatographic analysis of nitrendipine and its pyridine metabolite in human plasma
8. Grapefruit juice and cimetidine inhibit stereoselective metabolism of nitrendipine in humans
9. An antibody to dihydropyridine calcium entry blockers. A comparison with the calcium channel receptor in skeletal muscle